中国科学院上海硅酸盐研究所常江

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常江,中国科学院上海硅酸盐研究所研究员、博士生导师，中国科学院上海硅酸盐研究所生物材料与组织工程研究中心主任。国际生物材料学会联合会Fellow（FBSE），国际可注射骨与关节材料学会副主席，美国生物材料学会会员，国际组织工程学会会员，中国生物材料学会常务理事，中国生物医学工程学会生物材料专委会委员，全国外科植入物和矫形器械标准化技术委员会骨科植入物分技委委员，上海生物医学工程学会理事。国际学术期刊Ceramics International编委。


姓 名:常江        
性    别:男
专家类别:百人；研究员        
学 历:博士研究生
电 话:021-52412804        
传 真:021-52413903
电子邮件:jchang@mail.sic.ac.cn        
个人主页:无
邮政编码:200050        
通讯地址:上海市定西路1295号        
简历：
1991年德国达姆施达特工业大学获博士学位，1991年至2000年分别在德国卢卑克医科大学做博士后研究、新西兰奥克兰大学任研究员、美国纽约大学任研究助理教授、美国强生公司损伤修复技术中心任研究员，主要从事组织损伤修复及组织工程生物材料研究，包括皮肤、骨、软骨的组织工程再生修复。1996年获新西兰职业华人杰出成就奖。 2000年12月获中国科学院“引进国外杰出人才”（百人计划）基金，应聘回国，到中国科学院上海硅酸盐研究所从事科研工作。回国后创建了中科院上海硅酸盐研究所生物材料与组织工程研究中心，组建了生物材料研究团队。针对生物材料在人体组织创伤修复中的应用，系统地开展了在国际上具有特色的硅酸盐生物活性材料为主体的生物陶瓷及其复合材料、组织工程材料、纳米生物材料等方面的基础研究、应用研究、产品开发和产业化。与美国、日本、荷兰等国家的大学和科研机构建立了科研合作和学术交流关系。
以第一或通讯作者发表学术论文260余篇，其中包括材料学和生物材料领域顶级杂志Advanced Materials，Nano Letters，Small，J Control Release，Biomaterials，Chemical Communications和Nanoscale。申请国家发明专利51项，美国PCT发明专利3项。其中31项已经获得授权，3项专利实现技术转让，产生直接经济效益300多万元。
承担和完成20多项国家和地方科研项目，其中作为首席科学家承担并顺利完成上海市重大项目和中科院知识创新重要方向性项目各1项，作为子课题负责人承担并顺利完成国家科技部“973”项目1项，作为项目负责人完成国家自然基金重点项目1项和面上项目3项，作为课题负责人承担国家自然基金重大项目和国际合作与交流项目各1项。2006年获得上海市科技进步二等奖。
人才培养方面，已培养出站博士后5名 ，毕业博士研究生20名、硕士研究生11名。目前在读博士研究生5名，硕士研究生4名。

主要研究领域介绍


（1）可降解生物活性骨修复材料的研究
（2）作为药物载体的生物材料以及药物控制释放的研究
（3）纳米生物材料制备技术研究
近来发表的代表性专著及期刊论文（10年内）：
专著（按时间顺序）
Chengtie Wu. Jiang Chang. Yin Xiao. “Advanced bioactive inorganic materials for bone regeneration and drug delivery" Publisher. CRC Press and Taylor & Francis. January 11, 2013
Kaili Lin, Jiang Chang. Chapter 6: Preparation and mechanism of novel bioceramics with controllable morphology and crystal growth,in “Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery”, CRC press, March 29, 2013
Jiang Chang, Wenguo Cui, Yue Zhou, Lei Chen, Fabrication of Fibrous Scaffolds for Tissue Engineering by Electrospinning Techniques, Chapter 15 in The Handbook of Intelligent Scaffold for Regenerative Medicine, Ed. Gilson Khang, Publishers: Pan Stanford Publishing. 2012, 219-232
Wenguo Cui, Jiang Chang, Paul Dalton, Electrospun Fibers For Drug Delivery, in Comprehensive Biomaterials, Ed. Paul Ducheyne, Kevin E. Healy, Dietmar E. Hutmacher, David E. Grainger and C. James Kirkpatrick, Publisher: Elsevier Science. 2011,445-462
Jiang Chang, Yanling Zhou, Yue Zhou, Surface modification of bioactive glasses, in Bioactive Glasses, Ed. Heimo Ylänen, Publishers: Woodhead Publishing Ltd. 2011, 29-52
Chengtie Wu, Jiang Chang, Hala Zreiqat. “Engineered Ca-Si based ceramics for skeletal tissue reconstruction”. In Book: "Biomaterials for Bone Regenerative Medicine" by editors: N.Sooraj Hussain and J. D. Santos. Publishers: Trans Tech Publishers (Ttp), Switzerland, 2010, 121-150
Jiang Chang, Daming Zhang, Lingzhi Ye. “Biodegradable bioceramics/polymer composites for tissue regeneration” in 《Surface Design and Modification of Biomaterials for Clinical Application-Geometry of Material Surfaces, Cell Affinity and Immobilization of CAMs and Tropic Factors》 , Editor: Junzo Tanaka，Publisher: Research Signpost, 2009,173-188
Jiang Chang, Lei Chen. “Silicate-based bioactive materials for bone regeneration” in Biomaterials in Asia. Ed. Tetsuya Tateishi, World Scientific Publishing Co Pte Ltd. 2009,343-363
Ying-Jie Zhu, Jiang Chang. “Microwave-assisted Synthesis and Processing of Biomaterials” in NanoScience in Biomedicine. Ed. Donglu Shi, Publisher: Springer, 2009,154-177
期刊论文（按时间顺序，通讯作者 & IF > 5）
Xiaoguo Liu, Kaili Lin, Chengtie Wu, Yueyue Wang, Zhaoyong Zou, Jiang Chang*. Multilevel hierarchically ordered artificial biomineral. 2014, Small 10(1):152-159.
Haiyan Li, Ke Xue, Ni Kong, Kai Liu*, Jiang Chang*. Silicate bioceramics enhanced vascularization and osteogenesis through stimulating interactions between endothelia cells and bone marrow stromal cells. Biomaterials 2014, 35(12):3803-3818.
Chengtie Wu, Pingping Han, Xiaoguo Liu, Mengchi Xu, Tian Tian, Jiang Chang*, Yin Xiao*. Mussel-inspired β-tricalcium phosphate bioceramics with Ca-P/polydopamine hybrid nanolayer: preparation, formation mechanism and improved cellular bioactivity. Acta Biomaterialia 2014, 10(1):428-438.
Mengchi Xu, Dong Zhai, Jiang Chang*, Chengtie Wu*. In vitro assessment of 3D-Plotted nagelschmidtite bioceramic scaffolds with varied macropore morphology. Acta Biomaterialia 2014, 10(1):463-476.
Chengtie Wu, Yinghong Zhou, Mengchi Xu, Pingping Han, Lei Chen, Jiang Chang*, Yin Xiao*. Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity. Biomaterials 2013, 34(2):422-433.
Chengtie Wu*, Wei Fan, Jiang Chang*. Functional mesoporous bioactive glass nanospheres: synthesis, apatite mineralization, controllable delivery of doxorubicin and inhibitory effect on bone cancer cells. Journal of Materials Chemistry B 2013, 1(21): 2710-2718. (Cover paper)
Chengtie Wu, Pingping Han, Mengchi Xu, Xufang Zhang, Yinghong Zhou, Guangda Xue, Jiang Chang*, Yin Xiao*. Nagelschmidtite bioceramics with osteostimulation property: material chemistry activating osteogenic genes and WNT signalling pathway of human bone marrow stromal cells. Journal of Materials Chemistry B 2013, 1(6):876-885.
Chengtie Wu*, Minghui Zhang, Dong Zhai, Jianding Yu, Yan Liu, Huiying Zhu, Jiang Chang*. Containerless processing for preparation of akermanite bioceramic spheres with homogenous structure, tailored bioactivity and degradation. Journal of Materials Chemistry B. 2013, 1(7):1019-1026.
Chen Wang, Kaili Lin, Jiang Chang*, Jiao Sun*. Osteogenesis and angiogenesis induced by porous b-CaSiO3/PDLGA compositescaffold via activation of AMPK/ERK1/2 and PI3K/Akt pathways. Biomaterials .2013, 34(1):64-77.
Haiyan Li, Jiang Chang*. Stimulation of proangiogenesis by calcium silicate bioactive ceramic. Acta Biomaterilia. 2013; 9(2):5379-89.
He Xu, Haiyan Li*, Jiang Chang*. Controlled drug release from polymer matrix by patterned electrospun nanofibers with controllable hydrophobicity. Journal of Materials Chemistry B 2013, 1(33): 4182-4188.
Wanyin Zhai, Hongxu Lu, Chengtie Wu, Lei Chen, Xiaoting Lin, Kawazoe Naoki, Guoping Chen*, Jiang Chang*. Stimulatory effects of the ionic products from Ca-Mg-Si bioceramics on both osteogenesis and angiogenesis in vitro. Acta Biomaterialia 2013, 9(8): 8004-8014.
Haiyan Li, Jiang Chang*. Bioactive silicate materials stimulate angiogenesis in fibroblast and endothelial cell co-culture system through paracrine effect. Acta Biomaterialia 2013, 9(6):6981-6991.
Kaili Lin, Lunguo Xia, Jinbo Gan, Zhiyuan Zhang, Hong Chen*, Xinquan Jiang*, Jiang Chang*. Tailoring the Nanostructured Surfaces of Hydroxya patite Bioceramics to Promote Protein Adsorption, Osteoblast Growth, and Osteogenic Differentiation. ACS Applied Materials& Interfaces 2013, 5:8008-8017.
Kaili Lin, Lunguo Xia,Haiyan Li, Xinquan Jiang,Haobo Pan,Yuanjin Xu,William W Lu, Zhiyuan Zhang*, Jiang Chang*. Enhanced osteoporotic bone regeneration by strontium-substituted calcium silicate bioactive ceramics. Biomaterials 2013, 34 (38): 10028-42.   
Chengtie Wu, Yinghong Zhou, Jiang Chang*, Yin Xiao*. Delivery of dimethyloxallyl glycine in mesoporous bioactive glass scaffolds to improve angiogenesis and osteogenesis of human bone marrow stromal cells. Acta Biomaterialia 2013, 9(11):9159-9168.
Yan Han, Qiongyu Zeng, Haiyan Li*, Jiang Chang*. The calcium silicate/alginate composite: preparation and evaluation of its behavior as bioactive injectable hydrogels. Acta Biomaterialia 2013, 9: 9107-9117.
Lunguo Xia, Kaili Lin, Xinquan Jiang, Yuanjin Xu, Maolin Zhang, Jiang Chang*, Zhiyuan Zhang*. Enhanced osteogenesis through nano-structured surface design of macroporous hydroxyapatite bioceramic scaffolds via activation of ERK and p38 MAPK signaling pathways. Journal of Materials Chemistry 2013, 1:5403-5416.
Chengtie Wu, Jiang Chang*, Wei Fan*. Bioactive mesoporous calcium-silicate nanoparticles with excellent mineralization ability, osteostimulation, drug-delivery and antibacterial properties for filling apex root of tooth. Journal of Materials Chemistry 2012, 22:16801-16809.
Chengtie Wu, Yinghong Zhou, Chucheng Lin, Jiang Chang*, Yin Xiao*. Strontium-containing mesoporous bioactive glass scaffolds with improved osteogenic/cementogenic differentiation of periodontal ligament cells for periodontal tissue engineering. Acta Biomaterialia 2012, 8:3805-3815.
Meili Zhang, Chengtie Wu, Haiyan Li, Jones Yuen, Jiang Chang*, Yin Xiao*. Preparation, characterization and in vitro angiogenic capacity of cobalt substituted b-tricalcium phosphate ceramics. Journal of Materials Chemistry 2012, 22, 21686–21694.
Zhaoyong Zou, Xiaoguo Liu, Lei Chen, Kaili Lin*, Jiang Chang*. Dental enamel-like hydroxyapatite transformed directly from monetite. Journal of Materials Chemistry 2012, 22 (42), 22637 – 22641.
Yuandong Dou, Chengtie Wu, Jiang Chang*. Preparation, mechanical property and cytocompatibility of poly (L-lactic acid)/calcium silicate nanocomposites with controllable distribution of calcium silicate nanowires. Acta Biomaterialia 2012, 8(11):4139-4150
Wanyin Zhai, Hongxu Lu, Lei Chen, Xiaoting Lin, Yan Huang, Kerong Dai, Kawazoe Naoki, Guoping Chen*, Jiang Chang*. Silicate bioceramics induce angiogenesis during bone regeneration. Acta Biomaterialia 2012, 8:341-349.
Botao Song, Chengtie Wu, Jiang Chang*. Dual drug release from electrospun poly(lactic-co-glycolic acid)/mesoporous silica nanoparticles composite mats with distinct release profiles. Acta Biomaterialia 2012, 8:1901-1907.
Chen Wang, Xue Yang, Kaili Lin, Jianxi Lu, Jiang Chang*, Jiao Sun*.The enhancement of bone regeneration by the combination of osteoconductivity and osteostimulation using β-CaSiO3/β-Ca3(PO4)2 composite bioceramics. Acta Biomaterialia 2012, 8(1):350-360.   
Huijie Gu, Fangfang Guo,Xiao Zhou,Lunli Gong, Yun Zhang, Wanyin Zhai, Lei Chen, Lian Cen, Shuo Yin, Jiang Chang*, Lei Cui*. Ionic products from akermanite dissolution stimulate osteogenic differentiation of human adipose-derived stem cells via activation of ERK pathway. Biomaterials 2011, 32(29):7023-7033.
Kaili Lin, Yanling Zhou, Yue Zhou, Haiyun Qu, Feng Chen, Yingjie Zhu, Jiang Chang*. Biomimetic hydroxyapatite porous microspheres with co-substituted essential trace elements: Surfactant-free hydrothermal synthesis,enhanced degradation and drug release. Journal of Materials Chemistry 2011, 21:16558-16565.
Liang Wu, Yuandong Dou, Kaili Lin, Wanyin Zhai, Wenguo Cui, Jiang Chang*. Hierarchically structured nanocrystalline hydroxyapatite assembled hollow fibers as a promising protein delivery system. Chemical Communications 2011, 47(42):11674-11676.
Kaili Lin, Xiaoguo Liu, Jiang Chang*, Yingjie Zhu, Facile Synthesis of Hydroxyapatite Nanoparticles, Nanowires and Hollow Nano-structured Microspheres using Similar Structured Hard-precursors. Nanoscale 2011, 3(8): 3052-3055.
Yuandong Dou, Kaili Lin, Jiang Chang*. Polymer nanocomposites with controllable distribution and arrangement of inorganic nanocomponents. Nanoscale.2011, 3: 1508-1511.
Wanyin Zhai, Xiqin Lü, Jiang Chang*, Yanlin Zhou, Hongfeng Zhang, Quercetin crosslinked porcine heart valve matrix: mechanical property, stability, anti-calcification and cytocompatibility, Acta Biomaterialia 2010, 6:389-395.
Zhiguang Huan, Jiang Chang*. Novel bioactive composite bone cements based on β-tricalcium phosphate-monocalcium phosphate monohydrate composite cement system. Acta Biomaterialia 2009, 5: 1253-1264.
Yan Huang, Xiaogang Jin, Xiaoling Zhang, Hongli Sun, Jinwen Tu, Tingting Tang, Jiang Chang*, Kerong Dai.In vitro and in vivo evaluation of akermanite bioceramics for bone regeneration. Biomaterials 2009, 30: 5041-5048.
Daming Zhang, Jiang Chang*. Electrospinning of Three-Dimensional Nanofibrous Tubes with Controllable Architectures. Nano Letters 2008, 8(10):3283-3287.
Qihai Liu, Lian Cen, Shuo Yin, Lei Chen, Guangpeng Liu, Jiang Chang*, Lei Cui*. A comparative study of proliferation and osteogenic differentiation of adipose-derived stem cells on akermanite and β-TCP ceramics, Biomaterials 2008, 29: 4792-4799.
Songfeng Xu, Kaili Lin, Zhen Wang*, Jiang Chang*, Lin Wang, Jianxi Lu, Congqin Ning. Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics. Biomaterials 2008, 29: 2588-2596 ;
Daming Zhang, Jiang Chang*. Patterning of electrospun fibers using electroconductive templates. Advanced Materials 2007, 19:3664-3667.
Zhiguang Huan, Jiang Chang*. Self-setting properties and in vitro bioactivity of the calcium sulfate hemihydrate/tricalcium silicate composite bone cements. Acta Biomaterialia 2007, 3(6): 952-960.
Faming Zhang, Jiang Chang*, Jianxi Lu, Kaili Lin, Congqin Ning. Bioinspired Structure of Bioceramics for Bone Regeneration in Load Bearing Sites. Acta Biomaterialia 2007, 3: 896-904.
Hongli Sun, Chengtie Wu, Kerong Dai*, Jiang Chang*, Tingting Tang, Proliferation and osteoblastic differentiation of human bone marrow-derived stromal cells on akermanite bioactive ceramics. Biomaterials 2006, 27: 5651-5657.
Wanyin Zhai, Jiang Chang*, Kaili Lin, Junyin Wang, Qiang Zhao, Xiaoning Sun. Crosslinking of decellularized porcine heart valve matrix by procyanidins. Biomaterials 2006, 27: 3684-3690.
Wei Xia, Jiang Chang*. Well-ordered mesoporous bioactive glasses (MBG): a promising bioactive drug delivery system. Journal of Controlled Release 2006, 110:522-530.
Chengtie Wu, Jiang Chang*, Junying Wang, Shiyu Ni, Wanyin Zhai. Preparation and Characteristics of a Calcium Magnesium Silicate (Bredigite) Bioactive Ceramic. Biomaterials 2005, 26: 2925-2931.
Wenyuan Zhao, Wanyin Zhai, Zheng Wang, Junying Wang, Jiang Chang*. The self-setting property and in vitro bioactivity of tricalcium silicate. Biomaterials. 2005, 26: 6113-6121.
Haiyan Li, Jiang Chang*. Fabrication and characterization of bioactive wollastonite/PHBV composite scaffolds. Biomaterials 2004, 25: 5473-5480.
    详情：http://www.sic.cas.cn/kybm/bio/

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上海硅酸盐所在生物陶瓷用于组织修复与治疗领域发表综述文章

近期，中国科学院上海硅酸盐研究所研究员常江和吴成铁带领的研究团队在国际学术期刊Materials Today 与ActaBiomaterialia 分别发表综述论文。

　　众所周知，生物陶瓷主要用于人体硬组织的修复与替换。然而近年来，越来越多的证据表明生物陶瓷具有调节干细胞分化和调节干细胞与组织特异性细胞（包括软组织细胞）相互作用的生物活性，也就是说生物陶瓷不仅能用于硬组织修复，在软组织组织工程和再生医学领域也有巨大的发展潜力。与以往综述主要关注生物陶瓷的制备、特性及用于硬组织修复不同，发表在Materials Today上的综述论文主要关注细胞与生物陶瓷之间的相互作用及相关的生物学机制，特别是生物陶瓷的化学和结构信号对于干细胞微环境的影响，以及对硬组织和软组织的修复。该综述介绍了生物陶瓷释放的不同的生物活性离子对干细胞微环境和组织再生具有组合或协同作用，这将有助于设计具有多种组织修复功能的生物陶瓷。基于合适浓度的生物活性离子和特定的陶瓷表面微纳米形貌均能刺激干细胞分化和组织再生，首先提出了“基于生物陶瓷的化学和结构信号产生的生物学功能及相关作用机制对生物陶瓷进行设计，也就是通过精确控制生物陶瓷成分和结构，实现对于促进组织再生最佳的生物陶瓷”的理念。最后，对于生物陶瓷的组成和结构的复杂性，干细胞微环境的复杂性以及两者之间复杂的相互作用，提出了基于“生物材料系统生物学（biomaterials system biology）”可能是生物陶瓷未来发展的最重要的方法之一（Materials Today, 2018, https://doi.org/10.1016/j.mattod.2018.07.016）。

　　在此基础上，研究团队进一步将生物陶瓷通过3D打印方式制备成仿生人体结构的多孔复杂结构，并将其组织修复拓展到肿瘤治疗。由于交通事故、衰老、骨肿瘤等引起的骨组织缺损给人类健康和生活质量带来了巨大的危害。因此，许多研究关注于骨组织缺损修复材料的制备及设计。3D打印技术以其快速、精确、可控、个性化的制作工艺在骨组织工程中得到广泛应用，制备的三维支架提供了有利于细胞粘附和增殖的三维环境。传统的3D打印生物陶瓷支架主要用于骨组织再生，而此篇综述着重介绍了具有肿瘤治疗和骨再生功能的3D打印生物陶瓷支架的最新进展。这种功能性生物陶瓷支架在修复手术引起的骨缺损和杀灭可能残留的肿瘤细胞方面具有巨大的潜力，可达到骨肿瘤治疗的目的。该综述阐述了3D打印生物陶瓷支架的组成和结构(宏观、微观和纳米尺度)及其对力学、降解、渗透性和生物性能的影响。此外，还概述了3D打印生物陶瓷支架从骨组织再生到骨肿瘤治疗的发展趋势（ActaBiomaterialia,2018, https://doi.org/10.1016/j.actbio.2018.08.026）。

　　相关研究工作得到国家重点研发计划、国家自然科学基金、中科院先导计划、中科院前沿科学重点研发计划与上海市国际合作项目等的资助和支持。

　　论文链接：1 2

生物陶瓷释放的活性离子和表面微纳米形貌作用于干细胞微环境