蔡乐,云南大学教授。2000、2003和2006年先后获华西医科大学理学学士、四川大学理学硕士和博士学位。2007年至今在云南大学化学科学与工程学院工作。研究领域:微生物发酵改性中药材,微生物转化反应以及天然药物化学研究。
蔡乐(博士,教授,硕士生导师) 专业:分析化学 团队:分离分析团队 电话:0871-65033719 受教育经历及工作经历: 2000、2003和2006年先后获华西医科大学理学学士、四川大学理学硕士和博士学位; 2007年,云南大学化学科学与工程学院工作。 教学: 主讲《药用植物学》、《微生物学概论》和《化合物结构鉴定与表征》。 研究领域和兴趣: 微生物发酵改性中药材,微生物转化反应以及天然药物化学研究。 论文、专著: [1] Cai, Le; Zhao, Mian; Liu,Shi-Xi Yin, Tian-Peng Zhou, Hao; Dong, Jian-Wei; Yang, Ya-Bin; Ding, Zhong-Tao*Pashinintide A, the first plant cyclopeptide from Rosaceae, included a sucrose,suggests a new natural receptor for saccharide. Tetrahedron Letters 2014, 55,6231-6235. [2] Dong, Jian-Wei; Cai, Le*;Xiong, Jie; Chen, Xiu-Hua Wang, Wei-Ying; Shen, Ni; Liu, Bei-Lei; Ding,Zhong-Tao* Improving the antioxidant and antibacterial activities offermented Bletilla striata with Fusarium avenaceum and Fusariumoxysporum.Process Biochemistry 2015, 50, 8-13. [3] Dong, Jian-Wei; Cai, Le*;Zhu, Xiu-Fang, Huang, Xing, Yin, Tian-Peng, Fang, Hai-Xian; Ding, Zhong-Tao*Antioxidant activities and phenolic compounds of Cornhusk, Corncob and StigmaMaydis. Journal of the Brazilian Chemical Society2014,25,1956-1964. [4] Cai, Le; Liu, Chuan-Shui;Fu, Xiao-Wei; Shen, Xiao-Jing; Yin, Tian-Peng; Yang, Ya-Bin; Ding, Zhong-Tao*.Two new glucosides from the pellicle of the walnut (Juglans regia). NaturalProduct and Bioprospecting2012, 2, 150-153 [5] Cai, Le, Fang, Hai-Xian,Yin, Tian-Peng, Yu, Jing, Li, Zhen-Jie, Dong, Jian-Wei, Ding, Zhong-Tao*. UnusualC19-diterpenoid alkaloids from Aconitum vilmorinianum var. patentipilum. PhytochemistryLetters2015, 14, 106-110. [6] Yang, Ming-Hui; Fang, Yun-Shan; Cai,Le*; Li, Ying; Dong, Jian-Wei; Yin, Tian-Peng; Huang, Cai-Li; Ding,Zhong-Tao. A new flavone C-glycoside and a new bibenzyl from Bulbophyllumretusiusculum. Natural Product Research 2016, 30,1617–1622. [7] Cai, Le; Dong, Jian-Wei;Zhao, Li- Xing; Zhou, Hao; Xing, Yun; Li, Ying; Li, Zhen-Jie; Duan, Wei-He; Li,Xue-Jiao; Ding, Zhong-Tao. An improved water-soluble/stereospecificbiotransformation of aporphine alkaloids in Stephania epigaea to4R-hydroxyaporphine alkaloids by Clonostachys rogersoniana. ProcessBiochemistry 2016, 51, 933-940. [8] Xing, Yun; Cai, Le*; Yin,Tian-Peng; Chen, Yang; Yu, Jing; Wang, Ya-Rong; Ding, Zhong-Tao*. Improving theantioxidant activity and enriching salvianolic acids by the fermentationof Salvia miltiorrhizae with Geomyces luteus. Journalof Zhejiang University-Science B (Biomedicine &Biotechnology) 2016, 17, 391-398. [9] Dong, Jian-Wei; Cai, Le*;Xing, Yun; Yu, Jing; Ding, Zhong-Tao. Re-evaluation of ABTS*+ Assay for TotalAntioxidant Capacity of Natural Products. Natural productcommunications 2015, 10, 2169-2172. [10] Yin, Tian-Peng, Cai, Le,Fang, Hai-Xian, Fang, Yun-Shan, Li, Zhen-Jie, Ding, Zhong-Tao*. Diterpenoidalkaloids fromAconitum vilmorinianum. Phytochemistry 2015,116, 314-319. [11] Li, Ying, Cai, Le, Dong,Jian-Wei, Xing, Yun, Duan, Wei-He, Zhou, Hao, Ding, Zhong-Tao*. Innovative approachto the accumulation of rubrosterone by fermentation of Asparagusfilicinus with Fusarium oxysporum. Journal ofAgricultural and Food Chemistry 2015, 63, 6596-6602. [12] 马迎聪,俞静,王家鹏,蔡乐*,丁中涛.韭菜根的化学成分研究.中国药学杂志 2016, 51, 972-975. [13] 韦琨,蔡乐*,刘金,周皓,曹秋娥.我校新开教学实验“荷包牡丹碱的分离纯化”的设计.中国医药导报 2016, 13, 167-169. 科研项目、成果和专利: 1.苏铁蕨活性成分研究以及brainicineB 及其异构体的合成研究,国家自然科学基金(21002084),2011.1-2013.12。(负责,已结题) 2.四种滇产乌头的发酵改性及发酵乌头的镇痛抗炎活性物质基础研究,国家自然科学基金(81460648),2015.1-2018.12。(负责,在研) 3.棠梨花和短瓣兰的抗肿瘤和抗氧化活性成分研究,云南省自然科学基金(2010CD017),2015.1-2018.12。(负责,在研) 4.丁中涛,蔡乐,李莹.“通过尖孢镰刀菌发酵改性小百部富集红苋甾酮的新方法”,中国发明专利,专利号:201510284205.1。 5.丁中涛,蔡乐,李振杰.“苯丙烯酸类化合物顺反两种异构体相互转化的方法”,中国发明专利,专利号:201610362724.X。 6.丁中涛,蔡乐,董建伟.“通过Clonostachyssp. 发酵转化荷包牡丹碱为(4S,6aR)-4-羟基荷包牡丹碱的方法”,中国发明专利,专利号:201610361978.X。
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