华东师范大学化学与分子工程学院邢栋

erdingxi

邢栋
副研究员 硕士研究生导师
化学与分子工程学院
上海分子治疗与新药创制工程技术研究中心
联系电话： 021-62233026
传 真：主页网址：
办公地点： 上海市中山北路3663号华东师范大学理科大楼B1517
电子邮箱： dxing@sat.ecnu.edu.cn
通讯地址： 上海市中山北路3663号华东师范大学理科大楼B1517室
研究方向
有机合成方法学研究；多样性导向的小分子化合物库的构建及相关药物化学研究


工作经历：       
2015.12-至今：        华东师范大学        副研究员
2016.06-2018.01：美国芝加哥大学 博士后
2016.01-2016.05：        美国德克萨斯大学奥斯汀分校        博士后
2012.06-2015.12：华东师范大学        晨晖学者
2011.03-2012.03：        香港大学        研究助理


教育经历：
2006.09-2011.02：        香港大学        博士
1999.09-2006.06：华东师范大学学士、硕士


学术成果
26.        Li, J.; Ma, C.; Xing, D.*; Hu, W.* Catalyst-Free gem-Difunctionalization of Fluoroalkyl-Substituted Diazo Compound with Diselenide or Disulfide and NFSI. Org. Lett. 2019, 21, 2101-2105
25.        Xing D.; Qi X.; Marchant D.,; Liu P.*; Dong G.* Branched-Selective Direct  a-Alkylation  of  Cyclic  Ketones  with  Simple Alkenes. Angew. Chem. Int. Ed. 2019, 58, 4366-4370
24.        Alavala, G. K. R.; Sajjad, F.; Shi, T.; Kang, Z.; Ma, M.; Xing, D.*; Hu, W.* Diastereoselective synthesis of isochromans via the Cu(II)-catalysed intramolecular Michael-type trapping of oxonium ylides. Chem. Commun.2018, 54, 12650-12653.
23.Chen. T; Yang, Y. Xie, L.; Yang, H.; Dong, G.*; Xing, D.* Ni(0)-Catalyzed α-Allylic Alkylation of Regular Ketones with 1,3-Dienes under pH and Redox-neutral Conditions" ChemRxiv. Preprint. [doi]
22.        Lv, X.; Kang, Z.; Xing, D.*; Hu, W.* Cu(I)-Catalyzed Three-Component Reaction of Diazo Compound with Terminal Alkyne and Nitrosobenzene for the Synthesis of Trifluoromethyl Dihydroisoxazoles. Org. Lett., 2018, 20 (16), pp 4843–4847
21.        Xiao, G.; Chen, T.; Ma, C.; Xing, D.*; Hu, W.* Rh(II)/Chiral Phosphoric Acid-Cocatalyzed Enantioselective Synthesis of Spirooxindole-Fused Thiaindans. Org. Lett., 2018, 20 (16), pp 4531–4535
20.Xiao, G.; Ma, C.; Wu, X.; Xing, D.*; Hu, W.* Synthesis of γ-Sulfur-Substituted Ketones via Rh(II)/Sc(III) Cocatalyzed Three-Component Reaction of Diazo Compounds with Thiophenols and Enones. J. Org. Chem. 2018, 83 (8), pp 4786–4791
19.        Xing, D.; Dong, G.* Branched-Selective Intermolecular Ketone a-Alkylation with Unactivated Alkenes via An Enamide Directing Strategy. J. Am. Chem. Soc.2017, 139, 13664-13667
18.        Xiao, G.; Ma,C.; Xing, D.*; Hu, W.* Enantioselective Synthesisof α-Mercapto-β-amino Esters via Rh(II)/Chiral Phosphoric Acid-CocatalyzedThree-Component Reaction of Diazo Compounds, Thiols, and Imines. Org.Lett. 2016, 18, 6086-6089 Highlighted by Synfacts, 2017, 13(02), 0181
17.        Ma, C.; Xing, D.*; Hu, W.* Catalyst-Free Halogenation of α-Diazocarbonyl Compounds with N-Halosuccinimides: Synthesis of 3-Halooxindoles or Vinyl Halides. Org. Lett. 2016, 18 (13), 3134-3137
16.        Che, J.; Xing, D.*; Hu, W.* Metal-Catalyzed Cross-Coupling of Terminal Alkynes with Different Carbene Precursors. Curr. Org. Chem. 2016, 20 (1), 41-60. Invited Review
15.        Jing, C.; Xing, D.*; Gao, L.; Li, J.; Hu, W.* Divergent Synthesis of Multisubstituted Tetrahydrofurans and Pyrrolidines via Intramolecular Aldol-type Trapping of Onium Ylide Intermediates Chem.--Eur. J. 2015, 21, 19202-19207 Highlighted by Synfacts, 2016, 12(02), 0136
14.        Jing, C.; Xing, D.*; Hu, W.* Catalytic Asymmetric Four-Component Reaction for the Rapid Construction of 3,3-Disubstituted 3‑Indol-3’-yloxindoles. Org. Lett. 2015, 17 (17), 4336-4339
13.        Tang, M.; Xing, D.*; Huang, H.; Hu, W.* Divergent synthesis of chiral heterocycles via sequencing of enantioselective three-component reactions and one-pot subsequent cyclization reactions. Chem. Commun. 2015, 51 (53), 10612-10615 (Inside front cover) Highlighted by Synfacts, 2015, 11(10), 1074. Front Cover.
12.        Jing, C.; Xing, D.*; Hu, W.* Synthesis of 3-(hydroxymethyl)-3-indol-3`-yloxindoles via Rh(II)-catalyzed three-component reaction of 3-diazooxindoles, indoles and formalin. Tetrahedron 2015, 71 (22), 3597-3602.
11.        Jia, S.; Xing, D.*; Zhang, D; Hu, W.* Catalytic Asymmetric Aromatic C–H Functionalization via Electrophilic Trapping of Active Zwitterionic Intermediate. Angew. Chem. Int. Ed. 2014, 53 (48), 13098-13101. Highlighted by Synfacts, 2014, 10(11), 1171  Front Cover
10.        Zhai, C.; Xing, D.*; Jing, C.; Zhou, J.; Wang, C.; Wang, D.; Hu, W.* Facile Synthesis of 3-Aryloxindoles via Brønsted Acid Catalyzed Friedel–Crafts Alkylation of Electron-Rich Arenes with 3-Diazooxindoles. Org. Lett. 2014, 16 (11), 2934-2937.
9.        Wang, C.; Xing, D.*; Wang, D.; Wu, X.; Hu, W.* Synthesis of 3-Amino-3-hydroxymethyloxindoles and 3-Hydroxy-3-hydroxymethyloxindoles by Rh2(OAc)4-Catalyzed Three-Component Reactions of 3-Diazooxindoles with Formaldehyde and Anilines or Water. J. Org. Chem. 2014, 79 (9), 3908-3916.
8.        Zhai, C.; Xing, D.*; Qian, Y.; Ji, J.; Ma, C.; Hu, W.* Trapping of Carboxylic Oxonium Ylides with N-Boc Imines for the Facile Synthesis of b-Amino Alcohol Derivatives. Synlett 2014, 25, 1745-1750.
https://www.thieme-connect.de/media/synlett/201412/i_w0260_ga_10-1055_s-0033-1338649.gif
7.        Xing, D.; Hu, W.* Recent advances in metal carbenoid mediated nitrogen-containing zwitterionic intermediate trapping process. Tetrahedron Lett. 2014, 55 (4), 777-783.
6.        Xing, D.*; Jing, C.; Li, X.; Qiu, H.; Hu, W.* Highly Efficient Synthesis of Mixed 3,3′-Bisindoles via Rh(II)-Catalyzed Three-Component Reaction of 3-Diazooxindoles with Indoles and Ethyl Glyoxylate. Org. Lett. 2013, 15, 3578-3581. Highlighted by Synfacts, 2013, 9(10), 1078
5.        Ma, C.; Xing, D.*; Zhai, C.; Che, J.; Liu, S.; Wang, J.; Hu, W.* Iron Porphyrin-Catalyzed Three-Component Reaction of Ethyl Diazoacetate with Aliphatic Amines and β,γ-Unsaturated α-Keto Esters. Org. Lett. 2013, 15, 6140-6143
4.        Jing, C.; Xing, D.; Hu, W.* Highly diastereoselective synthesis of 3-hydroxy-2,2,3-trisubstituted indolines via intramolecular trapping of ammonium ylides with ketones. Chem. Commun. 2014, 50, 951-953
3.
Jing, C.; Xing, D.; Qian, Y.; Hu, W., Rh2(OAc)4 and Chiral Phosphoric Acid Cocatalyzed Highly Diastereo- and Enantioselective Four-Component Reactions: Facile Synthesis of Chiral a,b-Diamino Acid Derivatives. Synthesis 2014, 46, 1348-1354
2.        Jing, C.; Xing, D.; Qian, Y.; Shi, T.; Zhao, Y.; Hu, W.* Diversity-Oriented Three-Component Reactions of Diazo Compounds with Anilines and 4-Oxo-Enoates. Angew. Chem. Int. Ed. 2013, 52, 9289-9292
1.        Jing, C.; Shi, T.; Xing, D.; Guo, X.; Hu, W.* CuSO4 catalyzed three-component reaction of α-diazo ester, water and isatin: an efficient approach to oxindole derivatives. Green Chem., 2013, 15,620




Previous work:
Xing, D.; Yang, D.* Pd(II)-Catalyzed Intramolecular 1,2-Aminoalkylation of Conjugated 1,3-Dienes for the Synthesis of Pyrrolizidines. Org. Lett. 2013, 15, 4370-4373.
Xing, D.; Yang, D.*, Gold(I)-Catalyzed Decarboxylative Allylic Amination of Allylic N-Tosylcarbamates. Org. Syn. 2012, 89, 450
Xing D.; Yang, D.*, Gold(I)-Catalyzed Highly Efficient Overman Rearrangement in Water. Beilstein J. Org. Chem. 2011, 7, 781-785.
Xing, D.; Yang, D.*, Gold(I)-Catalyzed Highly Regio- and Stereoselective Decarboxylative Amination of Allylic N-Tosylcarbamates via Base-Induced Aza-Claisen Rearrangement in Water. Org. Lett. 2010, 12 (5), 1068-1071.
Xing, D.; Xu, X. F.; Yang, L. P.*, Highly Chemoselective Rearrangement of 3-Aryloxaziridines to Nitrones or Amides. Synthesis-Stuttgart 2009, (20), 3399-3404.
Xing, D.; Guan, B. T.; Cai, G. X.; Fang, Z.; Yang, L. P.; Shi, Z. J.*, Gold(I)-Catalyzed Oxidative Cleavage of a C-C Double Bond in Water. Org. Lett. 2006, 8 (4), 693-696.
Wan, X. B.; Xing, D.; Fang, Z.; Li, B. J.; Zhao, F.; Zhang, K. Y.; Yang, L. P.; Shi, Z. J.*, Multiple Deprotonations and Deaminations of Phenethylamines to Synthesize Pyrroles. J. Am. Chem. Soc.2006, 128 (37), 12046-12047.
Guan, B. T.; Xing, D.; Cai, G. X.; Wan, X. B.; Yu, N.; Fang, Z.; Yang, L. P.; Shi, Z. J.*, Highly Selective Aerobic Oxidation of Alcohol Catalyzed by a Gold(I) Complex with an Anionic Ligand. J. Am. Chem. Soc. 2005, 127 (51), 18004-18005.