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房鹏飞，中国科学院上海有机化学研究所研究员。2001年9月~ 2010年6月，中国科学技术大学生命科学学院，依次获理学学士学位和哲学博士学位。2010年7月~ 2016年1月，美国Scripps研究所，助理研究员。2016年1月~至今，中国科学院上海有机化学研究所，“百人计划”研究员。2016年1月入选第十二批国家“##计划（青年项目）”。
简历：姓 名:房鹏飞
性 别:男
职 称:研究员
学 历:博士研究生
电 话:021-54925301
传 真:021-64166128
电子邮件:FangPengfei@sioc.ac.cn
个人主页:
通讯地址:上海市零陵路345号 2000032
研究方向：
人源氨酰tRNA合成酶多酶复合物的化学及结构基础；结构指导的氨酰tRNA合成酶靶向的药物设计；人源GCN2信号通路的调控机理研究。
专家类别：
##计划;研究员
获奖及荣誉：
2001：中国科学技术大学优秀学生奖学金
2003：中国科学技术大学优秀学生奖学金
2004：中国科学技术大学优秀学生奖学金
2010：中国科学技术大学优秀毕业研究生奖学金
2013-2015：PGA-WCAD Postdoctoral Fellowships in Cancer Biology
2016：第十二批国家“##计划（青年项目）”
代表论著：
1.Fang P#, Han H, Wang J, Chen K, Chen X, Guo M#. Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor. Chemistry and Biology. 2015. #Co-corresponding authors.
2.Fang P & Guo M. Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode Classification. Life 2015. 5(4):1703-1725.
3.Mirando AC, Fang P, Williams TF, Baldor LC, Howe AK, Ebert AM, . . . Francklyn CS.. Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor. Sci Rep. 2015. 5, 13160. doi: 10.1038/srep13160
4.Fang P, Guo M. The Nature’s Clever Trick for Making Cyclic Dinucleotide. Structure. 2015. 23(5): 801-2.
5.Fang P*, Yu X*, Jeong S, Mirando A, Chen K, Chen X, … Guo M. Structural Basis for Full-Spectrum Inhibition of Translational on a tRNA Synthetase. Nat Commun. 2015. *Co-first authors.
6.Slade D, Fang P, Dreyton C, Zhang Y, Fuhrmann, J, Rempel D, …Thompson P. Protein Arginine Deiminase 2 Binds Calcium in an Ordered Fashion: Implications for Inhibitor Design. ACS Chem Biol. 2015.
7.Rachmin I, Amsalem E, Golomb E, Beeri R, Gilon D, Fang P, …Tshori S. FHL2 switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy. Int J Cardiol. 2015. 195: 85-94.
8.Park H, González àL, Yildirim I, Tran T, Lohman JR, Fang P, …Disney MD. Crystallographic and computational analyses of AUUCU repeating RNA that causes spinocerebellar ataxia type 10 (SCA10). Biochemistry. 2015.
9.Kim DG, Lee JY, Kwon NH, Fang P, Zhang Q, Wang J, … Kim S. Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction. Nat Chem Biol. 2014. Jan;10(1):29-34.
10.Ofir-Birin Y*, Fang P*, Bennett SP, Zhang HM, Wang J, Rachmin I, …Guo M. Structural switch of lysyl-tRNA synthetase function between translation and transcription. Mol. Cell, 2013. 49(1):30-42.
11.Zhu Y, Dai J, Zhang T, Li X, Fang P, Wang H, …Teng M. Structural insights into the neutralization mechanism of monoclonal antibody 6C2 against ricin. J Biol Chem. 2013 Aug 30;288(35):25165-72.
12.Wang J, Fang P, Schimmel P, Guo M. Side Chain Independent Recognition of Aminoacyl-Adenylates by the Hint1 Transcription Suppressor. Journal of Physical Chemistry, 2012 Jun 14;116(23):6798-805
13.Jones JE, Slack JL, Fang P, Zhang X, Subramanian V, Causey CP, … Thompson PR. Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. ACS Chem Biol., 2012 Jan 20;7(1):160-5
14.Kumar A, Park H, Fang P, Parkesh R, Guo M, Nettles KW, Disney MD. Myotonic Dystrophy Type 1 RNA Crystal Structures Reveal Heterogeneous 1x1 Nucleotide UU Internal Loop Conformations. Biochemistry, 2011 Nov 15;50(45):9928-35
15.Wang J, Gossing M, Fang P, Zimmermann J, Li X, von Mollard GF, … Teng M. Epsin N-terminal homology domains bind on opposite sides of two SNAREs. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12277-82.
16.Fang P*, Zhang HM*, Shapiro R, Marshall AG, Schimmel P, Yang XL, Guo M. Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex. Proc. Natl. Acad. Sci. USA, 2011 May 17;108(20):8239-44
17.Kumar A, Fang P, Park H, Guo M, Nettles KW, Disney MD. A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome. Chembiochem, 2011 Sep;12(14):2140-2
18.Xing L, Zhu Y, Fang P, Wang J, Zeng F, Li X, … Li X. Crystallization and preliminary crystallographic studies of UbiG, an O-methyltransferase from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Jun 1;67(Pt 6):727-9
19.Fang P, Li X, Wang J, Xing L, Gao Y, Niu L, Teng M. Crystal structure of the protein L-isoaspartyl methyltransferase from Escherichia coli. Cell Biochem Biophys, 2010 Dec;58(3):163-7
20.Fang P, Li X, Wang J, Niu L, Teng M. Structural basis for the specificity of the GAE domain of yGGA2 for its accessory proteins Ent3 and Ent5. Biochemistry, 2010 Sep 14;49(36):7949-55
21.Fang P, Wang J, Li X, Guo M, Xing L, Cao X, … Teng M. Crystallization and preliminary X-ray analysis of Escherichia coli RNase G. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 Jun 1;65(Pt 6):586-8
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发表于 2017-9-28 14:24:09
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