苏州大学纳米科学技术学院殷黎晨

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殷黎晨

教授 博士生导师

        2005年7月获复旦大学生物科学专业学士学位；2010年7月获复旦大学生物化学与分子生物学专业博士学位。2010年11月至2014年1月在美国伊利诺伊大学香槟分校（UIUC）材料科学与工程系从事博士后研究工作。2014年1月加盟苏州大学功能纳米与软物质研究院，被聘为特聘教授、博士生导师。

邮箱：lcyin@suda.edu.cn

电话：0512-65882039

  

个人介绍：

主要从事生物医用高分子和药物载体的开发并研究其在抗肿瘤、抗炎治疗中的应用。共发表SCI论文70余篇，其中以第一作者、通讯作者在Nat Chem Biol、Nat Commun、Angew Chem Int Ed、Adv Mater、ACS Nano、Biomaterials等生物材料知名期刊上发表论文40余篇。论文他引2300余次，H因子27，多篇论文被包括C&EN News，Materials View China，Fierce Drug Delivery等媒体亮点报道。撰写国际专著1部（章）。获中国发明专利3项，美国专利2项。获国家优秀青年科学基金资助，并入选“江苏省特聘教授”（重点资助）。主持国家重点研发计划“纳米专项”课题1项，国家自然科学基金面上项目和青年项目各1项，江苏省自然科学基金青年项目1项，苏州工业园区-滑铁卢大学联合课题1项。担任JACS、Adv Mater、Biomaterials、Biomacromolecules、Acta Biomater等20余个期刊的独立审稿人。

  

研究方向：

（1）多功能生物材料的开发与应用：研究可用于药物载体、组织工程、生物传感的合成高分子或天然高分子（如多肽、聚酯、多糖等），探索高分子材料和生物体的作用机制。

（2）新型药物给药系统：研究可改善蛋白质、多肽、核酸、小分子抗肿瘤药物功效的新型给药载体的加工、改性、组装、体内外作用机理及其给药系统的设计。

（3）抗炎治疗与抗肿瘤治疗：根据肿瘤或炎症的发病机制及其病灶部位的生理特点，设计新型纳米药物和递送策略，用于肿瘤和炎症性疾病（如溃疡性结肠炎、急性肝炎、心肌梗死、急性肺损伤、类风湿性关节炎等）的治疗。

  

招生方向：

本课题组热忱欢迎有志从事科研工作的本科生、硕士研究生和博士研究生加盟。本课题组的研究为交叉学科，招生方向包括“化学”、“生物学”以及“材料学”，欢迎具有化学、材料或生物背景的同学报考。如有咨询，[url=mailto:%E8%AF%B7%E8%81%94%E7%B3%BBlcyin@suda.edu.cn]请联系lcyin@suda.edu.cn[/url]。

  

招聘信息：

博士后：拟招收2-3名从事高分子生物材料合成、纳米药物设计、基因药物递送研究的博士后研究人员，要求能够独立开展研究工作，具有良好的英文写作与交流能力；易于沟通，可以协助指导研究生。具有高分子化学、有机化学、生物材料或药剂学背景的申请者优先考虑。待遇优厚，且有机会到国外交流访学。[url=mailto:%E6%9C%89%E6%84%8F%E8%80%85%E8%AF%B7%E5%8F%91%E7%AE%80%E5%8E%86%E8%87%B3lehe@suda.edu.cn]如有兴趣，请联系lcyin@suda.edu.cn。[/url]

讲师/副教授：拟招聘1-2名课题组讲师/副教授，要求获得（或即将获得）博士学位，具有高分子化学、生物材料或药剂学背景，在主流期刊上发表过SCI论文，能够独立开展研究并指导研究生。[url=mailto:%E6%9C%89%E6%84%8F%E5%90%91%E8%80%85%E8%AF%B7%E5%8F%91%E9%80%81%E7%AE%80%E5%8E%86%E5%92%8C%E4%B8%89%E4%BD%8D%E6%8E%A8%E8%8D%90%E4%BA%BA%E4%BF%A1%E6%81%AF%E8%87%B3lcyin@suda.edu.cn]有意向者请发送简历和三位推荐人信息至lcyin@suda.edu.cn[/url]。

  

代表性论文（*为通讯作者）：

1. Ziyuan Song, Rachael A. Mansbach, Hua He, Kuo-Chih Shih, Ryan Baumgartner, Nan Zheng, Xiaochu Ba, Yinzhao Huang, Deepak Mani, Yun Liu, Yao Lin, Mu-Ping Nieh, Andrew L. Ferguson*, Lichen Yin*, Jianjun Cheng*. Nat Commun, 2017, 8:92.

2. Hua Wang, Ruibo Wang, Kaimin Cai, Hua He, Yang Liu, Jonathan Yen, Zhiyu Wang, Ming Xu, Yiwen Sun, Xin Zhou, Qian Yin, Li Tang, Iwona T Dobrucki, Lawrence W Dobrucki, Eric J Chaney, Stephen A Boppart, Timothy M Fan, Stéphane Lezmi, Xuesi Chen*, Lichen Yin*, Jianjun Cheng*. Selective in vivo metabolic cell-labeling-mediated cancer targeting. Nat Chem Biol, 2017, 13, 415-424.

3. Menghua Xiong, Ziyuan Song, Lichen Yin*, Jianjun Cheng*. Bacteria-Assisted Activation of Antimicrobial Polypeptides via Random Coil-to-Helix Transition. Angew Chem Int Ed, in press.

4. Fangfang Li, Yongjuan Li, Zhuchao Zhou, Shixian Lv, Qiurong Deng, Xin Xu, Lichen Yin*. Engineering the Aromaticity of Cationic Helical Polypeptides toward “Self-Activated” DNA/siRNA Delivery. ACS Appl Mater Interfaces, 2017, 9, 23586−23601.

5. Lipeng Zhu, Jessica M. Simpson, Xin Xu, Hua He, Donghui Zhang*, Lichen Yin*. Optimizing the Molecular Characteristics of Cationic Polypeptoids toward Efficient Non-Viral Gene Delivery. ACS Appl Mater Interfaces, 2017, 9, 23476−23486.

6. Nan Zheng, Ziyuan Song, Jiandong Yang, Yang Liu, Fangfang Li, Jianjun Cheng*, Lichen Yin*. Manipulating the Membrane Penetration Mechanism of Helical Polypeptides via Aromatic Modification for Efficient Gene Delivery. Acta Biomater, 2017, 58, 146-157.

7. Shixian Lv, Yuchen Wu, Jingqi Dang, Zhaohui Tang, Ziyuan Song, Sheng Ma, Xiao Wang, Xuesi Chen, Jianjun Cheng*,  Lichen Yin*. Investigation on the controlled synthesis and post-modification of poly-[(N-2-hydroxyethyl)-aspartamide]-based polymers. Polym Chem, 2017, 8, 1872-1877.

8. Benchun Jiang, Hua He, Li Yao, Tong Zhang, Jianping Huo, Wei Sun*, Lichen Yin*. Harmonizing the Intracellular Kinetics toward Effective Gene Delivery Using Cancer Cell-Targeted and Light-Degradable Polyplexes. Biomacromolecules, 2017, 18, 877−885.

9. Kaimin Cai, Andrew Z. Wang, Lichen Yin*, Jianjun Cheng*. Bio-nano interface: The impact of biological environment on nanomaterials and their delivery properties. J Control Release, in press.

10. Hua He, Nan Zheng, Ziyuan Song, Kyung Hoon Kim, Catherine Yao, Rujing Zhang, Chenglin Zhang, Yuhui Huang, Fatih M. Uckun, Jianjun Cheng, Yanfeng Zhang, Lichen Yin*. Suppression of Hepatic Inflammation via Systemic siRNA Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide Hybrid Nanoparticles. ACS Nano, 2016, 10, 1859−1870.

11. Hua Wang, Li Tang, Yang Liu, Iwona T. Dobrucka, Lawrence W. Dobrucki, Lichen Yin*, Jianjun Cheng*. In Vivo Targeting of Metabolically Labeled Cancers with Ultra-Small Silica Nanoconjugates. Theranostics, 2016, 6, 1467-1476.

12. Hua He, Yugang Bai, Jinhui Wang, Qiurong Deng, Lipeng Zhu, Fenghua Meng, Zhiyuan Zhong*, and Lichen Yin*. Reversibly cross-linked polyplexes enable cancer-targeted gene delivery via self-promoted DNA release and self-diminished toxicity. Biomacromolecules, 2015, 16, 1390-1400.

13. Nan Zheng, Ziyuan Song, Yang Liu, Rujing Zhang, Ruoyan Zhang, Catherine Yao, Fatih M. Uckun, Lichen Yin*, Jianjun Cheng*. Redox-responsive, reversibly-crosslinked thiolated cationic helical polypeptides for efficient siRNA encapsulation and delivery. J Control Release, 2015, 205, 231-239.

14. Xiaojian Deng, Nan Zheng, Ziyuan Song, Lichen Yin*, Jianjun Cheng*. Trigger-responsive, fast-degradable poly(β-amino ester)s for enhanced DNA unpackaging and reduced toxicity. Biomaterials, 2014, 35, 5006-5015.

15. Rujing Zhang, Nan Zheng, Ziyuan Song, Lichen Yin*, Jianjun Cheng*. The effect of side-chain functionality and hydrophobicity on the gene delivery capabilities of cationic helical polypeptides. Biomaterials, 2014, 35, 3443-3454.

16. Lichen Yin, Xin Zhao, Shizhao Ji, Chunbai He, Guangyi Wang*, Cui Tang*, Shaohua Gu*, Chunhua Yin. The use of gene activated matrix to mediate effective SMAD2 gene silencing against hypertrophic scar. Biomaterials, 2014, 35, 2488-2498.

17. Lichen Yin, Ziyuan Song, Kyung Hoon Kim, Nan Zheng, Nathan P. Gabrielson, Jianjun Cheng*. Non-viral gene delivery via membrane-penetrating, mannose-targeting supramolecular self-assembled nanocomplexes. Adv Mater, 2013, 25, 3063-3070.

18. Lichen Yin♯, Haoyu Tang#, Kyung Hoon Kim, Nan Zheng, Ziyuan Song, Nathan P. Gabrielson, Hua Lu, Jianjun Cheng*. Trigger-responsive helical polypeptides capable of reducing toxicity and unpacking DNA: toward nonviral gene delivery. Angew Chem Int Ed, 2013, 52, 9182-9186.

19. Lichen Yin, Ziyuan Song, Qiuhao Qu, Kyung Hoon Kim, Nan Zheng, Catherine Yao, Isthier Chaudhury, Haoyu Tang, Nathan P. Gabrielson, Fatih M. Uckun, Jianjun Cheng*. Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation. Angew Chem Int Ed, 2013, 52, 5757�5761.

20. Lichen Yin, Ziyuan Song, Kyung Hoon Kim, Nan Zheng, Haoyu Tang, Hua Lu, Nathan P. Gabrielson, Jianjun Cheng*. Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery. Biomaterials, 2013, 34, 2340-2349.

rongyi

骨质疏松症是一种进行性骨骼疾病，其特征在于骨矿物质密度和质量下降、骨微观结构破坏和骨脆性增加。在绝经期妇女中，雌激素缺乏会上调RANKL，进一步激活NF-κB通路和MAPK通路，导致破骨细胞分化和骨质流失。同时，雌激素缺乏会上调TNF-α，从而诱导成骨细胞凋亡、抑制矿化结节的产生。目前清除RANKL和TNF-α的疗法在骨质疏松症治疗中展现了巨大潜力。临床上OPG和Denosumab等抗体已被广泛应用于清除RANKL和抑制骨质疏松。然而，这些抑制剂经常受限于血液循环时间短、生物分布不理想、制造过程复杂和抗体耐药性等缺点。此外，骨质疏松症的病理背景通常与多个靶标相关，单一靶标治疗无法获得理想的疗效。因此，迫切需要发展更安全有效的药物用于骨质疏松症治疗。

        近日，纳米科学技术学院殷黎晨教授团队开发了前破骨细胞膜包被的纳米诱饵（RAW-PLGA），用于治疗绝经后骨质疏松症。RAW-PLGA纳米诱饵可模拟源细胞，表面高度表达RANK和TNF-α受体。因此，该纳米诱饵可高效结合并清除RANKL和TNF-α，从而抑制破骨细胞分化、促进成骨细胞生成，高效治疗骨质疏松。这是细胞膜纳米技术首次用于骨质疏松症治疗，也是首次报道利用细胞膜清除RANKL。因此，该仿生纳米材料为重建破骨细胞/成骨细胞平衡提供了有效的策略，并为绝经后骨质疏松症的临床治疗提供了新的思路，相关成果在Science Advances上发表（Sci. Adv. 2021, 7, abl6432）。
       文章链接：https://www.science.org/doi/10.1126/sciadv.abl6432
        文章题目：Cytokine-scavenging nanodecoys reconstruct osteoclast/osteoblast balance toward the treatment of postmenopausal osteoporosis
        作者信息：Yang Zhou, Yekun Deng, Zhongmin Liu, Mengyuan Yin, Mengying Hou, Ziyin Zhao, Xiaozhong Zhou, Lichen Yin*
         项目资助：This study was supported by The National Natural Science Foundation of China (51873142), Collaborative Innovation Center of Suzhou Nano Science & Technology, The 111 project, and Joint International Research Laboratory of Carbon-Based Functional Materials and Devices.