清华大学材料学院王秀梅

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王秀梅，女，36岁，工学博士，清华大学材料学院教授。1996年从吉林考入清华大学材料科学与工程系，于2000年和2005年分别获得工学学士和工学博士学位。2005年7月至2006年6月在美国罗切斯特大学骨科研究中心从事博士后研究。2006年6月至2008年1月在美国麻省理工学院生物医学工程中心从事博士后研究。2008年1月在清华大学工作至今。长期从事生物材料基础研究及生物医用材料产品开发，主要包括组织工程与再生医学及生物矿化机理研究等。主持或参加多项国家973、863、“十二五”科技支撑计划、国家自然科学基金项目的研究工作。曾荣获2011年度国家自然科学二等奖（第二完成人）、2010年度北京市科学技术奖二等奖（第二完成人）、2010-2011年度中华医学科技奖三等奖（第四完成人）、2012年度清华大学“学术新人奖”，入选教育部2013年度“新世纪优秀人才支持计划”和第12届霍英东教育基金会青年教师基金。已发表生物材料研究相关学术论文、专利、书籍等70多篇（部），其中在Biomaterials, Acta Biomaterialia, Nanoscale，Soft Matter, Nano today等国际著名期刊上发表SCI收录论文48篇。此外，目前担任期刊Current Tissue Engineering亚洲区域编辑，《中国组织工程研究》执行编委，中国生物材料学会学术委员会秘书长，青年委员会委员，科普委员会委员。
【联系方式】
联系电话: 010-62782966 （逸夫楼2812房间）
传真: 010-62771160
E-mail: wxm@tsinghua.edu.cn
个人主页：MSE/wangxiumei

教育背景
09/2000-01/2005：清华大学 材料科学与工程专业 博士学位
09/1996-07/2000：清华大学 材料科学与工程专业 学士学位

工作履历
12/2013至今：清华大学材料学院，教授，博士生导师
12/2008-12/2013：清华大学材料学院，副教授，硕士生导师
01/2008-12/2008：清华大学材料学院，讲师，硕士生导师
06/2006-01/2008：美国麻省理工学院 生物医用工程中心 博士后研究员
07/2005-06/2006：美国罗切斯特大学 医学院骨骼肌肉研究中心 博士后研究员

学术兼职
中国生物材料学会，学术委员会秘书、青年委员会委员、科普委员会委员
中国硅酸盐学会特种陶瓷分会，理事
期刊Current Tissue Engineering，Regional Editor of Asia
期刊Frontiers of Materials Science, Editor
期刊Regenerative Biomaterials, Managing Editor
《中国组织工程研究》期刊，执行编委
期刊Biomedical Materials、Journal of Biomaterials and Tissue Engineering，Guest Editor
全国外科植入物和矫形器械标准化技术委员会组织工程医疗器械产品分技术委员会骨再生标准工作组专家

研究领域
主要从事生物材料基础研究及生物医用材料开发，主要包括（1）组织工程与再生医学（神经损伤修复；促血管生成；骨组织工程）；（2）生物矿化机理研究；（3）纳米生物材料-干细胞相互作用。

奖励与荣誉
2011 年度国家自然科学二等奖（2011-Z-108-2-03第二完成人）
2011 年度中华医学科技奖三等奖（201103069U0201第四完成人）
2010 年度北京市科学技术奖二等奖（2010材-2-004第二完成人）
2012 年度清华大学“学术新人奖”
入选2013 年度教育部“新世纪优秀人才”支持计划
第12届霍英东教育基金会青年基金奖（霍英东教育基金会）
2009-2010年度北京高校优秀辅导员（中国北京市教委）
2009.12：首都国庆60周年群众游行优秀工作者称号（首都国庆60周年群众游行指挥部）
2012年：清华大学优秀招生新人奖（清华大学）
2009年：清华大学“刘述礼育才奖”（清华大学）
2003年：清华大学“一二九优秀辅导员奖”（清华大学）

学术成果
【学术成果】
专著（章节）
1. Wang XM, Yao SL, Guan FY. Hyaluronic acid-based scaffolds for brain tissue engineering. Hyaluronic Acid for Biomedical and Pharmaceutical Applications. Chapter 6. Edited by Maurice N. Collins. 2014, Smithers Rapra.
2. Wang XM, Liu ZX, Cui FZ. Biomimetic synthesis of self-assembled mineralized collagen based composites for bone tissue engineering. Biomimetics: Advancing Nanobiomaterials and Tissue Engineering. Chapter 2. Edited by Ramalingam M, Wang XM, Chen GP, Ma P, and Cui FZ. 2013, Wiley-Scrivener Publishing, USA.
3. Gelain F. Wang XM, Horii A, et al. Designer self-assembling peptide scaffolds for 3D tissue cell cultures. Methods in Bioengineering: 3D Tissue Engineering. Chapter 4, pp. 59-81. Edited by Berthiaume F. and Morgan J. 2010, Artech House.
4. Horri A, Wang XM, and Zhang SG. Desinger self-assembling peptide scaffolds for tissue engineering and regenerative medicine. Nanotechnology and Tissue Engineering: The Scaffold. Chapter 11, pp. 283-294. Edited by Laurencin C.T. and Nair L.S. 2008, CRC Press.
5. Cui FZ and Wang XM. Mechanical and structural properties of skeletal bone in wild-type and mutant zebrafish (Danio rerio). Handbook of Biomineralization. pp. 381-396. Edited by E. Bauerlein. 2007, Wiley-VCH.
6. 崔福斋，王秀梅。《组织诱导性生物材料国际发展动态》，第11章，2010年，科学出版社。
7. 王秀梅。《中国新材料产业发展报告（2009）》，第10章，2009年，化学工业出版社。
8. 崔福斋，王秀梅，胡堃。《基因材料》，2005，化工出版社。
学术论文（部分）
1. Wang RH, Wang Q, Wang XM*, et al. Enhancement of nano-hydroxyapatite bonding to dentin through a collagen/calcium dual-affinitive peptide for dentinal tubule occlusion. Journal of Biomaterials Applications. 2014. DOI: 10.1177/0885328214523057.
2. Tao H, Zhang Y, Wang C, Zhang C, Wang XM, et al. Biological evaluation of human degenerated nucleus pulposus cells in functionalized self-assembling peptide nanofiber hydrogel scaffold. Tissue Eng Part A. 2014 DOI: 10.1089/ten.tea.2013.0279.
3. Liu X, Wang XM*, Wang XJ, et al. Functionalized self-assembling peptide nanofiber hydrogels mimic stem cell niche to control human adipose stem cells behaviors in vitro. Acta Biomaterialia. 2013. 9: 6798-6805.
4. Liu X, He J, Zhang SM, Wang XM*, et al. Adipose stem cells controlled by surface chemistry. Journal of Tissue Engineering and Regenerative Medicine. 7(2): 112-117; 2013.
5. Xiao YY, Zhang WZ, Wang XM*, et al. Optimized Preparation of Thiolated Hyaluronic Acid Hydrogel with Controllable Degree of Substitution. Journal of Biomaterials and Tissue Engineering. 2014. Accepted.
6. Peng C, Alec N, Zhao MM, Cai Qiang, Yao YW, Wang XM, Sun XD. A novel inorganic gatekeeper strategy for obtaining controlled release in mesoporous silica nanoparticles. Chemistry Letters. 2014.
7. Lian XJ, Liu HY, Wang XM*, et al. Antibacterial and biocompatible properties of vancomycin-loaded nano-hydroxyapatite/collagen/poly (lactic acid) bone substitute (VCM/nHAC/PLA). Progress in Natural Science-Materials International. 2013. 23(6): 549-556.
8. Yao SL, Liu X, Wang XM*, et al. Directing neural stem cell fate with biomaterial parameters for injured brain regeneration. Progress in Natural Science-Materials International. 2013. 23(2):103-112.
9. Yao SL, Wang XM*, Liu X, et al. Effects of ambient relative humidity and solvent properties on the electrospinning of pure hyaluronic acid nanofibers. Journal of nanoscience and nanotechnology. 2013. 13, 4752-4758.
10. Yu XL, Xu SJ, Shao JD, Du C*, Chen SF, Zhang B, Wang YX, Wang XM*. Different fate of cancer cells on several chemical functional groups. Surface & Coatings Technology. 228, s48-s54; 2013.
11. Yan HJ, He J, Yin YB, Wang XM*, et al. Self-assembled monolayers with different chemical group substrates for the study of MCF-7 breast cancer cell line behavior. Biomedical Materials. 2013, 8(3), 035008.
12. Liu JH, Mao KZ, Liu ZS, Wang XM, et al. Injectable Biocomposites for Bone Healing in Rabbit Femoral Condyle Defects. PLOS ONE. 2013, 8(10), e75668.
13. Li LH, Deng YH, He J, Lan GB, Li M, Yang XM, Cui FZ, Zhang Y, Wang XM, Xia H. Influence of Surface Chemistry on the Biological Feature of Giant Cell Tumor of Bone Stromal Cells In Vitro. Journal of biomaterials and tissue engineering. 2013. 3(5): 554-563.
14. Bai B, He J, Li YS, Wang XM, et al. Activation of the ERK1/2 Signaling Pathway during the Osteogenic Differentiation of Mesenchymal Stem Cells Cultured on Substrates Modified with Various Chemical Groups. BioMed Research International. 2013. http://dx.doi.org/10.1155/2013/361906.
15. Wu DJ, Liu ZX, Gao CZ, Shen XC, Wang XM*, Liang H*. Effect of Methyl and Hydroxyl Functional Group Surfaces on Crystallization of Hydroxyapatite Coating. Surface & Coatings Technology. 2013, 228, s24-s27.
16. Zhou Q, Yu XL, Cao Y*, Yang L, Wang XM*, Li JB, Liu ZX. Effects of functional groups on the crystallization of ferric (oxyhydr) oxides. Surface & Coatings Technology. 228, s44-s47; 2013.
17. Liu X, Wang XM*, Horii A, et al. In vivo studies on angiogenic activity of two designer self-assembling peptide scaffold hydrogels in the chicken embryo chorioallantoic membrane. Nanoscale. 2012, 4 (8), 2720- 2727.
18. Wang XM*, He J, Wang Y, and Cui FZ. Hyaluronic acid-based scaffold for central neural tissue engineering. Interface Focus. 2012, 2, 278-291.
19. He J, Wang XM*, Sepctor M, and Cui FZ. Scaffolds for central nervous system tissue engineering. Frontiers of Materials Science. 2012. 6(1): 1-25.
20. Deng H#, Wang XM#, Du C, et al. Combined effect of ion concentration and functional groups on the surface chemistry modulated CaCO3 crystallization. CrystEngComm.14, 6647-6653; 2012.
21. Liu ZX#, Wang XM#, Wang Q, et al. Evolution of calcium phosphate crystallization on three functional group surfaces with the same surface density. CrystEngComm. 14, 6695-6701; 2012.
22. Kong XD, Xu SJ, Wang XM, et al. Calcium carbonate microparticles used as a gene vector for delivering p53 gene into cancer cells. Journal of Biomedical Materials Research Part A. 100A (9): 2312-2318; 2012.
23. Hu NM, Chen ZG, Liu X, Liu HY, Lian JL, Wang XM, and Cui FZ. Mechanical properties and in vitro bioactivity of injectable and self-setting calcium sulfate/nano-HA/collagen bone graft substitute. Journal of the mechanical behavior of biomedical materials. 12: 119-128; 2012.
24. Yu X, Xu L, Cui FZ, Qu Y, Lian XJ, Wang XM, Wang Y. Clinical Evaluation of Mineralized Collagen as a Bone Graft Substitute for Anterior Cervical Intersomatic Fusion. Journal of Biomaterials and Tissue Engineering. 2: 170-176; 2012.
25. Shi XL, Wang QB, Hu K, Wang XM. Exploration on the safety assessment of nanomaterials in China. Interface Focus. 2012. 2, 387-392.
26. Wang Q, Wang XM*, Cheng ZJ, et al. In situ remineralization of partially demineralized human dentine mediated by a biomimetic non-collagen peptide. Soft Matter. 7: 9673-9680: 2011.
27. Wang XM*, Qiao L, Horii A. Screening of functionalized self-assembling peptide nanofiber scaffolds with angiogenic activity for endothelial cell growth. Progress in Natural Science-Materials International. 21: 111-116; 2011.
28. Wang Y, Wei YT, Zu ZH, Ju RK, Guo MY, Wang XM, et al. Combination of hyaluronic acid hydrogel scaffold and PLGA microspheres for supporting survival of neural stem cells. Pharmaceutical Research. 28(6): 1406-1414; 2011.
29. Chen ZJ, Wang Q, Wang XM*, et al. Enamel Distribution, Structure and Mechanical Alterations in col1-caPPR Mice Molar. Archives of Oral Biology. 56: 1020-1026; 2011.
30. Yu XL, Zhang B, Wang XM, et al. Cancer cell proliferation controlled by surface chemistry in its microenvironment. Frontiers of Materials Science. 5(4): 412-416; 2011.
31. Liu X, Wang Y, He J, Wang XM, et al. Various fates of neuronal progenitor cell observed on several different chemical functional groups. Frontiers of Materials Science. 5(4): 358-366; 2011.
32. Shi Y, Wang S, Wang XM, et al. Hierarchical self-assembly of a collagen mimetic peptide (PKG)n(POG)2 n(DOG)n via electrostatic interactions. Frontiers of Materials Science. 5(3): 293-300; 2011.
33. Chen ZJ, Wang XM, Ge J, et al. The mechanical anisotropy on a longitudinal section of human enamel studied by nanoindentation. Journal of Materials Science-Materials in Medicine. 21 : 1811-1816 ; 2010.
34. Liu X, Wang XM, Chen ZG, et al. Injectable bone cement based on mineralized collagen. Journal of Biomedical Materials Research Part B-Applied Biomaterials. 94B: 72-79; 2010.
35. Cheng ZJ, Wang XM, Ge J, et al. Disturbed Enamel Biomineralization in col1-caPPR Mouse Incisor. Calcified Tissue International. 84 : 494-501 ; 2009.
36. Yang JX, Cui FZ, Lee IS, Wang XM. Plasma surface modification of magnesium alloy for biomedical application. Surface & Coatings Technology. 205: S182-S187; 2010.
37. Wei YT, He Y, Xu CL, Wang Y, Liu BF, Wang XM, et al. Hyaluronic acid hydrogel modified with nogo-66 receptor antibody and poly-(L)-lysine to promote axon regrowth after spinal cord injury. Journal of Biomedical Materials Research Part B-Applied Biomaterials. 95B: 110-117; 2010.
38. Yang YL, Khoe UG, Wang XM, et al. Designer Self-assembling Peptide Nanomaterials. Nano Today. 4: 193-210; 2009.
39. Ren YJ, Zhang H, Huang H, Wang XM, et al. In vitro behavior of neural stem cells in response to different chemical functional groups. Biomaterials. 30: 1036-1044; 2009.
40. Cheng ZJ, Wang XM, Cui FZ, et al. The enamel softening and loss during early erosion studied by AFM, SEM and nanoindentation. Biomedical Materials. 4: 015020; 2009.
41. Zhang M, Xie R, Hou W, Wang BL, Shen R, Wang XM, et al. PTHrP Prevents Chondrocyte Premature Hypertrophy by Inducing Cyclin D1-Dependent Runx2 and Runx3 Phosphorylation, Ubiquitination and Proteasome Degradation. Journal of Cell Science. 122(9): 1382-1389; 2009.
42. Yang JX, Cui FZ, Yin QS, Zhang Y, Zhang T, and Wang XM. Characterization and Degradation Study of Calcium Phosphate Coating on Magnesium Alloy Bone Implant In Vitro. IEEE Transaction on Plasma Science. 37: 1161-1168; 2009.
43. Wang XM, Horii A, and Zhang Shuguang. Designer Functionalized Self-assembling Peptide Nanofiber Scaffolds for Growth, Migration, and Tubulogenesis of Human Umbilical Vein Endothelial Cells. Soft Matter. 4: 2388-2395; 2008.
44. Horii A, Wang XM, et al. Biological designer self-assembling peptide nanofiber scaffolds significantly enhance osteoblast proliferation, differentiation and 3-D migration. PLoS ONE. 2(2): e190; 2007.
45. Ge J, Cui FZ, Wang XM. New evidence of surface mineralization of collagen fibrils in wild type zebrafish skeleton by AFM and TEM. Materials Science and Engineering C-Biomimetic and Supramolecular Systems 27(1): 46-50; 2007.
46. Shen R, Wang XM, et al. Cyclin D1-Cdk4 Induces Runx2 ubiquitination and Degradation. The Journal of Biological Chemistry. 284(24): 16347-16353; 2006.
47. Ge J, Wang XM, Cui FZ. Microstructural characteristics and nanomechanical properties across the thickness of the wild-type zebrafish skeletal bone. Materials Science and Engineering C-Biomimetic and Supramolecular Systems 26(4): 710-715; 2006.
48. Wang Y, Cui FZ, Zhai Y, Wang XM. Investigations of the initial stage of recombinant human-like collagen mineralization. Materials Science and Engineering C-Biomimetic and Supramolecular Systems 26 (4): 635-638; 2006.
49. Kong XD, Wang XM, Yu X, et al. Preparation of hydroxyapatite-fibroin nanocomposites. ASBM6: Advanced Biomaterials VI, Key Engineering Materials. 288-289: 191-194; 2005.
50. Ge J, Cui FZ, Wang XM., et al. Property variations in the prism and the organic sheath within enamel by nanoindentation. Biomaterials 26 (16): 3333-3339; 2005.
51. Wang XM, Cui FZ, et al. Hierarchical structural studies of bones from gene-mutated lilputdtc232 Zebrafish. Journal of Structural Biology. 145: 236-245; 2004.
52. Wang XM, Cui FZ, et al. Variation of nano-mechanical properties of bone by gene-mutation in the zebrafish. Biomaterials. 23: 4557-4563; 2002.
53. Wang XM, Cui FZ, et al. Alterations in Mineral Properties of Zebrafish Skeletal Bone induced by liliputdtc232 Gene Mutation. Journal of Crystal Growth. 258(3-4): 394-401; 2003.
54. Zhang Y, Cui FZ, Wang XM, et al. Properties of skeletal bone in gene-mutated stöpseldtl28d and wild-type zebrafish (Danio rerio) measured by AFM-based nanoindentation. Bone 30(4): 541-546; 2002.
55. Kong XD, Cui FZ, Wang XM, et al. Silk fibroin regulated mineralization of hydroxyapatite nanocrystals. Journal of crystal growth 270 (1-2): 197-202; 2004.

授权专利
1. 王秀梅，金玉顺，夏雪，崔福斋，《一种微米级聚甲基丙烯酸甲酯微球的制备方法》（专利号：CN101787138B）
2. 王秀梅，王琼，《一种评价细胞迁移行为的细胞培养器》（专利号：CN203112849U）
3. USA patent: Akihiro Horii, Shuguang Zhang, Xiumei Wang, Fabrizio Gelain. Modified self-assembling peptides. Patent No: 8022178 (September 20, 2011).

dasaochu

神经-血管的协同作用在神经组织的发育和再生中起着十分重要的作用。神经和血管在发育过程中几乎同时发生，在解剖结构上也是并行排列，密不可分。由神经和血管组成的特殊微环境叫做“神经血管单元”（neurovascular unit, NVU），其维持着神经元的正常生理功能以及受损神经元的修复，强调神经元、神经胶质细胞和血管细胞之间相互联系及相互影响的重要性，有助于神经组织的发育和再生。因此，利用生物活性材料构建人工神经血管微环境，促进神经新生与血管新生的协调，是修复神经组织、促进再生的策略之一。

        近日，清华大学材料学院王秀梅教授课题组在Nano Research在线发表了题为“Crosstalk between PC12 cells and endothelial cells in an artificial neurovascular niche constructed by a dual-functionalized self-assembling peptide nanofiber hydrogel”的研究论文。此项研究利用脑源性神经营养因子（BDNF）和内皮生长因子（VEGF）模拟肽RGI和KLT合成双功能化肽纳米纤维水凝胶（RADA/RGI/KLT）构建人工神经血管微环境，并利用体外细胞实验、体内大鼠脑损伤实验分别验证双功能 SAP 水凝胶的协同作用。同时，建立了低成本、易操作的体外共培养模型，来探索神经细胞和内皮细胞的相互作用。
        该研究表明，RADA/RGI/KLT水凝胶体外能促进PC12细胞的神经突生长和HUVECs成血管，体内动物实验模型进一步验证了 RADA/RGI/KLT 能在受损区域发挥协同作用，双功能 SAP 支架材料能够在损伤区有效地募集神经和内皮细胞，促进体内“血管神经单元”的重建。通过间接共培养模型研究发现RADA/RGI/KLT可以通过调节PC12细胞和HUVECs的旁分泌来有效地介导神经血管crosstalk。当两种细胞直接共培养在RADA/RGI/KLT上时，细胞间的通讯效率进一步提高，加速了PC12细胞的分化和成熟和HUVECs成血管。综上所述，双功能化自组装多肽水凝胶RADA/RGI/KLT成功构建了一个仿生的神经血管微环境，该环境能够直接调节神经和血管内皮细胞的行为，并通过旁分泌和细胞-细胞直接接触的方式介导神经-血管协调作用。


         文章信息
          Zhe Zhang, Yi Chai, He Zhao, Shuhui Yang, Wei Liu, Zihui Yang, Weilong Ye, Chenlong Wang, Xiaohan Gao, Xiangdong Kong, Xiaodan Sun, Lingyun Zhao, Tuoyu Chen, Yuqi Zhang, Jiaju Lu* & Xiumei Wang*. Crosstalk between PC12 cells and endothelial cells in an artificial neurovascular niche constructed by a dual-functionalized self-assembling peptide nanofiber hydrogel. Nano Research https://doi.org/10.1007/s12274-021-3684-5.