西北大学化学与材料科学学院有机化学与化学生物学学部李剑利

yanyan

  姓名：李剑利          性别：男          民族：汉
  部门：有机化学与化学生物学学部           出生年月：1973-02
  籍贯：陕西扶风          职称：教授
  邮箱：lijianli@nwu.edu.cn          电话：13363988385(H)    029-81535026(O)
研究方向：        有机化学，化学生物学
简    介
　　李剑利，理学博士，教授、博士生导师，现任陕西省化学会副秘书长，陕西省高等教育学会副秘书长。曾任职西北大学化学与材料科学学院院长助理，西北大学国家级化学实验教学示范中心主任。1993年至1997年在西北大学化学系有机化学专业本科（基础人才培养基地班），获理学学士学位(导师朱兴才教授)，留校任教；2002年至2007年在西北大学化学系有机化学专业硕-博连读，获理学博士学位（导师史真教授），研究方向仿生有机合成新反应及方法学研究；2007年至2011年在西北大学生命科学学院生物学博士后流动站合作研究（导师赵桂仿教授），主要从事复杂结构功能化合物（化学生物学光敏荧光探针）的设计合成与生物学应用研究；2012年1月-4月在法国斯特拉斯堡大学短期访学，从事生命体系光敏超分子识别研究；2015年入选“陕西省中青年科技创新领军人才支持计划”。
　　主要研究方向：仿生有机化学、有机合成新反应和新方法、功能有机分子的设计合成及应用、有机能源化学研究。主持研究项目：国家自然科学基金面上项目（No.21572177；21272184；20972124）3项；中国博士后科学基金面上项目（No.20080441180）1项；陕西省科技统筹创新工程重大项目预研项目（No.2011K12-77）1项；陕西省自然科学基金重点项目（No.2015JZ003）1项、面上项目（No.2007B04）1项；陕北能源化工基地建设C1化学专项研究子课题1项、生态修复惠民工程子项目1项；陕西省教育厅自然科学基金专项（No.12JK0584；08JK456）2项；西安市科技攻关项目（No.CXY1429-6；CXY1123-1）2项；西北大学自然科学研究基金项目（No.05NW45）1项，以及陕西省教学改革研究重点项目（No.13BZ21）等多项教研项目。
　　获奖情况摘要：国家教学成果奖二等奖1项；陕西省教学成果奖特等奖1项；陕西省科学技术奖壹等奖1项、叁等奖1项；陕西省高等学校科学技术奖壹等奖1项、贰等奖1项；2008-2011连续4届指导大学生国家级创新性实验计划项目获优秀；指导学生获“挑战杯”课外学术科技作品竞赛2011年校级、省级特等奖，2013年省级壹等奖、全国三等奖，个人荣获第十三届“挑战杯”全国大学生课外学术科技作品竞赛“优秀指导教师奖”。
　　近年来，以第一作者或通讯作者先后在《Organic Letters》、《Journal of Organic Chemistry》、《Analytical Chemistry》、《Inorganic Chemistry》、《Scientific Reports》、《Chemistry–An Asian Journal》、《Analytica Chimica Acta》、《European Journal of Organic Chemistry》、《Sensors and Actuators B:Chemical》、《Dyes and Pigments》、《RSC Advances》、《Tetrahedron》、《Tetrahedron Letters》、《Synthesis》、《Journal of Luminescence》、《Chinese Chemical Letters》、《Chinese Journal of Chemistry》、《高等学校化学学报》等国内外权威学术期刊发表研究论文60余篇，国家授权发明专利13项，国家受理发明专利10项。


　　近期代表性论文：
　　1.Xilang Jin;Shaoping Wu;Mengyao She;Yifan Jia;Likai Hao;Bing Yin;Lanying Wang;Martin Obst;Yehua Shen;Yongmin Zhang;Jianli Li*.Novel Fluorescein-Based Fluorescent Probe for Detecting H2S and Its Real Applications in Blood Plasma and Biological Imaging.Analytical Chemistry,2016,88,11253-11260.
　　2.Mengyao She;Zheng Yang;Likai Hao;Zhaohui Wang;Tianyou Luo;Martin Obst;Ping Liu;Yehua Shen;Shengyong Zhang;Jianli Li*.A novel approach to study the structure-property relationships and applications in living systems of modular Cu2+fluorescent probes.Scientific Reports,2016,|6:28972|DOI:10.1038/srep28972.
　　3.Zheng Yang;Mengyao She;Siyue Ma;Bing Yin;Ping Liu;Xiangrong Liu;Shunsheng Zhao;Jianli Li*.Rhodamine based guanidinobenzimidazole functionalized fluorescentprobe for tetravalent tin and its application in living cells imaging.Sensors and Actuators B:Chemical,2016,DOI:10.1016/j.snb.2016.09.170.
　　4.Yuelu Zhu;Cheng Li;Jidong Zhang;Mengyao She;Wei Sun;Kerou Wan;Yaqi Wang;Bin Yin;Ping Liu;Jianli Li*.A Facile FeCl3/I2‑Catalyzed Aerobic Oxidative Coupling Reaction:Synthesis of Tetrasubstituted Imidazoles from Amidines and Chalcones.Organic Letters,2015,17,3872-3875.
　　5.Hongmei Li;Cuiling Wang;Mengyao She;Yuelu Zhu;Jidong Zhang;Zheng Yang;Ping Liu*;Yaoyu Wang;Jianli Li*.Two rhodamine lactam modulated lysosome-targetable fluorescence probes for sensitively and selectively monitoring subcellular organelle pH change.Analytica Chimica Acta,2015,900,97-102.
　　6.Chen Li;Bing Yin;Yifan Kang;Ping Liu*;Liang Chen;Yaoyu Wang;Jianli Li*.Mixed Ligand CuIIN2O2 Complexes:Biomimetic Synthesis,Activities in Vitro and Biological Models,Theoretical Calculations.Inorganic Chemistry,2014,53,13019-13030.
　　7.Zheng Yang;Mengyao She;Bing Yin;Likai Hao;Martin Obst;Ping Liu*;Jianli Li*.Solvent-dependent turn-on probe for dual monitoring of Ag+and Zn2+in living biological samples.Analytica Chimica Acta,2015,868,53-59.
　　8.Xilang Jin;Likai Hao;Mengyao She;Martin Obst;Andreas Kappler;Bing Yin;Ping Liu;Jianli Li*;Lanying Wang;Zhen Shi.Visualizing tributyltin(TBT)in bacterial aggregates by specific rhodamine-based fluorescent probes.Analytica Chimica Acta,2015,853,514-520.
　　9.Chen Li;Haixia Ge;Bing Yin;Mengyao She;Ping Liu;Xiangdong Li;Jianli Li*.Novel 3,6-unsymmetrically disubstituted-1,2,4,5-tetrazines:S-induced one-pot synthesis,properties and theoretical study.RSC Advances,2015,5,12277-12286.
　　10.Siyue Ma;Zheng Yang;Mengyao She;Wei Sun;Bing Yin;Ping Liu;Shengyong Zhang;Jianli Li*.Design and synthesis of functionalized rhodamine based probes for specific intracellular fluorescence imaging of Fe3+.Dyes and Pigments,2015,115,120-126.
　　11.Cheng Li;Shujuan An;Yuelu Zhu;Jin Zhang;Yifan Kang;Ping Liu;Yaoyu Wang;Jianli Li*.Copper-catalyzed intermolecular cyclization of nitriles and 2-aminobenzylamine for 3,4-dihydroquinazolines and quinazolines synthesis via cascade coupling and aerobic oxidation.RSC Advances,2014,4,49888-49891.
　　12.Zheng Yang;Likai Hao;Bing Yin;Mengyao She;Martin Obst;Andreas Kappler;Jianli Li*.Six-Membered Spirocycle Triggered Probe for Visualizing Hg2+in Living Cells and Bacteria-EPS-Mineral Aggregates.Organic Letters,2013,15(17),4334-4337.
　　13.Li Xiangnan;Li Cheng;Yin Bing;Li Cong;Liu Ping;Li Jianli*;Shi Zhen.DDQ-Induced Dehydrogenation on Heterocycles for C-C Double Bond Formation:Synthesis of 2-Thiazoles and 2-Oxazoles.Chemistry–An Asian Journal,2013,8,1408-1411.
　　14.Shujuan An;Bing Yin;Ping Liu;Xiangnan Li;Chen Li;Jianli Li*;Zhen Shi.Microwave-Assisted Cascade Cycloaddition for C-N Bond Formation:An Approach to the Construction of 1,4,5,6-Tetrahydropyrimidine and 2-Imidazoline Derivatives.Synthesis,2013,45,2525-2532.
　　15.Zheng Yang;Mengjia Wang;Mengyao She;Bing Yin;Yangyang Huang;Ping Liu;,Jianli Li*;Shengyong Zhang.New aliphatic and aromatic dialdehyde bridged turn-on probes forhypochlorite detection in biological samples based on bis(fluorescein).Sensors and Actuators B:Chemical,2014,202,656-662.
　　16.Wei Sun;Zhao-Hui Wang;Meng-Yao She;Zheng Yang;Xi-Lang Jin;Ya-Qi Wang;Zhen Shi;Jian-Li Li*.Study on the inclusion behavior and solid inclusion complex of 5-amino-6-methyl-2-benzimidazolone with cyclodextrins.Chinese Chemical Letters,2016,27,1077-1082.
　　17.Yang-Yang Huang;Meng-Jia Wang;Zheng Yang;Meng-Yao She;Shu Wang;Ping Liu*;Jian-Li Li*;Zhen Shi.High efficient probes with Schiff base functional receptors for hypochlorite sensing under physiological conditions.Chinese Chemical Letters,2014,25,1077-1081.
　　18.Yanning Shi;Xilang Jin;Yechen Hu;Shuli Wang;Jianli Li*;Zhen Shi.Synthesis,characterization of bis[2-(1H-benzi midazol-2-yl)benzoa-to]nickel(II),and its application in the formation of dimethyl carbonate from methanol and CO2.Research on Chemical Intermediates,2014,40(3):1179-1186.
　　19.Xilang Jin;Likai Hao;Yanling Hu;Mengyao She;Yanning Shi;Martin Obst;Jianli Li*;Zhen Shi.Two novel fluorescein-based fluorescent probes for hypochlorite andits real applications in tap water and biological imaging.Sensors and Actuators B:Chemical,2013,186,56-60.
　　20.She Mengyao;Xiao Dawei;Yin Bing;Yang Zheng;Liu Ping;Li Jianli*;Shi Zhen.An efficiently cobalt-catalyzed carbonylative approach to phenylacetic acid derivatives.Tetrahedron,2013,69:7264-7268.
　　21.Zheng Yang;Mengyao She;Jin Zhang;Xiaoxiang Chen;Yangyang Huang;Hengyan Zhu;Ping Liu;Jianli Li*;Zhen Shi.Highly sensitive and selective rhodamine Schiff base“off-on”chemosensors for Cu2+imaging in living cells.Sensors and Actuators B:Chemical,2013,176,482-487.
　　22.Ge Haixia;Liu Ping;Li Xiangnan;Sun Wei;Li Jianli*;Yang Bingqin;Shi Zhen.S-Co(II)cascade catalysis:cyclocondensation of aromatic nitriles with alkamine.Tetrahedron,2013,69,6591-6597.
　　23.Likai Hao*#;Jianli Li#;Andreas Kappler;Martin Obst.Mapping of heavy metal ion sorption to cell-extracellular polymeric substance-mineral aggregates by using metal-selective fluorescent probes and confocal laser scanning microscopy.Applied and Environmental Microbiology,2013,79,6524-6534.
　　24.Yang Zheng;She Mengyao;Yin Bing;Cui Jihong;Zhang Yuze;Sun Wei;Li Jianli*;Shi Zhen.Three rhodamine-based"off-on"chemosensors with high selectivity and sensitivity for Fe3+imaging in living cells.Journal of Organic Chemistry,2012,77(2),1143-1147.
　　25.Li Xiangnan;Zhou Baoyue;Zhang Jin;She Mengyao;An Shujuan;Ge Haixia;Li Cong;Yin Bing;Li Jianli*;Shi Zhen.Solvent-free tandem synthesis of 2-thiazolines and 2-oxazolines catalyzed by acopper catalyst.European Journal of Organic Chemistry,2012,(8),1626-1632.
　　26.She Mengyao;Yang Zheng;Yin Bing;Zhang Jin;Gu Jia;Yin Wenting;Li Jian-li*,Zhao Guifang;Shi Zhen.A novel rhodamine-based fluorescent and colorimetric"off-on"chemosensor and investigation of the recognizing behavior towards Fe3+.Dyes and Pigments,2012,99(3),1337-1343.
　　27.Yin Wenting;Cui Hao;Yang Zheng;Li Chen;She Mengyao;Yin Bing;Li Jian-li*;Zhao Guifang;Shi Zhen.Facile synthesis and characterization of rhodamine-based colorimetric and“off–on”fluorescent chemosensor for Fe3+.Sensors and Actuators B:Chemical,2011,32(9),2046-2061.
　　28.Xianglong Wu;Xilang Jin;Yunxia Wang;Qibing Mei;Jianli Li*;Zhen Shi*.Synthesis and Spectral Properties of Novel Chlorinated Ph Fluorescent Probes.Journal of Luminescence,2011,131,776-780.
　　29.Zhang Jin;Wang Xiao;Yang Meipan;Wan Kerou;Yin Bing;Wang Yunxia;Li Jianli*;Shi Zhen.Copper-catalyzed synthesis of 2-imidazolines and their N-hydroxyethyl derivatives under various conditions.Tetrahedron Letters,2011,157(2),675-680.
　　30.Zhang Bin;Li Jianli*;Chen Wei;Wang Yunxia;Shi Zhen.Synthesis,crystal structure of Co(II)(6-methoxybenzothiazole-2-carboxylate)2(DMF)2 and its application to carbonylation of benzyl chloride.Chinese Journal of Chemistry,2010,28(1),111-114.
　　31.Xiao Dawei;Zhang Bin;Li Jianli*;Shi Zhen.Synthesis and characterization of anew ligand 2-(4,5-dihydro-2-thiazolyl)-6-methoxylbenzothiazole and its dinuclear Co(II)complex.Chinese Journal of Structural Chemistry,2010,29(11),1712-1716.
　　32.黄阳阳;王梦嘉;厍梦尧;杨征;刘萍;李剑利*;史真.基于氧杂蒽结构可控官能化的荧光探针研究新进展,有机化学,2014,34(1),1-25.(本期封面文章)
　　33.周葆悦;张金;李向南;厍梦尧;张劲;李剑利*;史真.2-咪唑啉类化合物的合成及应用研究新进展,有机化学,2013,33(3),423-435.(本期封面文章)
　　34.李晨;杨征;厍梦尧;尹文婷;李剑利*;赵桂仿;史真.超氧化物歧化酶化学模拟的新进展,高等学校化学学报,2011,32(9),2046-2061.
　　35.李娜;刘美玲;尹文婷;杨征;李剑利*;史真.罗丹明基“OFF-ON”型荧光探针研究的一些新进展,有机化学,2011,31(1),39-53.
　　36.李剑利;尹文婷;张金;郭媛;武祥龙;白银娟;史真*.环己基甲酮类化合物的仿生合成方法研究,高等学校化学学报,2008,29(1),100-103.