东北师范大学化学学院高分子研究室陈莉

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陈莉
东北师范大学化学学院
职　　称：教授
研究方向：智能性载体材料，纳米药物
办公电话：chenl686@nenu.edu.cn
办公地点：化学楼128室
电子邮件：chenl686@nenu.edu.cn
个人简历
陈莉，博士，教授，博士生导师。
东北师范大学化学学院高分子教研室教师，中科院长春应化所生态环境高分子材料重点实验室客座研究人员。“吉林省高校新世纪科学技术优秀人才”
　　主要从事智能性高分子载体材料的设计合成及其在药物控制释放、催化体系的应用研究。近年来，在天然多糖类生物医用高分子材料改性的基础上，进一步将其智能化，实现对口服蛋白类药物及抗肿瘤药物的控释释放，在Biomaterials、Biomacromolecules、Chemical Communications, Polymer、Polymer Chemistry,Journal of Materials Chemistry,Langmuir,Soft Matter等杂志发表SCI论文50余篇，申请专利10项，其中6项已授权。
　　主持国家自然科学基金面上项目、国家自然科学基金青年基金、吉林省科技厅重点项目、吉林省青年基金、吉林省科技厅国际合作项目、吉林省人力资源保障厅留学回国人员科研启动项目、吉林省环境保护厅项目10余项。曾获第四十二届博士后基金二等奖资助。参与完成的项目获2007年吉林省科技进步奖一等奖。
　　从事本科生和研究生的教学工作，讲授本科生的高等有机、有机合成实验、综合实验、功能高分子材料等课程；讲授硕士研究生的高分子化学课程；博士研究生的高分子前沿导论。
　　指导博士研究生5名，硕士研究生22名，指导30名本科生毕业设计，指导本科生科研立项3项。
　　目前形成了科研方向明确，年轻富有朝气的科研团队，欢迎对生物医用高分子材料感兴趣的同学作为新生力量补充我们的科研力量加入我们的团队。
【主要研究方向】
可完全生物降解医用高分子材料的研究，具体从事智能型水凝胶、微凝胶及纳米胶的合成及其在药物缓释体系的应用；基于天然产物的生物纳米复合物的制备及性能研究；智能型高分子/无机复合材料的开发应用。
【受教育经历】
2003/09 - 2006/12，中科院长春应用化学研究所，高分子化学与物理，博士
2000/09 - 2003/06，东北师范大学，有机化学，硕士
1992/09 - 1996/06，哈尔滨工业大学，高分子化学与物理，学士
【研究工作经历】
2016/07 - ， 东北师范大学，化学学院，教授、博士生导师
2007/12 - 2016/06， 东北师范大学，化学学院，副教授、博士生导师
2016/11 - 2017/11， 美国伊利诺伊大学香槟分校，工学院材料系 访问学者
2009/11 - 2010/11， 德国慕尼黑大学，药学院 博士后
2007/01 - 2009/09， 中粮吉林华润生化有限公司，博士后
2003/12 - 2007/12， 东北师范大学，化学学院，讲师
2002/06 - 2003/12， 东北师范大学，化学学院，助教
【主要科研项目】
1.模块化多功能抗肿瘤纳米载药体系的设计合成 国家自然科学基金委面上项目
　 2013.1-2016.12　　　 项目主持 80万
2. 纳米淀粉/聚乳酸复合材料的研究　 国家自然科学基金委青年基金
　 2010.1.1-2012.12.31　项目主持 20万
3. 模块化多功能抗肿瘤纳米载药体系 吉林省科技厅高新重点项
　 2013.1.1-2015.12.30 项目主持 16万
4. 智能性天然多糖基抗肿瘤载药体系的设计合成 吉林省科技厅国际合作项目
　 2012.1-2013.12　　项目主持　7万
5. 智能性淀粉基抗肿瘤纳米给药体系的设计合成
　 吉林省人力资源和社会保障厅留学回国人员科技创新项目
　 2011.9-2013.12　　项目主持　7万
6. 纳米淀粉基水处理高分子絮凝剂的合成及性能研究 吉林省环境保护厅
　 2012.1-2013.12　　项目主持　7万
7. 纳米淀粉/聚乳酸复合材料的研究　吉林科技厅青年基金
　 2009.8-2011.12　　项目主持　4万
8. 基于可再生资源的生物纳米复合物的制备研究 校内青年基金
　 2008.1-2009.12　　项目主持　3万 优秀结题
9. 可完全生物降解的淀粉基脂肪族聚酯接枝共聚物的合成校内青年基金　　　
　 2005.1－2006.12　 项目主持 2.5万 优秀结题
10. 二酮席夫碱金属化合物的合成、晶体结构和催化性能表征
　 2008.1-2010.12　　项目主持 5万
11. 功能化脂肪族聚酯的合成及应用　
　 2006.6－2007.6　　项目主持　8万
12.植物性杀虫胶的研制及其在害虫防治中的应用技术　吉林省科技厅
　 2007.1－2008.12　 第二参加人
13.淀粉/脂肪族聚酯生物纳米复合物的制备 第42批博士后科学基金二等资助
【主要科研成果】
已发表的论文：（*Corresponding Author）
2015年
[1] Li Chen,* Zhe Zhang, Xiaofei Chen, Xuemei Yao, Chaoliang He, and Xuesi Chen. Fabrication of modular multifunctional delivery for antitumor drugs based on host–guest recognition, Acta Biomaterialia, 18, 168–175, 2015
[2] Zhe Zhang, Qiang Lv, Xiaoye Gao, Li Chen,* Yue Cao, Chaoliang He, and Xuesi Chen. pH-Responsive poly(ethylene glycol)/poly(L-lactide) supramolecular micelles based on host−guest interaction, ACS Applied Materials & Interfaces, 7, 8404-8411, 2015
[3] Xuemei Yao, Xiaofei Chen, Chaoliang He, Li Chen*, and Xuesi Chen. Dual pH-responsive mesoporous silica nanoparticles for efficient combination of chemotherapy and photodynamic therapy, J. Materials Chemistry B, 3(23), 4707-4714, 2015
[4] Xuemei Yao, Li Chen,* Xiaofei Chen, Zhigang Xie, Jianxun Ding, Chaoliang He, Jingping Zhang, Xuesi Chen. pH-Responsive metallo-supramolecular nanogel for synergistic chemo-photodynamic therapy. Acta Biomaterialia, 25, 162–171, 2015
[5] Xiaofei Chen, Xuemei Yao, Chunran Wang, Li Chen*, and Xuesi Chen. Hyperbranched PEG-based supramolecular nanoparticles for acid-responsive targeted drug delivery, Biomater. Sci. 3, 870–878, 2015
[6] Zhiyong Sun, Yangxue Li, Li Chen,* Zhigang Xie, and Xiabin Jing. Fluorescent Hydrogen-Bonded Organic Framework for Sensing of Aromatic Compounds,Cryst. Growth Des. 15, 542−545, 2015
[7] Li Chen*, Zhe Zhang, Xuemei Yao, Xiaofei Chen, and Xuesi Chen. Intracellular pH-operated mechanized mesoporous silica nanoparticles as potential drug carries, MICROPOR MESOPOR MAT. 201, 169-175, 2015
[8] Xiaowei Wu, Yanfang Hu, Xiaohong Wang, Li Chen*. Thermo-responsive polymer micelle-based nanoreactors for intelligent polyoxometalate catalysis, Catalysis Communications 58, 164-168, 2015
[9] Xiaofei Chen, Xuemei Yao, Li Chen*. Intracellular pH-sensitive dextran-based micelles as efficient drug delivery platforms, POLYM. INT. 64(3), 430-436, 2015
[10]Xiaofei Chen, Xuemei Yao, Chunran Wang, Li Chen*, and Xuesi Chen. Mesoporous silica nanoparticles capped with fluorescence-conjugated cyclodextrin for pH-activated controlled drug delivery and imaging, MICROPOR MESOPOR MAT. 217, 46-53, 2015
[11]Xiaofei Chen, Xuemei Yao, Chunran Wang, Li Chen*, and Xuesi Chen. Acid-sensitive nanogels for synergistic chemo-photodynamic therapy, Macromolecular Bioscience, 15, 1563-1570, 2015
[12]Xiaofei Chen, Xiaoye Gao, Xuemei Yao, Li Chen*, Chaoliang He, and Xuesi Chen. Targeted dextran-b-poly(3-caprolactone) micelles for cancer treatments, Zhe Zhang, RSC Advances, 5, 18593–18600, 2015
2014年
[1] Xiaofei Chen, Li Chen,* Xuemei Yao, Zhe Zhang, Chaoliang He, Jingping Zhang and Xuesi Chen. Dual responsive supramolecular nanogels for intracellular drug delivery, Chemical Communication, 50, 3789-3791, 2014
[2] Xuemei Yao, Li Chen,* Xiaofei Chen, Zhe Zhang, Hui Zheng, Chaoliang He, Jingping Zhang, and Xuesi Chen. Intracellular pH-sensitive metallo-supramolecular nanogels for anticancer drug delivery, ACS Applied Materials & Interfaces, 6(10), 7816-7822, 2014
[3] Xiaowei Wu, Xiaofei Chen, Hongyu Guan, Xiaohong Wang, Li Chen*. A recyclable thermo-responsive catalytic system based on poly (N-isopropylacrylamide)-coated POM@SBA-15 nanospheres, Catalysis Communications 51, 29-32, 2014
[4] Zhiyong Sun, Yangxue Li, Xingang Guan, Tingting Sun, Li Chen,* Zhigang Xie and Xiabin Jing. A single-step emulsion approach to prepare fluorescent nanoscale coordination polymers for bioimaging, RSC Advances, 4, 14803–14806, 2014
[5] Xuemei Yao, Li Chen*, Xiaofei Chen, Chaoliang He, Hui Zheng, Xuesi Chen. Metallo-supramolecular nanogels for intracellular pH-responsive drug release,Macromolecular Rapid Communications, 35, 1697−1705, 2014
[6] Xuemei Yao, Li Chen*, Xiaofei Chen, Chaoliang He, Hui Zheng, Xuesi Chen. Intercellular pH-responsive histidine modified dextran-g-cholesterol micelle for anticancer drug delivery, Colloids and Surfaces B: Biointerfaces, 121, 36-43 2014
[7] Li Chen,* Zhe Zhang, Ziwei Zhao, Xiaohong Wang, Xuesi Chen. Polyoxometalates acid treatment for preparing starch nanoparticles, Carbohydrate Polymers, 112, 520-524, 2014
[8] Zhiyong Sun, Yangxue Li, Xingang Guan, Tingting Sun, Li Chen,* Zhigang Xie and Xiabin Jing. Rational design and synthesis of covalent organic polymers with hollow structure and excellent antibacterial efficacy, RSC Advances, 4(76), 40269-40272, 2014
[9] Xiaofei Chen, Xuemei Yao, Zhe Zhang, and Li Chen*. Plug-and-play multifunctional mesoporous silica nanoparticles as potential platforms for cancer therapy, RSC Advances, 4(90), 49137-49143, 2014
[10] Ziwei Zhao, Xuemei Yao, Zhe Zhang, Li Chen*, Chaoliang He, and Xuesi Chen. Boronic acid shell-crosslinked dextran-b-PLA micelles for acid-responsive drug delivery, Macromolecular Bioscience, 14(11)1609-1618, 2014
[11] Xiaowei Wu, Xiaofei Chen, Hongyu Guan, Xiaohong Wang, Li Chen*. Facile one-pot synthesis of mesoporous heteropolyacids-silica hybrid for catalytic wet hydrogen peroxide oxidation of phenol,J SOL-GEL SCI TECHN, 72, 663-667, 2014
2013年
[1] Zhe Zhang, Jianxun Ding, Xiaofei Chen, Chunsheng Xiao, Chaoliang He, Xiuli Zhuang, Li Chen,* and Xuesi Chen. Intracellular pH-Sensitive Supramolecular Amphiphiles Based on Host-Guest Recognition between Benzimidazole and β-Cyclodextrin as Potential Drug Delivery Vehicle, Polymer Chemistry-UK, 2013， 4, 3265-3271
[2] Aiping Zhang, Zhe Zhang, Fenghua Shi, Jianxun Ding, Chunsheng Xiao,Xiuli Zhuang, Chaoliang He, Li Chen* and Xuesi Chen. Disulfide crosslinked PEGylated starch micelles as efficient intracellular drug delivery platforms, Soft Matter, 2013, 9, 2224-2233
[3] Jianxun Ding, Fenghua Shi, Di Li, Li Chen*, Xiuli Zhuang and
Xuesi Chen. Enhanced endocytosis of acid-sensitive doxorubicin derivatives with intelligent nanogel for improved security and efficacy, Biomaterials Science, 2013, 1, 633-646
[4] Zhe Zhang, Hongling Shan, Jingru Sun, Yun Weng, Xiu Wang, Jie Xiong, Li Chen* and Xuesi Chen. Facile preparation of corn starch nanoparticles by alkali-freezing treatment, RSC Advances, 2013,3(32):13406-13411
[5] Aiping Zhang, Zhe Zhang, Fenghua Shi, Chunsheng Xiao, Jianxun Ding , Xiuli Zhuang, Chaoliang He, Li Chen,* and Xuesi Chen. Redox-sensitive Shell Cross-linked Polypeptide-block-Polysaccharide Micelles for Efficient Intracellular Anticancer Drug Delivery, Macromolecular Bioscience, 2013, 13:1249-1258
[6] Zhe Zhang, Hongling Shan, Li Chen,* Chaoliang He, Xiuli Zhuang,and Xuesi Chen.Synthesis of pH-Responsive Starch Nanoparticles Grafted Poly (L-glutamic acid) for Insulin Controlled Release, European Polymer Journal, 2013, 49(8): 2082-2091
[7] Zhe Zhang, Xiaofei Chen, Li Chen,* Shuangjiang Yu, Yue Cao, Chaoliang He, and Xuesi Chen, Intracellular pH-Sensitive PEG-block-Acetalated-Dextrans as Efficient Drug Delivery Platforms, ACS Applied Materials & Interfaces, 2013,5(21):10760-10766
[8] Ziwei Zhao, Zhe Zhang, Li Chen,* Yue Cao, Chaoliang He, and Xuesi Chen Biodegradable Stereocomplex Micelles Based on Dextran-block-polylactide as Efficient Drug Deliveries, Langmuir, 2013, 29(42):13072-13080页
2012年
[1] Fenghua Shi, Jianxun Ding, Xiuli Zhuang, Chunsheng Xiao, Chaoliang He, Li Chen*, Xuesi Chen. Intracellular environment responsive PEGylated polypeptides nanogels with ionizable cores for efficient doxorubicin loading and triggered release，Journal of Materials Chemistry, 2012, 22, 14168-14179
[2] Yunyan Bai, Zhe Zhang, Aiping Zhang, Li Chen,* Chaoliang He, Xiuli Zhuang, Xuesi Chen. Novel thermo- and pH-responsive hydroxypropyl cellulose- and poly(L-glutamic acid)-based microgels for oral insulin controlled release, Carbohydrate Polymers, 2012, 89, 1207-1214
[3] Yunyan Bai, Zhe Zhang, Mingxiao Deng, Li Chen,* Chaoliang He, Xiuli Zhuang, Xuesi Chen. Thermo- and pH-responsive microgels for controlled release of insulin, Polymer International,2012, 61, 1151-1157
[4] Zhe Zhang, Xiaoye Gao, Aiping Zhang, Xiaowei Wu, Li Chen*, Chaoliang He, Xiuli Zhuang, Xuesi Chen. Biodegradable pH-dependent thermo-sensitive hydrogels for oral insulin deliveries, Macromolecular Chemistry and Physics, 2012, 213, 713-719
2011年
[1] Jianxun Ding, Fenghua Shi, Chunsheng Xiao, Lin Lin, Li Chen,* Chaoliang He, Xiuli Zhuang, Xuesi Chen. One-step preparation of reduction-responsive poly(ethylene glycol)-poly(amino acid)s nanogels as efficient intracellular drug delivery platforms, Polymer Chemistry, 2011, 2(12), 2857-2864
[2] Zhe Zhang, Li Chen*, Changwen Zhao, Yunyan Bai, Mingxiao Deng, Hongling Shan, Xiuli Zhuang, Xuesi Chen, Xiabin Jing. Thermo- and pH-responsive HPC-g-AA/AA hydrogels for controlled drug delivery applications, Polymer, 2011,52(3):676-682
[3] Zhe Zhang, Li Chen*, Mingxiao Deng, Yunyan Bai, Xuesi Chen, Xiabin Jing.Biodegradable thermo- and pH-responsive hydrogels for oral drug delivery, Journal of Polymer Science Part A: Polymer Chemistry，2011，49:2941–2951
2010年前
[1] Li Chen*, Zhe Zhang, Xiuli Zhuang, Xuesi Chen, Xiabin Jing. Compatibilizing effect of starch-grafted-poly(L-lactide) on the poly(e-caprolactone)/starch composites, Journal of Applied Polymer Science, 2010, 117:2724-2731
[2] Li Chen, Zhigang Xie, Xiuli Zhuang, Xuesi Chen, Xiabin Jing. Controlled Release of Urea Encapsulated by Starch-g-poly(L-lactide), Carbohydrate Polymers, 2008, 72: 342-348
[3] Li Chen, Zhigang Xie, Junli Hu, Xueyu Qiu, Xuesi Chen, Xiabin Jing. Enantiomeric PLA-PEG block copolymers and their stereocomplex micelles used as Rifampin delivery，Journal of Nanoparticle Research, 2007，9，777-785
[4] Li Chen, Xueyu Qiu, Mingxiao Deng, Zhongkui Hong, Rui Luo, Xuesi Chen, Xiabin Jing. The starch grafted poly(L-lactide) and the physical properties of its blending composites, Polymer, 2005, 46(15): 5723-5729
[5] Li Chen, Yushan Ni, Xinchao Bian, Xueyu Qiu, Xiuli Zhuang, Xuesi Chen, Xiabin Jing. A novel approach to grafting polymerization of ε-caprolactone onto starch granules,　Carbohydrate Polymers, 2005, 60(1): 103-109
[6] Li Chen, Xueyu Qiu, Zhigang Xie, Zhongkui Hong, Jingru Sun, Xuesi Chen, Xiabin Jing. Poly(L-lactide)/starch blends compatibilized with poly(L-lactide)-g-starch copolymer, Carbohydrate Polymers, 2006, 65: 75-80
[7] Chen L, Chen XS, Deng MX, et al., Synthesis and characterization of ABBA block copolymer of glycolide and epsilon-caprolactone, Chemical Research in Chinese Universities, 2005, 21(3): 340-344
[8]Hong Zhongkui, Zhang Peibiao, He Chaoliang, Qiu Xueyu, Liu Aixue, Chen Li, Chen Xuesi, and Jing Xiabin.Nano-composite of Poly(L-lactide) and surface grafted hydroxyapatite: mechanical properties and biocompatibility, Biomaterials, 2005, 26(32): 6296-6304
[9]Qiu Xueyu, Hong Zhongkui, Hu Junli, Chen Li, Chen Xuesi, and Jing Xiabin, Hydroxyapatite Surface Modified by L-Lactic Acid and Its Subsequent Grafting Polymerization of L-Lactide, Biomacromolecules, 2005; 6(3); 1193-1199
[10]Xueyu Qiu, Li Chen, Junli Hu, Jingru Sun, Zhongkui Hong, Aixue Liu, Xuesi Chen, Xiabin Jing, Surface-modified hydroxyapatite linked by L-lactic acid oligomer in the absence of catalyst, Journal of Polymer Science Part A: Polymer Chemistry, 2005, 43(21): 5177-5185
[11]Zhigang Xie, Huili Guan, Li Chen, Huayu Tian, Xuesi Chen and Xiabin Jing，Novel biodegradable poly(ethylene glycol)-block-poly(2-methyl-2- carboxyl -propylene　carbonate) copolymers: Synthesis, characterization, and micellization, Polymer, 2005, 46(23):10523-10530
[12]Zhigang Xie, Huili Guan, Li Chen, Huayu Tian, Xuesi Chen, Xiabin Jing. Novel biodegradable poly(ethylene glycol)-block-poly(2-methyle-2-carboxyl-propylene carbonate) copolymers: synthesis, characterization, and micellization, Polymer, 2005, 46, 10523-10530.
[13]Zhigang Xie, Changhai lu, Xuesi Chen, Li Chen, Yu wang,　Xiuli Hu, Quan Shi, Xiabin Jing. Synthesis and Characterization of Novel Poly (carbonate-ester)s Based on Pentaerythritol, Journal of Polymer Science, Part A: Polymer Chemistry, 2007(9), 45, 1737-1745
[14]Zhigang Xie，Changhai lu, Xuesi Chen, Li Chen, Xiuli Hu, Quan Shi, Xiabin Jing. A Facile Approach to Biodegradable Poly(ε-caprolactone)-Poly(ethylene glycol)-Based Polyurethanes Containing Pendant Amino Groups, European Polymer Journal, 2007, 43, 2080-2087
[15]Zhongkui Hong, Peibiao Zhang, Aixue Liu, Chen Li, Xuesi Chen, Xiabin Jing. Composites of poly(lactide-co-glycolide) and the surface modified carbonated hydroxyapatite nanoparticles, Journal of Biomedical Materials Research Part A,　2007, 81A(3), 515-522
[16]Zhongkui Hong, Aixue Liu, Chen Li, Xuesi Chen, Xiabin Jing. Preparation of bioactive glass ceramic nanoparticles by combination of sol-gel and coprecipitation method, J NON-CRYST SOLIDS, 2009, 355:368-372
获奖情况
1. 陈莉 邓明虓. 生物可降解载体材料的设计与应用 吉林省自然科学奖，三等奖，2014.11
2. 陈莉 张喆 赵紫薇 吴晓伟 王晓红 庄秀丽 陈学思. 一种固体杂多酸催化水解制备非水溶性多糖纳米颗粒的方法
首届发明创造大赛，三等奖，2013
3. 陈莉. 智能性药物载体的设计合成 吉林省自然科学学术成果奖 二等奖 2014
授权专利：
[1] 陈莉 张喆 白云艳 单红玲 陈学思 庄秀丽，一种聚（L-谷氨酸-g-甲基丙烯酸羟乙酯）与羟丙基纤维素-g-丙烯酸共聚水凝胶及制法, 2013.02.13，中国，ZL201010205252.X
[2] 陈莉 单红玲 张喆 孙静茹 庄秀丽 陈学思， 一种可完全生物降解的纳米淀粉接枝聚谷氨酸苄酯，2012.08.22，中国， Zl201110104623.x
[3] 陈莉 单红玲 张喆 孙静茹 庄秀丽 陈学思，可完全生物降解的纳米淀粉接聚乳酸，2012.08.22，中国，ZL201110104620.6
[4] 陈莉 张喆 陈学思 庄秀丽 白云艳 单红玲， 一种pH 和温度敏感性水凝胶及其制备方法，2012.02.08，中国，ZL200910217799.9
[5] 陈莉 张爱平 张喆 赵紫薇 庄秀丽 陈学思，葡聚糖基两亲性嵌段共聚物制备方法，中国，ZL201210075156.7
[6] 陈莉 姚雪梅 栗迪 张喆 邓明虓，一种羟乙基淀粉-阿霉素键合药的制备方法，中国，ZL201410029643.9
[7] 陈学思 陈莉 景遐斌 邱雪宇 洪重奎 庄秀丽，表面乳酸接枝改性淀粉与脂肪族聚酯接枝共聚物的制备方法, 中国，ZL200510016771.0
[8] 陈学思 陈莉 景遐斌 庄秀丽，一种冷水可溶性淀粉制备方法，中国，ZL200510119063.x
[9] 庄秀丽 陈莉 陈学思 王献红 景遐斌 孙静茹，可完全生物降解的淀粉基复合物及制备方法,中国，ZL200610016732.5
[10]陈学思 陈莉 庄秀丽 孙敬茹 景遐斌，一种尿素缓释肥的制备方法，中国ZL200710055312.2