|
Íõ±ó¾Ù£¬ÏÃÃÅ´óѧ½ÌÊÚ¡¢²©µ¼¡£2012Ä격ʿ±ÏÒµÓÚÏÃÃÅ´óѧ£¬µ¼Ê¦²ÜÔóÐǽÌÊÚ¡£ËæºóÔÚÒÔÉ«ÁÐÏ£²®À´´óѧ´Óʲ©Ê¿ºóÑо¿£¬ºÏ×÷µ¼Ê¦ÎªÖøÃûÀíÂÛÓë¼ÆË㻯ѧ¼ÒSason Shaik½ÌÊÚ¡£2016ÄêÓÚÎ÷°àÑÀ°ÍÈûÂÞÄÇ´óѧ´Óʲ©Ê¿ºóÑо¿£¬ºÏ×÷µ¼Ê¦ÎªÌÇø¼ÆËãÁìÓòÏÈÇýCarme Rovira½ÌÊÚ¡£Íõ±ó¾Ù½ÌÊÚ£¬Ñо¿ÁìÓòΪˮÈÜÒº»·¾³ÏÂø´ß»¯·´Ó¦µÄ¶à³ß¶ÈÀíÂÛÄ£Ä⣬Ö÷Ҫͨ¹ýÁ¿×Ó»¯Ñ§¼ÆËã¡¢·Ö×Ó¶¯Á¦Ñ§Ä£Äâ¡¢Á¿×ÓÁ¦Ñ§/·Ö×ÓÁ¦Ñ§×éºÏ·½·¨¡¢ÒÔ¼°´ÓÍ·Ë㶯Á¦Ñ§Ä£ÄâµÈ¶à³ß¶ÈÀíÂÛÄ£Äâ·½·¨½Òʾ½ðÊôø´ß»¯»úÖÆ£¬ÌرðÊÇO2¡¢H2O2ÔÚ½ðÊôøÖеĻ¹ý³Ì¼°º¬ÑõÖмäÌå·´Ó¦ÐÔÖÊ¡¢µç×ÓÖÊ×ÓתÒÆ΢¹Û»úÀí£¬²¢Éè¼ÆÍØÕ¹½ðÊôøӦÓÃÓÚ·ÇÉúÎï´ß»¯ÁìÓò¡£ÔÚJACS, Angew. Chem. Int. Ed., Nat. Commun., ACS Catal., Chem. Sci.µÈȨÍþÆÚ¿¯·¢±íÂÛÎÄ38ƪ¡£
µç×ÓÓÊÏäwangbinju2018@xmu.edu.cn
¸öÈ˼òÀú£º
½ÌÊÚ (ÏÃÃÅ´óѧ2018.08~ÖÁ½ñ)
²©Ê¿ºó (°ÍÈûÂÞÄÇ´óѧ 2016.09 ~ 2018.08)
²©Ê¿ºó (Ү·ÈöÀäÏ£²®À´´óѧ 2012.09 ~ 2016.09)
²©Ê¿ (ÏÃÃÅ´óѧ 2007.09 ~ 2012.07)
ѧʿ (¹þ¶û±õ¹¤Òµ´óѧ 2003.09 ~ 2007.07)
Ñо¿ÐËȤ£º
±¾¿ÎÌâ×éÑо¿ÁìÓòÖ÷ÒªÊÇË®ÈÜÒºÒÔ¼°µ°°×»·¾³Ï»¯Ñ§·´Ó¦µÄ¶à³ß¶ÈÀíÂÛÄ£Ä⣬Ñо¿ÊֶΰüÀ¨¸÷ÖÖ¶à³ß¶ÈÀíÂÛÄ£Äâ·½·¨£¬ÈçÁ¿×Ó»¯Ñ§¼ÆË㣬·Ö×Ó¶¯Á¦Ñ§Ä£Ä⣬Á¿×ÓÁ¦Ñ§-·Ö×ÓÁ¦Ñ§×éºÏ·½·¨£¬ÒÔ¼°´ÓÍ·Ë㶯Á¦Ñ§Ä£Ä⡣ͨ¹ýÀíÂÛÄ£Ä⣬ÎÒÃÇÏ£Íû½â¾ö½ðÊôøÖÐһϵÁÐʵÑéÊֶβ»ÈÝÒ×½â¾öµÄºËÐÄÎÊÌ⣬°üÀ¨½ðÊôø´ß»¯»úÀí£¬O2ÒÔ¼°H2O2ÔÚ½ðÊôøÖл¹ý³ÌÒÔ¼°º¬ÑõÖмäÌå·´Ó¦ÐÔÖÊ£¬µç×ÓÖÊ×ÓתÒÆ΢¹Û»úÀí¡£ÔÚ¶Ôø´ß»¯»úÀíÓÐÉîÈëÈÏʶµÄ»ù´¡ÉÏ£¬ÎÒÃǽ«½øÒ»²½ºÍʵÑé¿ÎÌâ×éºÏ×÷£¬¿ª·¢Éè¼Æ»ùÓÚ½ðÊôøµÄÉúÎïºÏ³É·´Ó¦£¬ÓÃÓÚÖØÒªÒ©ÎïÖмäÌåÒÔ¼°»¯Ñ§Æ·ÖмäÌåµÄÉúÎïºÏ³É¡£
½üÆÚÖ÷Òª´ú±íÂÛÖø£º
1. B. Wang, D. Usharani, C. Li, S. Shaik*, Theory Uncovers an Unusual Mechanism of DNA Repair of a Lesioned Adenine by AlkB Enzymes. J. Am. Chem. Soc., 2014, 136, 13895¨C13901.
2. B. Wang, C. Li, K. Dubey, S. Shaik*, QM/MM Calculated Reactivity Networks Reveal How Cytochrome P450cam and Its T252A Mutant Select Their Oxidation Pathways. J. Am. Chem. Soc. 2015, 137, 7379¨C7390.
3. B. Wang, Z. Cao, D. Sharon, S. Shaik*, Computations Reveal a Rich Mechanistic Variation of Demethylation of N-Methylated DNA/RNA Nucleotides by FTO. ACS Catal., 2015, 5, 7077¨C7090.
4. K. Dubey#, B. Wang#, S. Shaik*. Molecular Dynamic and QM/MM Calculations Predict the Substrate ¨CInduced Gating of Cytochrome P450 BM3 and the Regio- and Stereo-selectivity of Fatty Acid Hydroxylation J. Am. Chem. Soc. 2016, 138, 837¨C845.
5. B. Wang,*, J. Lu, K.D. Dubey, G. Dong, W. Lai,* S. Shaik.* How do Enzymes Utilize Reactive OH Radicals? Lessons from Nonheme HppE and Fenton Systems. J. Am. Chem. Soc. 2016, 138, 8489-8496.
6. A. Li#, B. Wang#, A. Ilie, K. D. Dubey, G. Bange, I. V. Korendovych, S. Shaik, M. T. Reetz. A redox-mediated Kemp eliminase. Nat. Commun. 2017. 14876.
7. B. Wang, E. M. Johnston, P. Li, S. Shaik, G. J. Davies, P. H. Walton, C. Rovira. QM/MM Studies into the H2O2-Dependent Activity of Lytic Polysaccharide Monooxygenases: Evidence for the Formation of a Caged Hydroxyl Radical Intermediate. ACS Catal., 2018, 8, 1346¨C1351.
8. Zhou, H,# Wang, B,# Wang, F.; Yu, X.; Ma, L.; Li, A.; Reetz. M. Chemo©\and Regioselective Dihydroxylation of Benzene to Hydroquinone Enabled by Engineered Cytochrome P450 Monooxygenase. Angew. Chem. Int. Ed. 2019, 58, 764-768.
9. B. Wang, P. H. Walton, C. Rovira. The Molecular Mechanisms of Oxygen Activation and Hydrogen Peroxide Formation in Lytic Polysaccharide Monooxygenases. ACS Catal., 2019, 9, 4958¨C4969.
10. B. Wang,* Z. Cao, C. Rovira, J. Song, S. Shaik. Fenton-Derived OH Radicals Enable the MPnS Enzyme to Convert 2-Hydroxyethylphosphonate to Methylphosphonate: Insights from Ab Initio QM/MM MD Simulations. J. Am. Chem. Soc. 2019. In press.
|
ÉùÃ÷£º±¾Íø²¿·ÖÎÄÕºÍͼƬÀ´Ô´ÓÚÍøÂ磬·¢²¼µÄÎÄÕ½öÓÃÓÚ²ÄÁÏרҵ֪ʶºÍÊг¡×ÊѶµÄ½»Á÷Óë·ÖÏí£¬²»ÓÃÓÚÈκÎÉÌҵĿµÄ¡£ÈκθöÈË»ò×éÖ¯Èô¶ÔÎÄÕ°æȨ»òÆäÄÚÈݵÄÕæʵÐÔ¡¢×¼È·ÐÔ´æÓÐÒÉÒ壬ÇëµÚһʱ¼äÁªÏµÎÒÃÇ£¬ÎÒÃǽ«¼°Ê±½øÐд¦Àí¡£
|