中科院纳米生物效应与安全性重点实验室聂广军

hengqiang

聂广军，国家纳米科学中心研究员，博士生导师，课题组长；获中国科学院“百人计划”海外杰出人才择优支持；科技部973（纳米重大研究计划）首席科学家。2002年于中国科学院生物物理所获博士学位，之后在加拿大McGill大学从事博士后研究。2008年加入国家纳米科学中心。回国以来在Adv Mater, Angew Chem Int Ed, Biomaterials, Blood, Brit J Haematol, J Am Chem Soc, J Biol Chem和Small等国际学术期刊上发表学术论文50余篇。
姓    名:        聂广军        
性    别:        男
职    称:        研究员
通讯地址:        北京市海淀区中关村北一条11号
邮政编码:        100190        电子邮件:        niegj@nanoctr.cn         

主要的研究方向
1．基于肿瘤微环境调控的抗肿瘤纳米材料设计和抗肿瘤机制的研究；
2．生物分子指导的功能性纳米材料合成及其在生物医学上的应用；
3．细胞膜囊泡系统及其在纳米材料生物效应中的分子机制；
4．血细胞分化及其相关疾病的病理机制。
研究领域：
结合分子生物学、医学、化学和材料学等交叉学科的方法，以生理和病理的视角研究在纳米尺度上新型材料与生物体的相互作用等纳米生物医学中的基本问题。
代表论著：
Tianjiao Ji, Ying Zhao, Yanping Ding and Guangjun Nie, Using nanotechnology to target and regulate the tumor microenvironment: diagnostic and therapeutic applications, Advanced Materials, doi: 10.1002/adma.201300299.pdf
Yanping Ding, Suping Li & Guangjun Nie, Nanotechnological strategies for therapeutic targeting and imaging of tumor vasculature, Nanomedicine, doi:10.2217/NNM.13.106.
Xin Tian, Motao Zhu, Libo Du, Jing Wang, Zhenlin Fan, Jun Liu Yuliang Zhao and Guangjun Nie, Intrauterine inflammation alters size-dependent materno-fetal transfer of nanoparticles in murine pregnancy, Small,doi: 10.1002/smll.201300817.pdf
Tianjiao Ji, Ying Zhao, Jing Wang, Xin Zheng, Yanhua Tian, Yuliang Zhao and Guangjun Nie, Tumor fibroblast specific activation of hybrid ferritin nanocage-based optical probe for tumor microenvironment imaging, Small, doi: 10.1002/smll.201300600.
Shishuai Su, Hai Wang, Xiaoguang Liu, Yan Wu, Guangjun Nie, iRGD-coupled responsive fluorescent nanogel for targeted drug delivery, Biomaterials, 2013, 34, 3523-3533.pdf
Hai Wang, Yan Wu, Ruifang Zhao and Guangjun Nie, Engineering the assemblies of biomaterial nanocarriers for delivery of multiple theranostic agents with enhanced antitumor efficacy, Advanced Materials, 2013, 25, 1616-1622.pdf
Motao Zhu, Sarah, Perrett and Guangjun Nie, Understanding the Particokinetics of Engineered Nanomaterials for Safe and Effective Therapeutic Applications, Small, 2013, 9, 1619-34.pdf
Hui Yang, Cuiji Sun, Zhenlin Fan, Xin Tian, Liang Yan, Libo Du, Yang Liu, Chunying Chen, Xing-jie Liang, Gregory J. Anderson, Jeffrey A. Keelan, Yuliang Zhao, Guangjun Nie, Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy, Scientific Report, 2012, 847; DOI:10.1038/srep00847.pdf
Wendi Zhang, Chi Wang, Zhenzhen Lu, Jun-Jie Yin, Yu-Ting Zhou, Xingfa Gao, Ying Fang, Guangjun Nie, Yuliang Zhao, Unraveling Stress-induced Toxicity Properties of Graphene Oxide and the Underlying Mechanism, Advanced Materials 2012, 24, 5391–5397.pdf
Motao Zhu, Xin Tian, Xiao Song, Yanhua Tian, Yuliang Zhao, and Guangjun Nie, Nanoparticle-Induced Exosomes Target Antigen-Presenting Cells to Initiate Th1-Type Immune Activation, Small, 2012, 24, 2841-2848.pdf
Gang Liu, Shiwen Niu, Ailian Dong, Hao Cai, Gregory J Anderson, Bing Han and Guangjun Nie, A Chinese family carrying novel mutations in the SEC23B and HFE2 genes, British Journal of Haematology, 2012, 158, 143-145.pdf
Xin Tian, Motao Zhu, Yanhua Tian, Ramm A. Grant, Yuliang Zhao, Guangjun Nie, A membrane vesicle-based dual vaccine against melanoma and Lewis lung carcinoma, Biomaterials, 2012, 33, 6147-6154.pdf
Motao Zhu, Yiye Li, Jian Shi, Weiyue Feng, Guangjun Nie, and Yuliang Zhao, Cellular Responses to Nanomaterials: Exosomes as Extrapulmonary Signaling Conveyors for Nanoparticle-Induced Systemic Immune Activation, Small, 2012, 8, 404-412.pdf
Bo Ning, Gang Liu, Yuanyuan Liu, Xiufen Su, Gregory J Anderson, Xin Zheng, Yanzhong Chang, Mingzhou Guo, Yuanfang Liu, Yuliang Zhao and Guangjun Nie, 5-aza-2'-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of TfR1 and ferrochelatase genes, J Biol Chem, 2011, 286, 37196-37206.pdf
Hai Wang, Ying Zhao, Yan Wu, Kaihui Nan, Guangjun Nie and Hao Chen, Enhanced antitumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxyPEG-PLGA copolymer nanoparticles, Biomaterials, 2011, 32, 8281-8290.pdf
Yiye Li, Yunlong Zhou, Hai-Yan Wang, Sarah Perrett, Yuliang Zhao, Zhiyong Tang, Guangjun Nie, Chirality of Glutathione Surface Coating Affects the Toxicity of Quantum Dots, Angew Chem Int Ed, 2011, 50, 5860-5864.pdf
Cuiji Sun, Hui Yang,Yi Yuan, Xin Tian, Liming Wang, Yi Guo, Li Xu, Jianlin Lei, Ning Gao, Gregory J. Anderson, Xing-jie Liang, Chunying Chen, Yuliang Zhao, Guangjun Nie, Controlling assembly of paired gold clusters within apoferritin nanoreactor for in vivo kidney targeting and biomedical imaging, J Am Chem Soc, 2011, 133, 8617–8624.pdf
Jia Fan, Jun-Jie Yin, Bo Ning, Xiaochun Wu, Ye Hu, Mauro Ferrari, Gregory J. Anderson, Jingyan Wei, Yuliang Zhao and Guangjun Nie, Direct evidence for catalase and peroxidase activities of ferritin-platinum nanoparticles, Biomaterials, 2011, 32, 6, 1611-1618.pdf
Guangjun Nie, Guohua Chen, Alex D. Sheftel, Kostas Pantopoulos and Prem Ponka. In Vivo Tumor Growth is Inhibited by Cytosolic Iron Deprivation Caused by the Expression of Mitochondrial Ferritin, Blood, 2006, 108:2428-34.pdf
Guangjun Nie, Alex Sheftel, Songwon Kim, Prem Ponka. Overexpression of Mitochondrial Ferritin Causes Cytosolic Iron Depletion and Changes Cellular Iron Homeostasis. Blood, 2005, 105:2161-7.pdf
承担科研项目情况：
基于肿瘤微环境调控的抗肿瘤纳米材料设计和机制研究 (国家重点基础研究发展计划973计划项目)，首席科学家
中国科学院“百人计划”海外引进杰出人才择优支持，项目负责人