湖南师范大学化学化工学院张友玉

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张友玉，女，博士，湖南师范大学分析化学教授，博士生导师。2005年毕业于湖南大学化学化工学院获理学博士学位。2002-2004年在香港大学访学、2008-2010年在美国访学。从事分析化学教学和光分析化学、化学/生物传感及化学生物学等方面的科研工作。在纳米材料合成与修饰、光谱分析、生物分析、化学/生物传感和小分子-生物大分子作用等方面开展了创新性研究。在Anal. Chem., Chem. Commun., J. Mater. Chem.等刊物发表SCI论文80余篇；获湖南省自然科学奖1项，中国分析测试学会科学技术奖1项，湖南省优秀学术论文奖1项。主持国家自然科学基金、教育部重点项目、湖南省自然科学基金和湖南省教育厅重点项目10余项。


张友玉
性  别：女
学历：博士
职称：教授
其他：教育部实验室专职副主任，博士生导师

科研工作情况：
在研课题:
1.      国家自然科学基金（21475043）, Ⅳ族元素量子点的电化学制备及其在生物分析中的应用。
2.      国家自然科学基金（21275051）, 基于上转换纳米编码探针的多种肿瘤标志物同时检测技术。
3.      教育部博士点基金（博导类，20134306110006)，肿瘤标志物的上转换荧光纳米探针检测技术研究。
4.      湖南省教育厅重点项目（12A084）, 生物活性物质的双光子荧光探针的设计合成及其应用。
5.      湖南省自然科学基金（09JJ3019）, 基于亲水性核壳结构分子导线的生物传感器研究。
近年来发表的代表性论文                                                         
2015
1.      Qiujun Lu, Jianhui Deng, Yuxin Hou, Haiyan Wang, Haitao Li, Youyu Zhang，Shouzhuo Yao, Hydroxyl-rich C-dots Synthesized with One-pot Method and Its Application in the Preparation of Nobel Metal Nanoparticles, Chem. Commun., 2015, 51, 7164-7167.
2.      Jianhui Deng, Qiujun Lu, Yuxin Hou,Meiling Liu, Haitao Li, Youyu Zhang*, Shouzhuo Yao, Nanosensor Composed of Nitrogen-Doped Carbon Dots and Gold Nanoparticles for Highly Selective Detection of Cysteine with Multiple Signals, Anal. Chem.,2015, 87, 2195-2203.
3.      Qian Long, Haitao Li, Youyu Zhang*, Shouzhuo Yao, Upconversion nanoparticle-based fluorescence resonance energy transfer assay for organophosphorus pesticides, Biosens. Bioelectron.,2015, 68, 168-174
4.      Xue Peng, Qian Long, Haitao Li, Youyu Zhang*, Shouzhuo Yao, “Turn on-off” fluorescent sensor for protamine and heparin based on label-free silicon quantum dots coupled with gold nanoparticles, Sensors  and  Actuators  B, 2015, 213, 131-138.
5.      Yuxin Hou, Qiujun Lu, Jianhui Deng, Haitao Li, Youyu Zhang*, Shouzhuo Yao, One-pot electrochemical synthesis of functionalized fluorescent carbon dots and their selective sensing for mercury ion, Anal. Chim. Acta, 2015.866, 69-74.
6.      Biao Gu, Naxiu Mi, Youyu Zhang, Peng Yin, Haitao Li*, Shouzhuo Yao,A tetraphenylimidazole-based fluorescent probe for the detection of hydrogen sulfide and its application in living cells, Anal. Chim. Acta,doi:10.1016/j.aca.2015.03.017.
7.      Qiujun Lu, Jiangna Zhao, Shanyan Xue, Peng Yin, Youyu Zhang*, Shouzhuo Yao, A “turn-on” fluorescent sensor for ultrasensitive detection of melamine based on a new fluorescence probe and AuNPs, Analyst, 2015,140, 1155-1160.
8.      Jianhui Deng, Qiujun Lu, Haitao Li, Youyu Zhang*, Shouzhuo Yao,Large scale preparation of graphene quantum dots from graphite oxide in pure water via one-step electrochemical tailoring, RSC Adv., 2015, 5, 29704-29707.
9.      Qiongqiong Wu, Qian Long, Haitao Li, Youyu Zhang*, Shouzhuo Yao, An upconversion fluorescence resonance energy transfer nanosensor for one step detection of melamine in raw milk, Talanta, 2015, 136, 47-53.
10.  Qian Long, Jiangna Zhao, Bangda Yin, Haitao Li, Youyu Zhang*, Shouzhuo Yao, Fluorescence resonance energy transfer sensor for protamine and heparin detection based on upconversion nanoparticles, Anal. Biochem., 2015, 477, 28–34.
2014
11.       Qiong Chen, Meiling Liu, Jiangna Zhao, Xue Peng, Xiaojiao Chen, Naxiu Mi, Bangda Yin, Haitao Li, Youyu Zhang*, Shouzhuo Yao, Water-dispersible silicon dots as peroxidase mimetics for the highly-sensitive colorimetric detection of glucose, Chem. Commun., 2014, 50, 6771-6774.
12.       Xiaojiao Chen, Yangzhong Wang, Youyu Zhang*, Zhuhai Chen, Yang Liu*, Zhaolong Li, Jinghong Li, Sensitive electrochemical aptamer biosensor for dynamic cell surface N-Glycan evaluation featuring multivalent recognition and signal amplification on dendrimer-graphene electrode interface, Anal. Chem., 2014, 86, 4278-4286.
13.       Xiaojiao Chen, Yao He, Youyu Zhang*, Meiling Liu, Yang Liu*, Jinghong Li, Ultrasensitive detection of cancer cells and glycan expression profiling based on a multivalent recognition and alkaline phosphatase-responsive electrogenerated chemiluminescence biosensor, Nanoscale, 2014, 6, 11196-11203.
14.       Jianhui Deng, Qiujun Lu, Naxiu Mi, Haitao Li, Meiling Liu, Mancai Xu, Liang Tan, Qingji Xie, Youyu Zhang*, Shouzuo Yao, Electrochemical Synthesis of Carbon Nanodots directly from Alcohols, Chem. Eur. J, 2014, 20, 4993-4999.
15.       Bangda Yin, Wenli Zhou, Qian Long, Chengzhi Li, Youyu Zhang*, Shouzhuo Yao, Salt-assisted Rapid Transformation of NaYF4: Yb3+, Er3+ Nanocrystals from Cubic to Hexagonal, CrystEngComm, 2014, 16, 8348-8355.
16.       Meiling Liu, Liping Wang, Yue Meng, Youyu Zhang*, Haitao Li, Shouzhuo Yao, (4-ferrocenylethyne) phenylamine functionalized graphene oxide modified for sensitive nitrite sensing, Electrochim. Acta,2014, 116, 504-511.
17.       Jiangna Zhao, Jianhui Deng, Yinhui Yi, Haitai Li, Youyu Zhang*, Shouzhuo Yao, Label-free Si quantum dots as fluorescent probe for selective and sensitive detection of copper ions, Talanta, 2014, 125, 372-377.
18.       Chang Liu, Youming Shen, Peng Yin, Lidong Li, Youyu Zhang, Haitao Li*, Shouzhuo Yao, Sensitive detection of acetylcholine based on a novel boronate intramolecular charge transfer fluorescence probe, Analytical Biochemistry, 2014, 465, 172-178.
19.       Youming Shen, Youyu Zhang*, Xiangyang Zhang, Chunxiang Zhang, Linli Zhang, Junling Jin, Haitao Li, Shouzhuo Yao, A new turn-on fluorescent sensor based on NBD for highly selective detection of Hg2+ in aqueous media and imaging in live cells, Anal. Method, 2014, 6, 4797-4802.
2013
20.  Yinhui Yi, Jianhui Deng, Youyu Zhang*, Haitao Li, Shouzhuo Yao, Label-free Si Quantum Dots as Photoluminescence Probe for Glucose Detection, Chem. Commun., 2013, 49, 612-614.
21.       Yinhui Yi, Gangbing Zhu, Chang Liu,Yan Huang, Youyu Zhang*, Haitao Li, Jiangna Zhao, Shouzhuo Yao, A Label-free Silicon Quantum Dots-Based Photoluminescence Sensor for Ultrasensitive Detection of Pesticides, Anal. Chem., 2013, 85, 11464-11470.
22.  Mingjie Wei, Peng Yin, Youming Shen, Lingli Zhang, Jianhui Deng, Shanyan Xue, Haitao Li, Bin Guo, Youyu Zhang*, Shouzhuo Yao, A new turn-on fluorescent probe for selective detection of glutathione and cysteine in living cells, Chem. Commun., 2013, 49, 4640-4642.
23.  Meiling Liu, Qiong Chen,Cailang Lai, Youyu Zhang,Jianhui Deng, Haitao Li*,Shouzhuo Yao, A double signal amplification platform for ultrasensitive and simultaneous detection of ascorbic acid, dopamine, uric acid and acetaminophen based on a nanocomposite of ferrocene thiolate stabilized Fe3O4@Au nanoparticles with graphene sheet, Biosens. Bioelectron., 2013, 48, 75-81.
24.  Meiling Liu,Jianhui Deng, Qiong Chen, Yan Huang, Linping Wang,Yan Zhao, Youyu Zhang*,Haitao Li, Shouzhuo Yao*,Sensitive detection of rutin with novel ferrocene benzyne derivative modified electrodes, Biosens. Bioelectron., 2013, 41, 275-281.
25.   Jie Zhao, Meiling Liu, Youyu Zhang*, Haitao Li, Yuehe Lin*, Shouzhuo Yao, Apoferritin Protein Nanoparticles Dually labeled with Aptamer and Horseradish Peroxidase as A Sensing Probe for Thrombin Detection, Anal. Chim. Acta, 2013, 759, 53-60.
26.       Jianhui Deng, Meilin Liu, Fanbo Lin, Youyu Zhang*, Yang Liu*, Shouzhuo Yao, Self-assembled oligo(phenylene ethynylene)s/graphene nanocomposite with improved electrochemical performances for dopamine determination, Anal. Chim. Acta, 2013, 767, 59-65.
27.  Bangda Yin, Jianhui Deng, Xue Peng, Qian Long, Jiangna Zhao, Qiujun Lu, Qiong Chen, Haitao Li, Youyu Zhang*, Shouzhuo Yao, Green Synthesis of Carbon Dots with Down- and Up-conversion Fluorescent Properties for Sensitive Detection of Hypochlorite with Dual-Readout Assay. Analyst, 2013, 138, 6551-6557.
28.  Jiangna Zhao, Yinhui Yi, Naxiu Mi, Bangda Yin, Mingjie Wei, Qiong Chen, Haitao Li, Youyu Zhang*, Shouzhuo Yao,Gold nanoparticle coupled with fluorophore for ultrasensitive detection of protamine and heparin, Talanta, 2013, 116, 951-957.
29.       Linping Wang, Yue Meng, Qiong Chen, Jianhui Deng, Youyu Zhang*, Haitao Li*, Shouzhuo Yao, Simultaneous electrochemical determination of dihydroxybenzene isomers based on the hydrophilic carbon nanoparticles and ferrocene-derivative mediator dual sensitized graphene composite, Electrochim. Acta, 2013, 92, 216-225.
30.  Lingli Zhang, Youyu Zhang*, Mingjie Wei, Yinhui Yi, Haitao Li, Shouzhuo Yao, A label-free fluorescent molecular switch for Cu2+ based on metal ion-triggered DNA-cleaving DNAzyme and DNA intercalator, New J. Chem., 2013, 37, 1252-1257.
31.  Fanbo Lin, Bangda Yin, Chengzhi Li, Jianhui Deng, Xiaoyu Fan, Yinhui Yi, Chang Liu, Haitao Li*, Youyu Zhang*, Shouzhuo Yao, Fluorescence Resonance Energy Transfer Aptasensor for Platelet-derived Growth Factor Detection Based on Upconversion Nanoparticles in 30% Blood Serum, Anal. Method, 2013, 5, 699-704.
32.       Yinhui Yi, Yan Huang, Gangbing Zhu, Fanbo Lin, Lingli Zhang, Haitao Li, Youyu Zhang*, Shouzhuo Yao,A Colorimetric and Fluorescence Sensing Platform for Two Analytes in Homogenous Solution Based on Aptamer-Modified Gold Nanoparticles, Anal. Method, 2013,5, 2477-2484.
33.  Lingli Zhang, Naxiu Mi, Youyu Zhang*, Mingjie Wei, Haitao Li, Shouzhuo Yao,Label-free DNA sensor for Pb2+ based on a duplex-quadruplex exchange, Anal. Method, 2013, 5, 6100-6105.
34.       Linping Wang, Meiling Liu, Yue Meng, Yan zhao, Jianhui Deng, Youyu Zhang*, Haitao Li*, Shouzhuo Yao, (4-Ferrocenylethyne) phenylamine on Graphene as the Signal Amplificator to Determinate Dopamine and Acetaminophen Simultaneously, Chin. J. Chem., 2013, 31, 845-854.
2012
35.  Jie Zhao, Fanbo Lin, Yinhui Yi, Yan Huang, Haitao Li, Youyu Zhang*, Shouzhuo Yao, Dual Amplification Strategy of Highly Sensitive Thrombin Amperometric Aptasensor Based on Chitosan-Au Nanocomposites, Analyst, 2012, 137, 3488-3495.
36.  Meiling Liu,linping Wang,Jianhui Deng,Qiong Chen, Yuzhen Li, Youyu Zhang,Haitao Li*, Shouzhuo Yao*, Highly sensitive and selective dopamine biosensor based on a phenylethynyl ferrocene/graphene nanocomposite modified electrode, Analyst, 2012, 137, 4577-4583
37.  Xiaoyu Fan, Haitao Li*, Jie Zhao, Fanbo Lin, Lingli Zhang, Youyu Zhang*, Shouzhuo Yao, A novel label-free fluorescent sensor for the detection of potassium ions based on DNAzyme, Talanta, 2012, 89, 57-62.
38.  Meiling Liu, Jianhui Deng, Cailang Lai, Qiong Chen,Qiangqing Zhao, Youyu Zhang, Haitao Li,*Shouzhuo Yao*,Synthesis, characterization of conjugated oligo-phenylene-ethynylenes and their supramolecular interaction with beta-cyclodextrin for salicylaldehyde detection, Talanta, 2012, 100, 229-238.
39.  Xiaoyu Fan, Fanbo Lin,Youyu Zhang*, Jiangna Zhao, Haitao Li, Shouzhuo Yao,A simple adenosine fluorescent aptasensor based on the quenching ability of guanine, New J. Chem., 2012, 36, 2260-2265.
2011
40.  Jie Zhao, Youyu Zhang*, Haitao Li, Yanqing Wen, Xiaoyu Fan, Fanbo Lin, Liang Tan, Shouzhuo Yao, Ultrasensitive electrochemical aptasensor for thrombin based on the amplification of aptamer-AuNPs-HRP conjugates, Biosens. Bioelectron., 2011, 26, 2297-2303.
41.  Youyu Zhang, Zhiwen Tang, Jun Wang, Hong Wu, Chiann-Tso Lin, Yuehe Lin*, Apoferritin Nanoparticle: A Novel and Biocompatible Carrier for Enzyme Immobilization with Enhanced Activity and Stability, J. Mater. Chem., 2011, 21, 17468-17475.
42.  Jiao Luo, Mingnan Dong, Fanbo Lin, Meiling Liu Haitao Li, Hao Tang, Youyu Zhang*, Shouzhuo Yao, Three-dimensional Network Polyamidoamine Dendrimer-Au Nanocomposites for the Construction of a Mediator-free Horseradish Peroxidase Biosensors, Analyst, 2011, 136, 4500-4506.
43.  Yuqin Zhang, Fanbo Lin, Youyu Zhang*, Haitao Li*, Yue Zeng, Hao Tang, Shouzhuo Yao, Quartz Crystal Microbalance Detection of DNA Single-base Mutation Based on Monobase-coded Cadmium Tellurium Nanoprobe, Anal. Sci., 2011, 27, 1229-1235.
专利
1. 一种具有上下转换荧光的碳点的绿色合成方法，专利号：ZL201310191704.7
2. 一种用酮电化学碳化制备荧光碳点的方法，专利号：ZL201310376464.8
联系方式：
email：zhangyy@hunnu.edu.cn,zhangyy0101@126.com
Tel:+86-0731-88865515,13787296080
Fox:+86-0731-88865515

pinghe

2018自然科学基金面上项目-癌细胞外泌体的生物分析新方法与临床样品检测研究
批准号        21874042        学科分类        基于可再生资源高分子 ( B040401 )
负责人        张友玉        职称                单位名称        湖南师范大学
资助金额        66万元        项目类别        面上项目        起止年月        2019年01月01日 至 2022年12月31日