西北大学化学与材料科学学院 高分子化学与物理学部宫永宽

zhiqiu

姓名：宫永宽          性别：男          民族：汉
部门：高分子化学与物理学部
籍贯：陕西          职称：教授
邮箱：gongyk@nwu.edu.cn          电话：    029－81535032（Lab）(O)
研究方向：        　1.功能化仿细胞膜结构聚合物的设计与合成；2.仿细胞膜结构及贻贝万能粘附表面改性；3.癌症精确诊断及治疗用新型纳米载体材料；4.仿细胞膜结构高性能人工器官研究；5.材料表面仿生改性。
简    介
　　1986年获西北大学硕士学位后留校从事教学及科研工作。1997－1998年在日本物质工学工业技术（筑波）研究所进行聚合物LB膜研究。1998－2001年在日本佐贺大学攻读博士学位，2001－2003年在加拿大蒙特利尔大学药学院进行博士后研究，2008-2009年在美国西北大学生物医学工程系进行访问研究，2011.10--2012.03在佐贺大学化学化工系进行访问研究。现任高分子化学与物理专业学术带头人、博士生导师、二级教授，西北大学材料科学新技术研究所所长，西安市仿生生物材料与器件工程实验室主任。
　　2004年以来，在西北大学开展高分子科学的教学与科学研究工作，主要从事生物医用高分子材料的合成及应用研究。仿照细胞膜的结构及功能，合成了含磷酰胆碱基团的高分子单体及多种聚合物，研究了含磷酰胆碱两亲共聚物在材料表面的调控组装及其聚集结构；建立了用仿细胞膜结构修饰生物材料表面的一系列方法。仿贻贝万能粘附作用，建立了在室温水溶液中构建功能基团数量关系明确的多功能涂层改性不同材料、器件及纳米药物的共性关键技术方法。主持国家自然科学基金、省部级科研计划等研究课题10余项；发表研究论文100余篇，申请发明专利28项（17项已获授权）。
　　**********“仿生生物材料实验室”为有识之士提供机会，欢迎本科生、博、硕士研究生及博士后加盟！**********
媒体报道：
1.《“隐形生物导弹”有望消除化疗副作用》在2015年6月5日科技日报显要位置报道。中国科技网，人民网，中国网，科教网，今日科学，世界中医药网，长城网，科技世界网，高端装备网，中国化工仪器网，中国商务新闻网,生物360网，光明网，中国聚合物网，中国科学院官网科技动态栏目等网络媒体已有转载及介绍。http://digitalpaper.stdaily.com/ ... t_305611.htm?div=-1
2.《宫永宽：给生物医用材料穿上仿细胞膜外衣》在2015年5月13日《科学中国人》报道。http://www.scichi.cn/content.php?id=1248
代表性论文：
Yan-Bing Wang, Ke-Hui Shi, Hong-Li Jiang*, Yong-Kuan Gong*. Significantly reduced adsorption and activation of blood components in amembrane oxygenator system coated with crosslinkable zwitterionic copolymer. Acta Biomaterialia, 2016, http://dx.doi.org/10.1016/j.actbio.2016.02.036


Yuan Dang, Cheng-Mei Xing, Miao Quan, Yan-Bing Wang, Shi-Ping Zhang, Su-Qing Shi and Yong-Kuan Gong*. Substrate independent coating formation and anti-biofouling performance improvement of mussel inspired polydopamine. Journal of Materials Chemistry B, 2015, 3:4181-4190.


Pengxiang Jia, Min He, Yongkuan Gong*, Xiao Chu, Jingfa Yang, and Jiang Zhao*. Probing the Adjustments of Macromolecules during Their Surface Adsorption. ACS Appl. Mater. Interfaces, 2015, 7(12):6422-6429.


Yuan Dang, Miao Quan, Cheng-Mei Xing, Yan-Bing Wang and Yong-Kuan Gong. Biocompatible and antifouling coating of cell membrane phosphorylcholine and mussel catechol modified multi-arm PEGs. Journal of Materials Chemistry B, 2015, 3:2350–2361.


Jing Zhao, Yu-Dong Chai, Jing Zhang, Peng-Fei Huang, Kenichi Nakashima, Yong-Kuan Gong. Long circulating micelles of an amphiphilic random copolymer bearing cell outer membrane phosphorylcholine zwitterions. Acta Biomaterialia, 2015, 16:94–102.


Yan-Bing Wang, Ming Gong, Shan Yang, K. Nakashima, Yong-Kuan Gong, Hemocompatibility and film stability improvement of crosslinkable MPC copolymer coated polypropylene hollow fiber membrane. Journal of Membrane Science, 2014, 452:29-36.


Ming Gong, Yuan Dang, Yan-Bing Wang, Shan Yang, Françoise M. Winnik and Yong-Kuan Gong. Cell membrane mimetic films immobilized by synergistic grafting and crosslinking. Soft Matter, 2013, 9:4501-4508.


Yong-kuan Gong, Liping Liu, Phillip B.Messersmith. Doubly Biomimetic Catecholic Phosphorylcholine Copolymer:A Platform Strategy for Fabricating Antifoul-ing Surfaces, Macromolecular Bioscience, 2012, 12:979-985.


Dominic E. Fullenkamp, JoséG Rivera, Yong-kuan Gong, K. H. AaronLau, Lihong He, Rahul Varshney, Phillip B. Messersmith, Mussel-inspired silver-releasing antibacterial hydrogels. Biomaterials, 2012, 33(15):3783-3791.


Yong-kuan Gong, Françoise M. Winnik. Strategies in biomimetic surface engineering of nanoparticles for biomedical applications. Nanoscale, 2012, 4:360-368.


Ming Gong, Yan-Bing Wang, Ming Li, Bi-Huang Hu, Yong-Kuan Gong. Fabrication and hemocompatibility of cell outer membrane mimetic surfaces on chitosan by layer by layer assembly with polyanion bearing phosphorylcholine groups. Colloids and Surfaces B:Biointerfaces, 2011, 85:48-55.


Suqing Shi, Pu Xiao, Kemin Wang, Yongkuan Gong and Jun Nie. Influence of chemical structures of benzodioxole-based coinitiators on properties of unfilled dental resins. Acta Biomaterialia, 2010, 6(8):3067-3071.


Peng-bo Huangfu, Ming Gong, Cunfu Zhang, Shan Yang, Jiang Zhao, Yong-kuan Gong. Cell outer membrane mimetic modification of across-linked chitosan surface to improve its hemocompatibility. Colloids and Surfaces B:Biointerfaces, 2009, 71:268-274.


Shan Yang, Shi-Ping Zhang, F.M.Winnik, F.Mwale, Yong-Kuan Gong. Group reorientation and migration of amphiphilic polymer bearing phosphorylcholine functionalities on surface of cellular membrane mimicking coating. J. Biomed. Mater. Res. A, 2008, 84A(3):837-841.


Ming Gong, Shan Yang, Jia-ni Ma, Shi-ping Zhang, Françoise M.Winnik, Yong-kuan Gong. Tunable cell membrane mimetic surfaces prepared with anovel phospholipid polymer. Appl. Surf. Sci., 2008, 255:555-558.


Yong-Kuan Gong, Li Luo, Alain Petit, David J.Zukor, Olga L.Huk, John Antoniou, Françoise M.Winnik, Fackson Mwale. Adhesion of human U937 macrophages to phosphorylcholine-coated surfaces. J. Biomed. Mater. Res. Part A, 2005, 72A(1):1-9.


Feng Shen, Anna Aihua Li, Yong-Kuan Gong, Sat Somers, Murray A. Potter, Francoise M. Winnik. Patricia L.Chang,Encapsulation of Recombinant Cells with aNovel Magnetized Alginate for Magnetic Resonance Imaging. Human Gene Therapy, 2005, 16(8):971-984.


Yong-Kuan Gong, Fackson Mwale, Michael R. Wertheimer, Francoise M. Winnik. Promotion of U937 cell adhesion on polypropylene surfaces bearing phosphorylcholine functionalities. J. Biomater. Sci., Polymer Edition, 2004, 15(11):1423-1434.


Yong-Kuan Gong and Kenichi Nakashima. Photoinduced Electron Transfer from Pyrenes to Alkyl Viologens on the Surface of Polystyrene Latex Particles:Effects of Polarities of the Donors and Charge Densities of the Particles. J. Phys. Chem. B, 2002, 106(4):803-808.


Yong-Kuan Gong, Kenichi Nakashima and Renliang Xu. A Novel Method to Determine Effective Charge of PS Latex Particles in Aqueous Dispersion. Langmuir, 2001, 17:2889-2892.


Yong-Kuan Gong and Kenichi Nakashima. Penetration of Pyrene and its derivatives into PS Latex Particles as Studied by Fluorescence Techniques. Chem. Commun., 2001, 1772-1773.


Yong-Kuan Gong, Kenichi Nakashima and Renliang Xu. Characterization of Polystyrene Latex Surfaces by Conductometric Titration,Rhodamine 6G Adsorption and Electrophoresis Measurements. Langmuir, 2000, 16(22):8546-8548.


Yong-Kuan Gong, Tsuyoshi Miyamoto, Kenichi Nakashima and Shuichi Hashimoto. Photoinduced Electron Transfer from 3-(9-Anthracence)propyl Ammonium Bromide and Pyrene to Methl viologen on the Surface of Polystyrene Latex Particles. J. Phys. Chem. B, 2000, 104(24):5772-5778.