代表性论文(Selected Research Publications):
1.Dual VEGFR2 and Aurora kinase inhibitor R1498 as a novel treatment for gastric cancer and hepatocellular cancer. PLOS ONE 2013; 8(6): e65264.
2.Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer. PLOS ONE2014; 9(1): e85296.
3.Targeting NEK2 as a promising therapeutic approach for cancer treatment. Cell Cycle2016; 15(7):895-907.
4.Design, Synthesis, and Biological Evaluation of New Cathepsin B-Sensitive Camptothecin Nanoparticles Equipped with a Novel Multifuctional Linker. Bioconjugate Chemistry 2016; 27(5):1267-75.
5.NIR fluorescent DCPO glucose analogues and their application in cancer cell imaging. RSC Adv 2016; 6(85): 81894-901.
6.Preclinical activity of MBM-5 in gastrointestinal cancer by inhibiting NEK2 kinase activity.Oncotarget 2016; 7(48):79327-41.
7.Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases.J Exp Clin Cancer Res2016; 35(1):183-97.
8.Characterization of a near-infrared fluorescent dcpo-tagged glucose analogue for cancer cell imaging. J Photoch Photobio B 2017;166:264-71.
9.Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as noveland potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem. 2017;126:1083-106.
10.ES2 enhances the efficacy of chemotherapeutic agents in ABCB1-overexpressing cancer cells in vitro and in vivo. Pharmacol Res2018 Mar; 129:388-399.
11.Tumor-targeting efficacy of aBF211 prodrug through hydrolysis by fibroblast activation protein-α. Acta Pharmacol Sin2018 Mar; 39(3):415-424.
12.Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis. Front Pharmacol2017 Dec 12; 8:915.
13.Design and synthesis of aryloxypropanolamine as β3-adrenergic receptor antagonist in cancer and lipolysis. Eur J Med Chem.2018 Apr 25;150:757-770.
14.Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors. Bioorg Med Chem. 2018 May 1. [Epub ahead of print]