北京大学化学与分子工程学院分析化学研究所刘锋

qiangzi

刘 锋
分析化学，教授
电话：010-62761187
传真：010-62751708
电子信箱：liufeng@pku.edu.cn
1982年获北京大学理学学士，
1989年获北京大学理学硕士。
1992-1993年，西班牙马德里大学化学学院，访问学者。         
主要研究方向：
生物与药物分子的识别及分离分析新方法
1.        DNA链置换反应的可控动力学及生物传感应用
2.        功能材料和免标记放大技术在生物传感中的发展和应用
2005 年以来发表的主要学术论文：
1.        Shichao Hu†, Wei Tang†, Yan Zhao, Na Li, Feng Liu*, Ultra-specific discrimination of single-nucleotide mutations using sequestration-assisted molecular beacons, Chem. Sci. 8, 1021–1026, 2017.
2.        Yan Zhao, Shichao Hu, Huaming Wang, Kaiwen Yu, Yan Guan, Xiaoyun Liu, Na Li, Feng Liu*, DNA Dendrimer−streptavidin nanocomplex: an efficient signal amplifier for construction of biosensing platforms, Anal. Chem. 89, 6907−6914, 2017.
3.        Yan Zhao, Huaming Wang, Wei Tang, Shichao Hu, Na Li, Feng Liu*, An in situ assembly of DNA-streptavidin dendrimer nanostructure: a new amplified quartz crystal microbalance platform for nucleic acid sensing, Chem. Commun. 51, 10660–10663, 2015.
4.        Huaming Wang, Wei Tang, Hejia Wei, Yan Zhao, Shichao Hu, Yan Guan, Wei Pan, Bin Xia, Na Li, Feng Liu*, Integrating dye-intercalated DNA dendrimers with electrospun nanofibers: a new fluorescent sensing platform for nucleic acids, proteins, and cells, J. Mater. Chem. B 3, 3541–3547, 2015.
5.        Wei Tang, Shichao Hu, Huaming Wang, Yan Zhao, Na Li, Feng Liu*, A universal molecular translator for non-nucleic acid targets that enables dynamic DNA assemblies and logic operations, Chem. Commun. 50, 14352–14355, 2014.
6.        Kai Su, Chao Wang, Honggang Nie, Yan Guan, Feng Liu*, Jitao Chen* Facile template-free synthesis of 3D porous MnO/C microspheres with controllable pore size for high-performance lithium-ion battery anodes, J. Mater. Chem. A 2, 10000–10006, 2014.
7.        Wei Tang, Huaming Wang, Dingzhong Wang, Yan Zhao, Na Li, Feng Liu*, DNA tetraplexes-based toehold activation for controllable DNA strand displacement reactions, J. Am. Chem. Soc. 135, 13628–13631, 2013.
8.        Huaming Wang, Dingzhong Wang, Zhou Peng, Wei Tang, Na Li, Feng Liu*, Assembly of DNA-functionalized gold nanoparticles on electrospun nanofibers as a fluorescent sensor for nucleic acids, Chem. Commun. 49, 5568–5570, 2013.
9.        Dingzhong Wang, Gengjia Chen, Huaming Wang, Wei Tang, Wei Pan, Na Li, Feng Liu*, A reusable quartz crystal microbalance biosensor for highly specific detection of single-base DNA mutation, Biosens. Bioelectron. 48, 276–280, 2013.
10.        Kai Su, Feng Liu*, Jitao Chen* Preparation of high performance carbon-coated LiMnPO4 nanocomposite by an acetate-assisted antisolvent precipitation method, J. Power Sources 232, 234–239, 2013.
11.        Wei Tang, Dingzhong Wang, Yi Xu, Na Li, Feng Liu*, A self-assembled DNA nanostructure-amplified quartz crystal microbalance with dissipation biosensing platform for nucleic acids, Chem. Commun. 48, 6678–6680, 2012.
12.        Dingzhong Wang, Wei Tang, Xiaojie Wu, Xinyi Wang, Gengjia Chen, Qiang Chen, Na Li, Feng Liu*, Highly selective detection of single-nucleotide polymorphisms using a quartz crystal microbalance biosensor based on toehold-mediated strand displacement reaction, Anal. Chem. 84, 7008–7014, 2012.
13.        Yuanyuan Long, Haibo Chen, Huaming Wang, Zhou Peng, Yufei Yang, Guoqing Zhang, Na Li, Feng Liu*, Jian Pei* Highly sensitive detection of nitroaromatic explosive using an electrospun nanofibrous sensor based on a novel fluorescent conjugated polymer, Anal. Chim. Acta 744, 82–91, 2012.
14.        Huaming Wang, Zhou Peng, Yuanyuan Long, Haibo Chen, Yufei Yang, Na Li, Feng Liu*, A simple and reusable fluorescent sensor for heme proteins based on a conjugated polymer-doped electrospun nanofibrous membrane, Talanta 94, 216–222, 2012.
15.        Yufei Yang, Huaming Wang, Kai Su, Yuanyuan Long, Zhou Peng, Na Li, Feng Liu*, A facile and sensitive fluorescent sensor using electrospun nanofibrous film for nitroaromatic explosive detection, J. Mater. Chem. 21, 11895–11900, 2011.
16.        Qiang Chen, Xiaojie Wu, Dingzhong Wang, Wei Tang, Na Li, Feng Liu*, Oligonucleotide-functionalized gold nanoparticles-enhanced QCM-D sensor for mercury(II) ions with high sensitivity and tunable dynamic range, Analyst 136, 2572–2577, 2011.
17.        Guoqing Zhang, Qing Cao, Na Li, Kean Li, Feng Liu*, Tris(hydroxymethyl)aminomethane-modified magnetic microspheres for rapid affinity purification of lysozyme, Talanta 83, 1515–1520, 2011.
18.        Qing Cao, Yueyan Yin, Li Quan, Na Li, Kean Li, Feng Liu*, Weak affinity ligands selection using quartz crystal microbalance biosensor: Multi-hydroxyl amine ligands for protein separation, Anal. Chim. Acta 703, 250–256, 2011.
19.        Qiang Chen, Wei Tang, Dingzhong Wang, Xiaojie Wu, Na Li, Feng Liu*, Amplified QCM-D biosensor for protein based on aptamer-functionalized gold nanoparticles, Biosens. Bioelectron. 26, 575–579, 2010.
20.        Li Quan, Qing Cao, Zhiyu Li, Na Li, Kean Li, Feng Liu*, Highly efficient and low-cost purification of lysozyme: A novel tris(hydroxymethyl)aminomethane immobilized affinity column, J. Chromatogr. B 877, 594–598, 2009.
21.        Yu Yang, Yuanyuan Long, Zhiyu Li, Na Li, Kean Li, Feng Liu*, Real-time molecular recognition between protein and photosensitizer of photodynamic therapy by quartz crystal microbalance sensor, Anal. Biochem. 392, 22–27, 2009.
22.        Yufei Yang, Xing Fan, Yuanyuan Long, Kai Su, Dechun Zou, Na Li, Jiang Zhou, Kean Li, Feng Liu*, A simple fabrication of electrospun nanofiber sensing materials based on fluorophore-doped polymer, J. Mater. Chem. 19, 7290–7295,2009.
23.        Yuanyuan Long, Haibo Chen, Yu Yang, Huaming Wang, Yufei Yang, Na Li, Kean Li, Jian Pei*, Feng Liu*, Electrospun nanofibrous film doped with a conjugated polymer for DNT fluorescence sensor, Macromolecules 42, 6501–6509, 2009.
24.        Chiyang He, Yuanyuan Long,Junlan Pan,Kean Li,Feng Liu*, A method to coat colloidal particles with molecularly imprinted silica film, J. Mater. Chem.18, 2849–2854, 2008.
25.        Jianjun Wu, Na Li, Kean Li,Feng Liu*, J-Aggregates of diprotonated tetrakis (4-sulfonatophenyl) porphyrin induced by ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate, J. Phys. Chem. B 112, 8134–8138, 2008.
26.        Li Quan, Dengguo Wei, Xiaolu Jiang, Yang Liu, Zhiyu Li, Na Li, Kean Li, Feng Liu*, Luhua Lai* Resurveying the Tris buffer solution: the specific interaction between Tris (hydroxymethyl) aminomethane and lysozyme, Anal. Biochem. 378, 144–150, 2008.
27.        Chiyang He, Yuanyuan Long, Junlan Pan, Kean Li, Feng Liu*, Molecularly imprinted silica prepared with immiscible ionic liquid as solvent and porogen for selective recognition of testosterone, Talanta 74, 1126–1131, 2008.
28.        Yu Yang, Yuanyuan Long, Qing Cao, Kean Li, Feng Liu*, Molecularly imprinted polymer using b-cyclodextrin as functional monomer for the efficient recognition of bilirubin, Anal. Chim. Acta 606, 92–97, 2008.
29.        Qing Cao, Li Quan, Chiyang He, Na Li, Kean Li, Feng Liu*, Partition of horseradish peroxidase with maintained activity in aqueous biphasic system based on ionic liquid, Talanta 77, 160–165, 2008.
30.        Chiyang He, Yuanyuan Long, Junlan Pan, Kean Li, Feng Liu*, Applications of molecularly imprinted polymer in solid-phase extraction of analytes from real samples, J. Biochem. Bioph. Meth. 70, 133–150, 2007.
31.        Shehong Li, Chiyang He, Fei Gao, Daobing Li, Zheng Chen, Huwei Liu, Kean Li, Feng Liu*, Extraction and determination of morphine in compound liquorice using an aqueous two-phase system of poly (ethylene glycol)/K2HPO4 coupled with HPLC, Talanta 71, 784–789, 2007.
32.        Qing Cao, Shehong Li, Chiyang He, Kean Li, Feng Liu*, Extraction and determination of papaverin in pericarpium papaveris using aqueous two-phase system of poly(ethylene glycol)-(NH4)2SO4 coupled with high-performance liquid chromatography, Anal. Chim. Acta 590, 187–194, 2007.
33.        Chiyang He, Kean Li, Huwei Liu, Feng Liu*, Molecularly imprinted polymer film grafted from porous silica for selective recognition of testosterone, Anal. Lett. 39, 275–286, 2006.
34.        Hailing Liu, Chiyang He, Dawei Wen, Huwei Liu, Kean Li, Feng Liu*, Extraction of testosterone and epitestosterone in human urine using 2-propanol-salt-H2O system, Anal. Chim. Acta 557, 329–336, 2006.
35.        Shehong Li, Chiyang He, Huwei Liu, Kean Li, Feng Liu*, Ionic liquid-based aqueous two-phase system, a sample pretreatment procedure prior to high-performance liquid chromatography of opium alkaloids, J. Chromatogr. B 826, 58–62, 2005.
36.        Chiyang He, Shehong Li, Huwei Liu, Kean Li, Feng Liu*, Extraction of testosterone and epitestosterone in human urine using aqueous biphasic system consisting of ionic liquid and salt, J. Chromatogr. A 1082, 143–149, 2005.
37.        Shehong Li, Chiyang He, Huwei Liu, Kean Li, Feng Liu*, Ionic liquid-salt aqueous two-phase system, a novel system for the extraction of abused drugs, Chin. Chem. Lett. 16, 1074–1076, 2005.