华东师范大学化学与分子工程学院徐志爱

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徐志爱，华东师范大学化学与分子工程学院教授。2006年在中科院长春应用化学研究所取得博士学位，主要研究方向：生物大分子的组装及在生物分析中的应用、荧光探针的合成和生物分析应用、神经退行性疾病相关分析检测。


徐志爱
教授，博导
化学与分子工程学院
化学系
联系电话： 021-54340053
办公地点： 化学楼335室
电子邮箱： zaxu@chem.ecnu.edu.cn
通讯地址： 上海市东川路500号


研究经历
2018.1--至今，华东师范大学，化学与分子工程学院，教授；
2012.5--2017.12，华东师范大学，化学与分子工程学院，副教授；
2009.6--2012.4，日本东北大学，理学院，助教授；
2007.6--2009.5，日本东北大学，理学院，JSPS博士后，导师：Norio Teramae教授；
2001.9--2006.12，中科院长春应用化学研究所，电分析化学国家重点实验室，直博，获博士学位，导师：董绍俊 研究员


研究方向
生物大分子的组装及在生物分析中的应用
荧光探针的合成和生物分析应用
神经退行性疾病相关分析检测

代表性研究论文：

[1]Y. Lai, Z. Xu,* X. Hu, L. Lei, L. Li, L. Dong, H. Yu,* W. Zhang*. Peptide Nanotube-Templated Biomineralization of Cu2-xS Nanoparticles for Combination Treatment of Metastatic Tumor. Small 2019,1904397.

[2]L. Lei, R. Geng, Z. Xu,* Y. Dang, X. Hu, L. Li, P. Geng, Y. Tian, W. Zhang*. Glycopeptide Nanofiber Platform for Ab-Sialic Acid Interaction Analysis and Highly Sensitive Detection of Ab. Anal. Chem. 2019, 91, 8129-8136.

[3]R. Geng, D. Lu, Y. Lai, S. Wu, Z. Xu* and W. Zhang*, Peptide nanotube for carbon dioxide chemisorption with regeneration properties and water compatibility. Chem. Commun. 2019, 55, 3797-3800.

[4]L. Lei, Z. Xu*, X. Hu, Y. Lai, J. Xu, B. Hou, Y. Wang, H. Yu*, Y. Tian, W. Zhang*. Bioinspired Multivalent Peptide Nanotubes for Sialic Acid Targeting and Imaging-Guided Treatment of Metastatic Melanoma. Small 2019, 15(22), 1900157.

[5]F. Wang, S. Yu, Z. Xu, * L. Li, Y. Dang, X. Xu, Y. Luo, Z. Cheng, H. Yu, W. Zhang, A. Zhang, and C. Ding*. Acid-Promoted D-A-D Type Far-Red Fluorescent Probe with High Photostability for Lysosomal Nitric Oxide Imaging, Anal. Chem. 2018, 90 (13), 7953-7962.

[6]F. Lin, Y. Zhou, Q. Li, X. Zhou, Y. Shao,* B. Habermeyer, H. Wang, X. Shi, and Z. Xu,*Prototropically Allosteric Probe for Superbly Selective DNA Analysis, Anal. Chem. 2017,89 (17), 9299–9306.

[7]F. Wang, C. Feng, Z. Xu,*W. Zhang,*A ratiometric fluorescent probe for rapid and sensitive detection of biothiols in fetal bovine serum, Talanta,2017, 169, 149-155.

[8]C. Feng, F. Wang, Y. Dang, Z. Xu,* H. Yu, and W. Zhang. A Self-Assembled Ratiometric Polymeric Nanoprobe for Highly Selective Fluorescence Detection of Hydrogen Peroxide, Langmuir, 2017, 33, 3287–3295.

[9]Y. Hu, F. Lin, T. Wu, Y. Zhou, Q. Li, Y. Shao,*Z. Xu,* DNA Duplex Engineering for Enantioselective Fluorescent Sensor, Anal. Chem., 2017, 89, 2181-2185.

[10]L. Lu, C. Feng, J. Xu, F. Wang, H. Yu, Z. Xu,* W. Zhang, Hydrophobic-carbon-dot-based dual-emission micelle for ratiometric fluorescence biosensing and imaging of Cu2+ in liver cells, Biosensors and Bioelectronics, 2017, 92, 101-108.

[11]F. Wang, † Q. Sun, † B. Feng, Z. Xu, * J. Zhang, J. Xu, L. Lu, H. Yu, M. Wang, Y. Li and W. Zhang*, Polydopamine-Functionalized Graphene Oxide Loaded with Gold Nanostars and Doxorubicin for Combined Photothermal and Chemotherapy of Metastatic Breast Cancer, Adv. Healthc. Mater., 2016, 5, 2227–2236.

[12]J. Zhang, J. Liu, Y. Zhu, Z. Xu, *J. Xu, T. Wang, H. Yu and W. Zhang*, Photodynamic micelles for amyloid β degradation and aggregation inhibition, Chem. Commun., 2016, 52, 12044-12047.

[13]B. Feng†, F. Zhou†, Z. Xu† (first coauthor), T. Wang, D. Wang, J. Liu, Y. Fu, Q. Yin, Z. Zhang, H. Yu,* and Y. Li*, Versatile Prodrug Nanoparticles for Acid-Triggered Precise Imaging and Organelle-Specific Combination Cancer Therapy. Adv. Funct. Mater. 2016, 26,7431–7442.

[14]Y. Wang, L. Lu, H.Peng, J. Xu, F. Wang, R. Qi, Z. Xu* and W. Zhang*, Multi-doped carbon dots with ratiometric pH sensing properties for monitoring enzyme catalytic reactions. Chem. Commun., 2016, 52, 9247-9250.

[15]L. Zhu, J. Zhang, F. Wang, Y. Wang, L. Lu, C. Feng, Z. Xu*, W. Zhang*. Selective amyloid β oligomer assay based on abasic site-containing molecular beacon and enzyme-free amplification, Biosensors and Bioelectronics, 2016,78, 206-212.

[16]Y. Wang, J. Zhang, L. Zhu, L. Lu, C. Feng, F. Wang, Z. Xu* and W. Zhang*. Activation of Mg2+-dependent DNAzymes based on AP site-containing triplex for specific melamine recognition. Analyst, 2015, 140, 7508-7512.

[17]B. Feng†, Z. Xu† (first coauthor), F. Zhou, H. Yu, Q. Sun, D. Wang, Z. Tang, H. Yu, Q. Yin, Z. Zhang and Y. Li. Near infrared light-actuated gold nanorods with cisplatin–polypeptide wrapping for targeted therapy of triple negative breast cancer. Nanoscale, 2015, 7, 14854-14864

[18]Y. Wang, Q. Sun, L. Zhu, J. Zhang, F. Wang, L. Lu, H. Yu, Z. Xu* and W. Zhang*. Triplex molecular beacons for sensitive recognition of melamine based on abasic-site-containing DNA and fluorescent silver nanoclusters. Chem. Commun.,2015, 51, 7958-7961.

[19]B. Lin, D. Lu, Y. Fu, Q. Sun, K. Liu, Z. Xu* and W. Zhang*. Label-free Colorimetric Protein Assay and Logic Gates Design Based on the Self-assembly of Hemin-Graphene Hybrid Nanosheet.Langmuir, 2014, 30(8), 2144-251.

[20]Y. An, Y. Fu, D. Lu, Y. Wang, W. Bi, Z. Xu,* S. Dong, S. Zhang, C. Wang and W. Zhang*. A TiO2-Au–polymer hybrid system for the photoelectrochemical immunoassay of SirT1. J. Mater. Chem. B, 2014, 2, 1644-1652.

[21]Y. Fu, K. Liu, Q. Sun, B. Lin, D. Lu, Z. Xu*, Chen Hu, G. Fan, S. Zhang, C. Wang, W. Zhang*. A highly sensitive immunosensor for calmodulin assay based on enhanced biocatalyzed precipitation adopting a dual-layered enzyme strategy. Biosensors and Bioelectronics, 2014, 56, 258-263.