吉林大学化学学院李继贞

yujiaxue

李继贞
女 教授 有机化学系
邮箱： lijizhen11@yahoo.com; ljz@jlu.edu.cn


研究领域与兴趣
有机化学和药物化学
教育背景与学术经历
1991.09--1995.07 兰州大学 化学系 学士
1995.09--2001.06 中国科学院长春应化所 博士
2001.08--2002.02 西班牙马德里药物化学研究所 博士后
2002.02--2004.04 美国西雅图华盛顿大学生物化学系 博士后
教学情况
1、有机分析 本科生选修课
承担项目与课题
1、生物碱Asmarine衍生物的组合合成和构效关系研究 中国教育部 2005-20072、吉林大学青年教师基金 吉林大学 2004-2006
3、吉林大学科学前沿与交叉学科创新项目 吉林大学 2009-2011
4、吉林省科技厅应用基础研究项目 吉林省 2009-2011
代表性论文及著作
1.Jizhen Li*, Yuhua Mi，Jianghua He, Xuyang Luo, Erkang Fan. “Synthesis of 2-Amino 3-Substituted Quinazolin-4(3H)-one Derivatives Via Iodine-Mediated Guanidinylation of Pbf-Activated Thiourea”, Journal of Heterocyclic Chemistry, 2011, May, Accepted.
2.Jizhen Li*, Jingping Kou, Yuhua Mi.“Polymer Supported Synthesis of Multi-substituted Pyrimidine-4-one Derivatives Via Pbf-activated Thiourea”. Chemical Research in Chinese Universities, 2011, 27(2), 221-223. 3.Jizhen Li*, Yuhua Mi, Jianghua He, Xuming Deng.“A Short and Efficient Synthesis of Licochalcone E”. Synlett, 2010, 15, 2289-2292.
4.Jizhen Li*, JingPing Kou, Xuyang Luo, and Erkang Fan, “A Facile Synthesis of 2-(N-alkylamino)-pyrimidin-4-one Derivatives”, Tetrahedron Letters, 2008, 49, 2761-2763.
5.CuiYing Qin, Erkang Fan, Jizhen Li*, “Iodine-Mediated Guanidine Formation through Aryl Sulfonyl-Activated Thioureas”, SynLett, 2009, 15, 2465-2468.
6.Jingping Kou, Yujuan Lu, Xuyang Luo, Jizhen Li*, “Michael addition of amines to α,β-unsaturated olefins promoted by Zn-NH4Cl system”, Chemical Research in Chinese Universities, 2009, 25(4),1-4.
7.JingPing Kou, Xuyang Luo, Cuiying Qin, Jizhen Li*, “Synthesis of Pbf-NCS (2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl isothiocyanate”, Huaxue Shiji (China), 2009, 31(1), 67-70.
8.Yinghuan Fu, Jizhen Li, Xu Bai, Jinchang Wu, Shu Gao, Tonghao Wu, “Selective Debenzylation of Dibenzylimine Compounds under Different Conditions”, Journal of JiLin University Science Edition, 2006, 2, 123-125.
9.Fu Yinghuan, Li jizhen*, Wu Tonghao, “The application of ring closing metathesis reaction in the synthesis procedure of natural products”, Huaxue TongBao (Chemistry Reports,China), 2005, 7, 481-489.
10.Yujuan Lu, Jizhen Li*, Jie Tang, Bo Wei, Jianhong Liu, “The removal of Indigo Carmine from water by solvent sublation”, Separation Science and Technology, 2005, 40(5), 1115-1127.
11.Yujuan Lu, Jizhen Li, Xueli Zhang, Jianhong Wei, Bo Liu, “Studies on the mechanism of Indigo Carmine removal by solvent sublation”, Journal of Colloid and Interface Science, 2005, 292 (1): 210-218, 2005.
12.Xueli Zhang, Yujuan Lu, Jizhen Li and Seik Weng Ng, “Catena- poly[bis[aquacopper(I) -μ-4,4’- bipyridine-κ2N:N’]terephthalate dihydrate]”, Acta Cryst, 2005, E61, m1061-m1062.
13.Xueli Zhang, Yujuan Lu, Jizhen Li and Seik Weng Ng, “Hexaaquazinc(II) bis (6- hydroxypyridine 3-carboxylate)”, Acta Cryst, 2005, E61, m1063-m1064.
14.Jizhen Li, Zhenfa Zhang, Erkang Fan, “Solid-phase synthesis of 1,5-substituted 2-(N–alkylamino)–imidazolidin–4–ones”, Tetrahedron Letters, 2004, 45, 1267-1269.
15.Jizhen Li, Guangtao Zhang, Zhongsheng Zhang, Erkang Fan, “TFA-sensitive arylsulfonylthiourea-assisted synthesis of N,N’-substituted guanidines”, Journal of Organic Chemistry, 2003, 68, 1611-1614.
16.Jizhen Li, Lianxun Gao, Mengxian Ding, “The Chemical Resolution of cis-2–Hydroxymethyl–5-(Cytosine-1’–yl)-1,3-Oxathiolane (BCH-189)---One Direct Method to Obtain Lamivudine as Anti-HIV and Anti-HBV Agent”, Synthetic Communications, 2002, 32(15), 2355-2359.
17.Li jizhen, Qiu Xuepeng, Gao Lianxun, Ding Mengxian, “Synthesis of cis-2- Hydroxymethyl- 5-(Cytosine-1'-yl)-1,3-Oxathiolane (BCH-189)”, Chinese Chemical Letters, 2001,12(6), 487-488.


专利：
1、抗乙肝药物拉米呋定的制备 2001, CN: 2**.
2、一种甘草查尔酮E的合成方法 2010, CN: **5.8