学术任职
l 中国质谱学会常务理事,中国质谱学会有机质谱专业委员会委员 (2008.9 – 2012.8),生物质谱专业委员会副主任委员(2012.8 –)
l 中国生物化学与分子生物学学会蛋白质组专业委员会委员 (2011.4 –)
l 美国化学会会员
l 中国化学会会员
l 国际生物无机化学学会会员
代表论文
S. Y. Liu, K. Wu,* W. Zheng, Y. Zhao, Q. Luo, S. X. Xiong, F. Y. Wang,* Identification and Discrimination of Binding Sites of an Organoruthenium Anticancer Complex to Single-Stranded Oligonucleotides by Mass Spectrometry, Anlayst, 2014, 10.1039/c4an00807c.
G. J. Zhai, X. Y. Wu, Q. Luo, K. Wu, Y. Zhao, Y. L. Min, J. A. Liu, X. S. Xiong, Y. Q. Feng, L. P. Yang,* F. Y. Wang,* Absolute Quantification of Serum Phosphopeptides by Mass Spectrometry Coupled to Titania Coated Magnetic Mesoporous Silica Microsphere Enrichment, Talanta, 2014, 125, 411–417.
Z. Du, Q. Luo, L. Yang, T. Bing, X. Li, W. Guo, K. Wu, Y. Zhao, S. Xiong, D. Shangguan, F.-Y. Wang*, Mass Spectrometric Proteomics Reveals that Nuclear Protein Positive Cofactor PC4 Selectively Binds to Cross-Linked DNA by a trans-Platinum Anticancer Complex, J. Am. Chem. Soc. 2014, 136, 2948-2951.
Y. Zhao, N. J. Farrer, H. Li, J. S. Butler, R. J. McQuitty, A. Habtemariam, F.-Y. Wang*, P. J. Sadler*, De Novo Generation of Singlet Oxygen and Ammine Ligands by Photoactivation of a Platinum Anticancer Complex, Angew. Chem. Int. Ed. 2013, 52, 13633-13637.
W. Zheng, Q. Luo, Y. Lin, Y. Zhao, X. Wang, Z. Du, X. Hao, Y. Yu, S. Lu, L. Ji, X. Li, L. Yang, F.-Y. Wang*, Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis, Chem. Commun. 2013, 49, 10224-10226.
K. Wu, S. Liu, Q. Luo, W. Hu, X. Li, F.-Y, Wang*, R. Zheng, J. Cui, P. J. Sadler, J. Xiang, Q. Shi, S. Xiong, Thymines in Single-Stranded Oligonucleotides and G-Quadruplex DNA Are Competitive with Guanines for Binding to an Organoruthenium Anticancer Complex, Inorg. Chem. 2013, 52 (19), 11332-11342
Y. Lin, Y-D Huang, W. Zheng, F.-Y. Wang*, A. Habtemariam, Q. Luo, X.-C. Li, K. Wu, P. J. Sadler, S.-X. Xiong, Organometallic ruthenium anticancer complexes inhibit human glutathione-S-transferase π, J Inorganic Biochem, 2013, 128, 77-84
W. Guo, W. Zheng, Q. Luo, X. Li, Y. Zhao, S. Xiong, F.-Y. Wang,* Transferrin Serves As a Mediator to Deliver Organometallic Ruthenium(II) Anticancer Complexes into Cells, Inorg. Chem. 2013, 52, 5328-5338.
K. Wu, W. Hu, Q. Luo, X. Li, S. Xiong, P. Sadler, F.-Y. Wang,* Competitive binding sites of a ruthenium arene anticancer complex on oligonucleotides studied by mass spectrometry: ladder-sequencing vs top-down, J. Am. Soc. Mass. Spectrom., 2013, 24, 410-420.
S. Lü, W. Zheng, L. Ji, Q. Luo, X. Hao, X. Li, F.-Y. Wang,* Synthesis, characterization, screening and docking analysis of 4-anilinoquinazoline derivatives as tyrosine kinase inhibitors, Eur. J. Med. Chem. 2013, 61, 84-94.
L. Ji, J.-H. Wu, Q. Luo, X. Li, W. Zheng, G. Zhai, F.-Y. Wang,* S. Lü, Y.-Q. Feng*, J. Liu, S. Xiong, Quantitative Mass Spectrometry Combined with Separation and Enrichment of Phosphopeptides by Titania Coated Magnetic Mesoporous Silica Microspheres for Screening of Protein Kinase Inhibitors, Anal. Chem. 2012, 84, 2284-2291.
K. Wu, Q. Luo, W. Hu, X. Li, F.-Y. Wang,* S. Xiong, P. J. Sadler,* Mechanism of Interstrand Migration of Organoruthenium Anticancer Complexes within a DNA Duplex, Metallomics, 2012, 4, 136-148.
Y. M. Han, Q. Luo, X. Hao, X. C. Li, F.-Y. Wang,* W. B. Hu, K. Wu, S. Lü, P. J. Sadler,* Reactions of an organoruthenium anticancer complex with 2-mercaptobenzanilide - a model for the active-site cysteine of protein tyrosine phosphatase 1B, Dalton Trans. 2011, 40, 11519-11529
W.B. Hu, Q. Luo, K. Wu, X.C. Li, F.-Y. Wang,* Y. Chen, X.Y. Ma, J.P. Wang, J.A. Liu, S.X. Xiong, P.J. Sadler,* The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin, Chem. Commun. 2011, 47, 6006–6008.
W. B. Hu, J. A. Liu, Q. Luo,* Y. M. Han, K. Wu, S. Lv, S. X. Xiong, F.-Y. Wang,* Elucidation of the Binding Sites of Sodium Dodecyl Sulfate to b-Lactoglobulin Using Hydrogen/Deuterium Exchange Mass Spectrometry Combined with Docking Simulation, Rapid Commun. Mass Spectrom. 2011, 25, 1429-1436.
Lv, Q. Luo, X. C. Li, K. Wu, J. A. Liu, S. X. Xiong, Y.Q. Feng, F.-Y. Wang,* Inhibitor Screening of Protein Kinases Using MALDI-TOF MS Combined with Separation and Enrichment of Phosphopeptides by TiO2 Nanoparticle Deposited Capillary Column, Analyst, 2010, 135, 2858-2863.
W. B. Hu, Q. Luo, X. Y. Ma, K. Wu, J. A. Liu, Y. Chen, S. X. Xiong, J. P. Wang, P. J. Sadler, F.-Y. Wang,* Arene control over thiolate to sulfinate oxidation in albumin by organometallic ruthenium anticancer complexes, Chem. Eru. J. 2009, 15, 6586-6594
F.-Y. Wang,* A. Habtemariam, E. P. L. van der Geer, R. J. Deeth, R. Gould, S. Parsons, P. J. Sadler,* synthesis, Characterization and reaction pathway for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex, J. Biol. Inorg. Chem., 2009, 14, 1065-1076
F.-Y. Wang, S. Weidt, J. Xu, C. L. Mackay, P. R. R. Langridge-Smith, P. J. Sadler,* Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography Fourier transform ion cyclotron mass spectrometry combined with 18O-labeling, J. Am. Soc. Mass Spectrom. 2008, 19, 544-549
F.-Y. Wang, A. Habtemariam, E. P. L. van der Geer, R. Fernández, M. Melchart, R. J. Deeth, R. Aird, S. Guichard, F. P. A. Fabbiani, P. Lozano-Casal, I. D. H. Oswald, D. I. Jodrell, S. Parsons, P. J. Sadler,* Controlling ligand substitution reactions of organometallic complexes: tuning cancer cell cytotoxicity, Proc. Natl. Acad. Sci. USA. 2005, 102, 18269-18274.
F.-Y. Wang, J. Xu, A. Habtemariam, J. Bella, P. J. Sadler,* Competition between glutathione and guanine for a ruthenium(II) arene anticancer complex: detection of a sulfenato intermediate. J. Am. Chem. Soc. 2005, 127, 17734-17743.
F.-Y Wang, H. M. Chen, S. Parsons, I. D. H. Oswald, J. E. Davidson, P. J. Sadler,* Kinetics of aquation and anation of ruthenium(II) arene anticancer complexes, acidity and X-ray structures of aqua adducts. Chem. Eur. J. 2003, 9, 5810-5820.
F.-Y. Wang, H. M. Chen, J. A. Parkinson, P. D. Murdoch, P. J. Sadler,* Reactions of a ruthenium(II) arene antitumor complex with cysteine and methionine. Inorg. Chem. 2002, 41, 4509-4523.