标题: 复旦大学化学系化学生物学张琪 [打印本页]
作者: sujue    时间: 2018-3-25 13:20
标题: 复旦大学化学系化学生物学张琪
张琪，理学博士，博士生导师，复旦大学化学系教授。2003年毕业于复旦大学化学系，获理学学士学位；2010年毕业于中科院上海有机化学研究所，获理学博士学位。2011年至2014年在美国伊利诺伊大学香槟分校开展博士后研究，2014年获得中组部资助，回到复旦大学化学系独立开展工作。主要研究兴趣涉及新型抗生素的发现、生物合成及作用机制研究。自2014年独立工作至今，以通讯作者在PNAS、Nat. Commmun.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed. 等国内外著名学术刊物发表论文二十余篇，相关研究成果被美国化学化工新闻周刊C&E News等媒体予以专文报导，并被Science、Faculty of 1000、Nat．Prod. Rep.、Curr. Opin. Biotech.等多个杂志予以亮点评述。曾获得包括国际化学生物学会青年化学生物学家奖 (2107)、化学结构学会奖 (2016) 等多个国际性奖项，目前担任《Frontiers in Chemistry》杂志副主编。

张琪，有机化学、化学生物学，教授，博士生导师
电子邮箱：qizhang_chem@fudan.edu.cn; qizhang@sioc.ac.cn
办公地点：邯郸路220号复旦大学袁成英楼415
电话：86-21-65648172
传真：86-21-65648172
课题组主页：http://www.chemfudan.com/
研究兴趣
活性多肽类化合物的化学生物学研究
特殊金属酶学机制。
学术任职
《Frontiers in Chemistry》杂志副主编，《Science》等多个杂志特约审稿人
获奖情况
学习工作经历
1999.9年9月至2003年7月 复旦大学化学系获得学士学位
授课情况



化学生物学导论CHEM130091.01
代表性论文或专著

1.  Characterization of a C3 deoxygenation pathway reveals a key branch point in aminoglycoside biosynthesis
Meinan Lv, Xinjian Ji, Junfeng Zhao, Yongzhen Li, Chen Zhang, Li Su, Wei Ding, Zixin Deng, Yi Yu* and Qi Zhang*
J. Am. Chem. Soc. 2016, In press.

2.  Biosynthetic investigation of phomopsins revealed a widespread pathway for ribosomal natural products in filamentous fungi
Wei Ding, Wan-Qiu Liu, Youli Jia, Yongzhen Li, Wilfred A van der Donk*, and Qi Zhang*
Proc. Natl. Acad. Sci. 2016, 113, 3521-6


3.  Mechanistic Insights into the Radical S-adenosyl-l-methionine Enzyme NosL From a Substrate Analogue and the Shunt Products.
Xianjian Ji, Yongzhen Li, Youli Jia, Wei Ding, Qi Zhang*
Angew Chem Int Ed Engl. 2016, 55, 3334-7

4.  Substrate-Tuned Catalysis of the Radical S-Adenosyl-L-Methionine Enzyme NosL Involved in Nosiheptide Biosynthesis
Xianjian Ji, Yongzhen Li, Wei Ding, Qi Zhang*
Angew Chem Int Ed Engl. 2015, 54, 9021-4

5.  Substrate-controlled stereochemistry in enzyme catalysis
Wei Ding, Yongzhen Li, and Qi Zhang*
ACS Chem Biol. 2015, 10, 1590-8

6. Expanded natural product diversity revealed by analysis of lanthipeptide-like gene clusters in Actinobacteria
Qi Zhang, James R. Doroghazi, Xiling Zhao, Mark C. Walker, and Wilfred A. van der Donk*
Appl. Environ. Microbiol., 2015, 81, 4339-50

7. High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesis
Qi Zhang, Xiao Yang, Huan Wang, and Wilfred A. van der Donk*
ACS Chem. Biol. 2014, 9, 2686-2694

8. Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS
Qi Zhang, Manuel A. Ortega, Yanxiang Shi, Huan Wang, Joel O. Melby, Douglas A. Mitchell, and Wilfred A. van der Donk*
Proc. Natl. Acad. Sci. 2014, 111,12031-12036

9. Aromatic Polyketides Produced by Bacterial Iterative Type I Polyketide Synthases
Qi Zhang, Bo Pang, Wei Ding, and Wen Liu*
ACS Catal., 2013, 3, 1439–1447

10. Biosynthesis of thiopeptide antibiotics and their pathway engineering
Qi Zhang and Wen Liu*
Nat. Prod. Rep., 2013, 30, 218-226

11. Evolution of lanthipeptide synthetases
Qi Zhang, Yi Yu, Juan E. Vélasquez, and Wilfred. A. van der Donk*
Proc. Natl. Acad. Sci., 2012, 109, 18361-18366.

12. Catalytic promiscuity of a bacterial α-N-methyltransferase
Qi Zhang and Wilfred. A. van der Donk*
FEBS Lett., 2012, 586, 3391-3397


13. Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS
Qi Zhang, Wilfred. A. van der Donk*, and Wen Liu*
Acc. Chem. Res., 2012, 45, 555-64.

14. Complex Biotransformations Catalyzed by Radical S-Adenosylmethionine Enzymes
Qi Zhang* and Wen Liu*
J. Biol. Chem., 2011, 286, 30245-30252.

15. Characterization of NocL Involved in Thiopeptide Nocathiacin I biosynthesis: A [4Fe-4S] Cluster and the Catalysis of a Radical S-Adenosylmethionine Enzyme
Qi Zhang, Dandan Chen, Jin Lin, Rijing, Liao, Wei Tong, and Wen Liu*
J. Biol. Chem., 2011, 286, 21287-21294.

16. Radical-Mediated Enzymatic Carbon Chain Fragmentation-Recombination.
Qi Zhang, Yuxue Li, Dandan Chen, Yi Yu, Lian Duan, Ben Shen, and Wen Liu*
Nat. Chem. Biol., 2011, 7, 154-160. [This paper was highlighted in (1) Science. 2011, 331, 1366; (2) Nat. Chem. Biol., 2011, 7, 133-134; (3) Faculty 1000, F1000.com/8771961; (4) Nature China 2011, doi: 10.1038/nchina.2011.9]



作者: yymeme345    时间: 2022-9-12 00:15

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