浙江大学化学系洪鑫

guiruyou

洪鑫,浙江大学特聘研究员。2010年毕业于中国科学技术大学化学系，2014年于美国加州大学洛杉矶分校获得有机化学博士学位，之后分别于美国加州大学洛杉矶分校、斯坦福大学进行博士后研究工作。2016年6月加入浙江大学化学系，任特聘研究员，博士生导师。洪鑫研究员主要从事过渡金属催化反应机理研究以及基于人工智能的高通量反应虚拟筛选和设计。独立工作以来，以通讯作者和共同通讯作者身份在 J. Am. Chem. Soc., Angew. Chem. Int. Ed. 等期刊发表科研论文42篇，H因子24。曾获加州大学洛杉矶分校Saul and Sylvia Winstein Dissertation Award，中国化学会物理有机化学新人奖。



姓名：洪鑫
单位：浙江大学化学系
个人简介
主要学习经历：
2006-2010 中国科技大学 本科 化学，导师：傅尧教授
2010-2014 加州大学洛杉矶分校 博士 有机化学， 导师： Kendall N. Houk 美国科学院院士，世界上研究物理有机化学最著名的几位学者之一
主要工作经历：
2014-2015 加州大学洛杉矶分校 博士后， 导师： Kendall N. Houk 美国科学院院士
2015-2016 斯坦福大学 博士后，导师： Jens K. Norskov 美国工程院外籍院士，世界上研究异相催化化学机理和催化剂设计最著名的几位学者之一
主要荣誉：
2016 入选第十二批“国家青年##”计划
2014 Invited Speech in Graduate Research Symposium, ACS Org. Chem. Division， UCLA 化学仅选两名代表
2014 Saul and Sylvia Winstein Dissertation Award, UCLA，全系有机毕业生最高荣誉
2013        Christopher Foote Fellowship, UCLA
2012 Excellence in Second Year Academics and Research, UCLA
2010        Excellent Undergraduate Thesis, USTC
2008 First Prize Scholarship, USTC
2007        Chinese National Scholarship, Chinese Ministry of Education
欢迎本科生来组开展研究探索和毕业设计
每年计划招收博士生（含硕博连读生）3名，硕士生2名
招收多名博士后和研究助理，待遇面谈
(办公室）浙江省杭州市天目山路148号浙大西溪校区西七431
欢迎来电或者通过hxchem@zju.edu.cn联系和商讨加入事宜。
工作研究领域
通过计算化学的手段研究有机化学和催化领域前沿的转化反应，从原子层面揭示反应发生的途径和方式，在理解反应的基础之上提出控制活性和选择性的决定因素，进而指导反应和催化剂设计。主要关注的反应涉及选键活化、有机小分子催化、自由基化学和二氧化碳的催化还原。此外，课题组还从事数据库建设和机器学习在指导催化剂和反应设计方面的工作。
联系方式
电话：13735445027
电子信箱：hxchem@zju.edu.cn


发表论文
1. Nickel-catalyzed Amination of Aryl Carbamates and Sequential Site-selective Cross-couplings
Mesganaw, T.; Silberstein, A. L.; Ramgren, S. D.; Nathel, N. F. F.; Hong, X.; Liu, P.; Garg, N. K.* Chemical Science 2011, 2, 1766.
2. Mechanism and Origins of Ligand-Controlled Selectivities in [Ni(NHC)]-Catalyzed Intramolecular (5+2) Cycloadditions and Homo-Ene Reactions: A Theoretical Study
Hong, X.; Liu, P.; Houk, K. N.* Journal of the American Chemical Society 2013, 135, 1456.
3. Mechanism and Origins of Selectivity in Ru(II)-Catalyzed Intramolecular (5+2) Cycloadditions and Ene Reactions of Vinylcyclopropanes and Alkynes from Density Functional Theory
Hong, X.; Trost, B. M.*; Houk, K. N.* Journal of the American Chemical Society 2013, 135, 6588.
4. Distortion-Accelerated Cycloadditions and Strain-Release-Promoted Cycloreversions in the Organocatalytic Carbonyl-Olefin Metathesis
Hong, X.; Liang, Y.; Griffith, A. K.; Lambert, T. H.; Houk, K. N.* Chemical Science 2014, 5, 471.
5. Mechanisms and Origins of Switchable Chemoselectivity of Ni-Catalyzed C(aryl)-O and C(acyl)-O Activation of Aryl Esters with Phosphine Ligands
Hong, X.; Liang, Y.; Houk, K. N.* Journal of the American Chemical Society 2014, 136, 2017.
6. How Tethers Control the Chemo- and Regioselectivities of Intramolecular Cycloadditions between Aryl-1-Aza-2-Azoniaallenes and Alkenes
Hong, X.; Liang, Y.; Brewer, M.*; Houk, K. N.* Organic Letters 2014, 16. 4260.
7. Mechanism and Selectivity of N-triflylphosphoramide Catalyzed (3++2) Cycloaddition between Hydrazones and Alkenes
Hong, X.; Küçük, H. B.; Maji, M. S.; Yang. Y. –F.; Rueping, M.*; Houk, K. N.* Journal of the American Chemical Society 2014, 136, 13769.
8. Mechanism, Reactivity, and Selectivity of Nickel-Catalyzed [4+4+2] Cycloadditions of Dienes and Alkynes
Hong, X.; Holte, D.; Götz, D. C. C. G.; Baran, P. S.*; Houk, K. N.* The Journal of Organic Chemistry 2014, 79, 12177.
9. Why Alkynyl Substituents Dramatically Accelerate Hexadehydro-Diels–Alder (HDDA) Reactions: Stepwise Mechanisms of HDDA Cycloadditions
Liang, Y.; Hong, X.; Yu, P.; Houk, K. N.* Organic Letters 2014, 16. 5702. (co-first author)
10. Reactivity and Chemoselectivity of Allenes in Rh (I)-Catalyzed Intermolecular (5+2) Cycloadditions with Vinylcyclopropanes: Allene-Mediated Rhodacycle Formation Can Poison Rh (I)-Catalyzed Cycloadditions
Hong, X.; Stevens, M. C.; Liu, P.; Wender, P. A.*; Houk, K. N.* Journal of the American Chemical Society 2014, 136, 17273.
11. [Ni(NHC)]-catalyzed Cycloaddition of Diynes and Tropone: Apparent Enone Cycloaddition Involving an 8π Insertion
Kumar, P.; Thakur, A.; Hong, X.; Houk, K. N.*; Louie, J.* Journal of the American Chemical Society 2014, 136, 17844.
12. Iodoarene-Catalyzed Stereospecific Intramolecular sp3 C–H Amination: Reaction Development and Mechanistic Insights
Zhu, C.; Liang, Y.; Hong, X.; Sun, H.; Sun, W. –Y.; Houk, K. N.; Shi, Z. Journal of the American Chemical Society 2015, 137, 7564.
13. Conversion of Amides to Esters by the Nickel-Catalyzed Activation of Amide C–N Bonds
Hie, L.; Nathel, N. F. F.; Shah, T. K.; Baker, E. L.; Hong, X.; Yang, Y. –F.; Liu, P.; Houk, K. N.*; Garg, N. K.* Nature 2015, 524, 79.
14. Mechanism and Dynamics of Intramolecular C-H Insertion Reactions of 1-Aza-2-azoniaallenes Salts
Hong, X.; Bercovici, D.; Yang, Z.; Al-Bataineh, N.; Srinivasan, R.; Dhakal, R. C.; Houk, K. N.*; Brewer, M.* Journal of the American Chemical Society 2015, 137, 9100.
15. Computational Exploration of Mechanism and Selectivities of (NHC)Nickel(II)hydride-Catalyzed Hydroalkenylations of Styrene with α-Olefins
Hong, X.; Wang, J.; Yang, Y. –F.; He, L.; Ho, C. –Y.; Houk, K. N. ACS Catalysis 2015, 5, 5545.
16.        Conversion of Amides to Esters by the Nickel-Catalysed Activation of Amide C-N Bonds
Hie, L.; Fine Nathel, N. F.; Shah, T. K.; Baker, E. L.; Hong, X.; Yang, Y.-F.; Liu, P.; Houk, K. N.; Garg, N. K. Nature 2015, 524, 79.
17.        Ligand-Controlled Diastereoselective 1,3-Dipolar Cycloadditions of Azomethine Ylides with Methacrylonitrile
Walton, M. C.; Yang, Y.-F.; Hong, X.; Houk, K. N.; Overman, L. E. Org. Lett. 2015, 17, 6166.
18.        Mechanistic Insights into Two-Phase Radical C–H Arylations
Baxter, R. D.; Liang, Y.; Hong, X.; Brown, T. A.; Zare, R. N.; Houk, K. N.; Baran, P. S.; Blackmond, D. G. ACS Cent. Sci. 2015, 1, 456.
19.        Conversion of Amides into Esters by the Nickel-Catalyzed Activation of Amide C-N Bonds
Garg, N.; Houk, K. N.; Baker, E. L.; Nathel, N. F.; Hie, L.; Hong, X.; Liu, P.; Shah, T. K.; Yang, Y.-F. Synlett. 2016, 27, A3.
20.        Nickel-Catalyzed Activation of Acyl C−O Bonds of Methyl Esters
Hie, L.; Fine Nathel, N. F.; Hong, X.; Yang, Y.-F.; Houk, K. N.; Garg, N. K. Angew. Chem. Int. Ed. 2016, 55, 2810.