南方科技大学化学系刘心元

tuxiayu

刘心元，南方科技大学化学系教授、博士生导师。2001年在安徽师范大学化学系获学士学位；2004年在中国科学院上海有机化学研究所与安徽师范大学联合培养获硕士学位，师从王绍武教授和朱仕正研究员；2010年在香港大学获博士学位，师从支志明院士。2010年4月至2012年9月，先后在香港大学和美国斯克普斯研究所 (The Scripps Research Institute) 从事博士后研究。2012年9月加入南方科技大学化学系，2018年1月晋升为终身正教授。曾获香港大学2009-2010年杰出研究生奖（2011）、日本化学会Distinguished Lectureship Award （2017）。入选深圳市海外高层次“孔雀计划”B类人才（2013）、国家优秀青年科学基金项目（2017）、教育部“长江学者奖励计划”青年学者项目（2017）。在自由基参与的不对称化学研究领域开展了系统的研究，独立开展工作以来，已在Science Advances、Chem、Nat. Commun.、J. Am. Chem. Soc.、Angew. Chem. 等国际著名期刊上发表研究论文46篇。



刘心元
教授
化学系
0755-88018314
liuxy@sustc.edu.cn
研究方向
非活性烯烃和炔烃的催化功能化等
2001年在安徽师范大学化学系获学士学位
2004年在中国科学院上海有机化学研究所与安徽师范大学联合培养硕士，师从王绍武教授和朱仕正研究员
2010年在香港大学获哲学博士学位，师从支志明院士
2010年4月至2012年9月先后在香港大学和美国The Scripps Research Institute从事博士后研究
2012年9月加入南方科技大学化学系


获得荣誉
2011，香港大学杰出研究生奖
2013，深圳市海外高层次人才“孔雀计划”入选者

研究方向
非活性烯烃和炔烃的催化功能化
不对称自由基化学
均相和非均相催化剂的设计与应用
有机氟化学的研究

科研项目
1. 973 项目，2013CB834800、25 万、主要参与人; 2015.1‐2017.8
2. 国家自然科学基金委面上项目，78 万、项目负责人；2016.1‐2019.12
3. 国家自然科学基金委青年基金，25 万、项目负责人；2014.1‐2016.12
4. 深圳市孔雀创新启动经费项目，570 万、项目负责人；2013.12‐2016.12
5. 深圳市孔雀创新团队资助项目，200 万、项目子课题；2015.8‐2020.8
6. 深圳市孔雀创新资助项目，80 万、项目负责人；2015.8‐2017.8
7. 深圳市基础科研项目，50 万、项目负责人；2015.8‐2017.8
8. 深圳市基础科研项目，10 万、项目负责人；2013.8‐2015.8
9. 南方科技大学副校长基金，50 万、项目负责人；2015.1‐2015.12

研究方向是围绕非活性烯烃和炔烃的不对称官能团化开展工作。以第一作者或通讯作者在国内外期刊上共发表SCI检索论文40篇如J. Am. Chem. Soc.(3篇)、Angew. Chem. Int. Ed. (9篇)、Nature Commun. (1篇)、ACS Catal. (3篇)、Chem. Commun. (4篇)、Org. Lett. (8篇)及 Chem. Eur. J. (3篇)等。其中9篇论文被Synfacts亮点评述(Synfacts 2016, 12, 86; 2015, 11, 1029; 2014,10, 1281; 2014, 10, 1272; 2014, 10, 754; 2014, 10, 530; 2013, 9, 1251; 2009, 5, 600; 2009, 5, 1363.)； 2篇论文受邀收录于Emerging Investigators专刊 (Chem. Commun., 2016, 52, 9052; Org. Chem. Front., 2016, 3, 324.)；4篇论文被选为封面和插图文章；2篇论文被选为热点文章；2篇论文被Organic Chemistry Portal(有机化学门户)亮点报道；1篇Org. Lett.论文在2009年被选为该杂志三年内发表的引用次数最多的20篇文章之一；1篇论文在有机化学亮点介绍 (Chin. J. Org. Chem. 2015, 35, 1802.)。引用次数达1500次；其中有三篇论文单篇引用次数达129次。
代表论文
1.   Jin-Shun Lin, Xiao-Yang Dong, Tao-Tao Li, Na-Chuan Jiang, Bin Tan, and Xin-Yuan Liu* A Dual-Catalytic Strategy to Direct Asymmetric Radical Aminotrifluoromethylation of Alkenes J. Am. Chem. Soc. 2016, 138, 9357.
2.   Zhi-Jia Fang, Sheng-Cai Zheng, Zhen Guo, Jing-Yao Guo, Bin Tan,* Xin-Yuan Liu*, Asymmetric Synthesis of Axially Chiral Isoquinolones: Nickel-Catalyzed Denitrogenative Transannulation Angew. Chem. Int. Ed. 2015,54, 9528.
Highlighted in Synfacts, 2015, 11, 1029.
3.   Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan,* Xin-Yuan Liu*, Brønsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter Angew. Chem. Int. Ed. 2015, 54, 7847.
Highlighted in Chin. J. Org. Chem., 2015, 35, 1802.
4. Peng Yu, Sheng-Cai Zheng, Ning-Yuan Yang, Bin Tan,* Xin-Yuan Liu*，Phosphine-Catalyzed Remote β-C-H Functionalization of Amine Triggered by Trifluoromethylation of Alkene: One-Pot Synthesis of Bistrifluoromethylated Enamides and Oxazoles, Angew. Chem. Int. Ed. 2015, 54, 4041.
Selected as Cover Picture.
5.  Peng Yu, Jin-Shun Lin, Lei Li, Sheng-Cai Zheng, Ya-Ping Xiong, Li-Jiao Zhao, Bin Tan*, and Xin-Yuan Liu*“Enantioselective C-H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene” Angew. Chem. Int. Ed. 2014, 53, 11890.
Highlighted in Synfacts, 2014, 10, 1281.
6.   Ji-Wei Zhang, Jin-Hui Xu, Dao-Juan Cheng, Chuan Shi, Xin-Yuan Liu*, Bin Tan,* Discovery and Enantiocontrol of Axially Chiral Urazoles via Organocatalytic Tyrosine Click Reaction Nature Commun. 2016,7, 10677.
7.   Jian Zhang, Shao-Xia Lin, Dao-Juan Cheng, Xin-Yuan Liu*, Bin Tan,* Phosphoric Acid-Catalyzed Asymmetric Classic Passerini Reaction J. Am. Chem. Soc. 2015, 137, 14039.
Highlighted in Synfacts, 2016, 12, 86.
8.  Ye-Hui Chen, Dao-Juan Cheng, Jian Zhang, Yong Wang, Xin-Yuan Liu*, Bin Tan,* Atroposelective Synthesis of Axially Chiral Biaryldiols via Organocatalytic Arylation of 2 Naphthols J. Am. Chem. Soc. 2015, 137, 15062.
9.  Ming-Yue Wu, Wei-Wei He, Xin-Yuan Liu*, Bin Tan,* Asymmetric Construction of Spirooxindoles via Organocatalytic Multicomponent Reactions of Diazooxindoles Angew. Chem. Int. Ed. 2015, 54, 9409.
10.  Dao-Juan Cheng, Liang Yan, Shi-Kai Tian,* Ming-Yue Wu, Lu-Xin Wang, Zi-Li Fan, Sheng-Cai Zheng, Xin-Yuan Liu,* and Bin Tan* “Highly Enantioselective Kinetic Resolution of Axially Chiral BINAM Derivatives Catalyzed by a Brønsted Acid” Angew. Chem. Int. Ed. 2014, 53, 3684.
Highlighted in Synfacts, 2014, 10, 530.
11.  Ning-Yuan Yang, Zhong-Liang Li, Liu Ye, Bin Tan and Xin-Yuan Liu* Organic base-catalysed solvent-tuned chemoselective carbotrifluoromethylation and oxytrifluoromethylation of unactivated alkenes Chem. Commun., 2016, 52, 9052.
From themed collection 2016 Emerging Investigators by Chem. Commun.
12.  Xiao-Long Yu, Liping Kuang, Su Chen, Xiao-Long Zhu, Zhong-Liang Li, Bin Tan, and Xin-Yuan Liu*Counteranion-Controlled Unprecedented Diastereo- and Enantioselective Tandem Povarov Reaction for Construction of Bioactive Octahydro-dipyrroloquinolines ACS Cat. 2016, in press.
13.  Na Wang, Sheng-Cai Zheng, Lin-Lin Zhang, Zhen Guo* and Xin-Yuan Liu* Nickel(0)-Catalyzed Denitrogenative Transannulation of Triazoles with Alkynes: Mechanistic Insights of Chemical Reactivity, Regio- and Enantioselectivity from Density Functional Theory and Experiment ACS Cat. 2016, 6, 3496.
14.  Taotao Li, Peng Yu, Jin-Shun Lin, Yonggang Zhi,* and Xin-Yuan Liu* Copper-Catalyzed Redox-Triggered Remote C－H Functionalization: Highly Selective Formation of C-CF3 and C-O Bonds Chin. J. Chem. 2016, 34, 490.
Invited paper for the Special Issue of “Trifluoromethylation and Trifluoromethythiolation Reactions”
15.  Can-Liang Ma, Xiao-Hua Li, Xiao-Long Yu, Xiao-Long Zhu, Yong-Zhou Hu, Xiao-Wu Dong,* Bin Tan* andXin-Yuan Liu* Gold-catalyzed tandem synthesis of bioactive spiro-dipyrroloquinolines and its application in the one-step synthesis of incargranine B aglycone and seneciobipyrrolidine (I) Org. Chem. Front. 2016, 3, 324.
From themed collection 2015 Emerging Investigators by OCF.
16.  Lin Huang, Jin-Shun Lin, Bin Tan,* Xin-Yuan Liu*, Alkene Trifluoromethylation-Initiated Remote α-Azidation of Carbonyl Compounds toward Trifluoromethyl γ-Lactam and Spirobenzofuranone-lactam ACS Cat. 2015, 5, 2826-2831.
17.  Lin Huang, Sheng-Cai Zheng, Bin Tan,* Xin-Yuan Liu*, Metal-Free Direct 1,6- and 1,2-Difunctionalization Triggered by Radical Trifluoromethylation of Alkenes Org. Lett. 2015, 17, 1589-1592.
18.  Lin Huang, Sheng-Cai Zheng, Bin Tan,* Xin-Yuan Liu*, Trifluoromethylation-Initiated Remote Cross-Coupling of Carbonyl Compounds to Form Carbon–Heteroatom/Carbon Bonds Chem. Eur. J. 2015, 21, 6718.
19.  Can-Liang Ma, Xiao-Long Yu, Xiao-Long Zhu, Yong-Zhou Hu, Xiao-Wu Dong, Bin Tan*, and Xin-Yuan Liu*“Platinum-Catalyzed Tandem Cyclization Reaction to Multiply Substituted Indolines under Microwave-Assisted Conditions” Adv. Synth. Catal. 2015, 357,569.
20.  Lei Li, Jing-Yao Guo, Xing-Guo Liu, Su Chen, Yong Wang, Bin Tan*, and Xin-Yuan Liu* “Amide Groups Switch Selectivity: C-H Trifluoromethylation of α,β-Unsaturated Amides and Subsequent Asymmetric Transformation” Org. Lett., 2014, 16, 6032.
21.  Jin-Shun Lin, Xiang-Geng Liu, Xiao-Long Zhu, Bin Tan,* and Xin-Yuan Liu* “Copper-Catalyzed Aminotrifluoromethylation of Unactivated Alkenes with TMSCF3: Construction of Trifluoromethylated Azaheterocycles” J. Org. Chem. 2014, 79, 7084.
22.  Xing-Li Zhu, Jin-Hui Xu, Dao-Juan Cheng, Li-Jiao Zhao, Xin-Yuan Liu* and Bin Tan* “In Situ Generation of Electrophilic Trifluoromethylthio Reagents for Enantioselective Trifluoromethylthiolation of Oxindoles”Org. Lett. 2014, 16, 2192.
Highlighted in Synfacts, 2014, 10, 754.
23.  Ya-Ping Xiong, Ming-Yue Wu, Xiang-Yu Zhang, Can-Liang Ma, Lin Huang, Li-Jiao Zhao, Bin Tan* and Xin-Yuan Liu* “Direct Access to α-CF3-enones via Efficient Copper-Catalyzed Trifluoromethylation of Meyer-Schuster Rearrangement” Org. Lett. 2014, 16, 1000.
This work is highlighted on the website http:// http://www.organic-chemistry.org/abstracts/lit4/389.shtm
24.  Lei Li, Min Deng, Sheng-Cai Zheng, Ya-Ping Xiong, Bin Tan* and Xin-Yuan Liu* “Metal-Free Direct Intramolecular Carbotrifluoromethylation of Alkenes to Functionalized Trifluoromethyl Azaheterocycles”Org. Lett. 2014, 16, 504.
25.  Jin-Shun Lin, Ya-Ping Xiong, Can-Liang Ma, Li-Jiao Zhao, Bin Tan,* and Xin-Yuan Liu* “Efficient Copper-Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen-Based Nucleophiles” Chem. Eur. J. 2014, 20, 1332.
26.  Tao Liu, Da-Qiang Li, Si-Yu Wang Yong-Zhou Hu, Xiao-Wu Dong,* Xin-Yuan Liu,* and Chi-Ming Che “Straightforward Installation of Carbon-Halogen, Carbon-Oxygen and Carbon-Carbon Bonds within Metal–Organic Frameworks via Direct C-H Functionalization” Chem. Commun., 2014, 50,13261.
   Highlighted in Synfacts, 2014, 10, 1272.
27. Tao Liu, Jin-Xin Che, Yong-Zhou Hu, Xiao-Wu Dong,* Xin-Yuan Liu,* Chi-Ming Che “Alkenyl/thiol-derived Metal–Organic Frameworks via Post-Synthetic Modification for Effective Mercury Adsorption” Chem. Eur. J.2014, 20,14090.

28. Xiao-Wu Dong, Tao Liu, Yong-Zhou Hu*, Xin-Yuan Liu*, Chi-Ming Che. Urea Postmodified in Metal-Organic Framework as Catalytically Active Hydrogen-Bond-Donating Heterogeneous Catalyst Chem. Commun., 2013, 49, 7681.
  Highlighted with a front cover in Chem. Commun.;
  Selected as HOT Chem. Comm. articles for May;
  Highlighted in Synfacts, 2013, 9, 1251.

29. Gaosheng Yang,* Chongrong Luo, Xiaolong Mu, Tingting Wang and Xin-Yuan Liu*, Highly efficient enantioselective three-component synthesis of 2-amino-4H-chromenes catalysed by chiral tertiary amine-thioureas Chem. Commun. 2012, 48, 5880-5882.

Graduate & Postdoctoral Publications
1. Xin-Yuan Liu, Ya-Ping Xiao, Fung-Ming Siu, Li-Chen Ni, Yong Chen, Lin Wang, and Chi-Ming Che*, “Highly regio-, diastereo- and enantioselective one-pot gold/chiral Brønsted acid-catalysed cascade synthesis of bioactive diversely substituted tetrahydroquinolines” Org. Biomol. Chem. 2012, 10, 7208-7219.

2. Xin-Yuan Liu,[+] Zhen Guo,[+] Sijia Dong,[+] Xiao-Hua Li, and Chi-Ming Che*, “Highly efficient and diastereoselective gold(I)-catalyzed synthesis of tertiary amines from secondary amines and alkynes: substrate scope and mechanical insights” Chem. Eur. J. 2011, 17, 12932-12945. [+]denotes equal contribution

3. Ya-Ping Xiao,[+] Xin-Yuan Liu,[+] and Chi-Ming Che*, “Efficient gold(I)-catalyzed direct intramolecular hydroalkylation of unactivated alkenes with simple α-ketones” Angew. Chem. Int. Ed. 2011, 50, 4937-4941. [+]denotes equal contribution

4. Xin-Yuan Liu, Chi-Ming Che*, “Highly enantioselective synthesis of chiral secondary amines by gold(I)/chiral Brønsted acid-catalyzed tandem intermolecular hydroamination and transfer hydrogenation reactions” Org. Lett. 2009, 11, 4204-4207.
  Selected by the Editorial Board of SYNFACTS and published in SYNFACTS issue  12/09.

5. Xin-Yuan Liu, Chi-Ming Che*, “Highly efficient and regioselective platinum(II)-catalyzed tandem synthesis of multiply substituted indolines and tetrahydroquinolines” Angew. Chem. Int. Ed. 2009, 48, 2367-2371.
   Selected by the Editorial Board of SYNFACTS and published in SYNFACTS  
   issue 06/09.

6. Xin-Yuan Liu, Chi-Ming Che*, “A highly efficient and selective AuI-catalyzed tandem synthesis of diversely substituted pyrrolo[1,2-α]quinolines in aqueous medium” Angew. Chem. Int. Ed. 2008, 47, 3805-3810.

7. Xin-Yuan Liu, Pan Ding, Jie-Sheng Huang, Chi-Ming Che*, “Synthesis of substituted 1,2-dihydroquinolines and quinolines from aromatic amines and alkynes by gold(I)-catalyzed tandem hydroamination-hydroarylation under microwave-assisted conditions” Org. Lett. 2007, 9, 2645-2648.
Selected on the ACS Publications website in 2009 as Top 20 most-cited articles published in the last three years.

8. Xin-Yuan Liu, Cheng-Hui Li, Chi-Ming Che*, “Phosphine gold(I)-catalyzed hydroamination of alkenes under thermal and microwave-assisted conditions” Org. Lett. 2006, 8, 2707-2710.
Featured on the ACS Publications website as one of “Organic Letters' Hot Papers” based on citation data obtained from Thomson ISI.
Highlighted on the website http://www.organic-chemistry.org/Highlights/2007/15August.shtm