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孟琴，浙江大学教授。自工作以来，研究兴趣主要在于：1）以生物质发酵手段生产生物表面活性剂，以代替健康、环境不友好的化学表面活性剂，并开拓其在各大工业领域的实际应用；2）以动物／人体细胞构建组织工程反应器，评价大宗化学品或医药品在体内的代谢、毒性以及生物活性作用。最近，上述过程研究又延伸出如膜分离、生物医学、表面与界面化学和生物材料等工程领域方面的相关研究。在完成六项国家自然科学基金项目的基础上，研究成果已陆续在罗氏制药上海研发中心、多个国内民营上市企业、中石化、中石油和钢铁厂等单位进行了中试到工业规模的应用。并且，所产生的学术研究成果已发表在Biotechnology Bioengineering, Water Research, Journal of MembraneScience, Plos One, Bioresource Technology, British J. Pharmacol., Journal ofMaterials Chemistry A 等国际知名刊物上，数量达60多篇，平均影响因子超过3.0。 姓名：孟琴 单位：化学工程与生物工程学院 职称：教授 个人简介 1991.2. 浙江大学生物化工专业，工学硕士 1999.12. 浙江大学化学工程专业，工学博士 1991-2002 浙江大学化工系讲师、副教授，硕士导师 2003.12至今 浙江大学化工系教授、博导 2000.2-2002.3 美国明尼苏达大学（Universityof Minnesota）访问副教授 2004.8-11 德国国家生物技术研究中心（GBF）访问教授 2006.7-8和2007.7-8 德国莱比锡大学访问教授 2011.1-4 美国哈佛大学（Harvard University）访问教授
联系方式 电话：0571-87953193 课程 细胞工程（硕士研究生） 专业外语与文献检索 细胞生理学与细胞工程 生物工程导论 化工专业博士英语（博士研究生） 发表论文 1) Shen C, Meng Q*, Zhang GL,Increased curvature of hollow fiber membranes could up-regulate differentialfunctions of renal tubular cell layers, Biotech Bioeng. 2013, 110(8):2173-83. 2) Lu Y, Zhang G, Shen C, Uygun K, Yarmush ML, Meng Q*, A novel 3D liverorganoid system for elucidation of hepatic glucose metabolism, Biotech Bioeng.2012,109(2): 595-604. 3) Long XW, Zhang GL, Shen C, Sun GS, Wang RX, Yin LJ, Meng Q*,Application of rhamnolipid as a novel biodemulsifier for destabilizing wastecrude oil, Bioresource Technol. 2013,131: 1–5. 4) Long XW, Zhang GL, Han L, Meng Q*. Dewatering of floated oilysludge by treatment with rhamnolipid. Water Res 2013, 47(13):4303-11. 5) Zhang, GL, Qin, L, Meng, Q, Fan, Z, Wu, DX.Aerobic MBR/reverse osmosis system enhancedby Fenton oxidation for advanced treatment of old municipal landfill leachate,2013, 142: 261-268. 6) Shen C, Meng Q*, Zhang GL, Chemically modification of polysulfonemembrane by polyethylene glycol for resisting drug adsorption and self-assemblyof hepatocytes, J Membr Sci, 2011,369(1-2): 474-81. 7) Jiang L, Shen C, Dai J, Meng Q*, Di-rhamnolipids improve effectof trehalose on both hypothermic preservation and cryopreservation of rathepatocytes, Appl Microbiol Biotech, 2013, 97(10):4553-61. 8) Long XW, Zhang GL, Sha R, Huang QL, Meng Q*, Two-stepultrafiltration of rhamnolipids using PSU-g-PEG membrane, J Membr Sci. 2012,409:105–112. 9) Deng X, Zhang G, Shen C, Yin J, Meng Q*. Hollow fiber cultureaccelerates differentiation of Caco-2 cells. Appl Microbiol Biotechnol.2013;97(15):6943-55. 10) Yin J, Qiu H, Dai J, Lu Y, Zhao R, Chen L, Meng Q*. Predictionof hepatic plasma clearance in vivo from gel-entrapped rat and humanhepatocytes.Can J Physiol Pharmacol. 2013, 91(2):178-86. 11) Qin, L, Zhang, G, Meng, Q. Enhanced MBR by internalmicro-electrolysis for degradation of anthraquinone dye wastewaterChem. Eng. J. 2013, 210: 575-584. 12) Qin L, Zhang G, Meng Q, Zhang H, Xu L, Lv B. Enhanced submergedmembrane bioreactor combined with biosurfactant rhamnolipids: performance forfrying oil degradation and membrane fouling reduction. Bioresour Technol. 2012，126:314-20. 13) Shen C, Zhang GL, Meng Q*, Regulation of epithelial cellmorphology and functions approaching to more in vivo-like by modifyingpolyethylene glycol on polysulfone membranes, PLoS ONE 2012， 7(4):e36110. 14) Jiang L, Long XW, Meng Q*, Rhamnolipids enhance epithelialpermeability in Caco-2 monolayers, Int J Pharm, 2013, 446(1-2):130-5. 15) Shen C, Meng Q*, Zhang G., Species-specific toxicity oftroglitazone on rats and human by gel entrapped hepatocytes, Toxicol ApplPharmacol, 258(1):19-25, 2012. 16) Shen C, Meng Q*, Prediction of CYP 450 mediated drug-druginteractions by three-dimensional cultured hepatocytes, Mini-Rev Med Chem.,2012, 12(10): 1028-36. 17) ShaR, Meng Q*, Jiang L, The addition of ethanol as defoamer in fermentation ofrhamnolipids, J Chem Tech Biotech, 2012, 87(3): 368-373. 18) Yin J, Meng Q*, Use of primary rat hepatocytes in the gelentrapment culture to predict in vivo biliary excretion, Xenobiotica, 42(5):417-428, 2012 19) Sha R, Jiang L, Meng Q*, Zhang G, Song Z. Producing cell-freeculture broth of rhamnolipids as a cost-effective fungicide against plantpathogens, J Basic Microbiol, 2012, 52(4): 458-466. 20) Lu Y,Meng Q*, Regulation of spheroid formation and function by microenvironmentalgeometric configuration, Biotechnol Lett, 2012, 34(1):37-43. 21) Shen C, Zhang L, Zhang G, Meng Q*, Polymer Membrane and CellModels for Drug Discovery, Comb Chem High Throughput Screen, 2012, 15(1):3-14. 22) Yin J, Meng Q*, Dong X, Auto-inhibition of verapamil metabolismin rat hepatocytes of gel entrapment culture, Biomed Pharmacother,2011,65(5):328-33. 23) Dai J, Meng Q*, Differential function of protective agents ateach stage of the hypothermic preservation of hepatocytes. J Biochem, 2011,149(6):739-45. 24) MengQ*, Three-dimensional culture of hepatocytes for prediction of drug-inducedhepatotoxicity, Expert Opin Drug Metab Toxicol, 6(6): 1-14, 2010 25) Ruan X, Shen C, Meng Q*, Establishment of a methodology forinvestigating protectants against ethanol-induced hepatotoxicity, Food ChemToxicol, 48(5):1145-51, 2010 26) Shen C, Zhang GL, Meng Q* Evaluation of amiodarone-inducedphospholipidosis by in vitro system of 3D cultured rat hepatocytes in gelentrapment. Biochem Eng J, 49(3): 308-16, 2010 27) Shen C, Zhang GL, Meng Q* Enhancement of the predicted drughepatotoxicity in gel entrapped hepatocytes within polysulfone-g-poly (ethyleneglycol) modified hollow fiber. Toxicol Appl Pharmacol, 2010, 249(2): 140-7. 28) Shen C, Zhang G, Meng Q*. Enhancement of the predicted drughepatotoxicity in gel entrapped hepatocytes within polysulfone-g-poly (ethyleneglycol) modified hollow fiber. Toxicol Appl Pharmacol, 2009,238(2):178-87. 29) Shen C, Meng Q. Evaluation of amiodarone-inducedphospholipidosis by in vitro system of 3D cultured rat hepatocytes in gelentrapment Biochem Eng J. 2009, 49(3):308-316. 30) Dai J, Zhang GL, Meng Q*. (2009) Interaction between hepatocytesand collagen gel in hollow fibers.Cytotechnology. 60 (1-3): 133-141. 31) Shen C, Meng Q*, Schmelzer E, Bader A. Gel entrapment culture ofrat hepatocytes for investigation of tetracycline-induced toxicity. ToxicolAppl Pharmacol 2009, 238(2):178-87. 32) Yin J, Meng Q*, Zhang GL, Sun YH. Differential methotrexatehepatotoxicity of rat hepatocytes in 2-D monolayer culture and 3-D gelentrapment culture. Chem Biol Interact. 2009, 180(3):368-75. 33) Lu YH, Dai J, Shen C, Meng Q*. Primary throughput screening ofprotectants for hypothermic preservation of bioartificial liver in gelentrapped hepatocytes, Biochem Eng J. 2009, 44 (2):160-166. 34) ShenC, Meng Q* .Investigation of rifampicin-induced hepatotoxicity in rathepatocytes maintained in gel entrapment culture, Cell Biol Toxicol. 2009,25(3):265-274. 35) Zhang HZ, Long XW, Sha RY, Zhang GL, Meng Q*. Biotreatment ofoily wastewater by rhamnolipids in aerated active sludge system. J ZhejiangUniv Sci B. 2009, 10(11):852-9. 36) Zhang H, Xiang H, Zhang G, Cao X, Meng Q*.Enhanced treatment ofwaste frying oil in an activated sludge system by addition of crude rhamnolipidsolution. J Hazard Mater. 2009, 167(1-3):217-23. 37) Shen C, Meng Q*, Zhang G. Differential effect of rifampicin onisoniazid-induced hepatotoxicity between rat and human hepatocytes intissue-like cultures. British J. Pharmacol. 2008, 153(4): 784-791. 38) Lu YH, Meng Q*, Zhang G, Bei X. Clozapine-induced hepatotoxicityin rat hepatocytes by gel entrapment and monolayer culture.Toxicology in Vitro. 2008,22(7):1754-60. 39) Yin J, Shen C, Meng Q*. Effects of glycyrrhizic acid oncocklebur-induced hepatotoxicity in rat and human hepatocytes. PhytotherapyResearch, 2008, 22(3): 395-400. 40) Liu, FN, Zhang, GL, Meng, Q, et al. Performance ofnanofiltration and reverse osmosis membranes in metal effluent treatment,Chinese J. Chem. Eng. 2008, 16（3）: 441-445. 41) Zuo, WR; Zhang, GL; Meng, Q, et al. Characteristics andapplication of multiple membrane process in plating wastewater reutilization:Desalinatioon, 2008, 222 (1-3) : 187-196. 42) Shen C, Zhang G, Meng Q* An in Vitro Model forLong-term Hepatotoxicity Testing Utilizing Rat Hepatocytes Entrapped in MicroHollow Fiber Reactor, Biochem Eng J. 2007,34：267-272. 43) Zhang GL, Lin L, Meng Q, Xu YY Distillation ofmethanol-water solution in hollow fibers, Sep Purif Technol. 2007, 56 (2):143-149. 44) Zhang, GL; Lin, L; Meng, Q, et al . Separation of alcohol-watersolutions by distillation through hollow fibers , Ind. Eng. Chem. Res. 2007,46, 7820-7825. 45) Zhu Y, Gan JJ, Zhang GL, Yao B, Zhu WJ, Meng Q* Reuse of wastefrying oil for production of rhamnolipids using Pseudomonas aeruginosa zju.u1M,J Zhejiang Univ Sci A. 2007,8(9): 1514-1520. 46) Meng Q*, Ru JH., Zhang, GL, Shen, C. Reevaluation of tacrinehepatotoxicity using gel entrapped hepatocytes. Toxicol. Letters. 2007,168:140-7. 47) Tang X, Zhu Y, Meng Q* Enhanced crude oil biodegradability ofPseudomonas aeruginosa ZJU after preservation in crude oil-containing mediumWord J. Microb. Biotech. 2007,23 (1): 7-14. 48) Shen, C., Zhang HZ， Zhang, GL,Meng Q*. Isoniazid-induced hepatotoxicity in rat hepatocytes of gelentrapment culture，Toxicol. Letters, 2006, 162: 53-61. 49) Shen, C., Zhang, GL, Meng Q* Acetaminophen-inducedHepatotoxicity of Gel Entrapped Hepatocytes in hollow fibers. Chem BiolInteract. 2006, 162: 53-61. 50) Meng Q*, Zhang, GL, Shen, C. Sensitivities of gel entrappedhepatocytes in hollow fibers to hepatotoxic drug. Toxicol. Letters. 2006, 166:19-26. 51) WuYT,Shen C,Yin J, Yu JP, Meng Q* Azathioprine hepatotoxicity and the protectiveeffect of liquorice and glycyrrhizic acid, Phytotherapy Research, 2006, 20:640-645. 52) Meng Q*, Wu DQ, Zhang G, Qiu H. Direct Self-assembly ofHepatocytes Spheroids within Hollow Fibers in Presence of Collagen. Biotech.Letters, 2006, 28 (4): 279 – 284. 53) LaiP, Meng Q, Hu WS. Hypothermic Preservation of Hepatocyte Spheroids. CellTransplantation. 2005，14（6），375-389. 54) Wu DQ, Shen C, Qiu H, Li H, Meng Q* Evaluation of Diffusion inGel Entrapment Cell Culture within Hollow Fibers. World J Gastroenterol. 2005，11(11):1599-1604。 55) Meng Q*, Zhang G, Wu DQ. Hepatocyte Culture in BioartificialLivers with Different Membrane Characteristics. Biotech. Letters. 2004，26:1407-1412. 56) Meng Q*, Hypothermic Preservation of Hepatocytes，BiotechnologyProgress. 2003，19（4）：1118-1127. 57) 大鼠肝细胞组织化培养用于药物Ｉ和ＩＩ相代谢研究， 浙江大学学报，2006, 35(5), 541-546. 58) 沈冲，徐小梅，孟琴等， 原代肝细胞体外培养用于利福平和异烟肼肝毒性的研究，中国药科大学学报，36（3）,250-253. 59) 沈冲，苏关关，孟琴. 凝胶包埋大鼠肝细胞用于醋氨酚肝毒性研究，浙江大学学报（工学版）2007，41（4）：169-730.
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发表于 2018-5-22 17:21:29
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