|
杨震,男,北京大学长江特聘教授兼北京大学深圳研究生院化学生物学和生物技术学院院长。1989-1992,在黄乃正院士的指导下,主要从事中草药丹参的化学成分分离,结构鉴定和有效成分的合成研究。利用腺苷A1 受体活性追踪的生物学方法,从丹参水溶液中分离得到了一类全新的腺苷A1 受体阻断剂。
1992-1995 年,师 从 K. C. Nicolaou 教 授 , 在 Scripps 参 加 了 天 然 产 物 分 子 紫 杉 醇 Taxol,Zaragozic Acid 和Epothilone A 的全合成。 1995-1998 年在Scripps 研究所任助理教授,在此期间完成了Brevetoxin A 的全合成工作。1998 年在哈佛药学院化学与细胞生物学研究所任研究员,主要从事化学生物学研究。在此期间,率先开展了一种全新的组合化学合成模式来探索和加速天然产物类似物的合成工作,为新药研究提供了一种有效的合成途径。2001-至今在北京大学工作,主要从事复杂天然产物的全合成,有机金属催化反应和抗病毒和抗肿瘤药物研究。
邮箱:zyang@pku.edu.cn
SELECTIVE PUBLICATIONS
1. Total Syntheses of Drimane-Type Sesquiterpenoids Enabled by a Gold-Catalyzed
Tandem Reaction
H. Shi, L. C. Fang, C. H. Tan, L. L. Shi, W. B. Zhang, C. C. Li, T. P. Luo, Yang, Z.
J. Am. Chem. Soc. 2011, 132, ASAP.
2. Diastereoselective Total Synthesis of (±)-Schindilactone A
Q. Xiao, W. W. Ren, Z. X. Chen, T. W. Sun, Y. Li, Q. D. Ye, J. X. Gong, F. K. Meng, L.
You, Y. F. Liu, M. Z. Zhao, L. M. Xu, Z. H. Shan, Y. Shi, Y. F. Tang, J. H. Chen, Yang, Z.
Angew. Chem. Int. Ed. 2011, 50, 7373.
3. Formal Synthesis of Cortistatins
L. C. Fang, Y. Chen, J. Huang, L. Z. Liu, J. M. Quan, C. C. Li, Yang, Z.
J. Org. Chem. 2011, 76, 2479.
4. A Concise Approach for the Total Synthesis of Pseudolaric Acid A
T. Xu, C. C. Li, Yang, Z.
Org. Lett. 2011, 13, 2630.
5. Asymmetric Total Synthesis and Structural Elucidation of NFAT-68
L. Wang, Y. M. Xi, S. L. Yang, R. Zhu, Y. F. Liang, J. H. Chen, Yang, Z.
Org. Lett. 2011, 13, 74.
6. Total Synthesis of Maoecrystal V
Gong, J.; Lin, G.; Sun, W.; Li, C.-C.; Yang, Z.
J. Am. Chem. Soc., 2010, 132, 16745.
7. Asymmetric Total Synthesis of Caribenol A
Liu, L.; Han, J.; Yue, G.; Li, C.-C.; Yang, Z.
J. Am. Chem. Soc., 2010, 132, 13608.
8. A model study for the concise construction of the oxapentacyclic core of cortistatins
through intramolecular Diels-Alder and oxidative dearomatization-cyclization reaction
Liu, L. Z.; Gao, Y. X.; Che, C.; Wu, N.; Wang, D. Z.; Li, C. C.;Yang, Z.
Chemical Communications 2009, 662-664.
9. Total synthesis of crisamicin A
Li, Z. T.; Gao, Y. X.; Tang, Y. F.; Dai, M. J.; Wang, G. X.; Wang, Z. G.; Yang, Z.
Org. Lett. 2008, 10, 3017-3020.
10. Diversity-Oriented Synthesis of Fused Pyran gamma-Lactones via an Efficient Pd-
Thiourea-Catalyzed Alkoxycarbonylative Annulation
Li, Z. T.; Gao, Y. X.; Jiao, Z. D.; Wu, N.; Wang, D. Z.; Yang, Z.
Org. Lett. 2008, 10, 5163-5166.
11. A One-Pot Synthesis of Quinoline-based Tetracycles by a Tandem Three-Component
Reaction
Che, C.; Xiang, J.; Wang, G. X.; Quan, J.-M.; Yang, Z.
J. Comb. Chem. 2007, 9, 982.
12. Development of a Concise and Diversity-Oriented Approach for the Synthesis of
Plecomacrolides via the Diene-Ene RCM
Lu, K.; Huang, M.; Xiang, Z.; Liu, Y.; Chen, J.; Yang, Z.
Org. Lett. 2006, 8, 1193.
13. Synthetic Study of 1,3-Butadiene-Based IMDA Approach to Construct a [5-7-6]
Tricyclic Core and Its Application to the Total Synthesis of C8-epi-Guanacastepene O
Li, C. ; Wang, C. ; Liang, B. ; Zhang, X. ; Deng, L. ; Liang, S. ; Chen, J. ; Wu, Y. ;
Yang, Z.
J. Org. Chem. 2006, 71, 6892.
14. Thioureas as Ligands in the Pd-Catalyzed Intramolecular Pauson-Khand Reaction
Tang, Y.; Deng, L.; Zhang, Y.; Dong, G.; Chen, J.; Yang, Z.
Org. Lett. 2005, 7, 1657.
15. A Highly Efficient Synthesis of the FGH Ring of Micrandilactone A. Application of
Thioureas as Ligands in the Co-catalyzed Pauson-Khand Reaction and Pd-Catalyzed
Carbonylative Annulation
Tang, Y.; Zhang, Y.; Dai, M.; Luo, T.; Deng, L.; Chen, J.; Yang, Z.
Org. Lett. 2005, 7, 885-888.
16. Total synthesis of Brevetoxin A
Nicolaou, K. C.; Yang, Z.; Shi, G.-Q.; Gunzner, J. L.; Agrios, K. A.; Garttner, P.
Nature 1998, 392, 264-269.
17. Total synthesis of Taxol
Nicolaou, K.C.; Yang, Z.; Liu, J.-J.; Ueno, H.; Nantermet, P.G.; Guy, R.K.; Claiborne,
C.F.; Renaud, J.; Couladouros, E.A.; Paulvannan,K.; Sorensen, E.J.
Nature, 1994, 367, 630-634.
|
声明:本网部分文章和图片来源于网络,发布的文章仅用于材料专业知识和市场资讯的交流与分享,不用于任何商业目的。任何个人或组织若对文章版权或其内容的真实性、准确性存有疑义,请第一时间联系我们,我们将及时进行处理。
|