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高春梅，深圳大学化学与工程学院副教授，现主要从事功能性小分子/聚合物热电材料的设计、合成及性能研究。结题项目：国家科技计划项目子课题1项，国家自然科学基金面上项目1项，国家自然科学青年基金1项，中国博士后基金1项，深圳市技术开发项目1项，深圳市基础研究项目2项。在研项目：国家自然科学基金面上项目1项，深圳市基础研究计划1项；以第一作者或通讯作者发表SCI收录论文40余篇。
高春梅 一、简历 u2017.6-至今，深圳大学化学与环境工程学院，副教授 u2009.3-2017.5，清华大学深圳研究生院，讲师，副教授 u2007.3-2009.3，清华大学，博士后 u2001.9-2006.12中国科学院广州化学研究所，博士 u1997.9-2001.7徐州师范大学，学士 二、研究方向 研究方向：有机小分子或聚合物的设计、合成及应用 1.热电材料领域 探索和开发新型可再生清洁能源和高效能量转换与存储技术，具有重要的理论意义和市场应用前景。将热电材料用于工业废热回收、汽车尾气余热回收来进行发电，或用于制备空调系统，不仅可提高燃油的利用率，还可降低废气的排放，保护环境。本课题组致力于小分子或高分子聚合物热电材料的研究，探讨化合物结构对热电性能的影响，研发性能优异的热电材料。 2.肿瘤治疗领域 肿瘤疾病严重威胁人类的生命健康，本课题组针对肿瘤的信号传导网络，设计研发新的药物先导化合物，研究其抗肿瘤活性及其作用机制。 三、科研项目
近年来主持科研项目如下： 1.吖啶/碳纳米管复合热电材料的制备及性能研究深圳市基础研究计划 2019-2020，50万元 2.基于系统药理学和高通量筛选技术的多靶点抗肿瘤药物研发，863子课题，2012-2015，2012AA020305，92.5万元 3.基于靶点拓扑异构酶和PARP1的吖啶类化合物的合成与抗肿瘤活性研究，国家自然科学基金面上项目，2014-2017，80万元 4.端粒酶抑制剂：特异性识别肿瘤细胞的吖啶酮类化合物的合成及活性研究，国家自然科学基金青年基金，2010-2012，20902053，19万元 5.新型磷酰化苯并内酰胺药物的合成和生物活性研究，中国博士后科学基金，2007-2009，3万元 6.普20150266：新靶点及多靶点组合抗肿瘤药物技术研发，深圳市技术开发，2015-2017，200万元 7.以DNA甲基转移酶与组蛋白去乙酰化酶为靶点的化合物的设计、合成与活性研究，深圳市基础研究计划，2015-2017， 30万元 四、论文发表 1.Shichao Wang,Fuwei Liu, Chunmei Gao*, Tao Wan, Luhai Wang, Li Wang, Lei Wang*Enhancement of the thermoelectric property of nanostructured polyaniline/carbonnanotube composites by introducing pyrrole unit onto polyaniline backbone via asustainable method,Chemical Engineering Journal, 2019, accept. IF:6.735(JCR1) 2.Tao Wan,Xiaojun Yin, Chenjun Pan, Danqing Liu, Xiaoyan Zhou, Chunmei Gao*,Wai-Yeung Wong*, Lei Wang *, Boosting the adhesivity of π-conjugated polymersby embedding platinum acetylides towards high-performance thermoelectric composites,Polymers, 2019, accept. IF: 2.935(JCR2) 3.Yan Zhou, YijiaLiu, Xiaoyan Zhou, Yuan Gao, ChunmeiGao*, and Lei Wang*, High performance p-type organic thermoelectricmaterials based on metalloporphyrin/single-walled carbon nanotube compositefilms, Journal of Power Sources, 2019, 423, 152-158. IF:6.945(JCR1) 4.Xiaoyan Zhou, Chengjun Pan, Ansheng, Liang, Luhai, Wang, Tao Wan,Guanghui Yang, Chunmei Gao* and Wai-Yeung Wong, Enhancedfigure of merit of poly(9,9-di-n-octylfluorene-altbenzothiadiazole) and SWCNTthermoelectric composites by doping with FeCl3, Journal of AppliedPolymer Science, 2019, 136, 47011. IF: 1.901 (JCR3) 5.Chunmei Gao, Yijia Liu, Yuan Gao*, Yan Zhou,Xiaoyan Zhou, Xiaojun Yin, Chengjun Pan, Chuluo Yang, Hanfu Wang, Guangming Chen*,and Lei Wang*, High-performance n-type thermoelectriccomposites of acridones with tethered tertiary amines and carbonnanotubes, Journal of Materials Chemistry A, 2018, 6, 20161–20169.IF: 9.931(JCR1)（2018JMCA hot papers） 6.Xiaojun Yin,Yuhao Peng, Jiajia Luo, Xiaoyan Zhoum, Chunmei Gao*, LeiWang*, Chuluo Yang*, Tailoring the framework of organic small moleculesemiconductors towards high-performance thermoelectric composites viaconglutinated carbon nanotube webs, Journal of Materials Chemistry A,2018, 6, 8323-8330. IF: 9.931(JCR1) 7.YufengXue, Chunmei Gao(共同一作), Lirong Liang,Xin Wang, Guangming Chen*. Nanostructure controlled construction ofhigh-performance thermoelectric materials of poly(mers and their composites, Journalof Materials Chemistry A, 2018, 6, 22381-90. IF: 9.931(JCR1) 8.Luhai Wang,Chengjun Pan*, Zhongming Chen, Xiaoyan Zhou, Chunmei Gao* andLei Wang*, A study of the thermoelectric properties ofbenzo[1,2-b:4,5-b′]dithiophene–based donoracceptor conjugated polymers, PolymerChemistry, 2018, 9, 4440-4447. IF: 4.927 (JCR1) 9.Bin Zhang, NingWang, Cunlong Zhang, Chunmei Gao*, Wei Zhang, Kang Chen,Yuyang Jiang*,Novel multi-substituted benzyl acridone derivatives as survivininhibitors for hepatocellular carcinoma treatment, European Journal ofMedicinal Chemistry, 2017, 129, 337-348. IF: 4.816 (JCR2) 10.Dan Li, ZigaoYuan, Shaopeng Chen, Cunlong Zhang, Lu Song, Chunmei Gao*, YuzongChen, Chunyan Tan, and Yuyang Jiang*, Synthesis and biological research ofnovel azaacridine derivatives as potent DNA-binding ligands and topoisomeraseII inhibitors, Bioorganic & Medicinal Chemistry, 2017, 25,3437-3446. IF: 2.881 (JCR3) 11.Zigao Yuan,Qinsheng Sun, Dan Li, Shuangshuang Miao, Shaopeng Chen, Lu Song, ChunmeiGao*, Yuzong Chen, Chunyan Tan, Yuyang Jiang*, Design, synthesis andanticancer potential of NSC-319745 hydroxamic acid derivatives as DNMT and HDACinhibitors, European Journal of Medicinal Chemistry, 2017,134,281-92. IF: 4.816 (JCR2) 12.Zigao Yuan,Shaopeng Chen, Qinsheng Sun, Ning Wang, Dan Li, Shuangshuang Miao, ChunmeiGao*, Yuzong Chen, Chunyan Tan, Yuyang Jiang*, Olaparib hydroxamic acidderivatives as dual PARP and HDAC inhibitors for cancer therapy, Bioorganic& Medicinal Chemistry, 2017, 25, 4100-4109. IF: 2.881 (JCR3) 13.Zigao Yuan,Jiwei Chen, Wenlu Li, Dan Li, Changjun Chen, Chunmei Gao*, YuyangJiang*, PARP inhibitors as antitumor agents: a patent update (2013-2015), ExpertOpinion on Therapeutic Patents, 2017, 27, 363-382. IF: 4.598(JCR2) 14.Zigao Yuan,Shaopeng Chen, Changjun Chen, Jiwei Chen, Chengken Chen, Qiuzi Dai, ChunmeiGao*, and Yuyang Jiang*, Design, synthesis and biological evaluation of4-amidobenzimidazole acridine derivatives as dual PARP and Topo inhibitors forcancer therapy European Journal of Medicinal Chemistry, 2017,138,1135-1146. IF: 4.816 (JCR2) 15.Zhishan Cui,Shaopeng Chen, Yanwei Wang, Chunmei Gao*, Yuzong Chen, Chunyan Tan,Yuyang Jiang*, Design, synthesis and evaluation of azaacridine derivatives asdual-target EGFR and Src kinase inhibitors for antitumor treatment. EuropeanJournal of Medicinal Chemistry, 2017, 136, 372-381. IF: 4.816 (JCR2) 16.Wei Zhang, BinZhang, Wei Zhang, Ti Yang, Ning Wang, Chunmei Gao*, Chunyan Tan,Hongxia Liu, Yuyang Jiang*. Synthesis and antiproliferative activity of9-benzylamino-6-chloro-2-methoxy-acridine derivatives as potent DNA-bindingligands and topoisomerase II inhibitors. European Journal of MedicinalChemistry, 2016,116, 59-70. IF: 4.816 (JCR2) 17.Huixiong Xie,Dan Tao, Jiangpeng Ni, Xiongzhi Xiang, Chunmei Gao*, Lei Wang*.Synthesis and properties of highly branched star-shaped sulfonated blockpolymers with sulfoalkyl pendant groups for use as proton exchangemembranes. Journal of Membrane Science,2016, 497, 55-66. IF: 6.578(JCR1) 18.Wenlu Li, XiLi, Bin Zhang, Chunmei Gao*, Yuzong Chen, Yuyang Jiang*. Currentprogresses and trends in the development of progesterone receptor modulators. CurrentMedicinal Chemistry, 2016,23, 2507-2554. IF: 3.469 (JCR2) 19.Zhishan Cui,Xi Li, Lulu Li, Bin Zhang*, Chunmei Gao*, Yuzong Chen, Chunyan Tan,Hongxia Liu, Weiyi Xie, Ti Yang, & Yuyang Jiang. Design, synthesis andevaluation of acridine derivatives as multi-target Src and MEK kinaseinhibitors for anti-tumor treatment. Bioorganic & MedicinalChemistry, 2016,24, 261-269. IF: 2.881 (JCR3) 20.Changjun Chen,HaiyangLiu, Bin Zhang, Yanwei Wang, Kai Cai, Ying Tan*, Chunmei Gao*,Hongxia Liu, Chunyan Tan, Yuyang Jiang. A simple benzimidazolequinoline-conjugate fluorescent chemosensor for highly selective detection ofAg+. Tetrahedron, 2016,72, 3980-3985. IF: 2.377 (JCR3) 21.ChunmeiGao*, Wei Zhang, Shengnan He, Shangfu Li, Feng Liu*, Yuyang Jiang,Synthesis and antiproliferative activity of 2,7-diaminol0-(3,5-dimethoxy)benzyl-9(10H)-acridone derivatives as potent telomericG-quadruplex DNA ligands, Bioorganic Chemistry, 2015, 60, 30-36.IF: 3.929 (JCR3) 22.Bin Zhang,Kang Chen, Ning Wang, Chunmei Gao*, Qinsheng Sun, Lulu Li, YuzongChen, Chunyan Tan, Hongxia Liu, Yuyang Jiang*, Molecular design, synthesis andbiological research of novel pyridyl acridones as potent DNA-binding andapoptosis-inducing agents. European journal of medicinal chemistry,2015, 93, 214-26. IF: 4.816 (JCR2) 23.Xi Li, ChunmeiGao*, Ti Yang, Bin Zhang, Chunyan Tan, Hongxia Liu, Yuyang Jiang*, APOCl3-mediated synthesis of substituted fused azoacridones derivatives. RscAdvances, 2015, 5, 28670-8. IF: 2.936 (JCR3) 24.ChunmeiGao*, Bin Li, Bin Zhang, Qinsheng Sun, Lulu Li, Xi Li, Changjun Chen,Hongxia Liu, Yuyang Jiang*, Synthesis and biological evaluation ofbenzimidazole acridine derivatives as potential DNA-binding andapoptosis-inducing agents. Bioorganic & Medicinal Chemistry,2015, 23, 1800-1807. IF: 2.881 (JCR3) 25.Hongbo Chen,Xiaobin Zeng, Chunmei Gao(并列一作), Pinghong Ming, Jianping Zhang, Caiping Guo,Lanzhen Zhou, Yin Lu, Lijun Wang, Laiqiang Huang*, Xiangjiu He*, Lin Mei*, Anew arylbenzofuran derivative functions as an anti-tumour agent by inducing DNAdamage and inhibiting PARP activity. Scientific Reports, 2015, 5,10893. IF: 4.122 (JCR3) 26.Bin Zhang, XiLi, Bin Li, Chunmei Gao*, Yuyang Jiang*,Acridine and itsderivatives: a patent review (2009-2013). Expert opinion on therapeuticpatents, 2014, 24, 647-664. IF: 4.598(JCR2) 27.Bin Li, ChunmeiGao*, Qinsheng Sun, Lulu Li, Chunyan Tan, Hongxia Liu, Yuyang Jiang*,Novel synthetic acridine-based derivatives as topoisomerase I inhibitors. ChineseChemical Letters, 2014, 25, 1021-1024. IF: 2.631(JCR4) 28.Xuliang Lang,Qinsheng Sun, Yuzong Chen, Lulu Li, Chunyan Tan, Hongxia Liu, ChunmeiGao*, Yuyang Jiang*, Novel synthetic 9-benzyloxyacridine analogue asboth tyrosine kinase and topoisomerase I inhibitor. Chinese ChemicalLetters,2013, 24, 677-680. IF: 2.631(JCR4) 29.Xuliang Lang,Lulu Li, Yuzong Chen, Qinsheng Sun, Qin Wu, Feng Liu, Chunyan Tan, Hongxia Liu, ChunmeiGao*, Yuyang Jiang*, Novel synthetic acridine derivatives as potentDNA-binding and apoptosis-inducing antitumor agents. Bioorganic &Medicinal Chemistry, 2013, 21:4170-7 IF: 2.881 (JCR3) 30.Jinshun Lin,Xiuli Jin, Yiwen Bu, Deliang Cao, Nannan Zhang, Shangfu Li, Qinsheng Sun,Chunyan Tan, Chunmei Gao*, Yuyang Jiang*, Efficient synthesis ofRITA and its analogues: derivation of analogues with improved antiproliferativeactivity via modulation of p53/miR-34a pathway. Organic &Biomolecular Chemistry, 2012, 10, 9734-46. IF: 3.423 (JCR2) 31.Chunmei Gao*,Shangfu. Li, Xuliang Lang, Hongxia Liu, Feng Liu, Chunyan Tan, & YuyangJiang*, Synthesis and evaluation of 10-(3,5-dimethoxy)benzyl-9(10H)-acridonederivatives as selective telomeric G-quadruplex DNA ligands, Tetrahedron,2012, 68, 7920-7925. IF: 2.377 (JCR3) 32.Xuliang Lang,Xudong Luan, Chunmei Gao*, Yuyang Jiang*, Recent Progress ofAcridine Derivatives with Antitumor Activity, Progress in Chemistry,2012, 24, 1497-505. IF: 0.82 (JCR4) 33.Lei Wang,Guangming Zhu, Junqin Li, Chunmei Gao*, Synthesis andcharacterization of partially fluorinated poly(fluorenyl ether ketone)s withdifferent degrees of sulfonation as proton exchange membranes, PolymerBulletin，2011,66 (7), 925-937. IF: 1.589 (JCR4) 34.Chunmei Gao,Feng Liu, Xudong Luan, Chunyan Tan, Hongxia Liu, Yonghua Xie, Yibao Jin, YuyangJiang*, Novel synthetic 2-amino-10-(3,5-dimethoxy)benzyl-9(10H)-acridinonederivatives as potent DNA-binding antiproliferative agents, Bioorganic& Medicinal Chemistry, 2010, 18, 7507-7514. IF: 2.881 (JCR3) 35.Chunmei Gao,Yuyang Jiang*, Chunyan Tan, Xuyu Zu, Huacheng Liu, Derong Cao, Synthesis andpotent antileukemic activities of 10-benzyl-9(10H)-acridinones. Bioorganic& Medicinal Chemistry, 2008, 16, 8670-8675. IF: 2.881 (JCR3) 36.Chunmei Gao,Huacheng Liu, Yuyang Jiang*, Chunyan Tan, Derong Cao, Synthesis of10-Benzyl-9-acridone and Its Reduction with NaBH4, Chinese Journal ofOrganic Chemistry, 2008, 28,1803-1806. IF: 1.392 (JCR4) 37.Chunmei Gao, Derong Cao*, Sheyang Xu, Herbert Meier,Acid-catalyzed cyclization of anthracenol derivatives to homotriptycenes, Journalof Organic Chemistry, 2006, 71, 3071-3076. IF: 4.805 (JCR2) 38.Chunmei Gao, Derong Cao, Sheyang Xu. Acid-catalyzed selectivecyclization of 10,10-dibenzyl-9(10H)-anthranol, Acta Chim Sinica,2006, 64, 1757-60. IF: 2.735 (JCR4)
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发表于 2019-9-9 15:00:47
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