西北大学化学与材料科学学院有机化学与化学生物学学部胡向东

yanyan

  姓名：胡向东          性别：男          民族：汉
  部门：有机化学与化学生物学学部           出生年月：1975-05
  籍贯：宁夏固原          职称：教授
  邮箱：xiangdonghu@nwu.edu.cn
研究方向：        有机合成方法学，天然产物全合成
简    介
　　兰州大学化学化工学院学士、博士（专业有机化学）；美国南佛罗里达大学博士后；现为西北大学化学与材料科学学院教授。研究兴趣包括新型催化反应，有机合成方法学研究和复杂天然产物全合成研究。
独立工作后代表性论文:
8. Xiuxiang Yan, Xiangdong Hu.* Protecting-Group-Free Synthesis of Taiwaniaquinone H Using a One-Pot Thermal Ring Expansion/4π-Electrocyclization Strategy. J. Org. Chem. 2014, 79, 5282−5286.
7.Sinan Gai, Qing Zhang, Xiangdong Hu.* Total Synthesis of Asterredione. J. Org. Chem. 2014, 79, 2111-2114.
6. Yong An, Yunxia Wang, Xiangdong Hu.* Total Synthesis of Carbazomycin G by a Thermal Ring Expansion/Self-Redox Reaction Cascade. Eur. J. Org. Chem. 2014, 3715-3718.
5. Xianhe Fang, Xiangdong Hu.* Total synthesis of mansonone E. J. Chem. Res.2014,38, 137-139.
4. Fenfen Xiao, Wu Liu, Yunxia Wang, Qing Zhang, Xiang Li,Xiangdong Hu.* Concise Synthesis of Linderaspirone A and Bi-linderone. Asian J. Org. Chem. 2013, 2, 216-219.
3. Wu Liu, Fenfen Xiao, Xiangdong Hu.* Concise Synthesis of Lucidone and Methyl Lucidone. Chin. J. Org. Chem. 2013, 33, 1587-1590.
2. Wenmin Dong, Moran Zhang, Fenfen Xiao, Yunxia Wang, Wu Liu, Xiangdong Hu,* Qiang
Yuan, Shaofei Zhang; Gold-catalyzed Intermolecular Carboalkoxylation of Alkenes. Synlett. 2012, 23, 2799-2802.
1. Moran Zhang, Yunxia Wang, Yang Yang, Xiangdong Hu.* An Alternative Approach to Direct Aldol Reaction Based on Gold-Catalyzed Methoxyl Transfer. Adv. Synth. Catal. 2012, 354, 981-985.
独立工作前代表性论文：
4. Xiangdong Hu, Roman Manetsch*. Kinetic target-guided synthesis. Chem. Soc. Rev. 2010, 39, 1316-1324.
3. Xiangdong Hu, Jiazhi Sun, Hong-Gang Wang, Roman Manetsch*. Bcl-XL-templated Assembly of its own Protein-protein Interaction Modulator from Fragments Decorated with Thio Acids and Sulfonyl Azides. J. Am. Chem. Soc. 2008, 130, 13820-13821.
2. Xiang-Dong Hu, Yong Qiang Tu,* En Zhang, Shuanhu Gao, Shaohua Wang, Aixia Wang, Chun-An Fan, Min Wang. Total Synthesis of (±) Galanthamine. Org.Lett. 2006, 8, 1823-1825.
1. Xiang-Dong Hu, Chun-An Fan, Fu-Min Zhang, Yong Qiang Tu*. A Novel Tandem Semipinacol Rearrangement /Alkylation of α-Epoxy Alcohols: Efficient and Stereoselective Approach to Multifunctional 1,3-Diols. Angew. Chem. Int. Ed. 2004, 43, 1702-1705.

taipingyang

三尖杉萜家族因其突出的生物学特性和独特的分子结构而受到有机合成化学家的广泛关注。近年来，西北大学胡向东课题组基于所发展的桥环张力与缩醛位阻协同调控的立体选择性Pauson–Khand反应策略完成了含有环庚三烯酮结构的(+)-3-deoxyfortalpinoid F、(+)-fortalpinoid A、(+)-cephinoid H (Angew. Chem., Int. Ed. 2021, 60, 18572) 和含有苯环结构的(–)-ceforalide B、(–)-cephanolides B–D (Org. Lett. 2022, 24, 7507) 等多种三尖杉二萜的不对称全合成。近日，胡向东课题组基于一种epoxide-opening/elimination/dual lactonization仿生合成方案，从不对称Michael加成出发，通过新颖的Pauson-Khand/deacyloxylation反应构筑核心四环骨架，再经epoxide-opening/elimination/dual lactonization实现螺旋桨型双内酯结构的构建和拥有异常拥挤七环结构和九个连续立体中心的(–)-cephalotanin B的对映选择性全合成(Angew. Chem. Int. Ed. 2023, e202312599)。

Enantioselective Total Synthesis of (–)-Cephalotanin B
Zezhong Sun,† Shuang Jin,† Jianing Song, Lihua Niu, Fan Zhang, Han Gong, Xin Shu, Yunxia Wang, Xiangdong Hu*Angew. Chem. Int. Ed. 2023, e202312599.
Enantioselective Total Synthesis of (–)‐Cephalotanin B - Sun - Angewandte Chemie International Edition - Wiley Online Library