近期主要代表论著:
01. “Asymmetric Total Synthesis of (+)-Majusculoic Acid via a Dimerization–Dedimerization Strategy and Absolute Configuration Assignment”
Chen, R.; Li, L.; Lin, N.; Zhou, R.; Hua, Y.; Deng, H.; Zhang, Y. Org. Lett. 2018, 20, 1477.
02. “Enantioselective total synthesis of periconiasin A”
Zeng, Z.; Chen, C.; Zhang, Y. Org. Chem. Front. 2018, 5, 838.
03. “Total Synthesis of Aplydactone by a Conformationally Controlled C−H Functionalization”
Liu, C.+; Chen, R.+; Shen, Y.; Liang, Z.; Hua, Y.; Zhang, Y. Angew. Chem. Int. Ed. 2017, 56, 8187-8190.
04. “Total Synthesis of (+)-Fusarisetin A Driven by a One-Pot Four-Reaction Process”
Liu, C.; Zeng, Z.; Chen, R.; Jiang, X.; Wang, Y.; Zhang, Y. Org. Lett. 2016, 18, 624-627.
05. Protecting-Group-Free Total Synthesis of (±)-Jiadifenolide: Development of a [4 + 1] Annulation toward Multisubstituted Tetrahydrofurans
Shen, Y.; Li, L.; Pan, Z.; Wang, Y.; Li, J.; Wang, K.; Wang, X.; Zhang, Y.; Hu, T.; Zhang, Y. Org. Lett. 2015, 17, 5480-5483.
06. The Cyano Group as a Traceless Activation Group for the Intermolecular [3+2] Cycloaddition of Azomethine Ylides: A Five-Step Synthesis of (±)-Isoretronecanol
Li, J.; Zhao, H.; Jiang, X.; Wang, X.; Hu, H.; Yu, L.; Zhang, Y. Angew. Chem. Int. Ed. 2015, 21, 6306-6310.
07. Diastereoselective Total Synthesis of (±)-Schindilactone A, Part 1: Construction of the ABC and FGH Ring Systems and Initial Attempts to Construct the CDEF Ring System
Sun, T.; Ren, W.; Xiao, Q.; Tang, Y.; Zhang, Y.; Li, Y.; ,Meng, F.; Liu, Y.; Zhao, M.; Xu, L.; Chen, J.; Yang, Z. Chem. Asian J. 2012, 7, 2321-2333.
08. Antarafacial Mediation of Oxygen Delivery by a Phenylsulfinyl Group in the Epoxidation of Proximal Double Bonds: Intramolecular Trapping of an Early Pummerer Intermediate with Stereoelectronic Control
Zhang, Y.; Lee, J. H.; Danishefsky, S. J. J. Am. Chem. Soc. 2011, 133, 752-755.
09. A Straightforward Route to Functionalized trans-Diels-Alder Motifs
Lee, J. H.; Zhang, Y. ; Danishefsky, S. J. J. Am. Chem. Soc. 2010, 132, 14330-14333.
10. Total Synthesis of (±)-Aplykurodinone-1: Traceless Stereochemical Guidance
Zhang, Y. ; Danishefsky, S. J. J. Am. Chem. Soc. 2010, 132, 9567-9569.
作者: danjuan 时间: 2020-5-21 19:28
张延东教授课题组与医学院胡天惠教授课题组合作在国际药物化学顶级期刊《Journal of Medicinal Chemistry》发表研究论文:“Structure-activity relationship study enables the discovery of a novel berberine analogue as RXRα activator to inhibit colon cancer”(DOI:10.1021/acs.jmedchem.0c00088),针对黄连素与视黄醇X受体(RXRa)的结合模式展开构效关系研究,发现了比黄连素活性更好、生物利用度更高的靶向药物先导物。