姓名:房雷 ·性别:男 ·出生年月:1979.10 ·民族:汉 ·职称:副教授 ·学历:博士 ·联系电话:13776633178 【研究方向】 靶向抗肿瘤药物及载体材料研究 多功能抗阿尔茨海默病药物研究 【经历】 1998.9-2002.7 中国药科大学化学制药专业,获学士学位 2002.9-2005.7 中国药科大学,药物化学专业,硕博连读硕士研究生阶段 2005.7 获得德意志学术交流中心“DAAD Sandwich”奖学金 2005.9-2006.7 同济大学留德预备部,获中级德语证书 2008.6-2008.10 Friedrich-Schiller-Universität Jena, 博士研究(与中国药科大学联合培养),08年6月于中国药科大学获博士学位 2009.1-2011.10 东南大学药物研究中心,江苏省生物药物高技术研究重点实验室,讲师 2011.10-2012.3 获得德国洪堡奖学金(Alexander von Humboldt Foundation),洪堡访问学者 2015.4-至今 东南大学药物研究中心,江苏省生物药物高技术研究重点实验室,副教授 【科研项目】 1、项目类别及编号:主持1项国家自然科学基金青年科学基金项目 (No. 81001361);名称:新型2,5,8-三取代二苯并呋喃及其NO供体偶联物的构建及抗AD活性研究;研究起止年月:2011.01-2013.12;资助金额:17万;进展情况:已结题。 2、项目类别及编号:主持博士点基金青年教师项目(No. 20100092120046);名称:新型肝靶向醌甲基前体型姜黄素衍生物的构建及抗肿瘤活性研究;研究起止年月:2011.01-2013.12;资助金额:3.6万;进展情况:已结题。 3、项目类别及编号:主持江苏省自然科学基金面上项目(No. BK20151402);名称:杂合交联型肿瘤靶向胶束给药系统的设计、合成及构效关系研究;研究起止年月:2015.07-2018.06;资助金额:10万;进展情况:正在进行。 【论文及获奖】 发表论文: 2016 Fang L(房雷), Feng M, Chen F, Liu X, Shen H, Zhao J, Gou S. Oleanolic acid-NO donor-platinum(II) trihybrid molecules: Targeting cytotoxicity on hepatoma cells with combined action mode and good safety.Bioorg Med Chem,2016, 24(19):4611-4619. Fang L(房雷), Chen M, Liu Z, Fang X, Gou S, Chen L.Ferulic acid-carbazole hybrid compounds: Combination of cholinesterase inhibition, antioxidant and neuroprotection as multifunctional anti-Alzheimer agents.Bioorg Med Chem,2016, 24(4): 886-893. Wang Z, Yu H, Gou S, Chen F, Fang L(房雷,通讯作者). Design, Synthesis, and Biological Features of Platinum(II) Complexes with Rigid Steric Hindrance.Inorg Chem,2016, 55(9):4519-4528. Yu H, Gou S, Wang Z, Chen F, Fang L(房雷,通讯作者).Toward overcoming cisplatin resistance via sterically hindered platinum(II) complexes.Eur J Med Chem,2016, 114:141-152. Lyu A, Qin X,Fang L(房雷,通讯作者), Gou S. Synthesis, cytotoxicity, and interaction with DNA of platinum(II) complexes of (1R,2R)N12amyl1,2diaminocyclohexane. J Coord Chem, 2016, 69(10):1653–1662. Zhao J(并列第一作者), Fang L(房雷,并列第一作者), Zhang X, Liang Y, Gou S.Synthesis and biological evaluation of new [1,2,4]triazolo[4,3-a]pyridine derivatives as potential c-Met inhibitors.Bioorg Med Chem, 2016, 24(16):3483-3493. 2015 Liu F, Gou S, Chen F, Fang L(房雷,通讯作者), Zhao J.Study on Antitumor Platinum(II) Complexes of Chiral Diamines with Dicyclic Species as Steric Hindrance. J Med Chem, 2015, 58(16): 6368-6377. Lyu A(并列第一作者), Fang L(房雷,并列第一作者), Gou S, Liu X. Design, Synthesis and Biological Evaluation of Lapatinib Derivatives as HER1/HER2 Inhibitors. Lett DrugDesDiscov, 2015, 12(7): 574-584. 2014 Fang L(房雷), Wang M,Gou S, Liu X, Zhang H, Cao F.Combination of Amino Acid/Dipeptide with Nitric Oxide-donating Oleanolic Acid Derivatives as PepT1 Targeting Antitumor Prodrugs. J Med Chem, 2014, 57(3):1116-1120. Fang L(房雷), Fang X, Gou S, Lupp A, Lenhardt I, Sun Y, Huang Z, Chen Y, Cheng L, Zhang Y, Fleck C. Design, synthesis and biological evaluation of D-ring openedgalantamine analogs as multifunctional anti-Alzheimer agents. Eur J Med Chem, 2014, 76:376-386. Fang L(房雷), Gou S, Liu X, Cao F, Cheng L.Design, synthesis and anti-Alzheimer properties of dimethylaminomethyl-substituted curcumin derivatives. Bioorg Med Chem Lett,2014, 24(1):40-43. Fang L(房雷), Zhang H, Fang X, Gou S, Cheng L. Preparation of carbazole and dibenzofuran derivatives by selective bromination on aromatic rings or benzylic groups with N-bromosuccinimide. Indian J Chem B, 53(5): 635-641. Lyu A(并列第一作者), Fang L(房雷,并列第一作者), Gou S. Design and synthesis of Lapatinib derivatives containing a branched side chain as HER1/HER2 targeting antitumor drug candidates. Eur J Med Chem, 2014, 87:631-642. 2013 Fang L(房雷), Gou S, Zhao J, Sun Y, Cheng L.Platinum(II) complexes with N-monoalkyl 1R,2R-diaminocyclohexane derivatives as carrierligands and 3-hydroxycyclobutane-1,1-dicarboxylate as a leaving group: potent cytotoxicity and DNAbinding ability. Eur J Med Chem,2013, 69:842-847. Fang L(房雷), Gou S, Fang X, Cheng L, Fleck C.Current progresses of novel natural products and their derivatives/analogues as anti-Alzheimer candidates: an update.Mini Rev Med Chem,2013, 13(6):870-887. Cao F, Gao Y, Wang M, Fang L(房雷,通讯作者), Ping Q.Propylene glycol-Linked Amino Acid/Dipeptide Diester Prodrugs of Oleanolic Acid for PepT1-Mediated Transport: Synthesis, Intestinal Permeability and Pharmacokinetics. Mol Pharmaceut, 2013, 10(4):1378-1387. Fang X, Fang L(房雷,通讯作者), Gou S, Cheng L.Design and synthesis of dimethylaminomethyl-substituted curcumin derivatives/analogues: Potent antitumor and antioxidant activity, improved stability and aqueous solubility compared with curcumin.Bioorg Med Chem Lett,2013, 23(5):1297-1301. 2012 Sun Y, Liu F, Gou S, Cheng L, Fang L (房雷,通讯作者), Yin R. Synthesis and in vitro antiproliferative activity of platinum(II) complexes withN-monoalkyl 1R,2R-diaminocyclohexane as ligands. Eur J Med Chem,2012,55:297-306. Fang X,Fang L(房雷,通讯作者), Gou S. Progresses in synthetic methods of carbazole and its derivatives. Chin J Org Chem, 2012, 32(7): 1217-1231. 2011 Fang L(房雷), Gou S, Zhang Y. Progresses in Total Synthesis of Galantamine. Chin J Org Chem,2011,31(3):286-296. 2010 Fang L(房雷),Jumpertz S, Zhang Y, Appenroth D, Fleck C, Mohr K, Tränkle C, Decker M. Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors. J Med Chem,2010, 53(5): 2094-2103. 2008 Fang L(房雷), Appenroth D, Decker M, Kiehntopf M, Roegler C, Deufel T, Fleck C, Peng, S, Zhang Y, Lehmann J. Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates. J Med Chem,2008, 51(4): 713-716. Fang L(房雷), Appenroth D, Decker M, Kiehntopf M, Lupp A, Peng S, Fleck C, Zhang Y, Lehmann J. NO-donating tacrine derivatives improve scopolamine-induced cognition impairment and show less hepatotoxicity. J Med Chem,2008, 51(24): 7666-7669. Fang L(房雷), Lehmann J. NO donor hybrid compounds as multifunctional therapeutic agents. Expert Opin Ther Pantents,2008, 18(10):1111-1125. Fang L(房雷), Kraus B, Lehmann J, Heilmann J, Zhang Y, Decker M. Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates. Bioorg Med Chem Lett,2008, 18(9):2905-2909. Fang L(房雷), Huang Z, Zhang Y, Ji H, Ding D. Synthesis, anti-inflammatory activity and safety of hydrocortisone derivatives coupled with furoxans and nitrates. Chin J Org Chem,2008,28(5):841-850. 2007 Fang L(房雷), Zhang Y, Lehmann J, Wang Y, Ji H, and Ding D. Design and synthesis of furoxan-based nitric oxide-releasing glucocorticoid derivatives with potent anti-inflammatory activity and improved safety. Bioorg Med Chem Lett, 2007, 17(4):1062-1066. 发明专利: 申请国家发明专利7项,已获授权4项。 获奖情况: 2009年江苏省优秀博士论文(导师:张奕华教授) 2010年全国优秀博士论文提名奖(导师:张奕华教授) 2011-2012获德国洪堡基金资助 2016年获第十届世界华人药物化学研讨会“优秀青年学者”称号
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