国家纳米科学中心中科院纳米生物效应与安全性重点实验室吴雁

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吴雁，国家纳米科学中心研究员，博士生导师。 2003年6月在南开大学高分子化学研究所获得博士学位。2003年8月-2005年6月期间在复旦大学高分子化学系从事博士后研究。 2005年8月加入国家纳米科学中心，2013年4月被聘为研究员。研究方向:主要从事各种功能高分子材料作为药物载体的研究，包括：运用高分子合成、有机合成及纳米技术构建各种功能聚合物纳米粒子（如：两亲性高分子材料的制备、组装），研究其作为药物载体及载药纳米粒体内外生物活性、生物利用度研究；具有多重环境响应的聚合物药物载体的制备及其体内外生物活性及生物利用度研究；具有超分子结构药物载体的构建及其体内外生物活性、生物利用度研究。医用纳米粒子的特性、组装及其作为药物载体的研究；天然生物医用高分子药物载体的化学修饰及其控制释放研究。目前发表SCI论文50余篇，授权专利6项。


姓    名:吴雁        
性    别:女
职    务:无        
职    称:研究员
通讯地址:北京市海淀区中关村北一条11号
邮政编码:100190        
电子邮件:wuy@nanoctr.cn        

研究领域：
         纳米药物载体制备及输送研究
代表论著：
　　1. Yanping Ding, Shishuai Su, Ruirui Zhang, Leihou Shao, Yinlong Zhang, Bin Wang, Yiye Li, Long Chen, Qun Yu, Yan Wu*, Guangjun Nie*. Precision combination therapy for triple negative breast cancer via biomimetic polydopamine polymer core-shell nanostructures.Biomaterials,2017, 113,243-252.
　　2. Shishuai Su, Yanping Ding, Yiye Li, Yan Wu*, Guangjun Nie*. Integration of photothermal therapy and synergistic chemotherapy by a porphyrin self-assembled micelle confers chemosensitivity in triplenegative breast cancer. Biomaterials, 2016,80,169-178.
　　3. Xiongwei Deng, Yihui Wang, Fang Zhang, Zhaoxia Yin, Qin Hu, Xiangqian Xiao, Zhixiang Zhou, Yan Wu,* Wang Sheng*, Yi Zeng. Acidic pH-induced charge-reversal nanoparticles for accelerated endosomal escape and enhanced microRNA modulation in cancer cells. Chemical Communications, 2016,52, 3243-3246.
　　4. Caiyan Zhao, Hongzhang Deng, Jing Xu, Shuyi Li, Lin Zhong, Leihou Shao, Yan Wu*, Xing-jie Liang*.“Sheddable” PEG-lipid to balance the contradiction of PEGylation between long circulation and poor uptake. Nanoscale, 2016, 6, 10832-10842.
　　5. Shishuai Su, Yanhua Tian, Yiye Li,Yanping Ding, Tianjiao Ji, Meiyu Wu, Yan Wu,* Guangjun Nie* .“Triple-Punch” Strategy for Triple Negative Breast Cancer Therapy with Minimized Drug Dosage and Improved Antitumor Efficacy. ACSNANO, 2015, 9,1367-1378.   
　　6. Xiongwei Deng, Minjun, Jiakun Zhang, Kelei Hu, Zhaoxia Yin, Zhixiang Zhou, Xiangqian Xiao, Yishu Yang, Wang Sheng *,Yan Wu*, Yi Zeng. Hyaluronic acid-chitosan nanoparticles for co-delivery of MiR-34a and doxorubicin in therapy against triple negative breast cancer. Biomaterials,2014, 35,4333-4344.
　　7. Shengliang Li, Kelei Hu, Weipeng Cao, Yun Sun, Wang Sheng, Feng Li, Yan Wu* , Xing-Jie Liang*. pH-responsive biocompatible fluorescent polymer nanoparticles based on phenylboronic acid for intracellular imaging and drug delivery. Nanoscale, 2014, 6, 13701-13709.
　　8. Liming Hu*, Yun Sun, Shengliang Li, Xiaoli Wang, Kelei Hu, Lirong Wang, Xingjie Liang, Yan Wu*. Multifunctional carbon dots with high quantum yield for imaging and gene delivery. CARBON, 2014, 67, 508 - 513.
　　9. Xin Nie, Jiakun Zhang, b Qing Xu, Xiaoguang Liu, Yaping Li, Yan Wu* , Chunying Chen*. Targeting peptide iRGD-conjugated amphiphilic chitosan-co-PLA/DPPE drug delivery system for enhanced tumor therapy. J. Mater. Chem. B, 2014, 2, 3232-3242.5.
　　10. Shishuai Su, Hai Wang, Xiaoguang Liu, Yan Wu*, Guangjun Nie*. iRGD-coupled responsive fluorescent nanogel for targeted drug delivery. Biomaterials, 2013, 34,3523-3533.
　　11. Minjun Cao,Xiongwei Deng,Shishuai Su,Fang Zhang,Xiangqian Xiao,Qin Hu,Yongwei Fu,Burton B. Yang, Yan Wu*, Wang Sheng*, Yi Zeng. Protamine sulfate–nanodiamond hybrid nanoparticles as a vector for MiR-203 restoration in esophageal carcinoma cells. Nanoscale, 2013, 5, 12120 -12125.
　　12. Nan Wu , Min Li, Zhi-Ting Chen, Xiao-Bing Zhang, Hui-Zhan Liu1, Zhou Li,Wei-Wei Guo, Li-Dong Zhao, Li-Li Ren1, Jia-Nan Li, Hai-Jin Yi, Dong Han,Wei-Yan Yang, Yan Wu*, Shi-Ming Yang*. In Vivo Delivery of Atoh1 Gene to Rat Cochlea Using a Dendrimer-Based Nanocarrier. J. Biomed. Nanotechnol., 2013, 9,1736-1745.
　　13.Yun Sun, Weipeng Cao, Shengliang Li, Shubin Jin, Kelei Hu, Liming Hu, Yuanyu Huang,Xueyun Gao, Yan Wu*, Xing-Jie Liang*. Ultrabright and Multicolorful Fluorescence of Amphiphilic Polyethyleneimine Polymer Dots for Efficiently Combined Imaging and Therapy. SCIENTIFIC REPORTS,2013, 3, 3036-3041.
　　14. Siyuan Han, Yuexian Liu, Xin Nie, Qing Xu, Fang Jiao, Wei Li, Yuliang Zhao, Yan Wu *, Chunying Chen*. Efficient Delivery of Antitumor Drug to the Nuclei of Tumor Cells by Amphiphilic Biodegradable Poly( L-Aspartic Acid-co-Lactic Acid)/DPPE Co-Polymer Nanoparticles, Small, 2012, 8,1596-1606.
　　15. Qing Xu, Yuexian Liu, Shishuai Su, Wei Li, Chunying Chen*, Yan Wu*. Anti-tumor activity of paclitaxel through dual- targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles, Biomaterials, 2012, 33, 1627-1639.
　　16. Yan Wu, Fang Jiao, Siyuan Han, Tengfei Fan, Ying Liu, Wei Li, Liming Hu, Yuliang Zhao, Chunying Chen*. Construction of amphiphilic copolymer nanoparticles based on hyperbranched Poly (Amine-Ester) and 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine as drug carriers for cancer therapy. Nanomedicine: Nanotechnology, Biology, and Medicine,2011,7,945-954.
承担科研项目情况：
1.国家重大科学研究计划课题 2.国家自然科学基金项目 3.横向项目