Career and education:
2021-now,上海科技大学,助理教授、研究员∣Assistant Professor (Tenure Track), Principal Investigator, ShanghaiTech University
2018-2021,德国明斯特大学,洪堡学者∣Humboldt Fellow, University of Münster (Mentor: Prof. Frank Glorius)
2017-2018,英国曼彻斯特大学,博士后∣EPSRC Postdoc Research Fellow, The University of Manchester (Mentor: Prof. David J. Procter)
2014-2017,英国曼彻斯特大学,哲学博士∣Ph.D. at The University of Manchester (Supervisor: Prof. David J. Procter)
Selected Awards & Honors:
n Alexander von Humboldt Fellowship (2018)
n CSC Chinese National Excellent Self-Funded Students Scholarship (2016)
n Prestigious President's Scholarship of The University of Manchester (2014)
Service:
n Reviewer for Springer Nature, Wiley, Cell Press, Elsevier and Royal Society of Chemistry journals, including:
n Angewandte Chemie n Nature Synthesis n Chem.Commun. n Chemical Science n Chem. Eur. J. n iScience
Research
We are a young research team working in School of Physical Science and Technology at ShanghaiTech University. Our research is focused on radical chemistry and catalysis.
At present, we have two main research directions:
1) Develop novel radical chemistry in the emerging areas, such as photoredox chemistry and electrosynthesis, to rapid construct complex bio-active molecules and provide alternative approaches to the solve the limitations in the area of medicinal, materials, energy and environmental chemistry.
2) Rationally design novel catalysts and ligands in order to discovery novel chemical transformations and contribute the development of develop sustainable chemistry.
Publication
2022
10. Jun-Jie Chen and Huan-Ming Huang*, N2O revalorization, Nature Chem. 2022, DOI: 10.1038/s41557-022-01007-x. (News & Views)
9. Huan-Ming Huang*, "Electrifying cross-electrophile coupling", Nature Synth. 2022, DOI: 10.1038/s44160-022-00102-8. (News & Views)
8. Ying Zhang,+ Jun-Jie Chen+ and Huan-Ming Huang*, "Radical Brook Rearrangement: Concept and Recent Developments", Angew. Chem. Int. Ed. 2022, DOI: 10.1002/anie.202205671.
7. Jun-Jie Chen,+ Ying Zhang+ and Huan-Ming Huang*, Radical umpolung chemistry enabled by dual catalysis: concept and recent advances, Catal. Sci. Technol. 2022, DOI: 10.1039/D2CY01161A.
6. Jun-Jie Chen and Huan-Ming Huang*, Merging Halogen-Atom transfer with transition metal catalysis, Tetrahedron Lett., 2022, 153945.
5. Huan-Ming Huang*,+ Peter Bellotti,+ Suhyeon Kim, Xiaolong Zhang and Frank Glorius*, “Catalytic multicomponent reaction involving a ketyl-type radical”, Nature Synth. 2022, DOI: 10.1038/s44160-022-00085-6.
4. Peter Bellotti,+ Huan-Ming Huang,+ Teresa Faber, Ranjini Laskar and Frank Glorius*, “Catalytic defluorinative ketyl–olefin coupling by halogen-atom transfer”, Chem. Sci. 2022, DOI:10.1039/d2sc02732a.
3. Huan-Ming Huang*,+ Peter Bellotti,+ and Frank Glorius*, “Merging Carbonyl Addition with Photocatalysis”, Acc. Chem. Res. 2022, 55, 1135.
2. Huan-Ming Huang,+ Peter Bellotti,+ Johannes E. Erchinger, Tiffany O. Paulisch and Frank Glorius*, “Radical Carbonyl Umpolung Arylation via Dual Nickel Catalysis”, J. Am. Chem. Soc. 2022, 144, 1899.
1. Huan-Ming Huang,+ Peter Bellotti,+ Pan-Pan Chen,+ Kendall N. Houk* and Frank Glorius*, “Allylic C(sp3)–H arylation of olefins via ternary catalysis”, Nature Synth. 2022, 1, 59.
Before joining ShanghaiTech
12. Huan-Ming Huang,‡ Peter Bellotti,‡ (‡These authors contributed equally) and Frank Glorius*, “Bifunctional Reagents in Organic Synthesis”, Nat. Rev. Chem. 2021, 5, 301.
11. Huan-Ming Huang, Peter Bellotti, Constantin Daniliuc and Frank Glorius*, “Radical Carbonyl Propargylation by Dual Catalysis”, Angew. Chem. Int. Ed. 2021, 60, 2464.
10. Huan-Ming Huang,‡ Peter Bellotti,‡ (‡These authors contributed equally) and Frank Glorius*, “Transition-metal catalysed allylic functionalization reaction involving radicals”, Chem. Soc. Rev. 2020, 49, 6186.
9. Huan-Ming Huang, Peter Bellotti, Philipp Miro Pflueger, J. Luca Schwarz, Bastian Heidrich and Frank Glorius*, “Three-Component, Interrupted Radical Heck/Allylic Substitution Cascade Involving Unactivated Alkyl Bromides”, J. Am. Chem. Soc. 2020, 142, 10173.
8. Huan-Ming Huang, Maximilian Koy, Eloisa Serrano, Philipp Miro Pflüger, J. Luca Schwarz and Frank Glorius*, “Catalytic radical generation of π-allylpalladium complexes”, Nat. Catal. 2020, 3, 393.
7. J. Luca Schwarz,‡Huan-Ming Huang,‡ (‡These authors contributed equally) Tiffany O. Paulisch, and Frank Glorius*, “Dialkylation of 1,3-Dienes by Dual Photoredox and Chromium Catalysis”, ACS Catal. 2020, 10, 1621.
6. Huan-Ming Huang, Monserrat H. Garduño-Castro, Charlotte Morrill and David J. Procter*, “Catalytic Cascade Reactions by Radical Relay”, Chem. Soc. Rev. 2019, 48, 4626.
5. Huan-Ming Huang, J. J. W. McDouall, and David J. Procter*, “SmI2-catalysed Cyclisation Cascades by Radical Relay”,Nat. Catal. 2019, 2, 211.
4. Huan-Ming Huang, J. J. W. McDouall and David J. Procter*, “Radical Anions from Urea-type Carbonyls: Radical Cyclisations and Cyclisation Cascades”,Angew. Chem. Int. Ed. 2018, 57, 4995.
3. Huan-Ming Huang and David J. Procter*, “Dearomatizing Radical Cyclisations and Cyclisation Cascades Triggered by Electron-Transfer Reduction of Amide-Type Carbonyls”, J. Am. Chem. Soc. 2017, 139, 1661.
2. Huan-Ming Huang and David J. Procter*, “Radical Heterocyclisation and Heterocyclisation Cascades Triggered by Electron Transfer to Amide-Type Carbonyls”, Angew. Chem. Int. Ed. 2017, 56, 14262.
1. Huan-Ming Huang and David J. Procter*, “Radical-Radical Cyclisation Cascades of Barbiturates Triggered by Electron-Transfer Reduction of Amide-Type Carbonyls”, J. Am. Chem. Soc. 2016, 138, 7770.
作者: taipingyang 时间: 2022-8-18 18:15
近日,上海科技大学物质科学与技术学院黄焕明课题组和德国科学院院士Frank Glorius课题组合作,通过将可见光催化化学和金属催化化学结合,首次实现了可见光催化条件下钯催化羰基自由基参与的多组分反应,论文在线发表于知名学术期刊Nature Synthesis。两组还受邀在《化学研究评述》(Accounts of Chemical Research)发表自由基化学领域的专题综述,该综述已成为期刊当月下载量前三的综述论文。
实现原子经济性、步骤经济性一直是合成化学家们追求的目标。由于可以一步构建多个化学键,多组分反应已受到化学家们的广泛关注。羰基自由基是自由基化学领域中一类比较重要的反应中间体,在全合成领域有较大的应用,如何在催化条件下实现相关的化学转化一直是合成化学中的一个难点 (图1)。