复旦大学化学系有机化学陈勤

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陈勤，药理学，青年研究员
电子邮箱：chenq@fudan.edu.cn
办公地点：遗传学楼416室
研究兴趣
-重大疾病药物筛选模型的建立和应用
-活性化合物分子药理学的研究
-新药的研发
获奖情况
2014年上海交通大学医学院“九龙医学优秀青年人才奖”
学习工作经历

1999.9-2003.7            浙江师范大学生物系本科，获得理学学士学位

2003.9-2008.7            中科院上海药物研究所硕博连读，获得理学博士学位

2009.4-2011.12          美国纽约州立大学石溪分校，博士后

2012.3-2016.5           上海交通大学医学院，副研究员

2016.6-2017.8           上海科技大学，副研究员

2017.9起                    复旦大学化学系，青年研究员

代表性论文或专著

• Qin Chen, Xian Zhao, Hailong Zhang, Haihua Yuan, Miaojun Zhu, Qian Sun, Xueping Lai,  Yanli Wang, Jian Huang, Jianshe Yan, Jianxiu Yu. MiR-130b Suppresses Prostate Cancer Metastasis through Down-regulation of MMP2. Molecular Carcinogenesis 2015, 54(11):1292

• Miaojun Zhu*, Qin Chen*, Xin Liu*, Qian Sun, Xian Zhao, Rong Deng, Yanli Wang, Jian Huang, Ming Xu, Jianshe Yan, Jianxiu Yu. lncRNA H19/MiR-675 axis represses prostate cancer metastasis by targeting TGFBI. 2014, 281:3766. (*Equal contribution)

• Qian Sun#, Xian Zhao#, Xin Liu, Yanli Wang, Jian Huang, Jiang Bin, Qin Chen#, Jianxiu Yu#. miR-146a Functions as a Tumor Suppressor in Prostate Cancer by Targeting Rac1. Prostate 2014, 74(16):1613 (#Corresponding author)

• Qin Chen, Tsunaki Hongu, Takanobu Sato, Yi Zhang, Wahida Ali, Julie-Ann Cavallo, Adrianus van der Velden, Huasong Tian, Gilbert Di Paolo, Bernhard Nieswandt, Yasunori Kanaho, Michael A. Frohman Key Roles for the Lipid Signaling Enzyme Phospholipase D1 in the Tumor Microenvironment During Tumor Angiogenesis and Metastasis. Science Signaling 2012, 5(249): ra79

• He Huang, Qin Chen, Xin Ku, Linghua Meng, Liping Lin, Xiang Wang, Caihua Zhu, Yi Wang, Zhi Chen, Ming Li, Hualiang Jiang, Kaixian Chen, Jian Ding, Hong Liu. A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase II alpha catalytic activity. Journal of Medicinal Chemistry 2010, 53(8): 3048-3064 ()

• Qin Chen, Ling-hua Meng, Cai-hua Zhu, Li-ping Lin, He Lu, Jian Ding. ADAM15 suppresses cell motility by driving integrin α5β1 cell surface distribution via Erk inactivation. Int J Biochem Cell B 2008, 40: 2164-2173