东南大学化学化工学院房雷

wuhai

姓名：房雷

·性别：男

·出生年月：1979.10

·民族：汉

·职称：副教授

·学历：博士

·联系电话：13776633178

·电子信箱：lei.fang@seu.edu.cn

课题组网址：http://pcseu.gotoip2.com/index.html

【研究方向】

靶向抗肿瘤药物及载体材料研究

多功能抗阿尔茨海默病药物研究

【经历】

1998.9-2002.7

中国药科大学化学制药专业，获学士学位

2002.9-2005.7

中国药科大学，药物化学专业，硕博连读硕士研究生阶段

2005.7

获得德意志学术交流中心“DAAD Sandwich”奖学金

2005.9-2006.7

同济大学留德预备部，获中级德语证书

2008.6-2008.10

Friedrich-Schiller-Universität Jena, 博士研究(与中国药科大学联合培养)，08年6月于中国药科大学获博士学位

2009.1-2011.10

东南大学药物研究中心，江苏省生物药物高技术研究重点实验室，讲师

2011.10-2012.3

获得德国洪堡奖学金(Alexander von Humboldt Foundation),洪堡访问学者

2015.4-至今

东南大学药物研究中心，江苏省生物药物高技术研究重点实验室，副教授

【科研项目】

1、项目类别及编号：主持1项国家自然科学基金青年科学基金项目 (No. 81001361)；名称：新型2,5,8-三取代二苯并呋喃及其NO供体偶联物的构建及抗AD活性研究；研究起止年月：2011.01-2013.12；资助金额：17万；进展情况：已结题。

2、项目类别及编号：主持博士点基金青年教师项目(No. 20100092120046)；名称：新型肝靶向醌甲基前体型姜黄素衍生物的构建及抗肿瘤活性研究；研究起止年月：2011.01-2013.12；资助金额：3.6万；进展情况：已结题。

3、项目类别及编号：主持江苏省自然科学基金面上项目(No. BK20151402)；名称：杂合交联型肿瘤靶向胶束给药系统的设计、合成及构效关系研究；研究起止年月：2015.07-2018.06；资助金额：10万；进展情况：正在进行。

【论文及获奖】

发表论文：

2016

Fang L(房雷), Feng M, Chen F, Liu X, Shen H, Zhao J, Gou S. Oleanolic acid-NO donor-platinum(II) trihybrid molecules: Targeting cytotoxicity on hepatoma cells with combined action mode and good safety.Bioorg Med Chem,2016, 24(19):4611-4619.

Fang L(房雷), Chen M, Liu Z, Fang X, Gou S, Chen L.Ferulic acid-carbazole hybrid compounds: Combination of cholinesterase inhibition, antioxidant and neuroprotection as multifunctional anti-Alzheimer agents.Bioorg Med Chem,2016, 24(4): 886-893.

Wang Z, Yu H, Gou S, Chen F, Fang L(房雷,通讯作者). Design, Synthesis, and Biological Features of Platinum(II) Complexes with Rigid Steric Hindrance.Inorg Chem,2016, 55(9):4519-4528.

Yu H, Gou S, Wang Z, Chen F, Fang L(房雷,通讯作者).Toward overcoming cisplatin resistance via sterically hindered platinum(II) complexes.Eur J Med Chem,2016, 114:141-152.

Lyu A, Qin X,Fang L(房雷,通讯作者), Gou S. Synthesis, cytotoxicity, and interaction with DNA of platinum(II) complexes of (1R,2R)N12amyl1,2diaminocyclohexane. J Coord Chem, 2016, 69(10):1653–1662.

Zhao J(并列第一作者), Fang L(房雷,并列第一作者), Zhang X, Liang Y, Gou S.Synthesis and biological evaluation of new [1,2,4]triazolo[4,3-a]pyridine derivatives as potential c-Met inhibitors.Bioorg Med Chem, 2016, 24(16):3483-3493.

2015

Liu F, Gou S, Chen F, Fang L(房雷,通讯作者), Zhao J.Study on Antitumor Platinum(II) Complexes of Chiral Diamines with Dicyclic Species as Steric Hindrance. J Med Chem, 2015, 58(16): 6368-6377.

Lyu A(并列第一作者), Fang L(房雷,并列第一作者), Gou S, Liu X. Design, Synthesis and Biological Evaluation of Lapatinib Derivatives as HER1/HER2 Inhibitors. Lett DrugDesDiscov, 2015, 12(7): 574-584.

2014

Fang L(房雷), Wang M,Gou S, Liu X, Zhang H, Cao F.Combination of Amino Acid/Dipeptide with Nitric Oxide-donating Oleanolic Acid Derivatives as PepT1 Targeting Antitumor Prodrugs. J Med Chem, 2014, 57(3):1116-1120.

Fang L(房雷), Fang X, Gou S, Lupp A, Lenhardt I, Sun Y, Huang Z, Chen Y, Cheng L, Zhang Y, Fleck C. Design, synthesis and biological evaluation of D-ring openedgalantamine analogs as multifunctional anti-Alzheimer agents. Eur J Med Chem, 2014, 76:376-386.

Fang L(房雷), Gou S, Liu X, Cao F, Cheng L.Design, synthesis and anti-Alzheimer properties of dimethylaminomethyl-substituted curcumin derivatives. Bioorg Med Chem Lett,2014, 24(1):40-43.

Fang L(房雷), Zhang H, Fang X, Gou S, Cheng L. Preparation of carbazole and dibenzofuran derivatives by selective bromination on aromatic rings or benzylic groups with N-bromosuccinimide. Indian J Chem B, 53(5): 635-641.

Lyu A(并列第一作者), Fang L(房雷,并列第一作者), Gou S. Design and synthesis of Lapatinib derivatives containing a branched side chain as HER1/HER2 targeting antitumor drug candidates. Eur J Med Chem, 2014, 87:631-642.

2013

Fang L(房雷), Gou S, Zhao J, Sun Y, Cheng L.Platinum(II) complexes with N-monoalkyl 1R,2R-diaminocyclohexane derivatives as carrierligands and 3-hydroxycyclobutane-1,1-dicarboxylate as a leaving group: potent cytotoxicity and DNAbinding ability. Eur J Med Chem,2013, 69:842-847.

Fang L(房雷), Gou S, Fang X, Cheng L, Fleck C.Current progresses of novel natural products and their derivatives/analogues as anti-Alzheimer candidates: an update.Mini Rev Med Chem,2013, 13(6):870-887.

Cao F, Gao Y, Wang M, Fang L(房雷,通讯作者), Ping Q.Propylene glycol-Linked Amino Acid/Dipeptide Diester Prodrugs of Oleanolic Acid for PepT1-Mediated Transport: Synthesis, Intestinal Permeability and Pharmacokinetics. Mol Pharmaceut, 2013, 10(4):1378-1387.

Fang X, Fang L(房雷,通讯作者), Gou S, Cheng L.Design and synthesis of dimethylaminomethyl-substituted curcumin derivatives/analogues: Potent antitumor and antioxidant activity, improved stability and aqueous solubility compared with curcumin.Bioorg Med Chem Lett,2013, 23(5):1297-1301.

2012

Sun Y, Liu F, Gou S, Cheng L, Fang L (房雷,通讯作者), Yin R. Synthesis and in vitro antiproliferative activity of platinum(II) complexes withN-monoalkyl 1R,2R-diaminocyclohexane as ligands. Eur J Med Chem,2012,55:297-306.

Fang X,Fang L(房雷,通讯作者), Gou S. Progresses in synthetic methods of carbazole and its derivatives. Chin J Org Chem, 2012, 32(7): 1217-1231.

2011

Fang L(房雷), Gou S, Zhang Y. Progresses in Total Synthesis of Galantamine. Chin J Org Chem,2011,31(3):286-296.

2010

Fang L(房雷),Jumpertz S, Zhang Y, Appenroth D, Fleck C, Mohr K, Tränkle C, Decker M. Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors. J Med Chem,2010, 53(5): 2094-2103.

2008

Fang L(房雷), Appenroth D, Decker M, Kiehntopf M, Roegler C, Deufel T, Fleck C, Peng, S, Zhang Y, Lehmann J. Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates. J Med Chem,2008, 51(4): 713-716.   

Fang L(房雷), Appenroth D, Decker M, Kiehntopf M, Lupp A, Peng S, Fleck C, Zhang Y, Lehmann J. NO-donating tacrine derivatives improve scopolamine-induced cognition impairment and show less hepatotoxicity. J Med Chem,2008, 51(24): 7666-7669.

Fang L(房雷), Lehmann J. NO donor hybrid compounds as multifunctional therapeutic agents. Expert Opin Ther Pantents,2008, 18(10):1111-1125.

Fang L(房雷), Kraus B, Lehmann J, Heilmann J, Zhang Y, Decker M. Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates. Bioorg Med Chem Lett,2008, 18(9):2905-2909.

Fang L(房雷), Huang Z, Zhang Y, Ji H, Ding D. Synthesis, anti-inflammatory activity and safety of hydrocortisone derivatives coupled with furoxans and nitrates. Chin J Org Chem,2008,28(5):841-850.

2007

Fang L(房雷), Zhang Y, Lehmann J, Wang Y, Ji H, and Ding D. Design and synthesis of furoxan-based nitric oxide-releasing glucocorticoid derivatives with potent anti-inflammatory activity and improved safety. Bioorg Med Chem Lett, 2007, 17(4):1062-1066.

发明专利：

申请国家发明专利7项，已获授权4项。

获奖情况：

2009年江苏省优秀博士论文(导师：张奕华教授)

2010年全国优秀博士论文提名奖(导师：张奕华教授)

2011-2012获德国洪堡基金资助

2016年获第十届世界华人药物化学研讨会“优秀青年学者”称号