姓 名:陈怀侠 出生年月:1966年7月 职称职务:博士、教授、博士生导师,分析化学研究室主任、支部书记 专业方向:分析化学 办公电话:027-88662747 研究领域与兴趣: (1) 现代分离技术:样品前处理方法、色谱-质谱分析; (2) 环境分析:环境(微)微污染物分析; (3) 食品分析:食品农残等毒物分析和食品安全; (4) 药物分析:药物(代谢)分析、药物体内过程研究、中药活性成分分离分析。 教育与研究经历: 武汉大学分析化学专业本科、硕士和博士研究生毕业。 长期从事复杂样品分离分析科研,主要内容包括:(1)新型(微)萃取介质合成及其应用:分子印迹聚合物、整体柱、纳米磁微粒、新型碳材料、金属有机骨架材料等;(2)生物、食品和环境等实际样品微量及痕量组分分析:药物分析、药物体内过程、食品农残、环境(微)污染物等;教育部入库专家,中国化学学会会员,主持国家自然科学基金、教育部重点基金项目、湖北省自然科学基金、湖北省教育厅重点基金项目和省科技厅科技攻关项目等20多项;发表科研论文100余篇,其中SCI收录78篇。 教学情况: 1、主讲课程:主讲“分析化学”及实验、“仪器分析”及实验和“现代分离科学”(本科生和研究生)等课程,教学质量评价优秀,湖北省“分析化学”资源共享课程负责人。 2、编写出版教材: (1)《仪器分析实验》主编,科学出版社,2017年; (2)《无机及分析化学》副主编,科学出版社,2009年; (3)《无机及分析化学》主审,中国林业出版社,2012年。 3、主持教研项目: (1)湖北大学教研项目“制药工程专业人才培养平台全方位搭建与实践”,2017.5-2019.8; (2)湖北大学教研项目“现代分析化学课程群”,2016.12-2018.12; (3)湖北大学教研项目“现代分离科学教材建设”,2016.12-2018.12; (4)湖北大学教学专项建设项目“制药工程专业建设”,2016.6-2020.12; (5)湖北省高等学校省级教学研究项目“分析化学课程群新体系构建与实践”,2015.1-2016-12; (6)湖北省高等学校省级教学研究项目“设计性(研究性)实践教学内容的研究与实践”,2006.1-2008-12; (7)湖北大学教学研究项目“分析化学精品课程群建设”,2011.1-2013.7。 4、教研论文:在“大学化学”和“化工高等教育”等刊物发表教研论文26篇。 承担项目与课题(10项代表): (1)国家自然科学基金“新型微污染物PPCPs及其代谢转化物分布调查和迁移转化规律研究”(20975030),主持人; (2)国家自然科学基金重点项目“确有疗效复方中药痹祺胶囊的药代动力学研究”(30630075),主要成员; (3)国家自然科学基金重点项目“新荧光探针标记磷酸化蛋白的毛细管电泳测定和细胞成像研究”(20575047),主要成员; (4) 教育部科学技术研究重点项目“湖北地道药材黄连活性成分代谢及其与血浆蛋白结合研究”(208090),主持人; (5) 湖北省自然科学基金“新型微污染物PPCPs及其代谢转化物分析研究”(2009CDB364),主持人; (6) 湖北省科技厅科技攻关项目“莨菪烷类生物碱药代动力学药代产物研究”(2004AA301C106),主持人; (7)湖北省教育厅重点项目“湖北省水环境中防晒剂污染分析及自然光降解研究”(D20120106),主持人; (8) 省部共建教育部重点实验室项目“中药黄酮类化合物指纹图谱及含量测定研究”(2005-KL-009),主持人; (9) 湖北省中药生物技术重点实验室开放基金“中药生物碱活性成分的代谢研究”(2005CTM001),主持人; (10) 湖北大学人才专项基金“中药复方药物代谢研究”(ky2006004),主持人; 代表性研究成果(30篇代表作): (1) Jianli Zhu, Dongping Chen, Youhong Ai, XuepingDang, Jianlin Huang, Huaixia Chen*. A dummy molecularlyimprinted monolith for selective solid-phase microextraction of vanillin andmethyl vanillin prior to their determination by HPLC. Microchim Acta 2017,184(4):1161-1167. (3) Di Chen, Xiaoxuan Han, QiWang, Liujing Xie, Youhong Ai, Xueping Dang, Jianlin Huang, HuaixiaChen*. Magnetic molecular imprinted polymers for selective extraction anddetermination of naphthols. Microchim Acta 2017, 184: 3373-3379. (4) BinSun, Chunpeng Wang, Qi Wang, Ling Chen, Xueping Dang, Jianlin Huang, HuaixiaChen*. Preparation of acryloyl β-cyclodextrin organic polymer monolithiccolumn and its application in solid phase microextraction and HPLC analysis forcarbofuran and carbaryl in rice. Food Anal Methods 2017, 10:3847-3855. (5) Yang Yang, Xiaowei Ma,Fan Feng, Xueping Dang, Jianlin Huang, Huaixia Chen*. Magneticsolid-phase extraction of triclosan using core-shell Fe3O4@MIL-100magnetic nanoparticles, and its determination by HPLC with UV detection. MicrochimActa 2016, 183(8): 2467-2472. (6) Bo Wu, Jinxia Li, Huaixia Chen*, Yong Ye.Fate of metronidazole under solar irradiation.Environ Eng ManagJ 2016, 15(1): 1003-1008 (7) Xueping Dang, Chengguo Hu, Huaixia Chen,Jianlin Huang, Dongyun Zheng, Shengshui Hu. Photoelectrochemistry and sensor ofNO based on a supramolecular system composed of polyhydroqinone andfullerene. Sensor Actuat B-Chem 2016, 228: 709-715. (9) Xiaofang Liu, Shu Zhou,Quanfei Zhu, Yong Ye, Huaixia Chen*. Ultra preconcentration ofpolycyclic aromatic hydrocarbons in smoked bacon by a combination of SPE andDLLME.J Chromatogr Sci 2014, 52(8): 932-937. (10) QuanfeiZhu, Chao Ma, Huaixia Chen*, Yaqi Wu, Jianlin Huang. A molecularimprint-coated stirrer bar for selective extraction of caffeine, theobromineand theophylline. Microchim.Acta 2014, 181(3-4): 303-311. (11) TingYang, Chao Ma, Huaixia Chen*, Yajie Zhang, Xueping Dang, JianlinHuang. A molecularly imprinted organic-inorganic hybrid monolithic column forselective extraction and high-performance liquid chromatography determinationof isoprocarb residues in rice. J Sep Sci 2014, 37: 587–594. (12) XiaofangLiu, Quanfei Zhu, Huaixia Chen∗, Liuzi Zhou, Xueping Dang, Jianlin Huang. Preparation of2,4-dichlorophenoxyacetic acid imprinted organic–inorganic hybrid monolithiccolumn and application to selective solid-phase microextraction. JChromatogr B2014, (951-952): 32–37. (13) TingZhang, Chao Ma, Mei Wu, Yong Ye, Huaixia Chen*, Jianlin Huang.Selective microextraction of carbaryl and naproxen using organic-inorganicmonolithic columns containing a double molecular imprint. MicrochimActa 2013, 180: 695–702. (14) TingZhang, Bo Wu, Na Sun, Yong Ye, Huaixia Chen*. Sorption anddegradation of wastewater-associated pharmaceuticalsand personal care products in agricultural soils and sediment. Water SciTechnol 2013, 68 (5): 991-998. (15) XiaofangLiu, Na Sun, Quanfei Zhu, Mei Wu, Yong Ye, Huaixia Chen*.Preparation, characterization and application of organic-inorganic hybridcaffeine imprinted monolith. J Chromatogr A 2013, 1304: 10-17. (17) ShuZhou, Huaixia Chen*, Bo Wu, Chao Ma, Yong Ye. Sensitivedetermination of carbamates in fruit and vegetables by a combination ofsolid-phase extraction and dispersive liquid-liquid microextraction prior toHPLC. Microchim Acta 2012, 176: 419–427. (18) ShuZhou, Bo Wu, Chao Ma, Yong Ye. Huaixia Chen*. Solid-phaseextraction followed by dispersive liquid-liquid microextraction for thesensitive determination of carbamates in environmental water byhigh-performance liquid chromatography. J Liq Chromatogr R T 2012,35: 1-13. (19) BoWu, Ting Zhang, Jinxia Li, Yong Ye. Huaixia Chen*. Thephotodegradation of metronidazole in the presence of coexistingpharmaceuticals. Water Sci Technol 2012, 735-740. (20) NaSun, Shengli Wu, Huaixia Chen*, Daijun Zheng, Junwen Xu, Yong Ye.Determination of sulfamethoxazole in milk using molecularly imprinted polymermonolith microextraction coupled to HPLC. Microchim Acta 2012,179: 33-40. (21) ChaoMa, Hui Chen, Na Sun, Yong Ye, Huaixia Chen*. Preparation ofMolecularly Imprinted Polymer Monolith with an Analogue of Thiamphenicol andApplication to Selective Solid-Phase Microextraction. Food AnalMethods 2012, 5: 1267–1275. (22) JinfangZhou, Chao Ma, Shu Zhou, Peili Ma, Fangrong Chen, Yue Qi, Huaixia Chen*. Preparation, evaluation and application of molecularlyimprinted solid-phase microextraction monolith for selective extraction ofpirimicarb in tomato and pear. J Chromatogr A 2010, 1217:7478-7483. (23) Huaixia Chen*, Jianlin Huang, Juan Li. Characterization of metabolites of worenine in rat biologicalsamples using liquid chromatography–tandem mass spectrometry. J PharmBiomed Anal 2010, 51: 236-243. (24) HuaixiaChen*, Hui Chen, Lei Liao, Jun Ying, and Jianlin Huang. Determination ofthiamphenicol in honey by dispersive liquid-liquid microextractionwithhigh-performance liquid chromatography. J Chromatogr Sci 2010,48: 450-455. (25) HuaixiaChen*, Hui Chen, Jun Ying, Jianlin Huang, Lei Liao. Dispersiveliquid-liquid microextraction followed by high-performance liquidchromatography as an efficient and sensitive technique for simultaneousdetermination of chloramphenicol and thiamphenicol in honey. Anal ChimActa 2009, 632:80-85. (26) Huaixia Chen*, Yong Chen, Peng Du,Fengmei Han. Structural elucidation of in vivo and in vitro metabolites ofanisodine by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal 2007, 44: 773-778. (27) B.Y.Ge, H.X. Chen, F.M. Han, Y. Chen. Identification of Amygdalin andits major metabolites in Rat Urine by LC-MS/MS. J Chromatogr B 2007,857:281-286. (28) MingmingZhu, Fengmei Han, Huaixia Chen, Zhihong Peng, Yong Chen.Identification of palmatine and its metabolites in rat urine by liquidchromatography-tandem mass spectrometry. Rapid Commun MassSpectrum 2007, 21(13):2019-2022. 引用8次(2013.4.7) (29) ZhihongPeng, Wei Song, Fengmei Han, Huaixia Chen, Mingming Zhu, Yong Chen.Chromatographic tandam mass spectrometric setection of papaverine and its majormetabolites in rat urine. Int J MassSpectrom 2007,266: 114-121. (30) HuaixiaChen, Yong Chen, Hong Wang, Peng Du, Fengmei Han, Huashan Zhang*. Analysisof scopolamine and its eighteen metabolites in rat urine by Liquidchromatography-tandem mass spectrometry. Talanta 2005, 67/5:984-991. 获奖与荣誉: 中共湖北省委“优秀党务工作者”; 湖北省教学成果一等奖(排名第四); 湖北大学教学成果一等奖(排名第六); 湖北大学优秀党员; 湖北大学教学名师; 湖北大学2009年度和2001年度本科教学质量优秀奖; 湖北大学优秀教师; 湖北大学工会优秀女会员; 学校优秀教案三等奖。
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