武汉大学化学与分子科学学院无机化学研究所严琨

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严琨

博士 , 副教授
研究方向： 无机化学, 化学生物学
联系电话：
Email: kyan@whu.edu.cn

教育与研究经历

1996-2000     理学学士，武汉大学化学与分子科学学院

2000-2003     理学硕士，武汉大学化学与分子科学学院，有机化学专业，导师吴成泰教授

2003-2007     哲学博士，香港大学化学系，化学生物学专业，导师支志明院士

2007-2008     博士后，香港大学化学系, 支志明院士课题组

2009-2011     博士后，美国约翰霍普金斯大学医学院放射学系，Prof. Jinyuan Zhou课题组

2011-2012     博士后，美国约翰霍普金斯大学医学院Bayview Proteomics Center，Prof. Jennifer VanEyk课题组

2012.4-至今   副教授, 武汉大学化学与分子科学学院

研究领域与兴趣

过渡金属配合物的合成、生物活性及机理

蛋白质组学在药物开发和疾病诊断中的应用

核磁共振分子成像、磁性/光学探针肿瘤诊断、多模式影像指导下的肿瘤治疗

主讲本科生必修课《无机化学》、《工程化学》；通识课《生物无机化学》

主讲研究生必修课《生物无机化学》、《无机化学前沿》（部分）

1. 国家自然科学基金 (21401144)

2. 湖北省自然科学基金 （2013CFB236）

1.    Yan, Kun; Fu,Zongming; Yang, Chen; Zhang, Kai; Jiang, Shenshan; Lee, Dong-Hoon; Heo,Hye-Young; Zhang, Yi; Cole, Robert N.; Van Eyk, Jennifer E.; Zhou, Jinyuan*. “AssessingAmide Proton Transfer (APT) MRI Contrast Origins in 9 L Gliosarcoma in the RatBrain Using Proteomic Analysis” Mol. Imaging Biol. 2015, DOI:10.1007/s11307-015-0828-6

2.    Lin, Iris Wing-Shan;Lok, Chun-Nam; Yan, Kun; Che, Chi-Ming*. “A silver complex ofN,N''''''''-disubstituted cyclic thiourea as an anti-inflammatory inhibitor ofIκB kinase” Chem. Commun. 2013, 49, 3297-3299.

3.    Siu, Fung-Ming†; Lin,Iris Wing-Shan†; Yan, Kun†; Lok, Chun-Nam; Low, Kam-Hung; Leung, ThomasYun-Chung; Lam, Tin-Lun; Che, Chi-Ming*. “Anticancer Dirhodium(II) Carboxylatesas Potent Inhibitors of Ubiquitin-Proteasome System” Chemical Science 2012, 3,1785-1793. (Back Cover, †Equal Contributions)

4.    Zhou, Jinyuan*; Yan,Kun; Zhu, He. “A Simple Model for Understanding the Origin of the Amide ProtonTransfer MRI Signal in Tissue”, Appl. Magn. Reson 2012, 42, 393-402.

5.    Wang, Silun; Chen,Yifei; Lal, Bachchu, Ford, Eric; Tryggestad, Erik; Armour, Michael; Yan, Kun;Laterra, John; Zhou, Jinyuan*. “Evaluation of Radiation Necrosis and MalignantGlioma in Rat Models Using Diffusion Tensor MR Imaging”, J Neurooncol. 2012,107, 51-60.

6.    Zhou, Jinyuan*;Tryggestad, Erik; Wen, Zhibo; Lal, Bachchu; Zhou, Tingting; Grossman, Rachel;Wang, Silun; Yan, Kun; Fu, De-Xue; Ford, Eric; Tyler, Betty; Blakeley, Jaishri;Laterra, John; van Zijl, Peter C.M. “Differentiation between glioma andradiation necrosis using molecular magnetic resonance imaging of endogenousproteins and peptides”, Nature Medicine 2011, 17, 130-134.

7.    Yan, Kun; Lok,Chun-Nam; Bierla, Katarzyna; Che, Chi-Ming*. “Gold(I) complex ofN,N’-disubstituted cyclic thiourea with in vitro and in vivo anti-cancerproperties - potent tight-binding inhibition of thioredoxin reductase”, Chem.Commun. 2010, 46, 7691–7693. (Inside Cover)

8.    Zhang, Zhi; Guo,Qian-ni; Lu, Yun-guo; Jia, Tao; Yan, Kun*; Li, Zao-ying*. “Interaction betweennovel porphyrin-dextran nanoparticles and human serum albumin”, J. PorphyrinsPhthalocyanines 2010, 14, 264–270.

9.    Zhang, Zhi; He, Rui;Yan, Kun; Guo, Qian-ni; Lu, Yun-guo; Wang, Xu-xia; Lei, Hao; Li, Zao-ying*.“Synthesis and in vitro and in vivo evaluation of manganese(III)porphyrin–dextran as a novel MRI contrast agent”, Bioorg. Med. Chem. Lett.2009, 19, 6675-6678.

10.  Siu, Fung-Ming; Ma, Dik-Lung;Cheung, Yee-Wai; Lok; Chun-Nam, Yan, Kun; Yang, zhiqi; Yang, Mengsu; Xu,SongXiao; Ko, Ben Chi-Bun; He, Qing-Yu; Che, Chi-Ming*. “Proteomic andtranscriptomic study on the action of a cytotoxic saponin (Polyphyllin D):Induction of endoplasmic reticulum stress and mitochondriamediated apoptoticpathways”, Proteomics 2008, 8, 3105–3117.