中国科学院化学研究所活体分析化学实验室马会民

dahuangfeng

马会民，中国科学院化学研究所研究员，博士生导师；中科院活体分析化学重点实验室和学术委员会副主任；中国科学院大学教授；国家杰出青年基金获得者。主要从事生物分子的光学探针与传感分析、生物光谱学与选择性探测研究。曾获中国分析测试协会科学技术一等奖、北京市科学技术二等奖、政府特殊津贴、《科学通报》优秀编委等。在Chem.Re、 Angew. Chem. Int. Ed.，J. Am. Chem. Soc.等刊物上发表学术论文200余篇，并应邀（曾）担任《科学通报》、《Current Chemical Biology》、《分析化学》《分析科学学报》《光谱学与光谐分析》等刊物的编委。

马会民 研究员
   1979-1983　山东大学化学系本科   
　1986年　     获中国科学院化学所硕士，随后在中科院半导体所工作　
　1990年　     获中国科学院化学所博士　
　1990-1992　武汉大学化学系博士后　
　1992-至今　中国科学院化学所工作，现任研究员，博士生导师。　
　曾于1996-1997年、1999年10月-2000年2月和2001年10-11月，先后三次作为德国洪堡学者在 Bremen University 从事研究工作。　
　现任《Current　Chemical　Biology》、《科学通报》、《分析化学》、《分析科学学报》等刊物的编委；中国化学会永久会员。　
　2003年度中国分析测试协会科学技术二等奖(CAIA奖)　
　2006年度中国分析测试协会科学技术一等奖(CAIA奖)
　2005年度获得国家基金委杰出青年基金项目资助
研究方向
本课题组的研究方向为分析化学，生化分析，光学探针与标记分析，分子识别，具体内容包括：
1.  光学识别试剂与生化分析：利用光诱导电子转移、电荷转移、能量转移等各种光物理过程，设计新型光学(包括吸光、荧光、发光)探针，研究对生物与环境毒物的标记、荧光显微分析等
2.  分子光谱的基础研究
3.  生物光谱学与选择性检测
4.  研制生物、临床医学分析中的试剂盒、临床试纸等

发表论文

• Xiaohua Li*, Xinghui Gao, Wen Shi, Huimin Ma*. Design strategies for water-soluble small molecular chromogenic and fluorogenic probes. Chem. Rev. 2014, 114, 590-659
• Yangyang Zhang, Wen Shi, Xiaohua Li, Huimin Ma*. Sensitive detection of ozone by a practical resorufin-based spectroscopic probe with extremely low background signal. Sci. Rep. 2013, 3, 2830.
• Duan Feng, Yanchao Song, Wen Shi, Xiaohua Li, Huimin Ma*. Distinguishing folate-receptor-positive cells from folate-receptor-negative cells using a fluorescence off-on nanoprobe. Anal. chem. 2013, 85, 6530-6535.
• Zhao Li, Xinghui Gao, Wen Shi, Xiaohua Li, Huimin Ma*. 7-((5-Nitrothiophen -2-yl)methoxy)-3H-phenoxazin-3 -one as a spectroscopic off-on probe for highly sensitive and selective detection of nitroreductase. Chem. Commun. 2013, 49, 5859-5861.
• Qiongqiong Wan, Yanchao Song, Zhao Li, Xinghui Gao and Huimin Ma*. In vivo monitoring of hydrogen sulfide using a cresyl violet-based ratiometric fluorescence probe. Chem. Commun., 2013, 49, 502–504.
• Tingting Feng and Huimin Ma*. Fluorescence sensing of adenosine deaminase based on adenosine induced self-assembly of aptamer structures. Analyst, 2013, 138, 2438–2442.
• Zhao Li, Xiaohua Li*, Xinghui Gao, Yangyang Zhang, Wen Shi, and Huimin Ma*. Nitroreductase detection and hypoxic tumor cell imaging by a designed sensitive and selective fluorescent probe, 7-[(5-nitrofuran-2-yl)methoxy]-3H-phenoxazin-3-one. Anal. Chem., 2013, 85, 3926–3932.
• Tingting Feng, Duan Feng, Wen Shi, Xiaohua Li* and Huimin Ma*. A graphene oxide-peptide fluorescence sensor for proteolytically active prostate-specific antigen. Mol. BioSyst., 2012, 8, 1441–1445.
• Wen Shi and Huimin Ma*. Spectroscopic probes with changeable π-conjugated systems. Chem. Commun., 2012, 48, 8732–8744.
• Wen Shi*, Xiaohua Li, and Huimin Ma*. A Tunable Ratiometric pH Sensor Based on Carbon Nanodots for the Quantitative Measurement of the Intracellular pH of Whole Cells. Angew. Chem. Int. Ed., 2012, 51, 6432–6435.
• Yanchao Song, Wen Shi, Wei Chen, Xiaohau Li and Huimin Ma*. Fluorescent carbon nanodots conjugated with folic acid for distinguishing folate-receptor-positive cancer cells from normal cells.J. Mater. Chem., 2012, 22, 12568–12573.
• Suming Chen, Wei Chen, Wen Shi, and Huimin Ma*, Spectroscopic response of ferrocene derivatives bearing a BODIPY moiety to water: new dissociation reaction, Chem. Eur. J., 2012, 18, 925-930.
• Wei Chen, Zhao Li, Wen Shi, and Huimin Ma*, A new resorufin-based spectroscopic probe for simple and sensitive detection of benzoyl peroxide via deboronation, Chem. Commun., 2012, 48, 2809-2811.
• Yangyang Zhang, Wei Chen, Duan Feng, Wen Shi*, Xiaohua Li, and Huimin Ma*, A spectroscopic off-on probe for simple and sensitive detection of carboxylesterase activity and its application to cell imaging, Analyst , 2012, 137, 716-721.
• Chengdong Sun, Wen Shi, Yanchao Song, Wei Chen and Huimin Ma*, An unprecedented strategy for selective and sensitive fluorescence detection of nitric oxide based on its reaction with a selenide, Chem. Commun., 2011, 47, 8638-8640.
• Duan Feng, Yangyang Zhang, Tingting Feng, Wen Shi, Xiaohua Li and Huimin Ma*, A graphene oxide–peptide fluorescence sensor tailor-made for simple and sensitive detection of matrix metalloproteinase 2, Chem. Commun., 2011 , 47, 10680-10682.
• Wei Chen, Wen Shi, Zhao Li, Huimin Ma*, Yang Liu, Jinghua Zhang, Qingjun Liu, Simple and fast fluorescence detection of benzoyl peroxide in wheat flour by N-methoxy rhodamine -6G spirolactam based on consecutive chemical reactions, Anal. Chim. Acta, 2011, 708(1-2), 84-88.
• Jinxin Lu, Chengdong Sun, Wei Chen, Huimin Ma*, Wen Shi, Xiaohua Li*, Determination of non-protein cysteine in human serum by a designed BODIPY-based fluorescent probe Catalyst, Talanta, 2011, 83, 1050-1056.
• Yangyang Zhang, Wen Shi, Duan Feng, Huimin Ma*, Yan Liang, Jianru Zuo, Application of rhodamine B thiolactone to fluorescence imaging of Hg2+ in Arabidopsis thaliana, Sensors Actuat. B-Chem., 2011, 153(1), 261-265.
• Jia Jia and Ma HuiMin*, A water-soluble fluorescence resonance energy transfer probe for hypochlorous acid and its application to cell imaging, Chinese Sci. Bull., 2011 , 56(31), 3266-3272.
• Ma HuiMin*, Bio-spectroscopic sensing, Chinese Sci. Bull., 2011, 56(31), 3233.
• Sun Chengdong, Chen Jianming Ma Huimin*, Liu Yang, Zhang Jinghua and Liu Qingjun, A new Cu2+-induced color reaction of a rhodamine derivative N-(3-carboxy)acryloyl rhodamine B hydrazide, Sci. China Chem. , 2011, 54(7), 1107-1114.
• Su-Ming Chen, Jin-Xin Lu, Cheng-Dong Sun and Hui-Min Ma*, A highly specific ferrocene-based fluorescent probe for hypochlorous acid and its application to cell imaging, Analyst , 2010 , 135, 577-582.
• Jia Jia, Wei Chen, Hui-Min Ma*, Ke Wang and Chuan Zhao, Use of a rhodamine-based bifunctional probe in N-terminal specific labeling of thermomyces lanuginosus xylanase, Molecular BioSystems, 2010 , 6, 1829-1833.
• Duan Feng, Yang-Yang Zhang, Wen Shi, Xiao-Hua Li and Hui-Min Ma*, A simple and sensitive method for visual detection of phosgene based on the aggregation of gold nanoparticles, Chem. Commun., 2010 , 46, 9203-9205.
• Jia Jia, Ke Wang, Wen Shi, Suming Chen, Xiaohua Li, Huimin Ma*, Rhodamine B piperazinoacetohydrazine a water-soluble spectroscopic reagent for pyruvic acid labeling, Chem. Eur. J., 2010, 16(22), 6638-6643.
• Wen Shi, Shuna Sun, Xiaohua Li and Huimin Ma*, Imaging different interactions of mercury and silver with live cells by a designed fluorescence probe rhodamine B selenolactone, Inorg. Chem., 2010 49(3) 1206-1210.
• Xiaohua Li*, Wen Shi, Suming Chen, Jia Jia, Huimin Ma* and Otto S. Wolfbeis, A near-infrared fluorescent probe for monitoring tyrosinase activity, Chem. Commun., 2010, 46, 2560-2562.
• Suming Chen, Jinxin Lu, Chengdong Sun, Huimin Ma*, A highly specific ferrocene-based fluorescent probe for hypochlorous acid and its application to cell imaging, Analyst , 2010, 135, 577-582.
• Ke Wang, Wen Shi, Jia Jia, Suming Chen, Huimin Ma.* Characterization of 2-phenylbenzo[g]quinoxaline derivatives as viscosity-sensitive fluorescent probes,Talanta, 2009, 77, 1795-1799.
• Xinqi Chen, Jia Jia, Huimin Ma*, Shujuan Wang and Xiaochun Wang. Characterization of rhodamine B hydroxylamide as a highly selective and sensitive fluorescence probe for Cu(II), Anal. Chim. Acta, 2009, 632, 9-14.
• Suming Chen, Xiaohua Li, Huimin Ma*. New approach for local structure analysis of tyrosine domain in proteins by using site-specific and polarity-sensitive fluorescent probe. ChemBioChem, 2009, 10, 1200-1207.
• Shujuan Wang, Xiaochun Wang, Wen Shi, Ke Wang, Huimin Ma.* Detection of local polarity and conformational changes at the active site of rabbit muscle creatine kinase with a new arginine-specific fluorescent probe. Biochim. Biophys, Acta. Proteins and Proteomics, 2008, 1784, 415-422.
• Wen Shi and Huimin Ma*. Rhodamine B thiolactone: a simple chemosensor for Hg2+ in aqueous media,Chem. Commun., 2008, 1856-1858.
• Shuna Sun, Zhijuan Bao, Huimin Ma*, Deqing Zhang, Xiaoping Zheng. Singlet oxygen generation from the decomposition of α-linolenic acid hydroperoxide by cytochrome c and lactoperoxidase, Biochemistry, 2007, 46, 6668-6673.
• Zhijuan Bao, Shujuan Wang, Wen Shi, Suying Dong and Huimin Ma.* Selective modification of Trp 19 in β-lactoglobulin by a new diazo fluorescence probe, J. Proteome Res., 2007, 6, 3835-3841.
• Suying Dong, Zhenwen Zhao, Huimin Ma.* Characterization of local polarity and hydrophobic binding sites of beta-lactoglobulin by using N-terminal specific fluorescence labeling J. Proteome Res. 2006, 5, 26-31.
• Zhijuan Bao, Shuna Sun, Jun Li, Xinqi Chen, Suying Dong and Huimin Ma*, Direct identification of tryptophan in a mixture of amino acids by the naked eye, Angew. Chem. Int. Ed., 2006, 45, 6723-6725.
• Suying Dong, Huimin Ma*, Xuejun Duan, Xinqi Chen, Jun Li. Detection of local polarity of a-lactalbumin by N-terminal specific labeling with a new tailor-made fluorescent probe, J. Proteome Res., 2005, 4, 161-166.
• Xuejun Duan, Zhen Zhao, Jianping Ye, Huimin Ma* Andong Xia* Guoqiang Yang Chihchen Wang*. Donor-donor energy-migration measurements of dimeric DsbC labeled at its N-terminal amines with fluorescent probes: a study of protein unfolding, Angew. Chem. Int. Ed., 2004, 43, 4216-4219.
• Xiaohua Li, Guanxin Zhang, Huimin Ma* Deqing Zhang*, Jun Li and Daoben Zhu.* 45-Dimethylthio-4'-[2-(9-anthryloxy)ethylthio]tetrathiafulvalene a highly selective and sensitive chemiluminescence probe for singlet oxygen, J. Am. Chem. Soc., 2004, 126, 11543-11548.
• Lihua Nie, Huimin Ma*, Xiaohua Li, Ming Sun, Shaoxiang Xiong. Recognition of thymine by a triazine fluorescent probe through intermolecular multiple hydrogen bonding, Biopolymers(Biospectroscopy) , 2003, 72, 274-281.
• Ming Sun, Dihua Shangguan, Huimin Ma*, Lihua Nie, Xiaohua Li, Shaoxiang Xiong Guoquan Liu Wolfram Thiemann. Simple Pb(II) fluorescent probe based on the Pb(II)-catalyzed hydrolysis of phosphodiester, Biopolymers(Biospectroscopy), 2003, 72, 413-420.
• Hui-Min Ma*, Zhi-Hua Wang, Mei-Hong Su. New triazine spectroscopic reagent for separation of DL-amino acids by micellar electrokinetic chromatography, J. Chromatogr. A, 2002, 955, 125-131.
• Huimin Ma*, Ute Jarzak and Wolfram Thiemann*, In situ fluorescent labeling of highly volatile methylamine with 8-(46-dichloro-135- triazinoxy)quinoline, New J. Chem., 2001, 25, 872-874.
• Huimin Ma*, Jens Wohlers, Uwe Meierhenrich, Axel Bernecker, Vera Suling, Wolfram Thiemann*, Analysis of oxidative degradation products of 246- trichlorophenol treated with air ions, Anal. Chem., 2001, 73, 3506-3510.
• Meihong Su, Yong Liu, Huimin Ma*, Quanli Ma, Zhihua Wang, Junlin Yang and Meixiang Wang*, 19-Dihydro-3-phenyl-4H-pyrazolo[34-b]quinolin-4-one a novel fluorescent probe for extreme pH measurement, Chem. Commun., 2001, 960-961.