华东理工大学化学与分子工程学院张伟安

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张伟安，华东理工大学教授。2003年，博士毕业于中国科学技术大学高分子科学与工程系；2004年，为上海交通大学化学与化工学院讲师；2008-2010年，受洪堡基金会资助在德国拜罗伊特大学大分子II系进行访问研究，洪堡学者；2011-2012年，受欧盟第七框架(PF7)项目资助在英国利兹大学化学院进行访问研究，玛丽居里学者；2007年-至今，为华东理工大学化学与分子工程学院副教授，教授。主要从事功能性高分子材料的构建和应用研究。近五年来，以通讯作者共发表SCI论文55篇，其中包括Prog. Polym. Sci., Adv. Mater., Angew. Chem. Int. Ed.和Macromolecules 等期刊，五年内论文SCI他引1300余次，单篇论文最高SCI他引200余次。

张伟安，博士，教授，博士生导师

        联系地址：实验六楼205室
        Email: wazhang@ecust.edu.cn
        Tel: 021-64253033

     

个人简介：

    2003年博士毕业于中国科技大学高分子科学系；2004年为上海交通大学高分子科学系讲师；2007年-至今，为华东理工大学化学与分子工程学院副教授，教授。期间，受洪堡基金会资助在德国Bayreuth大学进行访问研究，洪堡学者；以及欧盟第七框架(PF7)资助在英国利兹大学进行访问研究，玛丽居里学者。
    近五年来，主要从事功能性高分子材料的构建和应用研究，尤其生物医用高分子材料，特种高分子材料制备技术等，在国际高分子学科杂志上以通讯作者发表SCI论文31篇（影响因子大于3论文，27篇）和撰写英文专著两章节，其中包括Progress in Polymer Science （IF = 26.85）, Macromolecules 和Polymer Chemistry等杂志，论文引用1436次，H因子为20。在项目方面，以项目负责人主持了多项项目，其中包括两项人才项目和三项中国国家自然科学基金面上项目等。

研究方向：
1.含有光响应基元（如卟啉等）特定结构高分子的构建及其在抗癌治疗中的应用（诊断、成像和治疗等）；

2.生物医用高分子材料（尤其可供干细胞培养高分子材料）的构建、组装和应用；

3.高分子材料3D打印成型技术（打印原料的合成和成型工艺的设计等）；
4.高分子材料特种制备技术（聚合物反应加工技术、聚氨酯及改性材料等）。

招生专业和毕业学生去向：
  目前课题组主要在应用化学与先进材料与制备技术招生。毕业学生全部就职于上海，包括高校（上海交大和华东理工等），大型国企（中石化上海分公司，上海烟草集团和上海造币厂等）或跨国公司（如：德国瓦克聚合物公司和日本立邦公司）等。欢迎加盟本课题组攻读硕士或博士学位！

代表性论文：
   2016
  1. LeileiRui, Lichao Liu, Yong Wang, Yun Gao, Weian Zhang*, Orthogonal Approach to Construct Cell-Like Vesicles via Pillar[5]arene-Based AmphiphilicSupramolecular Polymers, ACS Macro Lett. 2016, 5, 112-117.
  2. Zhenghe Zhang, Pengcheng Zhang, Yong Wang, Weian Zhang*,Recent advances in organic/inorganic well-defined hybrid polymers using controlled living radical polymerization techniques, Polymer Chemistry, 2016, 7, 3950-3976.
  3. Ye Chen, LeileiRui, Lichao Liu, Weian Zhang*,Redox-responsive SupramolecularAmphiphilies Based on Pillar[5]arene for Enhanced Photodynamic Therapy, Polymer Chemistry, 2016, 7, 3268-3276.
  4. Qiang Zhou, Lei Xu, Feng Liu, Weian Zhang*,Construction of reduction-responsive photosensitizers based on amphiphilic block copolymers and their application for photodynamic therapy，Polymer, 2016, 97, 323-334.
  5. Xiuwei Pan, HaoGao, Guodong Fu, Yun Gao, Weian Zhang*, Synthesis, characterization and chondrocyte culture of polyhedral oligomericsilsesquioxane (POSS)-containing hybrid hydrogels, RSC Advances, 2016, 6, 23471-23478.
  6. Feng Liu, Yang Zhang, Xiuwei Pan, Lei Xu, YudongXue, Weian Zhang*,Doxorubicin-loaded Redox-Responsive Amphiphilic Dendritic Porphyrin Conjugates for Chemotherapy and Photodynamic Therapy, RSC Advances, 2016, 6, 57552-57562.
  7. Xiuwei Pan, Qiong Sun, HaiboCai*, Yun Gao*, Wensong Tan and Weian Zhang*,Encapsulated feeder cells within alginate beads for ex vivo expansion of cord blood-derived CD34+ cells, Biomaterials Science, 2016, DOI: 10.1039/C6BM00191B.
  2015
  8. Feng Liu*, Yuan Zhang, Lei Xu, Weian Zhang*,Morphylogy-controlled Self-assembly of an Organic/Inorganic Hybrid Porphyrin Derivative Containing Polyhedral OligomericSilsesquioxane (POSS), Chemistry – A European Journal, 2015, 21, 5540-5547.
  9. Bin Wu, Lei Xu, Shangfeng Wang, Yong Wang,Weian Zhang*, A PEGylated colorimetric and turn-on fluorescent sensor based on BODIPY for Hg(II) detection in water, Polymer Chemistry, 2015, 6, 4279-4289.
  10. Lei Xu, Lichao Liu, Feng Liu*, HaiboCai, Weian Zhang*, Porphyrin-containing Amphiphilic Block Copolymer for Photodynamic Therapy, Polymer Chemistry, 2015,6, 2945-2954.
  11. Lichao Liu,LeileiRui, Yun Gao,Weian Zhang*, Self-assembly and disassembly of redox-responsive ferrocene-containing amphiphilic block copolymer for controlled release, Polymer Chemistry, 2015,6, 1817-1829.
  12. Shangfeng Wang, Bin Wu, Feng Liu, Yun Gao,Weian Zhang*, A well-defined alternating copolymer based on a salicylaldimine Schiff base for highly sensitive zinc(II) detection and pH sensing in aqueous solution, Polymer Chemistry, 2015,6, 1127-1136.
  13. Lei Xu,Wenyan Zhang,HaiboCai,Feng Liu*,Yong Wang,Yun Gaoand Weian Zhang*,Photo Controllable Release and Enhancement of Photodynamic Therapy Based on Host-Guest SupramolecularAmphiphiles，Journal of Materials Chemistry B, 2015, 3, 7417-7426.
  14. Lei Xu, Lichao Liu, Feng Liu, Wen Li*, Ruobin Chen, Yun Gao,Weian Zhang*, Photodynamic Therapy of Oligoethylene Glycol Dendronized Reduction-Sensitive Porphyrins, Journal of Materials Chemistry B, 2015,3, 3062-3071.
  15. Zhenghe Zhang, Lizhi Hong, Jinxia Li, Feng Liu, HaiboCai, Yun Gao,Weian Zhang*, One-pot synthesis of well-defined amphiphilic alternating copolymer brushes based on POSS and their self-assembly in aqueous solution,RSC Advances, 2015,5, 21580-21587.
  16. Feng Liu, Yufei Ma, Lei Xu, Lichao Liu, Weian Zhang*, Redox-responsive Supramolecular Amphiphilies Constructed via Host-guest Interaction for Photodynamic Therapy, Biomaterials Science,2015, 3, 1218-1227.
  17. Jing Yang, Xu Dong, Yun Gao*, Weian Zhang*,One-step synthesis of methacrylated POSS cross-linked poly(N-isopropylacrylamide) hydrogels by γ-irradiation, Materials letters,2015, 157, 81-84.
  2014
  18. Lichao Liu, LeileiRui, Yun Gao,Weian Zhang*, A supramolecular approach for fabrication of photo-responsive block-controllable supramolecular polymers, Polymer Chemistry, 2014, 5, 5453-5460.
  19. Zhenghe Zhang, Lizhi Hong, Yun Gao,Weian Zhang*, One-pot synthesis of POSS-containing alternating copolymers by RAFT polymerization and their microphase-separated nanostructures, Polymer Chemistry, 2014,5, 4534-4541.
  20. QiongxiaShen, Lichao Liu, Weian Zhang*, Fabrication of a Photocontrolled Surface with Switchable Wettability Based on Host-Guest Inclusion Complexation and Protein Resistance,Langmuir, 2014, 30, 9361-9369.
  21. Lizhi Hong, Zhenghe Zhang, Yun Gao, Weian Zhang*, Synthesis and Self-Assembly of Stimuli-Responsive Amphiphilic Block Copolymers Based on Polyhedral OligomericSilsesquioxane, Journal of Polymer Science Part A-Polymer Chemistry, 2014, 52, 2669-2683.
  22. Feng Wang, Lei Xu, Feng Liu, Weian Zhang*, Morphology controlled supramolecular assemblies via the complexation between (5, 10, 15, 20-tetrakisphenyl-porphine) zinc and 4, 4’-bipyridine: from nanospheres to microrings, RSC Advances, 2014, 4, 61378-61382.
  23. Lizhi Hong, Zhenghe Zhang, Yun Gao, Weian Zhang*, Synthesis of Organic/Inorganic Polyhedral OligomericSilsesquioxane-Containing Block Copolymers via Reversible Addition-Fragmentation Chain Transfer Polymerization and Their Self-Assembly in Aqueous Solution. Industrial & Engineering Chemistry Research, 2014, 53, 10673-10680.
  24. Weian Zhang*, Lizhi Hong, P. C. McGowan*, A Giant Capsule from the Self-Assembly of a Penta-Telechelic Hybrid Poly(acrylic acid) Based on Polyhedral OligomericSilsesquioxane, Macromolecular Chemistry and Physics, 2014, 215, 900-905.
  2013
  25. Weian Zhang*, Axel H. E. Müller, Architecture, Self-assembly and Properties of Well-defined Hybrid Polymers Based on Polyhedral OligmericSilsequioxane (POSS), Progress in Polymer Science, 2013, 38, 1121-1162.
  26. Shaohua Wang, QiongxiaShen, MianHasnain Nawaz, Weian Zhang*,Photocontrolled reversible supramolecular assemblies of a diblockazo-copolymer based on β-cyclodextrin; Azo host and guest inclusion complexation, Polymer Chemistry, 2013, 4, 2151-2157.
  27. MianHasnain Nawaz, Lei Xu, Feng Liu, Weian Zhang*, Continuous fibrils from the self-assembly of monochelic polymeric porphyrin and PEGylated fullerene, RSC Advances, 2013, 3, 9206-9209.
  28. MianHasnain Nawaz, Jin Liu, Feng Liu, Xiaosong Wang, Weian Zhang*,Synthesis of porphyrinic polystyrenes and their self-assembly with pristine fullerene (C60), Materials Letters, 2013, 91, 71-74.

tuandui

报告题目一：特定结构卟啉高分子的构建及其在光动力治疗中的应用
报    告   人：华东理工大学 张伟安 教授


个人简介：
张伟安，华东理工大学教授。2003年，博士毕业于中国科学技术大学高分子科学与工程系；2004年，为上海交通大学化学与化工学院讲师；2008-2010年，受洪堡基金会资助在德国拜罗伊特大学大分子II系进行访问研究，洪堡学者；2011-2012年，受欧盟第七框架(PF7)项目资助在英国利兹大学化学院进行访问研究，玛丽居里学者；2007年-至今，为华东理工大学化学与分子工程学院副教授，教授。主要从事功能性高分子材料的构建和应用研究。近五年来，以通讯作者共发表SCI论文55篇，其中包括Prog. Polym. Sci., Adv. Mater., Angew. Chem. Int. Ed.和Macromolecules 等期刊，五年内论文SCI他引1300余次，单篇论文最高SCI他引200余次。


报告内容简述：
光动力疗法（Photodynamic Therapy, PDT）相对于化疗、手术、放疗等传统癌症治疗方法，因其具有能够选择性地杀伤癌细胞、对正常组织毒副作用小等特点，而受到广泛地青睐。但是在光动力学治疗过程中，起关键性作用的光敏剂因受限于药物负载率低、非特异选择性、聚集失活以及肿瘤乏氧等问题，进而导致光动力疗法在临床上的应用受到极大的限制。近年来，报告人主要围绕以上光敏剂在光动力治疗中存在的问题开展工作：基于高分子可控聚合技术，制备了一系列特定结构高分子光敏剂，实现了光敏基元在聚合物大分子结构中定点定量的精准构造；通过含有光敏基元的主体/客体之间的相互作用构建了超分子光敏剂自组装体，促进了光敏剂进入肿瘤组织和细胞，实现了光敏剂的有效递送；提出了交替结构降低光敏剂聚集诱导淬灭（Alternating-structure Reducing Aggregation-caused-quenching, ARACQ）的新策略，提升了光动力治疗的效果。