上海科技大学物质学院黄焕明

taipingyang

黄焕明研究员，博士毕业于英国曼彻斯特大学，导师是Prof. David Procter。随后在德国洪堡基金的资助下，在德国明斯特大学开展博士后研究，合作导师为德国科学院院士Prof. Frank Glorius。迄今为止，以（共同）通讯或（共同）第一作者身份发表学术论文数篇，包括:Nature Catalysis,Nature Synthesis,J. Am. Chem. Soc.,Angew. Chem. Int. Ed.,Chem. Soc. Rev.,Nature Rev. Chem.等。2021年，黄焕明研究员加入上海科技大学，组建自由基化学实验室，担任课题组长，获得多个重要项目资助。目前以通讯作者身份在Nature Synthesis,Angew. Chem. Int. Ed.,Acc. Chem. Res.等期刊发表论文数篇。


黄焕明，助理教授、研究员
Address: 上海科技大学物质学院3号楼405-2
Email: huanghm@shanghaitech.edu.cn
ORCiD: orcid.org/0000-0001-9461-6508
Researcher ID: AAB-1528-2019
Website: https://huanminghuang.wixsite.com/huanggroup


Career and education：
2021-now，上海科技大学，助理教授、研究员∣Assistant Professor (Tenure Track), Principal Investigator, ShanghaiTech University
2018-2021，德国明斯特大学，洪堡学者∣Humboldt Fellow, University of Münster (Mentor: Prof. Frank Glorius)
2017-2018，英国曼彻斯特大学，博士后∣EPSRC Postdoc Research Fellow, The University of Manchester (Mentor: Prof. David J. Procter)
2014-2017，英国曼彻斯特大学，哲学博士∣Ph.D. at The University of Manchester (Supervisor: Prof. David J. Procter)


Selected Awards & Honors：
n  Alexander von Humboldt Fellowship (2018)
n  CSC Chinese National Excellent Self-Funded Students Scholarship (2016)


n  Prestigious President's Scholarship of The University of Manchester (2014)


Service:
n  Reviewer for Springer Nature, Wiley, Cell Press, Elsevier and Royal Society of Chemistry journals, including:
     n Angewandte Chemie n Nature Synthesis n Chem.Commun. n Chemical Science n Chem. Eur. J. n iScience


Research
We are a young research team working in School of Physical Science and Technology at ShanghaiTech University. Our research is focused on radical chemistry and catalysis.
At present, we have two main research directions:
1) Develop novel radical chemistry in the emerging areas, such as photoredox chemistry and electrosynthesis, to rapid construct complex bio-active molecules and provide alternative approaches to the solve the limitations in the area of medicinal, materials, energy and environmental chemistry.
2) Rationally design novel catalysts and ligands in order to discovery novel chemical transformations and contribute the development of develop sustainable chemistry.


Publication
2022
10. Jun-Jie Chen and Huan-Ming Huang*, N2O revalorization, Nature Chem. 2022, DOI: 10.1038/s41557-022-01007-x. (News & Views)
9. Huan-Ming Huang*, "Electrifying cross-electrophile coupling", Nature Synth. 2022, DOI: 10.1038/s44160-022-00102-8. (News & Views)
8. Ying Zhang,+ Jun-Jie Chen+ and Huan-Ming Huang*, "Radical Brook Rearrangement: Concept and Recent Developments", Angew. Chem. Int. Ed. 2022, DOI: 10.1002/anie.202205671.
7. Jun-Jie Chen,+ Ying Zhang+ and Huan-Ming Huang*, Radical umpolung chemistry enabled by dual catalysis: concept and recent advances, Catal. Sci. Technol. 2022, DOI: 10.1039/D2CY01161A.
6. Jun-Jie Chen and Huan-Ming Huang*, Merging Halogen-Atom transfer with transition metal catalysis, Tetrahedron Lett., 2022, 153945.
5. Huan-Ming Huang*,+ Peter Bellotti,+ Suhyeon Kim, Xiaolong Zhang and Frank Glorius*, “Catalytic multicomponent reaction involving a ketyl-type radical”, Nature Synth. 2022, DOI: 10.1038/s44160-022-00085-6.
4. Peter Bellotti,+ Huan-Ming Huang,+ Teresa Faber, Ranjini Laskar and Frank Glorius*, “Catalytic defluorinative ketyl–olefin coupling by halogen-atom transfer”, Chem. Sci. 2022, DOI:10.1039/d2sc02732a.
3. Huan-Ming Huang*,+ Peter Bellotti,+ and Frank Glorius*, “Merging Carbonyl Addition with Photocatalysis”, Acc. Chem. Res. 2022, 55, 1135.
2. Huan-Ming Huang,+ Peter Bellotti,+ Johannes E. Erchinger, Tiffany O. Paulisch and Frank Glorius*, “Radical Carbonyl Umpolung Arylation via Dual Nickel Catalysis”, J. Am. Chem. Soc. 2022, 144, 1899.
1. Huan-Ming Huang,+ Peter Bellotti,+ Pan-Pan Chen,+ Kendall N. Houk* and Frank Glorius*, “Allylic C(sp3)–H arylation of olefins via ternary catalysis”, Nature Synth. 2022, 1, 59.


Before joining ShanghaiTech
12. Huan-Ming Huang,‡ Peter Bellotti,‡ (‡These authors contributed equally) and Frank Glorius*, “Bifunctional  Reagents in Organic Synthesis”, Nat. Rev. Chem. 2021, 5, 301.
11. Huan-Ming Huang, Peter Bellotti, Constantin Daniliuc and Frank Glorius*, “Radical Carbonyl Propargylation by Dual Catalysis”, Angew. Chem. Int. Ed. 2021, 60, 2464.
10. Huan-Ming Huang,‡ Peter Bellotti,‡ (‡These authors contributed equally) and Frank Glorius*, “Transition-metal catalysed allylic functionalization reaction involving radicals”, Chem. Soc. Rev. 2020, 49, 6186.
9. Huan-Ming Huang, Peter Bellotti, Philipp Miro Pflueger, J. Luca Schwarz, Bastian Heidrich and Frank Glorius*, “Three-Component, Interrupted Radical Heck/Allylic Substitution Cascade Involving Unactivated Alkyl Bromides”, J. Am. Chem. Soc. 2020, 142, 10173.
8. Huan-Ming Huang, Maximilian Koy, Eloisa Serrano, Philipp Miro Pflüger, J. Luca Schwarz and Frank Glorius*, “Catalytic radical generation of π-allylpalladium complexes”, Nat. Catal. 2020, 3, 393.
7. J. Luca Schwarz,‡Huan-Ming Huang,‡ (‡These authors contributed equally) Tiffany O. Paulisch, and Frank Glorius*, “Dialkylation of 1,3-Dienes by Dual Photoredox and Chromium Catalysis”, ACS Catal. 2020, 10, 1621.
6. Huan-Ming Huang, Monserrat H. Garduño-Castro, Charlotte Morrill and David J. Procter*, “Catalytic Cascade Reactions by Radical Relay”, Chem. Soc. Rev. 2019, 48,   4626.
5. Huan-Ming Huang, J. J. W. McDouall, and David J. Procter*, “SmI2-catalysed Cyclisation Cascades by Radical Relay”,Nat. Catal. 2019, 2, 211.
4. Huan-Ming Huang, J. J. W. McDouall and David J. Procter*, “Radical Anions from Urea-type Carbonyls: Radical Cyclisations and Cyclisation Cascades”,Angew. Chem. Int. Ed. 2018, 57, 4995.
3. Huan-Ming Huang and David J. Procter*, “Dearomatizing Radical Cyclisations and Cyclisation Cascades Triggered by Electron-Transfer Reduction of Amide-Type Carbonyls”, J. Am. Chem. Soc. 2017, 139, 1661.
2. Huan-Ming Huang and David J. Procter*, “Radical Heterocyclisation and Heterocyclisation Cascades Triggered by Electron Transfer to Amide-Type Carbonyls”, Angew. Chem. Int. Ed. 2017, 56, 14262.
1. Huan-Ming Huang and David J. Procter*, “Radical-Radical Cyclisation Cascades of Barbiturates Triggered by Electron-Transfer Reduction of Amide-Type Carbonyls”, J. Am. Chem. Soc. 2016, 138, 7770.

taipingyang

近日，上海科技大学物质科学与技术学院黄焕明课题组和德国科学院院士Frank Glorius课题组合作，通过将可见光催化化学和金属催化化学结合，首次实现了可见光催化条件下钯催化羰基自由基参与的多组分反应，论文在线发表于知名学术期刊Nature Synthesis。两组还受邀在《化学研究评述》（Accounts of Chemical Research）发表自由基化学领域的专题综述，该综述已成为期刊当月下载量前三的综述论文。
实现原子经济性、步骤经济性一直是合成化学家们追求的目标。由于可以一步构建多个化学键，多组分反应已受到化学家们的广泛关注。羰基自由基是自由基化学领域中一类比较重要的反应中间体，在全合成领域有较大的应用，如何在催化条件下实现相关的化学转化一直是合成化学中的一个难点 （图1）。

图1 羰基自由基参与的多组分催化反应探究

        联合团队利用可见光催化的手段，对商业化的钯催化剂进行激发，从而和原位产生的溴化物反应得到羰基自由基，再和相应的1，3-丁二烯以及亲核试剂反应，同时构建两个化学键。该方法较好解决了催化模式下产生羰基自由基难、反应类型局限等问题，为未来发展更多的自由基化学反应模式提供了指导。
        综述论文总结了两个课题组过去几年在可见光催化化学领域的进展和突破，为相关药物分子和有机合成方法学的发展展望了一些更加温和高效的合成手段和思路（图2）。希望在可见光催化化学的推动下，以羰基官能团为中心的合成化学能够重新得到更多的关注和发展。同时，该综述鼓励更多的药物化学家和材料科学家能够将这些方法投入到实际生产过程中去。

图2：合作团队在光催化化学领域的一系列进展

      第一项研究成果论文题为“catalytic multicomponent reaction involving a ketyl-type radical”。第二项综述论文题为“Merging Carbonyl Addition with Photocatalysis”。以上工作中，上科大物质学院助理教授黄焕明为共同第一作者和通讯作者，德国明斯特大学Frank Glorius院士为共同通讯作者。