聂宗秀，中国科学院化学研究所研究员，国家杰出青年基金获得者，中科院百人计划入选者。以大颗粒质谱构建及小分子质谱成像为主要研究方向，针对质谱在颗粒分析存在的关键科学与技术问题，在质谱仪器构建及应用等方面进行了系统探索研究。设计研制了多种颗粒离子化源及电荷探测器，构建了离子阱颗粒质谱装置平台，对微纳尺度颗粒进行了多参数表征；建立了基于指纹质谱的颗粒分析方法，获得了纳米颗粒的生物组织质谱成像，将质谱质量范围拓宽了8个数量级，从分子质谱的10e6 Da至颗粒的10e14Da；合成和发现了系列MALDI小分子新基质，获得了多种动物模型下的代谢小分子质谱成像。近年来在Nature Nanotech.、Angew. Chem.、Anal. Chem.等期刊发表论文90余篇。发表在Nature Nanotech.上的工作，由杂志社撰文在同期的“新闻视角”中进行了专栏评论，被Chem. Res. Toxicol.选为“研究亮点”，入选2016年Nature Nanotech.杂志10周年专刊。授权中国发明专利24项。
聂宗秀研究员
电话：010-62652123
E-mail: znie (AT) iccas.ac.cn
2009 研究员 中科院化学所
2003 博 士 中科院武汉物数所
2004-2005 讲师 武汉大学物理系
2005-2007 博后 台湾中研院原分所
2007-2008 博后 美国普度大学
2009年 中国科学院化学研究所“引进杰出青年人才”
2009年 入选中国科学院“技术百人”计划
研究方向
1. 生物颗粒（包括细胞、细菌和病毒）质谱分析。
2. 离子阱便携式质谱仪研制及质谱理论研究。
3. 活体质谱在线分析。
4. 基质辅助激光解吸电离-飞行时间质谱（MALDI-TOF）小分子质谱分析。
研究项目
1. 国家自然科学基金-国家重大科研仪器设备研制专项（21127901，项目参与人）：高分辨多功能化学成像系统；
2. 中国科学院-科研装备研制项目（YZ201126，项目负责人）：生物颗粒离子阱质谱；
3. 国家自然科学基金-面上基金（ 21175139 ，项目负责人）：离子阱细胞颗粒质谱学研究；
4. 中国科学院“引进杰出技术人才”（2010 ，项目负责人）：活体质谱分析；
5. 国家自然科学基金-仪器专项基金（20927006 ，项目负责人）：便携式离子阱质谱装置研制。
论文著作
J.N. Wang, J. Sun, J.Y. Wang, H.H. Liu, J.J. Xue and Z.X. Nie*, Hexagonal boron nitride nanosheets as a multifunctional background-free matrix to detect small molecules and complicated samples by MALDI mass spectrometry, Chem. Comm. 2017, 53, 8114-8117. (Back outside cover).
X.B. Xie, Z.P. Wang, Y.F. Li, L.P. Zhan, and Z.X. Nie*, Investigation and Applications of in-source oxidation in Liquid Sampling-Atmospheric Pressure Afterglow Microplasma ionization (LS-APAG) source, J. Am. Soc. Mass Spectrom. 2017, 28, 1036-1047.
H.H. Liu, W. Li, Q. He, J.J. Xue, J.Y. Wang, C.Q. Xiong, X.P. Pu, and Z.X. Nie*, Mass Spectrometry Imaging of Kidney Tissue Sections of Rat Subjected to Unilateral Ureteral Obstruction, Sci. Rep. 2017, 7, 41954.
J.J Xue, Y.F. Li, X.B. Xie, C.Q. Xiong, H.H. Liu, S.M. Chen, Z.X. Nie,* C.C. Chen, and J.C. Zhao*, Characterization of Organic Aerosol in Beijing by Laser Desorption Ionization Coupled with Fourier Transform Ion Cyclotron Resonance Mass spectrometry, Atmospheric Environment, 2017, 159, 55-65.
C.Q. Xiong, X.Y. Zhou, Q.He, X. Huang, J.Y. Wang, W.-P. Peng, H.-C. Cheng, and Z.X. Nie*, The development of visible-wavelength MALDI cell mass spectrometry (CMS) for high-efficiency single-cell analysis, Anal. Chem. 2016, 88, 11913-11918.
N. Zhang, K. Zhu, C.Q. Xiong, Y.R. Jiang, H.-C. Cheng, and Z.X. Nie*, Mass measurement of single intact nanoparticles in a cylindrical ion trap, Anal. Chem. 2016, 88, 5958-5962.
J. Hou, Q.N. Zheng, C.Q. Xiong, C.Z. Guan, S.M. Chen, N. Zhang, Y.F. Li, Q. He, X.B. Xie, J.N. Wang, Z.X. Nie*, D.Wang*, and L.J. Wan*, Ambient Electrospray Soft-landing for Printing Non-covalent Molecular Nanostructures using Charged Molecular Ink, Chem. Comm. 2016, 52, 13660. (Back inside cover).
N. Zhang, J. Hou, S.M. Chen, C.Q. Xiong, H.H. Liu, Y.L. Jin, J.N. Wang, Q. He, R. Zhao, and Z.X. Nie*, Rapidly Probing Antibacterial Activity of Graphene Oxide by Mass Spectrometry-based Metabolite Fingerprinting, Sci. Rep. 2016, 6, 28045.
Y.F. Li, J.N. Wang, L.P. Zhan, M. Wleklinski, J.Y. Wang, C.Q. Xiong, H.H. Liu, Y.M. Zhou, and Z.X. Nie*, The Bridge between thin layer chromatography-mass spectrometry and high-performance liquid chromatography-mass spectrometry: The realization of liquid thin layer chromatography-mass spectrometry (LTLC-MS), J. Chrom. A. 2016, 1460, 181-189.
J. Sun, S.M. Chen, H.H. Liu, C.Q. Xiong, J.Y. Wang, X.B. Xie, J.J. Xue, P.L. Chen, and Z.X. Nie*, Fluorographene nanosheets：A new carbon-based matrix for the detection of small molecules by MALDI-TOF MS, RSC Adv., 6, 99714-99719.
C.Q. Xiong*, X.Y. Zhou, N. Zhang, L.P. Zhan, Y.T. Chen, and Z.X. Nie*, Nonlinear Ion Harmonics in the Paul Trap with Added Octopole Field: Theoretical Characterization and New Insight into Nonlinear Resonance Effect, J. Am. Soc. Mass Spectrom. 2016, 27, 344-351.
J. Hou, S.M. Chen, C.Y. Cao, H.H. Liu, C.Q. Xiong, J.N. Wang, N. Zhang, Q. He, W.G. Song, and Z.X. Nie*, Flowerlike MgO/Organic Salt Matrix to Assist LDI Mass Spectrometry for Analysis of Lead in Natural Samples, Rapid Commun. Mass Spectrom., 2016, 30, 208-216.
J. Sun, Q. He, J.J. Xue, C.Q. Xiong, H.H. Liu, S.M. Chen* and Z.X. Nie*, Review of matrix-assisted laser desorption/ionization mass spectrometry in analysis and imaging of small molecules, Scientia Sinica Chimica, 2016, 46, 1119-1125.
X. B. Xie, L. Zhang, Q. He, J. Hou, C. M. Xu, N. Zhang, S. Z. Luo*, and Z. X. Nie*, Copper-catalyzed Aerobic Autoxidation of N-Hydroxycarbamates Probed by Mass Spectrometry, Chem. Eur. J., 2015, 21, 14630-14637.
S.M. Chen, C.Q. Xiong, H.H. Liu, Q.Q. Wan, J. Hou, Q. He, A. Badu-Tawiah, and Z.X. Nie*, Mass Spectrometry Imaging Reveals the Sub-organ Distribution of Carbon Nanomaterials, Nature Nanotech. 2015, 10, 176-182.
Q. He, A.K. Badu-Tawiah*, S.M. Chen, C.Q. Xiong, H.H. Liu, YM. Zhou, J. Hou, N. Zhang, Y.F. Li, X.B. Xie, J.N. Wang, L.Q. Mao, and Z.X. Nie*, Reactive Charged-droplets for Ambient Surface Modification Studied using Cyclic Voltammetry, Anal. Chem. 2015, 87, 3144-3148.
J.N. Wang, S.L. Qiu, S.M. Chen, C.Q. Xiong, H.H. Liu, J.Y. Wang, N. Zhang, J. Hou, Q. He, and Z.X. Nie*, MALDI-TOF MS Imaging of Metabolites with N-(1-naphthyl) Ethylenediamine Dihydrochloride (NEDC) Matrix and its Application to Colorectal Cancer Liver Metastasis, Anal. Chem. 2015, 87, 422-430.
C.Q. Xiong, X.Y. Zhou, N. Zhang, L.P. Zhan, and Z.X. Nie*, A Theoretical Method for Characterizing Nonlinear Effects in Paul Traps with Added Octopole Field, J. Am. Soc. Mass Spectrom. 2015, 26, 1338-1348. (Cover paper).
Huihui Liu, Rui Chen, Jiyun Wang, Suming Chen, Caiqiao Xiong, Jianing Wang, Jian Hou, Qing He, Ning Zhang, Zongxiu Nie*, Lanqun Mao*, 1,5-diaminonaphthalene hydrochloride assisted laser desorption/ionization mass spectrometry imaging of small molecules in tissues following focal cerebral ischemia, Anal. Chem., 2014, 86, 10114-10121.
Caiqiao Xiong, Xiaoyu Zhou, Ning Zhang, Lingpeng Zhan, Suming Chen, Jiyun Wang, Wen-Ping Peng, Huan-Cheng Chang, Zongxiu Nie*, Quantitative assessment of protein adsorption on microparticles with particle mass spectrometry, Anal. Chem. 2014, 86, 3876-3881.
Yueming Zhou, Ning Zhang, Yafeng Li, Caiqiao Xiong, Suming Chen, Yongtai Chen, Zongxiu Nie*, Plasma-based ambient sampling/ionization/transmission integrated source for mass spectrometry, Analyst, 2014, 139, 5387-5392.
Caiqiao Xiong, Xiaoyu Zhou, Ning Zhang, Lingpeng Zhan, Suming Chen, Zongxiu Nie*, Nonlinear effects in paul traps operated in the second stability region: analytical analysis and numerical verification ,J. Am. Soc. Mass. Spectrom., 2014, 25, 1882-1889.
J. Hou, S.M. Chen, J.N. Wang, C.Y. Cao, Q. He, J.Y. Wang, W.G. Song and Z.X. Nie*, Identification of Metal Ions in natural samples and MgO assisted lead profiling by MALDI Mass Spectrometry, Analyst, 2014, 139, 3469-3475.
N. Zhang, L.P. Zhan, C.Q. Xiong*, Z.X. Nie*,Review of Particle ion trap mass spectrometry,Scientia Sinica Chimica, 2014, 44, 801-806.
S.J. Wang, S.M. Chen, J.N. Wang, P. Xu, Y.M. Luo, Z.X. Nie*, and W.B. Du*, Interface Solution Isoelectric Focusing with in situ MALDI-TOF Mass Spectrometry, Electrophoresis, 2014, 35, 2528-2533.
J.T. Hu, H.C. Xu, P.J. Nie, X.B. Xie, Z.X. Nie*, and Y. Rao*, Synthesis of indazoles and azaindazoles by aerobic oxidative C-N coupling under transition metal free conditions, Chem. Eur. J. 2014, 20, 3932-3938.
Y.Y. Lv, L.S. Yu*, C.M. Jiang, S.M. Chen, and Z.X. Nie*, Synthesis of Layer-number-controlled Graphene Nanosheets Powder by Soluble Salt-assisted Route, RSC Adv. 2014,4, 13350-13354.
Luliang Wang, Juan Qiao, Huihui Liu, Jie Hao, Li Qi*, Xiaoping Zhou, Dan Li*, Zongxiu Nie, Lanqun Mao, Ratiometric fluorescent probe based on gold nanoclusters and alizarin red-boronic acid for monitoring glucose in brain microdialysate, Anal. Chem., 2014, 86, 9758-9764.
Liping Li, Shuai Chen, Linnan Xu, Yu Bai*, Zongxiu Nie, Huwei Liu, Limin Qi*, Template-free synthesis of uniform mesoporous SnO2 nanospheres for efficient phosphopeptide enrichment,J. Mater. Chem. B, 2014, 2, 1121-1124.
S.M. Chen, H.Z. Zheng, J.N. Wang, J. Hou, Q. He, H.H. Liu, X.L. Kong, and Z.X. Nie*, Carbon Nanodots As a Matrix for the Analysis of Low-Molecular-Weight Molecules in both Positive and Negative Ion MALDI-TOF MS and Quantification of Glucose and Uric Acid in Real Samples, Anal. Chem. 2013, 85, 6646-6652.
C.Q. Xiong, X.Y. Zhou, J.N. Wang, N. Zhang, S.M. Chen, W.-P. Peng, H.-C. Chang, and Z.X. Nie*, Ambient Aerodynamic Desorption/ionization Method for Microparticle Mass Measurement, Anal. Chem. 2013, 85, 4370-4375.
Y.F. Li, N. Zhang, J.N. Wang, Y.M. Zhou, C.Q. Xiong, S.M. Chen, and Z.X. Nie*, Induced Dual-Nanospray: A Novel Internal Calibration Method for Accurate Mass Measurement in Real Sample, J. Am. Soc. Mass Spectrom. 2013, 24, 1446-1449.
X.Y. Zhou, C.Q. Xiong, S. Zhang, N. Zhang, and Z.X. Nie*, Study of nonlinear resonance effect in Paul trap, J. Am. Soc. Mass Spectrom. 2013, 24, 794-800.
C. Zhen, Y.M. Zhou, N. Zhang, J.Y. Wang, and Z.X. Nie*, Differentiation of Chinese Liquors by Using Ambient Glow Discharge Ionization, Analyst 2013, 138, 3830-3835.
Q. He, S.M. Chen, J.N. Wang, J. Hou, J.Y. Wang, S.X. Xiong, Z.X. Nie*, 1-Naphthylhydrazine Hydrochloride: A New Matrix for the Quantification of Glucose and Homogentisic Acid in Real Samples by MALDI-TOF MS, Clin. Chim. Acta 2013, 420, 94-98.
N. Zhang, Y.F. Li, Y.M. Zhou, J. Hou, Q. He, X.G. Hu, Y.M. Jia, C.Y. Yu, and Z.X.Nie*, Rapid detection of polyhydroxy alkaloids in mulberry using leaf spray mass spectrometry, Anal. Meth. 2013, 5, 2455-2460.
C.-C. Hsieh, J.Y. Gou, S.-U. Hung, R. Chen, Z.X. Nie, H.-C. Chang, and C.-C. Wu*, Quantitative Analysis of Oligosaccharides Derived from Sulfated Glycosaminoglycans byNanodiamond-Based Affinity Purification and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, Anal. Chem. 2013, 85, 4342-4349.
Y.T. Yang, F.J. Huo, C.X. Yin*, A.M. Zheng, J.B. Chao, Y.Q. Li, Z.X. Nie, R. Martines-Manez, and D.S. Liu, Thiol-Chromene click chemistry: A coumarin-based derivativeand its use as regenerable thiol probe and in bioimaging applications, Biosensors and Bioelectronics 2013, 47, 300-306.
Li-Ping Li, Tao Zheng, Lin-Nan Xu, Ze Li, Ling-Dong Sun, Zong-Xiu Nie, Yu Bai, and Hu-Wei Liu, SnO2-ZnSn(OH)6: a novel binary affinity probe for global phosphopeptide detection, Chem. Commun.2013, 49, 1762-1764.
M. N. Wang , Y.X. Fan, Y.C. Han, Z.X. Nie, and Y.L. Wang*, Coacervation of cationic gemini surfactant with N-Benzoylglutamic acid in aqueous solution, Langmuir 2013, 29, 14839-14847.
X.Y. Mu , L. Qi* , P. Dong , J. Qiao, J. Hou, Z.X. Nie, H.M. Ma, Facile one-pot synthesis of L-proline-stabilized fluorescent gold nanoclusters and its application as sensing probes for serum iron, Biosensors and Bioelectronics 2013, 49, 249-255.
S.M. Chen, L. Chen, J.N. Wang, J. Hou, Q. He, J.A. Liu, J.Y. Wang, S.X. Xiong, G.Q. Yang and Z.X. Nie* , 2,3,4,5-Tetrakis (3',4'-dihydroxylphenyl) thiophene: A New Matrix for the Selective Analysis of Low Molecular Weight Amines and Direct Determination of Creatinine in Urine by MALDI-TOF MS, Anal. Chem. 84, 10291-10297 (2012).
N. Zhang, Y.M Zhou, C. Zhen, Y.F. Li, C.Q. Xiong, J.Y. Wang, H.Y. Li, Z.X. Nie*, Structural characterization of synthetic polymers using Thermal-Assisted Atmospheric Pressure Glow Discharge Mass Spectrometry, Analyst , 137 , 5051-5056(2012).
R. Chen, S.M. Chen, C.Q. Xiong, C.-C. Wu*, X.L. Ding, S.X. Xiong, H.-C. Chang, and Z. X. Nie*, N-(1-Naphthyl) Ethylenediamine Dinitrate: A New Matrix for Negative Ion MALDI-TOF MS Analysis of Small Molecules, J. Am. Soc. Mass Spectrom, 23, 1454-1460 (2012).
C.Q. Xiong, X.Y. Zhou, J.N. Wang, R. Chen, Y. Tang, W.-P. Peng, H.-C. Chang, Z. X. Nie*, The development of charge detection quadrupole ion trap mass spectrometry (CD-ITMS) driven by rectangular and triangular waves, Analyst, 137, 1199-1204 (2012).
X.Y. Zhou, G.P. Xu, C.Q. Xiong, R. Chen, H.X. Qiao, and Z. X. Nie*, Characteristicsof electrical field in surface-electrode ion traps, J. Mass Spectrom.47, 286-293 (2012).
R. Chen, W.J. Xu, C.Q. Xiong, X.Y. Zhou, S.X. Xiong, Z. X. Nie*, L.Q. Mao, Y. Chen, and H.-C. Chang*, A high-salt-tolerance matrix for facile detection of glucose in rat brain microdialysates by MALDI mass spectrometry, Anal. Chem. 84, 465-469 (2012).
C.Q. Xiong, X.Y. Zhou, R. Chen, Y.M. Zhang, W.-P. Peng, Z. X. Nie*, H.-C. Chang, H.W. Liu, and Y. Chen, Characterization of column packing materials in high-performance liquid chromatography by charge-detection quadrupole ion trap mass spectrometry, Anal. Chem. 83, 5400-5406 (2011).
R. Chen, L.P. Wang, C.Q. Xiong, Y.M. Zhou, C. Zhen, N. Zhang, Y. Tang, X.Y. Zhou, J.N. Wang, Z. X. Nie* and Y. Chen, Direct Analysis of Oligosaccharides and Alpha Hydroxy Acids in Fruits Using Electrosonic Spray Ionization Mass Spectrometry, Analyst,136,3809,(2011).
Z. Q. Zhu, C. Q. Xiong, G. P. Xu, H. Liu, X. Y. Zhou, R. Chen, W. P. Peng*, and Z. X. Nie* , Characteristics of bioparticles using a miniature cylindrical ion trap mass spectrometer operated at rough vacuum, Analyst , 136 , 1305 (2011).
X. Y. Zhou, C. Q. Xiong, G. P. Xu, L. Hao, Y. Tang, Z. Q. Zhu, R. Chen, H. W. Qiao, Y. H. Tzeng, W. P. Peng, Z. X. Nie* , and Y. Chen* , Potential distribution and transmission characteristics in a curved quadrupole ion guide, J. Am. Soc. Mass Spectrom. 22, 386 (2011).
J. Lv, L. Zhang, Y. M. Zhou, Z. X. Nie, S. Z. Luo,* and J. P. Cheng, Asymmetric Binary Acid Catalysis: A Regioselectivity Switch between Enantioselective 1,2- and 1,4-Addition through Different Counteranions of InIII, Angew. Chem. Int. Ed. 50, 6601-6614 (2011).
X.Y. Zhou, Z.Q. Zhu, C.Q. Xiong, R. Chen, W.J. Xu, H.W. Qiao, W.P. Peng, Z. X. Nie*, and Y. Chen*, Characteristics of stability boundary and frequency in nonlinear ion trap mass spectrometer, J. Am. Soc. Mass Spectrom. 21, 1588 (2010).
F.J. Hou, J. Su, Y.Q. Sun, C.X. Yin*, H.B. Tong, Z.X. Nie, A rhodamine-based dual chemosensor for the visual detection of copper and the ratiometric fluorescent detection of vanadium, Dyes & Pigments, 2010, 86, 50-55.
L. Gao, G. T. Li, J. Cyriac, Z. X. Nie, and R. Graham Cooks, Imaging of surface charge and the mechanism of desorption electrospray ionization mass spectrometry, J. Phys. Chem. C, 114, 5331 (2010).
Z. X. Nie, G. T. Li, M. P. Goodwin, L. Gao, J. Cyriac, and R. Graham Cooks, In situ SIMS analysis and reactions of surfaces after soft-landing of mass-selected cations and anions in an ion trap mass spectrometer, J. Am. Soc. Mass Spectrom. 20, 949(2009).
L. Gao, G. T. Li, Z. X. Nie , J. Duncan, Z. Ouyang, and R. Graham Cooks, Characterization of a discontinuous atmospheric pressure interface and use of multiple ion introduction pulses method for performance improvement, Int. J. Mass Spectrom. 283, 30(2009).
Z. X. Nie, F. P. Cui, M.-L. Chu, C.-H. Chen, and H.-C. Chang, Calibration of frequency-scan Quadrupole ion trap mass spectrometer for microparticles mass analysis, Int. J. Mass Spectrom. 270, 8 (2008).
W.-P. Peng, M. P. Goodwin, Z. X. Nie, M. Volny, Z. Ouyang, and R. Graham Cooks, Ion soft landing using a rectilinear ion trap mass spectrometer, Anal. Chem. 80 , 6640 (2008).
Z. X. Nie, F. P. Cui, Y.-K. Tzeng, H.-C. Chang, M.-L. Chu, H.-C. Lin, C.-H. Chen, H.-H. Lin, and A.-L. Yu, High-speed mass analysis of whole erythrocytes by charge-detection Quadrupole ion trap mass spectrometry, Anal. Chem. 79 , 7401 (2007).
Z. X. Nie, Y.-K. Tzeng, H.-C. Chang, C.-C. Chiu, C.-Y. Chang, C.-M. Chang and M.-H. Tao Microscopy-based mass spectrometry of single whole virus in a cylindrical ion trap, Angew. Chem. Int. Ed. 45 , 8131 (2006).
W.-P.Peng, Y.-C.Yang, M.-W.Kang, Y.-K.Tzeng, Z. X. Nie, H.-C.Chang, W.Chang, and C.-H.Chen, Laser-induced acoustic desorption mass spectrometry of single bioparticles Angew. Chem. Int. Ed. 45 , 1423 (2006).
Z. X. Nie, C.-W. Lin, W.-P. Peng , Y. T. Lee, and H.-C. Chang, Frequency scan of a quadrupole mass analyzer in the third stability region for protein analysis, J. Chin. Chem. Soc. ( Taipei ) 53 , 47 (2006).
Z. X. Nie, J.M. Li, Y.R. Jiang, Y.W. Zhu, H. Guan, H.L. Shu, H.L. Shao, and K.L. Gao, Character of store and reaction of ground multiply charged Fen+ (n=1-3) ions in a Paul trap, 物理学报, 53 , 1034 (2004).
K.L. Gao* (导师), Z. X. Nie, Y.R. Jiang, and J.M. Li, Measurement of charge transfer rate of Fe3+ ion coefficients with H2, N2 at electron-volt energy, Phys. Rev. A 67 , 022702 (2003).
蒋玉蓉，聂宗秀，李交美，高克林，射频阱中基态 Sc3+、Ti3+多电荷离子的产生及存储特性， 中国激光， 28 （ 2 ） 2002.
Z. X. Nie, M. Feng, J.M. Li, L. Shi, X.W. Zhu, and K.L. Gao, Effect of the double frequency of trap field in a Paul trap, Commu. Theor. Phys. 15, 593 (2001).
Y.R. Jiang, Z. X. Nie, J.M. Li, and K.L. Gao, Charge transfer of Sc3+ with N2 and H2 at electron-volt Energy, Chin. Phys. Lett. 18, 528 (2001).
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发表于 2017-9-16 09:37:24
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