苏州大学纳米科学技术学院彭睿

dexi

彭睿,苏州大学教授。1996年获南京大学理学学士学位；1999年获南京大学理学硕士学位；2005年获美国范德比尔特大学(Vanderbilt University) 分子生物学博士学位。2008年10月加入苏州大学功能纳米与软物质研究院，被聘为副教授、硕士生导师。

彭睿
教授 博士生导师

1996年获南京大学理学学士学位；

1999年获南京大学理学硕士学位；

2005年获美国范德比尔特大学（Vanderbilt University）分子生物学博士学位。

2008年10月加入苏州大学功能纳米与软物质研究院。

  

课题组内教师：许利耕

研究领域：
纳米生物学，分子生物学

研究方向：
纳米生物界面；纳米材料的生物学效应与调控；纳米材料的免疫学效应及应用；基于纳米载体的肿瘤免疫治疗

主要成果和技术贡献：
        在多年分子细胞生物学研究的基础上，结合纳米技术，在纳米生物学领域开展了系统深入的研究，从对纳米生物界面的深入理解出发，研究纳米生物界面的精确设计与精细调控，揭示其对纳米材料生物学效应的调控机制；在此基础上，开发相应的生物医学应用。揭示了不同碳基纳米材料与多种蛋白质、真核细胞、原核生物之间的相互作用及分子作用机制，并据此开发出其在酶工程、抗菌、微生物工程等方面的新型应用。系统研究了多种纳米材料的免疫学效应，发展了多种新型纳米载体用于肿瘤免疫联合治疗。

学术论文40余篇，发表于ACS Nano, Nat. Commun., Adv. Mater., Adv. Drug Deliver. Rev., Small, Biomaterials, Nano Res., Nanoscale, ACS Appl. Mater. Inter., J. Biol. Chem., RNA等材料和生物领域的国际权威期刊。授权国家发明专利2项。承担NSFC面上、重点及重大研究计划培育项目、国家973项目、重点研发专项、教育部基金等7项。

近五年代表性论文：

1. Yonghui Wang, Jun Xu, Ligeng Xu, Xiaofang Tan, Liangzhu Feng, Yinchan Luo, Jian Liu, Zhuang Liu, Rui Peng*. Functionalized graphene oxide triggers cell cycle checkpoint control through both the ATM and the ATR signaling pathways, Carbon, 2017, doi: 10.1016/j.carbon.2017.12.012

2. Jun Xu, Ligeng Xu,* Chenya Wang, Rong Yang, Qi Zhuang, Xiao Han, Ziliang Dong, Wenwen Zhu, Rui Peng*, and Zhuang Liu*. Near-Infrared-Triggered photodynamic therapy with multi-tasking upconversion nanoparticles in combination with checkpoint blockade for immunotherapy of colorectal cancer. ACS Nano, 2017, 11, 4463�4474

3. Guangbao Yang, Ligeng Xu, Yu Chao, Jun Xu, Xiaoqi Sun, Yifan Wu, Rui Peng & Zhuang Liu*. Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses. Nat. Commun., 2017, 8, 902

4. Qian Chen,‡ Ligeng Xu,‡ Chao Liang, Chao Wang, Rui Peng & Zhuang Liu*. Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy. Nat. Commun., 2016, 7, 13193

5. Ligeng Xu, Jian Xiang, Ye Liu, Jun Xu, Yinchan Luo, Liangzhu Feng, Zhuang Liu* and Rui Peng*, Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity. Nanoscale, 2016, 8, 3785 (2016 Hot Articles in Nanoscale)

6. Yinchan Luo, Xinxing Yang, Xiaofang Tan, Ligeng Xu*, Zhuang Liu, Jie Xiao, Rui Peng*, Functionalized graphene oxide in microbial engineering: An effective stimulator for bacterial growth, Carbon, 2016, 13, 172-180

7. Ligeng Xu, Jian Xiang, Rui Peng*, Zhuang Liu.* Recent advances in the development of nanomaterials for DC-based immunotherapy. Sci. Bull., 2016, 61, 514-523

8. Jian Xiang, Ligeng Xu*, Hua Gong, Wenwen Zhu, Chao Wang, Jun Xu, Liangzhu Feng, Liang Cheng, Rui Peng*, and Zhuang Liu*, Antigen-Loaded Upconversion Nanoparticles for Dendritic Cell Stimulation, Tracking, and Vaccination in Dendritic Cell-Based Immunotherapy. ACS Nano, 2015, 9, 6401�6411

9. Kai Yao, Pengli Tan, Yinchan Luo, Liangzhu Feng, Ligeng Xu, Zhuang Liu, Youyong Li*, and Rui Peng*, Graphene Oxide Selectively Enhances Thermostability of Trypsin. ACS Appl. Mater. Interfaces, 2015, 7, 12270�12277

10. Hua Gong, Jian Xiang, Ligeng Xu,* Xuejiao Song, Ziliang Dong, Rui Peng* and Zhuang Liu*, Stimulation of immune systems by conjugated polymers and their potential as an alternative vaccine adjuvant. Nanoscale, 2015,7, 19282-19292

11. Fei Tian, Guangcun Chen, Peiwei Yi, Jichao Zhang, Aiguo Li, Jing Zhang, Lirong Zheng, Zongwu Deng, Qin Shi*, Rui Peng*, and Qiangbin Wang*. Fates of Fe3O4 and Fe3O4@SiO2 Nanoparticles in Human Mesenchymal Stem Cells Assessed by Synchroton Radiation-Based Techniques. Biomaterials, 2014, 35, 6412-6421

12. Chao Wang, Ligeng Xu, Chao Liang, Jian Xiang, Rui Peng, and Zhuang Liu*. Immunological Responses Triggered by Photothermal Therapy with Carbon Nanotubes in Combination with Anti-CTLA-4 Therapy to Inhibit Cancer Metastasis. Adv. Mater., 2014, 26, 8154�8162

13. Tengfei Tian, Xiaoze Shi, Liang Cheng, Yinchan Luo, Ziliang Dong, Hua Gong, Ligeng Xu, Zengtao Zhong, Rui Peng*, and Zhuang Liu*. Graphene-Based Nanocomposite As an Effective, Multifunctional, and Recyclable Antibacterial Agent. ACS Appl. Mater. Interfaces, 2014, 6, 8542�8548

14. Liming Qu, Jinhai Xu, Xiaofang Tan, Zhuang Liu, Ligeng Xu*, and Rui Peng*. Dual-Aptamer Modification Generates a Unique Interface for Highly Sensitive and Specific Electrochemical Detection of Tumor Cells. ACS Appl. Mater. Interfaces, 2014, 6, 7309-7315

15. Shuai Fang, Chao Wang, Jian Xiang, Liang Cheng, Xuejiao Song, Ligeng Xu, Rui Peng*, and Zhuang Liu*. Aptamer-conjugated upconversion nanoprobes assisted by magnetic separation for effective isolation and sensitive detection of circulating tumor cells. Nano Res., 2014, 7, 1327-1336

16. Yanfeng Zhou, Xiangxu Jiang, Jia Tang, Yuanyuan Su, Fei Peng, Yimei Lu, Rui Peng*, and Yao He*. A Silicon-Based Antibacterial Material of Robust and High Antibacterial Activity. J. Mater. Chem. B, 2014, 2, 691-697

17. Ligeng Xu, Liang Cheng, Chao Wang, Rui Peng*, and Zhuang Liu*. Conjugated polymers for photothermal therapy of cancer. Polym. Chem., 2014, 5, 1573-1580 (2014's most accessed Polymer Chemistry Top10 articles) （邀请综述）

18. Hua Gong, Rui Peng*, Zhuang Liu*, Carbon nanotubes for biomedical imaging:  The recent advances. Adv. Drug Deliver. Rev. 2013, 65, 1951-63 （邀请综述）

19. Kai Yang, Yingjie Li, Xiaofang Tan, Rui Peng* and Zhuang Liu*, Behavior and Toxicity of Graphene and Its Functionalized Derivatives in Biological Systems. Small, 2013, 9: 1492-1503

20. Liangzhu Feng, Xianzhu Yang, Xiaozhe Shi, Xiaofang Tan, Rui Peng, Jun Wang*, Zhuang Liu*, Polyethylene Glycol and Polyethylenimine Dual-Functionalized Nano-Graphene Oxide for Photothermally Enhanced Gene Delivery. Small, 2013, 9, 1989-1997

21. Jia Tang, Qian Chen, Ligeng Xu, Shuai Zhang, Liangzhu Feng, Liang Cheng, Huan Xu, Zhuang Liu* and Rui Peng*, Graphene oxide-silver nanocomposite as a highly effective antibacterial agent with species-specific mechanisms. ACS Appl. Mater. Interfaces, 2013, 5, 3867�3874

22. Xiaofang Tan, Liangzhu Feng, Jing Zhang, Kai Yang, Shuai Zhang, Zhuang Liu* and Rui Peng*. Functionalization of Graphene Oxide Generates a Unique Interface for Selective Serum Protein Interactions. ACS Appl. Mater. Interfaces, 2013, 5, 1370�1377

23. Jing Zhang, Liangzhu Feng, Xiaofang Tan, Xiaozhe Shi, Ligeng Xu, Zhuang Liu* and Rui Peng*, Dual-Polymer-Functionalized Nanoscale Graphene Oxide as a Highly Effective Gene Transfection Agent for Insect Cells with Cell-Type-Dependent Cellular Uptake Mechanisms, Part. & Part. Syst. Char., 2013, 30, 794�803.

24. Liling Jin, Kai Yang, Kai Yao, Shuai Zhang, Huiquan Tao, Shuit-Tong Lee, Zhuang Liu* and Rui Peng*. Functionalized Graphene Oxide in Enzyme Engineering: A Selective Modulator for Enzyme Activity and Thermostability. ACS Nano, 2012, 6, 4864�4875  (Nanowerk亮点报道)

shenzhen