山东大学晶体材料研究所于晓强

jiegan523

1963年6月出生于吉林省长春市。
1999年7月在吉林大学获理学(物理化学)博士学位、然后进入山东大学材料科学与工程博士后流动站。2001年年11月出站后在山东大学晶体材料国家重点实验室工作，先后任副教授、教授(2005年)至今。
1999年开始从事高阶有机非线性光学材料，特别是具有三阶效应的双光子吸收材料的设计、合成及其应用研究。在双光子引发的光聚合方面取得了较大的成绩，在国内首先实现了双光子吸收引发的聚合反应，并利用双光子聚合技术在国内首先实现了聚合物型三维周期性结构的制备。目前的工作集中在有机高阶非线性光学材料的设计、合成、性能表征和应用方面，特别是激光与物质的相互作用方面。此领域是一项多学科密集交叉的国际前沿领域，正力争在该领域做出创造性的工作。经过十年的建设，实验室拥有先进有机材料制备、荧光性能表征、活性生物细胞与组织培育、生物荧光显微成像等一流设备。特别是材料的激光密聚焦诱导下的三阶非线性双光子荧光测试系统、双光子荧光显微成像系统是自行研制并建设的，得到了国际国内同行的认可，我们的实验数据已经为浙江大学、中国科学院化学研究所、吉林大学、中国海洋大学、重庆大学等单位提供数据，并协助其发表论文。
Email:yuxq@sdu.edu.cn
第一通讯作者论文：
AcceptedManuscript:         
Xuechen Li,Minggang Tian, Ge Zhang, Ruoyao Zhang, Ruiqing, Feng, Lifang Guo，Xiaoqiang Yu*, Ning Zhao*, Xiuquan He*. Aspatial-dependent fluorescent probe for detecting different situations ofmitochondrial membrane potential conveniently and efficiently. Anal. Chem. 2017.2.14,DOI: 10.1021/acs.analchem.6b03842.         
1. Minggang Tian,Yong Liu, Yuming Sun, Ruoyao Zhang, Ruiqing Feng, Ge Zhang, Lifang Guo, XuechenLi, Xiaoqiang Yu*, Jing Zhi Sun*,Xiuquan He*. A single fluorescent probe enables clearly discriminating andsimultaneously imaging liquid-ordered and liquid-disordered microdomains inplasma membrane of living cells. Biomaterilas 2017, 12, 46~56.      
2. Minggang Tian,Yuming Sun, Lifang Guo, Ruoyao Zhang, Ge Zhang, Ruiqing Feng, Xuechen Li,Huamiao Zhang, Ge Li，Xiaoqiang Yu*,XiuQuan He*. A small-structure two-photon platform equipped with weakelectrondonor: Development of permeable two-photon probes for lysosomesandmitochondria in living cells. Sensors and Actuators B 2017, 243, 955~962.      
3. Lifang Guo,Ruoyao Zhang, Yuming Sun, Minggang Tian, Ge Zhang, Ruiqing Feng, Xuechen Li,Huamiao Zhang, Li He, Xiaoqiang Yu*,Xiuquan He*. Styrylpyridine salts-based red emissive two-photon turn-on probefor imaging the plasma membrane in living cells and tissues. Analyst 2016,141(11), 3228~3232.      
4. Ge Zhang,Yuming Sun, Xiuquan He, Weijia Zhang, Minggang Tian, Ruiqing Feng, RuoyaoZhang, Xuechen Li, Lifang Guo, XiaoqiangYu*, Shangli Zhang*. Red-Emitting Mitochondrial Probe with UltrahighSignal-to-Noise Ratio Enables High-Fidelity Fluorescent Images in Two-PhotonMicroscopy. Analytical Chemistry 2015, 87(24), 12088~12095.      
5. Ruiqing Feng,Yuming Sun, Minggang Tian, Ge Zhang, Ruoyao Zhang, Lifang Guo, Xuechen Li, Xiaoqiang Yu*, Ning Zhao*. Amembrane-permeable dye for living cells with large two-photon excitedfluorescence action cross-sections for bioimaging. Journal of MaterialsChemistry B 2015, 3(44), 8644~8649.      
6. Guofen Song,Yuming Sun, Yong Liu, Xiankun Wang, Meiling Chen, Fang Miao, Weijia Zhang, Xiaoqiang Yu*, Jianling Jin*. Lowmolecular weight fluorescent probes with good photostability for imagingRNA-rich nucleolus and RNA in cytoplasm in living cells. Biomaterials 2014,35(7), 2103~2112.      
7. Fang Miao,Weijia Zhang, Yuming Sun, Ruoyao Zhang, Yong Liu, Fuqiang Guo, Guofen Song,Minggang Tian, Xiaoqiang Yu*. Novelfluorescent probes for highly selective two-photon imaging of mitochondria inliving cells. Biosens. Bioelectron. 2014, 55(15), 423~429.      
8. Minggang Tian,Fuqiang Guo, Yuming Sun, Weijia Zhang, Fang Miao, Yong Liu, Guofen Song, Cheuk-LamHo, Xiaoqiang Yu,* Jing Zhi Sun* andWai-Yeung Wong*. A fluorescent probe for intracellular cysteine overcoming theinterference by glutathione. Org. Biomol. Chem., 2014, 12(32), 6128~6133.      
9. Yong Liu,Weijia Zhang, Yuming Sun, Guofen Song, Fang Miao, Fuqiang Guo, Minggang Tian, Xiaoqiang Yu*, Jing Zhi Sun*.Two-photon fluorescence imaging of RNA in nucleoli and cytoplasm in livingcells based on low molecular weight probes. Dyes and Pigments, 2014, 103(6), 191~201.      
10. Junjie Wang,Yuming Sun, Weijia Zhang, Yong Liu, XiaoqiangYu*, Ning Zhao* A two-photon ratiometric fluorescent probe enables spatialcoordinates determination of intracellular pH. Talanta, 2014, 129, 241~248.      
11. Fang Miao,Guofen Song, Yuming Sun, Yong Liu, Fuqiang Guo, Weijia Zhang, Minggang Tian, Xiaoqiang Yu*. Fluorescent imaging ofacidic compartments in living cells with a high selective novel one-photonratiometric and two-photon acidic pH probe. Biosens. Bioelectron. 2013, 50(4) 42~49.      
12. Fuqiang Guo,Minggang Tian, Fang Miao, Weijia Zhang, Guofen Song, Yong Liu, Xiaoqiang Yu*, Jing Zhi Sun*, Wai-YeungWong*. Lighting up cysteine and homocysteine in sequence based on the kineticdifference of the cyclization/addition reaction. Org. Biomol. Chem., 2013,11(44), 7721~7728.      
13. Zhiguang Yang,Ning Zhao, Yuming Sun, Fang Miao,Yong Liu, Xin Liu, Yuanhong Zhang, Wentao Ai,Guofen Song, Xiaoyuan Shen, Xiaoqiang Yu*,Jingzhi Sun* and Wai-Yeung Wong*. Highly selective red- and green-emittingtwo-photon fluorescent probes for cysteine detection and their bio-imaging inliving cells. Chem. Commun. 2012, 48(28), 3442~3444.      
14. Guofen Song,Fang Miao, Yuming Sun, Xiaoqiang Yu*,Jing Zhi Sun*, Wai-Yeung Wong*, Fluorescence turn-on probes for intracellularRNA distribution and their imaging in confocal and two-photon fluorescencemicroscopy Sensor. Actuat. B-Chem. 2012, 173, 329~337.      
15. Xin Liu,Yuming Sun, Yuanhong Zhang, Fang Miao, Guancong Wang, HongshiZhao, Xiaoqiang Yu*, Hong Liu* and Wai-YeungWong*. A 2,7-carbazole-baseddicationic salt for fluorescence detection ofnucleic acids and two-photon fluorescence imaging of RNA in nucleoli andcytoplasm Org. Biomol. Chem. 2011, 9(10), 3615-3618.      
16. Xin Liu,Yuming Sun, Yuanhong Zhang, Ning Zhao, Guancong Wang, HongshiZhao, Xiaoqiang Yu,* Hong Liu* A Series ofCarbazole Cationic Compounds with Large Two-Photon Absorption Cross Sectionsfor Imaging Mitochondria in Living Cells with Two-Photon FluorescenceMicroscopy. J. Fluoresc. 2011, 21(2), 497-506.      
17. Zhang Y. H.,Wang J. J., Jia P. F., Yu X. Q.*,Liu H., Liu X., ZhaoN., Huang B. B. Two-photon fluorescence imaging of DNA inliving plant turbid tissue with carbazole dicationic salt. Org. Biomol. Chem.,2010, 8(20), 4582-4588.      
18. ZHAO Ning,ZHANG YuanHong, LIU Xin, YU XiaoQiang*,GE MaoFa. Carbazoletricationic salt: a novel potential two-photon fluorescentDNA probe for nucleic imaging of cells Chin. Sci. Bull. 2010, 55(32),3661-3667.      
19. ZHANGYuan-Hong, SUN Yu-Ming, LIU Xin, ZHAO Ning, YU Xiao-Qiang*, HUANG Bai-Biao*. Interaction Between DicationicCarbazole Derivatives and Nucleic Acidby Spectrum. CHEMICALJOURNAL OF CHINESEUNIVERSITIES 2010, 31(9), 1860-1863.
授权专利:
1.于晓强、孙渝明一种单、双光子半胱氨酸荧光探针及其应用 ZL 2010 1 0558433.0      
2.于晓强、冯瑞卿，孙渝明、苗芳一种单、双光子酸性细胞器荧光探针及其应用ZL201310018340.2      
3.于晓强、田明刚、孙渝明、苗芳一种单、双光子线粒体荧光探针及其应用ZL 201310256318.1        
4.于晓强、张革、孙渝明、宋国芬一种用于活细胞中RNA和核仁成像的吲哚吡啶盐类荧光探针，ZL 201310216501.9        
5.于晓强、张若瑶、孙渝明、张革、宋国芬一种用于活细胞中RNA和核仁成像的吡咯吡啶盐类荧光探针，ZL 201310215970.9