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王恒山，广西师范大学教授。2000年毕业于兰州大学，获理学博士学位， 2004任广西师范大学化学化工学院教授， 2006年11月赴美国杰克逊州立大学访问, 2007年获广西“新世纪十百##才工程”第二层次人选，广西师范大学“药用资源化学与药物分子工程”省部共建国家重点实验室主任助理。
先后主持973前期研究专项1项、国家自然科学基金项目3项、国际合作项目1项、国家科技支撑计划项目子课题1项，以及高等学校博士学科点专项基金、广西自然科学基金重点项目等其他省部级、厅级课题12项；以第三成员参加国家自然科学基金重点项目1项、973前期研究专项1项。共在 化学和药学类期刊发表论文220余篇，其中120余篇被SCI收录（含JCR二区论文30余篇）。研究成果在Chem. Rev., Chem. Soc. Rev. J. Am. Chem. Soc., ACS Catalysis Green Chem.等刊物被他人正面引用700余次，单篇最高引用频次108次。参编英文专著1部。获得广西自然科学三等奖1项（排名第一）、广西科技进步二等奖3项（排名第二、三、五）和广西自然科学奖二等奖（排名第六）、广西科技进步三等奖（排名第五）各1项。获7项国家发明专利授权，部分新产品已被美国Sigma-Aldrich等公司采用。在国内学术会议做邀请报告3次。已培养博士1名、硕士43名。
中国化学会员、中国化工学会专家库专家，广西化学化工学会理事，韶关市企业创新发展专家库专家，《广西植物》、《广西师范大学学报》编委和Adv. Synth. Catal., Eur. J. Med.Chem., J. Med. Food., Pharm. Bio., New J. Chem.., Molecular Nutrition&Food Research,等20余种SCI刊物的特约审稿人。
王恒山
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研究方向
中药与天然药物化学、手性药物的结构改造与分离分析研究，功能分子的合成方法学。
讲授课程
天然药物化学、波谱解析、天然产物开发与利用、中药鉴定及质量控制、表征技术
论著专利
1. Jiu-ling Li, Ying-chun Wang, Wei-ze Li, Heng-shan Wang,* Dong-liang Moa and Ying-ming Pan*. Facile synthesis of 2,5‐disubstituted oxazoles via a coppercatalyzed cascade reaction of alkenes with azides. Chem. Commun., 2015, 51, 17772-17774
2. Yan-li Xu, Ying-Ming Pan,* Qiang Wu, Heng-Shan Wang*, Pei-zhen Liu. Regioselective Synthesis of 1,3,5-Substituted Benzenes via the InCl3/2-iodophenol- Catalyzed Cyclotrimerization of Alkynes. J. Org. Chem. 2011, 76(20), 8472-08476.
3. Ying-Chun Wang, Yu-Yang Xie, Hong-En Qu, Heng-Shan Wang*, Ying-Ming Pan*, Fu-Ping Huang. Ce(OTf)3-catalyzed [3+2] cycloaddition of azides with nitroolefins: regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles. J. Org. Chem., 2014, 79, 4463−4469.
4. Yingchun Wang, Jiuling Li, Yan He, Yuyang Xie, Hengshan Wang,* and Yingming Pan,* Synthesis of Polysubstituted Imidazoles and Pyridines via Samarium(III) Triflate-Catalyzed [2+2+1] and [4+2] Annulations of Unactivated Aromatic Alkenes with Azide. Adv. Synth. Catal., 2015, 357, 3229– 3241
5. Yu-Yang Xie, Ying-Chun Wang, Hong-En Qu, Xian-Chun Tan, Heng-Shan Wang*, Ying-Ming Pan*. Regioselective synthesis of β-Aryl enaminones and 1,4,5-trisubstituted 1,2,3-triazoles from chalcones and benzyl azides. Adv. Synth. Catal., 2014, 356, 3347–3355.
6. Pei Liu, Ying-Ming Pan*, Yan-Li Xu, Heng-Shan Wang*. PTSA-catalyzed Mannich-type-cyclization-oxidation tandem reactions: one-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes. Org. Biomol. Chem., 2012, 10, 4696–4698.
7. Xu Wang, Ying-ming Pan*, Xiao-chao Huang, Zhong-yuan Mao and Heng-shan Wang*. A novel methodology for synthesis of dihydropyrazole derivatives as potential anticancer agents. Org. Biomol. Chem., 2014, 12, 2028-2032
8. Ying-chun Wang, Yu-yang Xie, Xian-chun Tan, Heng-shan Wang*, Ying-ming Pan*. Sc(OTf)3-mediated 1,3-dipolar cycloaddition-ring cleavage-rearrangement: a highly stereoselective access to Z-beta-enaminonitriles. Org. Biomol. Chem.,2015, 13, 513−519.
9. Man-Yi Ye, Gui-Yang Yao, Ying-Ming Pan, Zhi-Xin Liao, Ye Zhang, Heng-Shan Wang*. Synthesis and antitumor activities of novel α-aminophosphonate derivatives containing an alizarin moiety. Eur. J. Med. Chem., 2014, 83, 116–128
10. Jian-Fei Li, Ri-Zhen Huang, Gui-Yang Yao, Man-Yi Ye, Heng-Shan Wang*, Ying-Ming Pan*, Jing-Teng Xiao. Synthesis and biological evaluation of novel aniline-derived asiatic acid derivatives as potential anticancer agents. Eur. J. Med. Chem., 2014, 86, 175–188.
11. Hong-En Qu , Ri-Zhen Huang, Gui-Yang Yao, Jiu-Ling Li, Man-Yi Ye, Heng-Shan Wang*, Liangxian Liu*. Synthesis and pharmacological evaluation of novel bisindole derivatives bearing oximes moiety: Identification of novel proapoptotic agents, Eur. J. Med. Chem., 2015, 95, 400−415.
12. Xiao-Chao Huang, Le Jin, Meng Wang, Dong Liang, Zhen-Feng Chen, Ye Zhang*, Ying-Ming Pan, Heng-Shan Wang*.Design, synthesis and in vitro evaluation of novel dehydroabietic acid derivatives containing a dipeptide moiety as potential anticancer agents. Eur. J. Med. Chem., 2015, 89, 370−385.
13. Shi-Xian Hua, Ri-Zheng Huang, Man-Yi Ye, Ying-Ming Pan, Gui-Yang Yao, Ye Zhang*, Heng-Shan Wang,* Design, synthesis and in vitro evaluation of novel ursolic acid derivatives as potential anticancer agents. Eur. J. Med. Chem., 2015,95, 435−452.
14. Xiaochao Huang, Rizheng Huang, Zhixin Liao, Yingming Pan, Shaohua Gou*, Hengshan Wang*. Synthesis and pharmacological evaluation of dehydroabietic acid thiourea derivatives containing bisphosphonate moiety as an inducer of apoptosis. Eur. J. Med. Chem., 2016, 108, (27), 381-391
15. Xiao-Chao Huang, Meng Wang, Ying-Ming Pan, Gui-Yang Yao, Heng-Shan Wang*, Xiao-Yan Tian, Jiang-Ke Qin, Ye Zhang. Synthesis and antitumor activities of novel thiourea α-aminophosphonates from dehydroabietic acid. Eur. J. Med. Chem., 2013, 69, 508–520.
16. Qiang Wu, Pei Liu, Ying-Ming Pan*, Yan-Li Xu, Heng-Shan Wang*. Cu (otf) 2-catalyzed three-component annulation reaction: One-pot synthesis of 4, 5-dihydropyrazole from aldehydes, hydrazines and alkenes. RSC Advances. 2012, 2: 10167–10170.
17. Wei-Gen Huang, Heng-Shan Wang, Guo-Bo Huang, Yong-Ming Wu, Ying-Ming Pan. Enantioselective friedel–crafts alkylation of n‐methylindoles with nitroalkenes catalyzed by chiral bifunctional abietic‐acid‐derived thiourea‐ZnIIcomplexes. Eur. J. Org. Chem., 2012, 29, 5839–5843.
18. Gui-Yang Yao, Ya-Jun Li, Yong-Tao Zhu, Ying-Ming Pan, Fu-Ping Huang, Hengshan Wang*, Zhi-Xin Liao*. Protonation-controlled axial chirality in maleopimaric imides. New J. Chem., 2014, 38, 693–699.
19. Gui-yang Yao, Man-yi Ye, Ri-zhen Huang, Ya-jun Li, Yong-tao Zhu, Ying-ming Pan, Zhi-Xin Liao*, Heng-shan Wang*. Synthesis and antitumor activity evaluation of maleopimaric acid N-aryl imide atropisomers. Bioorg. Med. Chem. Lett., 2013, 23, 6755-6758
20. Gui-Yang Yao, Man-Yi Ye, Ri-Zhen Huang, Ya-Jun Li, Ying-Ming Pan, Qing Xu, Zhi-Xin Liao*, Heng-shan Wang*. Synthesis and antitumor activities of novel rhein α-aminophosphonates conjugates. Bioorg. Med. Chem. Lett., 2014, 24, 501–507
21. Xiao-Chao Huang, Meng Wang, Heng-Shan Wang, Zhen-Feng Chen, Ye Zhang*, Ying-Ming Pan*. Synthesis and antitumor activities of novel dipeptide derivativesderived from dehydroabietic acid. Bioorg. Med. Chem. Lett., 2014, 24, 1511–1518.
22. Xiao-Chao Huang, Meng Wang,, Ying-ming Pan, Xiao-Yan Tian, Heng-shan Wang*, Ye Zhang*. Synthesis and antitumor activities of novel α-aminophosphonates dehydroabietic acid derivatives. Bioorg. Med. Chem. Lett., 2013, 23(19), 5283–5289.
23. Pan, Yingming*; He, Chunhuan; Wang, Hengshan*; Ji, Xiaowen; Wang, Kai; Liu, Peizhen Antioxidant activity of microwave-assisted extract of Buddleia officinalis and its major active component. Food Chemistry, 2010, 121, 15, 497–502
24. Heng-Shan Wang*, Dian-Hua Gan, Xiao-Pu Zhang, Ying-Ming Pan. Antioxidant capacity of the extracts from pulp of Osmanthus fragrans and its components. LWT - Food Sci. Technol. 2010, 43, 319–325.
25. Ming-Xiong Tan, Dian-hua Gan, Liu-xin Wei, Ying-ming Pan, Shao-qing Tang, Heng-shan Wang*. Isolation and characterization of pigment from Cinnamomum burmannii’peel. Food Res. Int. 2011, 44: 2289–2294.
26. Heng-Shan Wang*, Xiao-Yan Tian, Da Yang, Ying-Ming Pan, Qiang Wu, Chun-Huan He. Synthesis and enantiomeric recognition ability of 22-crown-6 ethers derived from rosin acid and BINOL. Tetrahedron: Asymmetry, 2011, 22(4), 381–386.
27. Qi Gao, Shen-Yan Li, Ying-Ming Pan*, Yan-Li Xu, Heng-Shan Wang*. The indium-catalysed hydration of alkynes using substoichiometric amounts of PTSA as additive. Tetrahedron, 2013, 69(19), 3775–3781.
28. Pei Liu, Ying-Ming Pan*, Kun Hu, Xiao-Chao Huang, Ying Liang, Heng-Shan Wang*. Ligand-free indium(III)-catalyzed Heck reaction. Tetrahedron, 2013, 69(37), 7925–7930.
29. Ying-Chun Wang, Heng-Shan Wang*, Guo-Bao Huang, Fu-Ping Huang, Kun Hu, Ying-Ming Pan*. A one-pot approach to 4,5-dihydropyrazoles from ketones, arylacetylenes, and hydrazines. Tetrahedron, 2014, 70, 1621–1628.
30. Lu-Zhi Liu, Chun-Huan He, Lin Yang, Yan Huang, Qiang Wu, Wen-gui Duan, Heng-shan Wang*, Ying-ming Pan*. Novel C1-symmetric chiral crown ethers bearing rosin acids groups: synthesis and enantiomeric recognition for ammonium salts. Tetrahedron, 2014, 70, 9545–9553.
31. Le Jin, Hong-En Qu, Xiao-Chao Huang, Ying-Ming Pan, Dong Liang, Zhen-Feng Chen, Heng-Shan Wang,* and Ye Zhang*. Synthesis and Biological Evaluation of Novel Dehydroabietic Acid Derivatives Conjugated with Acyl-Thiourea Peptide Moiety as Antitumor Agents, Int. J. Mol. Sci. 2015, 16, 14571-14593.
32. Man-Yi Ye, Gui-Yang Yao, Jing-Chen Wei, Ying-Ming Pan*, Zhi-Xin Liao, Heng-Shan Wang*. Synthesis, cytotoxicity, DNA binding and apoptosis of rhein phosphonate derivatives as antitumor agents. Int. J. Mol. Sci., 2013, 14, 9424–9439.
33. Yajun Li, Caiyi Wang, Manyi Ye, guiyang yao*, Heng-Shan Wang*. Novel coumarin-containing aminophosphonates as antitumor agent: Synthesis, cytotoxicity, DNA-binding and Apoptosis evaluation. Molecules, 2015, 20, 14791-14809
34. Ying-Chun Wang, Lu-Zhi Liu, Ying-Ming Pan, Heng-Shan Wang*. Synthesis of a Dehydroabietyl Derivative Bearing a 2-(2′-Hydroxyphenyl) Benzimidazole Unit and Its Selective Cu2+ Chemosensing. Molecules, 2011, 16 (1), 100–106.
35. Yao, G., Ye, M., Zhu, Y., Liao, Z., & Wang, H. Synthesis and pharmacological evaluation of maleopimaric N-arylimides: Identification of novel proapoptotic agents, Anti-Cancer Agent. Med. Chem., 2015, PMID:26567625
36. Pingtan Lin, Shulin Zhao*, Xin Lu, Fanggui Ye, Hengshan Wang*. Preparation of a dual‐enzyme co‐immobilized capillary microreactor and simultaneous screening of multiple enzyme inhibitors by capillary electrophoresis, J. Sep. Sci., 2013, 36(15): 2538–2543.
37. Ying-Chun Wang, Chun-Hua Su, Fang-Yao Li, Lu-Zhi Liu, Ying-Ming Pan, Xiu-Rong Wu, Heng-Shan Wang*.Syntheses, characterization and fluorescent properties of two series of dehydroabietic acid C-ring derivatives. Spectrochim. Acta A, 2010, 76, 328–335.
38. Xi-Lin Ouyang, L-X Wei , Heng-Shan Wang , Ying-Ming Pan. Antioxidant activity and phytochemical composition of Osmanthus fragrans' pulps. S. Afr. J. Bot., 98 (2015) 162–166.
39. XL Ouyang, XM Fang, YM Pan, LX Wei, HS Wang*, Development of HPLC Fingerprint for the Quality Control of Euonymus fortunei and Distinguishing from Related Species. Acta Chromatogr., 2012, 24(2): 301-316.
40. Rui-Yun Yang, Xi-Lin Ouyang, Dian-Hua Gan, Heng-Shan Wang*, Yi-Zheng Li, Ying-Ming Pan*. Isolation and Determination of Iridoid Glycosides From the Seeds of Osmanthus fragrans by HPLC. Anal. Lett., 2012, 46: 745–752
41. Xi-Lin Ouyang,, Liu-Xin Wei, Xian-Ming Fang, Heng-Shan Wang*, Ying-Ming Pan*. Flavonoid constituents of Euonymus fortune. Chem. Nat. Compd., 2013, 49(3), 428–431.
42. Yingming Pan,*, Zhiren Zhu, Zhili Huang, Hengshan Wang*, Ying Liang, Kai Wang, Qian Lei, Min Liang. Characterisation and free radical scavenging activities of novel red pigment from Osmanthus fragrans’ seeds. Food Chem., 2009, 112: 909–913.2
43. Mingxiong Tan, Jinchan Zhu, Yingming Pan, Zhenfeng Chen, Hong Liang, Huagang Liu, Hengshan Wang*, Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with hesperetin, naringenin and apigenin. Bioinorg. Chem. Appl., 2009, ID 347872
44. Heng-Shan Wang*, Ying-Chun Wang, Ying-Ming Pan, Shu-Lin Zhao and Zhen-Feng Chen. Simultaneous reduction of nitro- to amino group in the palladium-catalyzed Suzuki cross-coupling reaction. Tetrahedron Lett, 2008, 49 (16): 2634–2637.
45. Yi-Zheng Li, Ying-Ming Pan, Xiao-Yan Huang, Heng-Shan Wang*. Withanolides from Physalis alkekengi var. francheti. Helv. Chim. Acta. 2008, 91: 2284－2291.
46. Hengshan Wang, Shulin Zhao*, Min He, Zhicai Zhao, Yingming Pan, Qian Liang. Sodium maleopimaric acid as pseudostationary phase for chiral separations of amino acids derivatives by capillary micellar electrokinetic chromatography. J.Sep. Sci., 2007, 30: 2748-2753.
47. Shulin Zhao, Hengshan Wang, Yingming Pan, Min He, Zhicai Zhao. 3-[(3- Dehydroabietamidopropyl) dimethylammonio] -1-propane-sulfonate as a new type of chiral surfactant for enantiomer separation in micellar electrokinetic chromatography.J. Chromatogr. A, 2007, 1145: 246–249.
48. Hengshan.Wang, Rongcan Zhang, Shulin Zhao*, Lidong Tang and Yingming Pan. Synthesis and application of dehydroabietylisothiocyante as a new chiralderivatizing agent for the enantiomeric separation of chiral compounds by capillary electrophoretic. Anal. Chim. Acta 2006, 560: 64–68.
49. Shulin Zhao*, Rongcan Zhang, Hengshan Wang*, Lidong Tang and Yingming Pan. Capillary electrophoresis enantioselective separation of vigabatrin enantiomers by precolumn derivatization. J. Chromatogr. B, 2006, 833 : 186–190.
50. Shulin Zhao, Hengshan Wang, Rongcan Zhang and Yiming Liu*. Degradingdehydro- abietylisothiocyanate as a chiral derivatizing reagent for enantiomeric separations by capillary electrophoresis, Electrophoresis, 2006, 27, 3428–3433
发明专利：
1. 王恒山; 潘英明; 黎霜. 从罗汉果残渣中提取多种成分，ZL 02133627.X，2004，中国专利授权
2. 王恒山; 童碧海; 潘英明. 松香基吖啶类化合物的合成、其制造方法及其用途， ZL 200410040714.1，2006，中国专利授权
3. 王恒山; 张业; 潘英明. 脱氢松香酸甲酯呋咱衍生物，其合成方法及其用途，申请号：200410081396.3，2004，中国专利
4. 王恒山, 戴伟龙, 潘英明, 姚贵阳, 程克光, 陈振锋, 田小艳. 茜素二氧杂环己烷衍生物及其制备方法和应用. 专利号: 201210324944.5.
5. 王恒山; 潘英明; 黄卫根; 谭恒; 刘志芳; 刘陆智. 脱氢松香基硫脲衍生物及其制备方法和应用 专利号:201010284217
6. 王恒山，黄日镇，潘英明，姚贵阳，戴伟龙，叶鳗仪，陈振锋. 大黄酸氨基膦酸酯衍生物及其合成方法和应用. 专利号:201310475681.2
7. 王恒山, 黄日镇, 潘英明, 姚贵阳, 戴伟龙, 叶鳗仪, 陈振锋. 双乙酰大黄酸氨基膦酸酯衍生物及其合成方法和应用. 专利号201310475685.0
科研项目
1. 973计划前期研究专项(No.2011CB512005)：基于广西主产中药活性成分的手性氨基膦酸酯基抗肿瘤和抗病毒药物的前期研究。
2. 国家自然科学基金(No. 81260472)项目名称: 天然萜烷和氨基酸背景(环)磷酰胺衍生物的手性与肿瘤细胞抑制作用相互关系。
3. 高等学校博士学科点专项科研基金博导类资助课题（No.20134504110002）: 三类天然骨架含氮磷小分子抗肿瘤药物的串联反应合成与活性研究。
4. 国家自然科学基金重点项目（No.21431001）: 基于中药活性成分的金属抗肿瘤配合物研究(第三成员)
获奖情况
1. 王恒山、潘英明、赵书林、梁英、王凯、何春欢，特色桂药抑制活性氧自由基损伤功效物质基础及作用机制的研究与应用，广西自然科学奖三等奖，2012年
2. 潘英明、王恒山、吴强、黄宇平、杨韶平、张业、王迎春、陈键泉、黄晓超. 松香手性产品深加工技术及其生产工艺的研发与应用，广西科技进步奖二等奖，2015年
3. 方显明、谢金鲜、覃振林、方兴、王恒山、唐友明、兰树彬、欧阳熙林、韦斌，广西特色壮药经血宁胶囊的研发与临床应用，广西科技进步奖二等奖，2014年
4. 赵书林、叶芳贵、卢 昕、田建袅、李舒婷、王恒山，微流控芯片和毛细管电泳新方法及其在单细胞和体液分析中的应用研究，广西自然科学奖二等奖，2010年
5. 赵书林、李舒婷、王恒山等，毛细管电泳新技术及其在生物和药物分析中的应用研究，广西科技进步奖二等奖，2007年
6. 张业、义祥辉、覃雯、潘英明、王恒山、程忠泉、陈力健，基于白藜芦醇骨架改造的化合物的制备及其抗氧化、抗肿瘤活性研究，广西科技进步奖三等奖，2014年
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发表于 2017-11-5 09:09:45
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