中国科学技术大学高分子科学与工程系洪春雁

zhudongchuji

洪春雁理学博士
高分子科学与工程系
教授 博士生导师
Tel: +86-551-63606081 (Lab)
E-mail: hongcy@ustc.edu.cn

个人简介
洪春雁，1974年2月出生。1992年9月-1997年7月，中国科学技术大学材料科学与工程系，获理学学士学位。1997年9月-2002年7月，中国科学技术大学高分子科学与工程系，获理学博士学位。2002年7月-2005年12月，中国科学技术大学高分子科学与工程系讲师。2004年10月-2005年4月，英国University of Warwick化学系访问学者。2005年12月-2010年6月，中国科学技术大学高分子科学与工程系副教授。2010年7月至今，中国科学技术大学高分子科学与工程系教授。2015年获得国家杰出青年科学基金。2008年度教育部“新世纪优秀人才支持计划”入选者。在包括J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mater., Adv. Funct. Mater., Chem. Mater., Macromolecules等在内的期刊共发表95篇SCI论文，其中影响因子大于3.0的80篇，发表的论文已被SCI期刊引用3000余次，H因子为32。获得的主要奖励有：2007年度中国化学会青年化学奖、2007年度中国化学会-约翰威立出版公司青年化学论文奖、2010年安徽省科学技术奖一等奖（排名第二）等。

主要研究方向
1. 活性聚合反应
2. 不同拓扑结构聚合物的可控合成
3. 环境响应性聚合物的合成及其在生物医药等领域的应用
4. 序列可控聚合物的合成
5. 聚合反应诱导自组装制备纳米材料

近期代表性论文
1. Zhou, JM; Zhang, WJ; Hong, CY*; Pan, CY. “Promotion of morphology transition of di-block copolymer nano-objects via RAFT dispersion copolymerization”, Polym. Chem., 2016, 7, 3259-3267.
2. Qiu, L; Liu, Q; Hong, CY*; Pan, CY*. “Unimolecular micelles of camptothecin-bonded hyperbranched star copolymers via beta-thiopropionate linkage: synthesis and drug delivery”, J. Mater. Chem. B, 2016, 4, 141-151.
3. Wu, Z; Chen X.; Li, JY; Pan, CY; Hong, CY*. “Au-polymer hybrid microgels easily prepared by thermo-induced self-crosslinking and in situ reduction”, RSC Adv. 2016, 6, 48927-48932.
4. Zhang, Z; You, YZ; Wu, DC; Hong, CY*. “Syntheses of Sequence-Controlled Polymers via Consecutive Multicomponent Reactions”, Macromolecules 2015, 48, 3414-3421.
5. Yu, L; Wang, LH; Hu, ZT; You, YZ; Wu, DC; Hong, CY*. “Sequential Michael addition thiol-ene and radical-mediated thiol-ene reactions in one-pot produced sequence-ordered polymers”, Polym. Chem., 2015, 6, 1527-1532.
6. Chen, X; Sun, JT; Pan, CY; Hong, CY*; “A facile synthesis of thermo-responsive Au-polymer hybrid microgels through temperature-induced co-aggregation and self-crosslinking", Polym. Chem., 2015, 6, 5989-5992.
7. Zhou, JM; Zhang, WJ; Hong, CY*; Pan, CY*. “Silica Nanotubes Decorated by pH-Responsive Diblock Copolymers for Controlled Drug Release", ACS Appl. Mater. Interfaces 2015, 7, 3618−3625.
8. Li, M; Fan, W; Hong, CY*; Pan, CY. “Synthesis and Characterization of Coumarin-Containing Cyclic Polymer and Its Photoinduced Coupling/Dissociation", Macromol. Rapid Commun. 2015, 36, 2192−2197.
9. Qu, L.; Hong, CY*; Pan, CY*. “Doxorubicin-loaded aromatic imine-contained amphiphilic branched star polymer micelles: synthesis, self-assembly, and drug delivery ", Int. J. Nanomed. 2015, 10, 3623–3640.
10. Zhang, WJ; Hong, CY*; Pan, CY*. “Formation of Hexagonally Packed Hollow Hoops and Morphology Transition in RAFT Ethanol Dispersion Polymerization", Macromol. Rapid Commun. 2015, 36, 1428−1436.
11. Zhang, Z.; You, YZ; Wu, DC; Hong, CY*. “A novel multicomponent reaction and its application in sequence-ordered functional polymer synthesis", Polymer 2015, 64, 221-226.
12. Zhang, WJ; Hong, CY*; Pan, CY*. “A unique fabrication strategy of hierarchical morphologies: combination of multi-step self-assembling and morphology transition", RSC Adv. 2015, 5, 42637-42644.
13. Li, M; Liu, C; Hong, CY*; Pan, CY. “Synthesis of graft copolymer with pendant macrocycles via combination of ATRP and click chemistry", Polymer 2015, 64, 23-30.
14. Yu, ZQ; Xu, XM; Hong, CY*; Wu, DC; You, YZ. “A Responsive Hyperbranched Polymer Not Only Can Self-Immolate but Also Can Self-Cross-Link”, Macromolecules, 2014, 47, 4136-4143.
15. Zhang, WJ; Hong, CY*; Pan, CY*. “Fabrication of Spaced Concentric Vesicles and Polymerizations in RAFT Dispersion Polymerization.” Macromolecules 2014, 47, 1664-1671.
16. Zhang, WJ; Hong, CY*; Pan, CY*. “Fabrication and characterization of silica nanotubes with controlled dimensions.” J. Mater. Chem. A, 2014, 2, 7819–7828.
17. Yan, JJ; Sun, JT; You, YZ; Wu, DC; Hong, CY*. “Growing Hyperbranched Polymers Using Natural Sunlight”, Sci. Rep., 2013, 3, 2841.
18. Sun, JT; Piao, JG; Wang, LH; Javed, M; Hong, CY*; Pan, CY. “One-Pot Synthesis of Redox-Responsive Polymers-Coated Mesoporous Silica Nanoparticles and Their Controlled Drug Release.” Macromol. Rapid Commun. 2013, 34, 1387-1394.
19. Wang, Y; Hong, CY*; Pan, CY*. "Galactose-Based Amphiphilic Block Copolymers: Synthesis, Micellization, and Bioapplication", Biomacromolecules, 2013, 14, 1444-1451.
20. Wang, ZK; Wang, LH; Sun, JT; Han, LF; Hong, CY*. “In situ generation of bioreducible and acid labile nanogels/microgels simply via adding water into the polymerization system” Polym. Chem., 2013, 4, 1694-1699.
21. Sun, JT; Hong, CY*; Pan, CY*. "Recent advances in RAFT dispersion polymerization for preparation of block copolymer aggregates", Polym. Chem., 2013, 4, 873-881.
22. Yan, JJ; Wang, ZK; Lin, XS; Hong, CY*; Liang, HJ; Pan, CY; You, YZ* “Polymerizing Nonfluorescent Monomers without Incorporating any Fluorescent Agent Produces Strong Fluorescent Polymers”, Adv. Mater., 2012, 24, 5617-5624.
23. Yu, ZQ; Sun, JT; Pan, CY; Hong, CY* “Bioreducible nanogels/microgels easily prepared via temperature induced self-assembly and self-crosslinking”, Chem. Commun., 2012, 48, 5623-5625.
24. Wang, Y; Hong, CY*; Pan, CY*. “Spiropyran-Based Hyperbranched Star Copolymer: Synthesis, Phototropy, FRET, and Bioapplication”, Biomacromolecules, 2012, 13, 2585-2593.
25. Sun, JT; Yu, ZQ; Hong, CY*; Pan, CY*. “Biocompatible Zwitterionic Sulfobetaine Copolymer-Coated Mesoporous Silica Nanoparticles for Temperature-Responsive Drug Release”, Macromol. Rapid Commun., 2012, 811-818.
26. Sun, JT; Hong, CY*; Pan, CY*. “Formation of the block copolymer aggregates via polymerization-induced self-assembly and reorganization”, Soft Matter, 2012, 8, 7753-7767.
27. Sun, JT; Hong, CY*; Pan, CY. “Selective Diels-Alder cycloaddition on semiconducting single-walled carbon nanotubes for potential separation application” Chem. Commun. 2011, 47, 10704-10706.
28. Sun, JT; Hong, CY*; Pan, CY. “Surface modification of carbon nanotubes with dendrimers or hyperbranched polymers”, Polym. Chem. 2011, 2, 998-1007.
29. Wang Y; Li X; Hong, CY*; Pan, CY. “Synthesis and Micellization of Thermoresponsive Galactose-Based Diblock Copolymers”, J. Polym. Sci., Part A: Polym. Chem. 2011, 49, 3280-3290.
30. You YZ;* Yu ZQ; Cui MM; Hong, CY*. “Preparation of Photoluminescent Nanorings with Controllable Bioreducibility and Stimuli-Responsivenes”, Angew. Chem. Int. Ed. 2010, 49, 1099-1102.
31. Sun, JT; Hong, CY*; Pan, CY. “Fabrication of PDEAEMA-Coated Mesoporous Silica Nanoparticles and pH-Responsive Controlled Release”, J. Phys. Chem. C 2010, 114, 12481-12486.
32. Cai WM, Wan WM, Hong CY*; Huang CQ; Pan CY.* “Morphology transitions in RAFT polymerization”, Soft Matter, 2010, 6, 5554-5561.
33. Li X, Hong, CY*; Pan, CY. “Preparation and characterization of hyperbranched polymer grafted mesoporous silica nanoparticles via self-condensing atom transfer radical vinyl polymerization”, Polymer 2010, 51, 92-99.

biyan

中国科学技术大学的洪春雁教授和张文建副研究员研究生徐效飞（一作）等人在Macromolecules上发表了一篇题为 “Polymerization-Induced Self-Assembly Generating Vesicles with Adjustable pH-Responsive Release Performance” 的文章，以聚乙二醇（PEG）为大分子链转移剂通过甲基丙烯酸2-（二异丙基氨基）乙酯（DIPEMA）和甲基丙烯酸苄酯（BzMA）的RAFT分散共聚合合成了一系列pH响应的囊泡。囊泡膜内DIPEMA的叔胺基团赋予囊泡pH敏感性。在酸性溶液中，DIPEMA的叔胺基团被质子化，导致囊泡膜内P（DIPEMA-co-BzMA）嵌段的亲水性增加。疏水性P（DIPEMA-co-BzMA）嵌段中DIPEMA/BzMA的摩尔比和P（DIPEMA-co-BzMA）的聚合度（DP）对囊泡的pH响应动力学以及负载物的释放动力学都具有很大影响。

本文通过DIPEMA和BzMA的RAFT分散共聚合制备了一系列具有不同pH响应行为的囊泡。疏水性P（DIPEMA-co-BzMA）嵌段中DIPEMA单元的含量和P（DIPEMA-co-BzMA）的DP均对囊泡的pH响应行为具有很大影响，并用于调控负载物的响应性释放动力学。P（DIPEMA-co-BzMA）嵌段中较高DIPEMA含量导致RhB的爆释。较长的P（DIPEMA-co-BzMA）链段导致RhB的释放速率较慢，因为其较严重的链缠结导致形成pH响应性跨膜通道的时间更长。具有可控的响应性和药物释放动力学的囊泡可能会引起材料科学领域的高度关注。

文献链接：Polymerization-Induced Self-Assembly Generating Vesicles with Adjustable pH-Responsive Release Performance（Macromolecules，2019，DOI: 10.1021/acs.macromol.9b00144）