中国科学院上海有机化学研究所陈椰林

dasaochu

姓 名:陈椰林       
性 别:男
职 称:研究员       
学 历:博士研究生
电 话:021-68582361       
传 真:
电子邮件:chenyelin@sioc.ac.cn       
个人主页:
通讯地址:
　上海市浦东新区秋月路26号6号楼　201203       
简历：
1997-2001           理学学士，生物化学及分子生物学，北京大学
2001-2002           理学硕士，生化分子工程，新加坡国立大学
2002-2007           博士，神经生物学，范德堡大学，美国
2007-2009      博士后, 麻省理工学院，美国
研究方向：
阿尔兹海默症致病机理；NMDA型谷氨酸受体功能和精神类疾病，以及相关药物开发。
专家类别：课题组长、研究员
职务：课题组长
代表论著：
1.      Chen Y and Geng Y. (2017) Synaptic engineering: A new level of brain modulation. Brain Res Bull. 129:23-29. (Review)
2.      Hackos DH, Lupardus PJ, Grand T, Chen Y, Wang TM, Reynen P, Gustafson A, Wallweber HJ, Volgraf M, Sellers BD, Schwarz JB, Paoletti P, Sheng M, Zhou Q, Hanson JE. (2016) Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron. 89:983-99.
Chen et al., (2014) Activity-induced Nr4a1 regulates spine density and distribution pattern of excitatory synapses in pyramidal neurons. Neuron. 83:431-43. (Recommended by F1000)
Chen et al., (2014) Regulation of neuronal gene expression and survival by basal NMDA receptor activity: a role for Histone Deacetylase 4. J Neurosci. 34:15327-39.
Nelson et al., (2013) Phosphorylation of Threonine-19 of PSD-95 by GSK-3beta is Required for PSD-95 Mobilization and Long-Term Depression. J Neurosci. 33:12122-35.
Alagille D., Dacosta H., Chen Y., Hemstapat K., Rodriguez A., Baldwin R.M., Conn J.P., Tamagnan G.D. (2011) Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series. Bioorg Med Chem Lett. 21:3243-7.
Ayala, J.E. *, Chen Y.* et al., (2009) mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning. Neuropsychopharmacology. 34:2057-71. (* contributed equally)
Chen Y. and Conn P.J. (2008) mGluR5 positive allosteric modulators. Drugs of the Future. 33:335
Chen Y., Goudet C., Pin J.P. and Conn P.J. (2008) CPPHA acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.  Mol Pharmacol. 73:909-18
Chen Y., Nong Y., Goudet C., Hemstapat K., de Paulis T., Pin J.P. and Conn J.P. (2007) Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Mol Pharmacol. 71:1389-98
Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, Tamagnan GD, Conn PJ. (2006) A novel class of positive allosteric modulators of mGluR1 interact with a site distinct from that of negative allosteric modulators.  Mol Pharmacol.  70:616-26
De Paulis T., Hemstapat K., Chen Y., Zhang Y., Saleh S., Alagille D., Baldwin R.M., Tamagnan G.D., Conn P.J. (2006) Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes.  J Med Chem. 49:3332-44