湖南大学化学化工学院蒋健晖

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蒋健晖，男，湖南大学教授，1971年10月出生于湖南省邵阳市，国家杰出青年科学基金获得者(2010)，英国皇家化学会会士(FRSC, 2014)。曾任《化学学报》、《化学通报》、《分析化学》、《Current Analytical Chemistry》、《Journal of Analysis and Testing》、《化学传感器》、《Analytical Chemistry》（A-pages，2012-2016年）等编委。湖南大学分析化学专业学士学位（1993年）、硕士学位（1996年）、理学博士学位（1999年）。日本关西学院大学博士后（2000.11-2001.12）、访问教授（2002.11-2003.2）。主要研究方向为生物传感与生化分析、高通量单分子检测、化学计量学。SCI收录论文300余篇，引用逾9000次，H指数50。通讯作者论文150余篇，他引约5000次，其中IF>5论文69篇(JACS 5篇；Angew Chem Int Ed 2篇；Chem Rev 1篇；Anal Chem 24篇)。中国发明专利申请23件（授权16件）。获2014年国家自然科学二等奖（排名第三）、2008年教育部自然科学一等奖（排名第三）、2003年国家自然科学二等奖（排名第五）、2002年Buchi国际近红外光谱学奖（排名第一）等。曾主持国家杰出青年科学基金项目、国家重大科学仪器研制项目、国家自然科学基金面上项目、欧盟FP7项目等 。


蒋健晖
教授，博士生导师
国家杰出青年科学基金获得者(2010)，英国皇家化学会会士(FRSC, 2014) ，国家“万人计划”科技创新领军人才(2017)
基本信息
教育背景
  1996/9 – 1999/6   湖南大学，分析化学，研究生/博士
  1993/9 – 1996/6   湖南大学，分析化学，研究生/硕士
  1989/9 – 1993/6   湖南大学，分析化学，本科/学士


工作履历
2017/11 – 至今     湖南大学，校长助理
2011/01 – 至今     湖南大学，化学化工学院 院长
2005/07 – 2012/12  湖南大学，化学化工学院 副院长
2004/12 – 至今     化学生物传感与计量学国家重点实验室，副主任
2003/05 – 至今     湖南大学，教授
2002/11 – 2003/02   日本关西学院大学，访问教授
    2001/03 – 2003/05   湖南大学，副教授
2000/11 – 2001/12   日本关西学院大学，博士后
1999/07 – 2001/03   湖南大学，讲师
研究领域
生物传感、生物成像、化学生物学、化学计量学
科研项目
1.        国家自然科学基金重大科研仪器研制项目，21527810，数字滚环扩增生物分析的单分子成像与计数装置研究，2016/01-2020/12，519万元，主持。
2.        国家自然科学基金杰出青年基金项目，21025521，生化分析及生物传感，2011/01-2014/12，200万元，主持。
3.        国家自然科学基金面上项目，20875027，基因突变分子传感新方法研究，2009/01-2011/12，30万元，主持。
4.        European Commission FP7-HEALTH-2010 Program, 260600, Glycomics by High-throughput Integrated Technologies, 2011/01-2014/06，7万欧元，主持。
5.        国家科技部国际合作项目，国科外字2011-16-1007，蛋白质糖基化的液相芯片分析新技术研究，2010/12-2013/12，53万元，主持。
学术成果
近年部分通讯作者论文
2018:
1. Lan Liu, Jin-Wen Liu, Han Wu, Xiang-Nan Wang, Ru-Qin Yu*, Jian-Hui Jiang*, Branched Hybridization Chain Reaction Circuit for Ultrasensitive Localizable Imaging of mRNA in Living Cells, Analytical Chemistry, 2017, 90, 1502-1505.
2. Jiyun Chen, Xiaomin Xu, Zhimei Huang, Yuan Luo, Lijuan Tang*, Jian-Hui Jiang*, BEAMing LAMP: single-molecule capture and on-bead isothermal amplification for digital detection of hepatitis C virus in plasma, Chemical Communications, 2018, 54, 291-294.
3. Zhan-Ming Ying, Bin Tu, Lan Liu, Hao Tang*, Li-Juan Tang, Jian-Hui Jiang*, Spinach-based fluorescent light-up biosensors for multiplexed and label-free detection of microRNAs, Chemical Communications, 2018, DOI: 10.1039/C8CC00123E

2017:
1. Zhan-ming Ying, Zhan Wu, Bin Tu, Weihong Tan, Jian-Hui Jiang*, Genetically-encoded Fluorescent RNA Sensor for Ratiometric Imaging of MicroRNA in Living Tumor Cells, Journal of the American Chemical Society, 2017, 139, 9779-9782.
2. Zhenkun Wu, Huanhuan Fan, Nitya Sai Reddy Satyavolu, WenJing Wang, Ryan Lake, Jian-Hui Jiang,* and Yi Lu*, Imaging Endogenous Metal Ions in Living Cells Using a DNAzyme–Catalytic Hairpin Assembly Probe, Angewandte Chemie International Edition, 2017, 56, 8721-8725.
3. Ying Tang, Xiao-Li Zhang, Li-Juan Tang, Ru-Qin Yu, Jian-Hui Jiang*, In Situ Imaging of Individual mRNA Mutation in Single Cells Using Ligation Mediated Branched Hybrization Chain Reaction (Ligation-bHCR), Analytical Chemistry, 2017, 89, 3445-3451.
4. Lan Liu, Jin-Wen Liu, Zhi-Mei Huang, Han Wu, Na Li, Li-Juan Tang*, and Jian-Hui Jiang*, Proton-Fueled, Reversible DNA Hybridization Chain Assembly for pH Sensing and Imaging, Analytical Chemistry, 2017, 89, 6944-6947.
5. Xueli Zhu, Jin Huang, Jinwen Liu, Hang Zhang, Jianhui Jiang*, Ruqin Yu*, Dual enzyme-inorganic hybrid nanoflowers incorporated microfluidic paper-based analytic devices (μPADs) biosensor for sensitive visualized detection of glucose, Nanoscale, 2017, 9, 5658-5663.
6. Yu-Min Wang, Jin-Wen Liu, Gary Brent Adkins, Wen Shen, Michael Trinh, Lu-Ying Duan, Jian-Hui Jiang*, Wenwan Zhong*, Enhancement of the Intrinsic Peroxidase-Like Activity of Graphitic Carbon Nitride Nanosheets by ssDNAs and Its Application for Detection of Exosomes, Analytical Chemistry, 2017, 89, 12327-12333.
7. Feng Liu, Hai-Juan Liu, Xian-Jun Liu, Wen Chen, Feng-Lin Wang*, Ru-Qin Yu, and Jian-Hui Jiang*, Mitochonrion-Targeting, Environment-Sensitive Red Fluorescent Probe for Highly Sensitive Detection and Imaging of Vicinal Dithiol-Containing Proteins, Analytical Chemistry, 2017, 89, 11203-11207.

2016:
1. Xiang-Cheng Lin, Ting Zhang, Lan Liu, Hao Tang*, Ru-Qin Yu, Jian-Hui Jiang*, Mass Spectrometry Based Ultrasensitive DNA Methylation Profiling Using Target Fragmentation Assay, Analytical Chemistry, 2016, 88, 1083-1087.
2. Jin-Wen Liu, Yu-Min Wang, Liu Xu, Lu-Ying Duan, Hao Tang*, Ru-Qin Yu, and Jian-Hui Jiang*, Melanin-like Nanoquencheron Graphitic Carbon Nitride Nanosheetsfor Tyrosinase Activity and Inhibitor Assay, Analytical Chemistry, 2016, 88, 8355-8358   
3. Chong-Hua Zhang, Ling-Wei Liu, Ping Liang, Li-Juan Tang*, Ru-Qin Yu, Jian-Hui Jiang*, Plasmon Coupling Enhanced Raman Scattering Nanobeacon for Single-Step, Ultrasensitive Detection of Cholera Toxin, Analytical Chemistry, 2016, 88, 7447-7452.
4. Wei Liu, Si-Jia Liu, Yong-Qing Kuang*, Feng-Yan Luo, Jian-Hui Jiang*, Developing Activity Localization Fluorescence Peptide Probe Using Thiol-Ene Click Reaction for Spatially Resolved Imaging of Caspase-8 in Live Cells, Analytical Chemistry, 2016, 88, 7867-7872.
5. Xiang-Cheng Lin, Xiang-Nan Wang, Lan Liu, Qian Wen*, Ru-Qin Yu, Jian-Hui Jiang*, Surface Enhanced Laser Desorption Ionization of Phospholipids on Gold Nanoparticles for Mass Spectrometric Immunoassay, Analytical Chemistry, 2016, 88, 9881-9884.
6. Ying Tang, Zhan Wu*, Chong-Hua Zhang, Xiao-Li Zhang and Jian-Hui Jiang*, Enzymatic activatable self-assembled peptide nanowire for targeted therapy and fluorescence imaging of tumors, Chemical Communications, 2016, 52, 3631-3634.
7. Wenfang Du, Mengmei Lv, Junjie Li, Ruqin Yu*, Jianhui Jiang,* A Ligation-Based Loop-Mediated Isothermal Amplification (Ligation-LAMP) Strategy for Highly Selective MicroRNA Detection, Chemical Communications, 2016, 52, 12721-12724
8. Chonghua Zhang, Ying Tang, Ying-Ying Sheng, Hui Wang, Zhan Wu*, Jianhui Jiang,* Ultrasensitive Detection of MicroRNAs using Catalytic Hairpin Assembly Coupled with Enzymatic Repairing Amplification, Chemical Communications, 2016, 52, 13584-13587.
9. Wang Xu, Zebing Zeng, Jian-Hui Jiang,* Young-Tae Chang,* Lin Yuan*, Discerning the Chemistry in Individual Organelles with Small-Molecule Fluorescent Probes, Angewandte Chemie International Edition, 2016, 55, 13658-13699.
10. Mei-Hao Xiang, Jin-Wen Liu, Na Li, Hao Tang*, Ru-Qin Yu and Jian-Hui Jiang*, Fluorescent Graphitic Carbon Nitride Nanosheet Biosensor for Highly Sensitive, Label-Free Detection of Alkaline Phosphatase, Nanoscale, 2016, 8, 4727-4732.
11. Jin-Wen Liu, Ying Luo, Yu-Min Wang, Lu-Ying Duan, Jian-Hui Jiang*, and Ru-Qin Yu*, Graphitic Carbon Nitride Nanosheets-based Ratiometric Fluorescent Probe for Highly Sensitive Detection of H2O2 and Glucose, ACS Applied Materials & Interfaces, 2016, 8, 33439-33445.

2015:
1. Zhan Wu, Gao-Qin Liu, Xiao-Li Yang, Jian-Hui Jiang*, Electrostatic Nucleic Acid Nanoassembly Enables Hybridization Chain Reaction in Living Cells for Ultrasensitive mRNA Imaging, Journal of the American Chemical Society, 2015, 137, 6829-6836.
2. Zhen-Kun Wu, Dian-Ming Zhou, Zhan Wu*, Xia Chu, Ru-Qin Yu and Jian-Hui Jiang*, Single-Base Mismatch Discrimination by T7 Exonuclease with Target Cyclic Amplification Detection, Chemical Communications, 2015, 51, 2954-2956.
3. Qing Li, Yan-Dan Wang, Guo-Li Shen, Hao Tang*, Ru-Qin Yu, Jian-Hui Jiang*, Split Aptamer Mediated Endonuclease Amplification for Small-Molecule Detection, Chemical Communications, 2015, 51, 4196-4199.
4. Jian Chen*, Weibang Zhong, Ying Tang, Zhan Wu, Ya Li, Pinggui Yi*, Jianhui Jiang*, Amphiphilic BODIPY-Based Photoswitchable Fluorescent Polymeric Nanoparticles for Rewritable Patterning and Dual-Color Cell Imaging, Macromolecules, 2015, 48, 3500-3508.

2014:
1. Liping Qiu, Tao Zhang, Jianhui Jiang*, Cuichen Wu, Guizhi Zhu, Mingxu You, Xigao Chen, Liqin Zhang, Cheng Cui, Ruqin Yu, Weihong Tan*, Cell Membrane-Anchored Biosensors for Real-Time Monitoring of the Cellular Microenvironment, Journal of the American Chemical Society, 2014, 136, 13090-13093.
2. Dian-Ming Zhou, Wen-Fang Du, Qiang Xi, and Jian-Hui Jiang*, A Novel Isothermal Nucleic Acid Amplification Strategy by Cyclic Enzymatic Repairing for Highly Sensitive MicroRNA Detection, Analytical Chemistry, 2014, 86, 6763-6767.
3. Qiang Xi, Dianming Zhou, Jin-Wen Liu, Ru-Qin Yu*, Jian-Hui Jiang*, Highly Sensitive and Selective Strategy for MicroRNA Detection Based on WS2 Nanosheet Mediated Fluorescence Quenching and Duplex-Specific Nuclease Signal Amplification, Analytical Chemistry, 2014, 86, 1361-1365.
4. Qing Li, Lin Liu, Jin-Wen Liu, Jian-Hui Jiang*, Ru-Qin Yu, Xia Chu*, Nanomaterial-based fluorescent probes for live-cell imaging, Trends in Analytical Chemistry, 2014, 58, 130-144.
5. Xin-Min Nie, Rong Huang, Cai-Xia Dong, Li-Juan Tang, Rong Gui*, Jian-Hui Jiang*, Plasmonic ELISA for the ultrasensitive detection of Treponema pallidum, Biosensors and Bioelectronics, 2014, 58, 314-319.
6. Qian Wen, Si-Jia Liu, Li-Juan Tang*, Ying Tang, Jian-Hui Jiang*, Gold Nanoparticle Supported Phospholipid Membranes as A Biomimetic Biosensor Platform for Phosphoinositide Signaling Detection, Biosensors and Bioelectronics, 2014, 62, 113-119.


2013:
1. Yu Wang, Lijuan Tang, Jianhui Jiang*, SERS-Based, Homogeneous, Multiplexed Immunoassay with Antibody-Fragments Decorated Gold Nanoparticles, Analytical Chemistry, 2013, 85, 9213-9220.
2. Qian Wen, Yi Gu, Li-Juan Tang*, Ru-Qin Yu, Jian-Hui Jiang*, Peptide-Templated Gold Nanocluster Beacon as a Sensitive, Label-Free Sensor for Protein Post-translational Modification Enzymes, Analytical Chemistry, 2013, 85, 11681-11685.
3. Zhan Wu, Zhen-Kun Wu, Hao Tang, Li-Juan Tang, Jian-Hui Jiang*, Activity-Based DNA-Gold Nanoparticle Probe as Colorimetric Biosensor for DNA Methyltransferase/Glycosylase Assay, Analytical Chemistry, 2013, 85, 4376-4383.
4. Liangliang Zhang, Jingjin Zhao, Min Duan, Hua Zhang, Jianhui Jiang*, Ruqin Yu*, Inhibition of dsDNA-Templated Copper Nanoparticles by Pyrophosphate as a Label-Free Fluorescent Strategy for Alkaline Phosphatase Assay, Analytical Chemistry, 2013, 85, 3797-3801.
5. Weihong Tan*, Michael J. Donovan, Jianhui Jiang*, Aptamers from Cell-Based Selection for Bioanalytical Applications, Chemical Reviews, 2013, 113, 2842-2862.
6. Yu Wang, Xianghua Deng, Jinwen Liu, Hao Tang*, Jianhui Jiang*, Surface Enhanced Raman Scattering Based Sensitive Detection of Histone Demethylase Activity using Formaldehyde-Selective Reactive Probe, Chemical Communications, 2013, 49, 8489-8491.
7. Cuihua Chen, Dianming Zhou, Hao Tang*, Jianhui Jiang*, A Sensitive, Homogeneous Fluorescence Assay of Thymine DNA Glycosylase Activity with Exonuclease-Mediated Amplification, Chemical Communications, 2013, 49, 5874-5876.
8. Yong Huang*, Jing Zhu, Guiyin Li, Zhencheng Chen, Jian-Hui Jiang*, Guo-Li Shen, Ru-Qin Yu, Electrochemical detection of point mutation based on surface hybridization assay conjugated Allele-Specific polymerase chain reaction, Biosensors and Bioelectronics, 2013, 42, 526-531.
9. Dianming Zhou, Qiang Xi, Manfen Liang, Cuihua Chen, Li-Juan Tang*, Jian-Hui Jiang*, Graphene Oxide-Hairpin Probe Nanocomposite as A Homogeneous Assay Platform for DNA Base Excision Repair Screening, Biosensors and Bioelectronics, 2013, 41, 359-365.
10. Cui Wang, Hui Zhou, Wenping Zhu, Hongbo Li, Jianhui Jiang*, Guoli Shen, Ruqin Yu*, Ultrasensitive electrochemical DNA detection based on dual amplification of circular strand-displacement polymerase reaction and hybridization chain reaction, Biosensors and Bioelectronics, 2013, 42, 324-328.


奖励与荣誉
2017年 科技部创新人才推进计划中青年科技创新领军人才
2016年 湖南省教学成果三等奖（排名第五）
2014年 国家自然科学二等奖（排名第三）
2011年 湖南省优秀博士论文导师
2008年 教育部自然科学一等奖（排名第三）
2005年 湖南省青年科技奖
2003年 国家自然科学二等奖（排名第五）
2002年 Buchi 国际近红外光谱学奖（排名第一）
2002年 湖南省科学技术进步奖一等奖
2002年 湖南省自然科学优秀学术论文一等奖

huian

开发能够对细胞过程进行高对比度光声成像的可激活型分子探针是目前研究所面临的一大难题。湖南大学蒋健晖教授和汪凤林博士合作开发了一种新的近红外对甲氨基酚衍生物探针Rhodol-NIR，它具有消光系数大、量子产率低和在酯化后结构会由开环型转变为封闭的螺内酯型等特点。

这些特点也使得该探针可以被特异性的脱酯化反应激活以形成具有高对比度的PA成像探针。实验通过将这一探针用于对肿瘤生物标志物醌氧化还原酶同工酶1 (hNQO1)进行PA成像，证明了其可以在活细胞和动物体内检测并成像hNQO1，并具有很好的对比度和敏感性。

Feng Liu, Fenglin Wang, Jian-Hui Jiang. et al. Engineering NIR Rhodol Derivative with Spirocyclic Ring-open Activation for High-Contrast Photoacoustic Imaging. Chemical Science. 2019

DOI: 10.1039/C9SC02764E

https://pubs.rsc.org/en/content/articlelanding/2019/sc/c9sc02764e#!divAbstract

yanshou

开发能够对细胞过程进行高对比度光声成像的可激活型分子探针是目前研究所面临的一大难题。湖南大学蒋健晖教授和汪凤林博士合作开发了一种新的近红外对甲氨基酚衍生物探针Rhodol-NIR，它具有消光系数大、量子产率低和在酯化后结构会由开环型转变为封闭的螺内酯型等特点。

这些特点也使得该探针可以被特异性的脱酯化反应激活以形成具有高对比度的PA成像探针。实验通过将这一探针用于对肿瘤生物标志物醌氧化还原酶同工酶1 (hNQO1)进行PA成像，证明了其可以在活细胞和动物体内检测并成像hNQO1，并具有很好的对比度和敏感性。

FengLiu, Fenglin Wang, Jian-Hui Jiang. et al. Engineering NIR Rhodol Derivativewith Spirocyclic Ring-open Activation for High-Contrast PhotoacousticImaging. Chemical Science. 2019

DOI:10.1039/C9SC02764E

https://pubs.rsc.org/en/content/articlelanding/2019/sc/c9sc02764e#!divAbstract

cuihuo

2019年度国家重点研发计划项目和国家科技重大专项课题评审结束，我校6个项目获批，较上年增长3项，立项经费达1.08亿。我院蒋健晖、张晓兵2位教授牵头项目获批立项。
化学化工学院蒋健晖教授获批主持“新一代DNA合成技术”项目。该项目以开发DNA生物合成新技术和自动化合成仪器为科学目标，设计筛选无模板依赖DNA合成酶和可控反应活性核苷单体，建立高效率DNA生物合成反应体系，发展DNA酶法合成新技术、仪器及配套试剂，实现高保真、长片段、高通量、低成本DNA生物合成，为合成生物学提供新一代使能技术，将显著提升我国在DNA生物合成的原创能力和合成生物学领域的国际地位。

haozi

7月21日，湖南省科技创新奖励大会在长沙召开。湖南大学26项成果获得湖南省科学技术奖励（含光召科技奖）殊荣，其中以第一完成单位牵头获奖15项，我院蒋健晖教授主持完成的“生物分子自组装新性质和生物传感新方法研究”项目湖南自然科学一等奖。
       湖南省委书记、省人大常委会主任许达哲出席大会并为获奖代表颁奖，省委副书记、省长毛伟明讲话。会前，许达哲、毛伟明等省领导会见了获奖代表。省委副书记乌兰主持会议。中国工程院院士、2020年度湖南省杰出贡献奖获得者、湖南大学罗安教授等作为获奖代表发言。
       会议表彰了2020年度湖南省科学技术奖励（含光召科技奖）。2020年度省科学技术奖共有授奖项目（团队、人选）265项，其中杰出贡献奖1项、自然科学奖83项、技术发明奖23项、科技进步奖152项、创新团队奖5项、国际合作奖1项。会议还表彰了7位第十二届湖南光召科技奖获奖者。
      湖南大学以第一完成人获湖南省杰出贡献奖1项、湖南省创新团队奖1项、湖南光召科技奖1项、科学技术一等奖8项（其中自然科学奖2项、技术发明奖2项、科技进步奖3项、专用项目1项）、二等奖4项（自然科学奖3项、科技进步奖1项）。