湖北大学刘志洪

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刘志洪，湖北大学教授，博士生导师，武汉大学“珞珈特聘”教授。2016年获得国家杰出青年科学基金，2017年入选科技部“创新人才推进计划”，2018年入选“万人计划”科技领军人才。探索性地提出了一系列上转换荧光分子及纳米材料的制备和表面功能化新策略，建立了一批适于复杂生物样品体内、体外分析的快速、高灵敏、高特异性检测方法和探针，被国际同行评价为“可望为生物医学检测带来革命性的变化”（Nano Today, 2012, 7, 532）。近5年来在JACS、Angew Chem Int Ed、Adv Funct Mater、Small、Chem Sci、Anal Chem、Chem Com 等期刊发表SCI论文100余篇，SCI他引逾5000次，4篇入选ESI高被引论文，参编学术专著3部。


研究领域
以肿瘤和神经性疾病为目标，围绕疾病诊断、治疗及相关生物过程的化学机制，利用前期所建立的各个方法平台，开展以下三项工作
1）疾病标志分子的体外快速均相检测，发展临床现场和床边诊断（point-of-care testing, POCT）新技术
2）疾病相关生物分子的体内和胞内实时监测与成像
3）基于小分子及纳米材料的药物输运、控制释放和多模式联合治疗，构建诊-疗一体化探针系统


近期论文

• Tao Liang, Zhen Li, Peipei Wang, Fangzhou Zhao, Jizhou Liu, Zhihong Liu.Breaking Through the Signal-to-Background Limit of Upconversion Nanoprobes Using a Target-Modulated Sensitizing Switch.J. Am. Chem. Soc.2018,140,14696-14703.
• Lingyu Zeng, Tian Xia, Wei Hu, Shiyu Chen, Siyu Chi, Yidi Lei, Zhihong Liu. Visualizing the Regulation of Hydroxyl Radical Level by Superoxide Dismutase via a Specific Molecular Probe.Anal. Chem.2018,90, 1317-1324.
• Zhiqiang Mao, Hong Jiang, Xinjian Song, Wei Hu, Zhihong Liu. Development of a Silicon-Rhodamine Based Near-Infrared Emissive Two-Photo Fluorescent Probe for Nitric Oxide.Anal. Chem.2017,89, 9620-9624.
• Zhiqiang Mao, Hong Jiang, Zhen Li, Cheng Zhong, Wei Zhang Zhihong Liu. An N-nitrosation reactivity-based two-photon fluorescent probe for the specific in situ detection of nitric oxide.Chem. Sci.2017,8, 4533-4538.
• Tao Liang, Zhen Li, Dan Song, Lin Shen, Qinggeng Zhuang, Zhihong Liu. Modulating the Luminescence of Upconversion Nanoparticles with Heavy Metal Ions: A New Strategy for Probe Design.Anal. Chem.2016,88, 9989−9995.
• Mengyuan He, Zhen Li, Yiying Ge, Zhihong Liu. Portable Upconversion Nanoparticles-Based Paper Device for Field Testing of Drug Abuse.Anal. Chem.2016,88, 1530−1534.
• Zhiqiang Mao, Wenqi Feng, Zhen Li, Lingyu Zeng, Weijie Lv, Zhihong Liu. NIR in, far-red out: developing a two-photon fluorescent probe for tracking nitric oxide in deep tissue. Chem. Sci.2016,7, 5230-5235.
• Xuefeng Li, Hao Ren, Zhijuan Zou, Jiaojiao Sun, Jingyu Wang*, Zhihong Liu. Energy gap engineering of polymeric carbon nitride nanosheets for matching with NaYF4:Yb,Tm: enhanced visible-near infrared photocatalytic activity.Chem. Commun.2016,52, 453-456.
• Li Zhen, Liang Tao, Lv Songwei, Zhuang Qinggeng, Liu Zhihong(*),A Rationally Designed Upconversion Nanoprobe for in Vivo Detection of Hydroxyl Radical,J. Am. Chem. Soc.2015, 137, 11179-11185. [3]
• Li Zhen，Lv Songwei，Wang Yali，Chen Shiyu，Liu Zhihong(*)，Construction of LRET-Based Nanoprobe Using Upconversion Nanoparticles with Confined Emitters and Bared Surface as Luminophore,J. Am. Chem. Soc.2015，137, 3421-3427.
• Xiao Yan，Zeng Lingyu，Xia Tian，Wu Zhengjun，Liu Zhihong(*)，Construction of an Upconversion Nanoprobe with Few-Atom Silver Nanoclusters as the Energy Acceptor,Angewandte Chemie International Edition, 2015, 54, 5323-5327.
• Chen Jin, Zeng Lingyu, Xia Tian, , Shuang Li, Tengfei Yan, Song Wu, Guofu Qiu, Liu Zhihong(*),Analytical Chemistry,DOI: 10.1021/acs.analchem.5b02032.
• Mao Zhiqiang, Hu Liang, Zhong Cheng, Zhang Heng, Liu Bifeng, Liu Zhihong(*),A dual-mechanism strategy to design a wide-range pH probe withmulticolor fluorescence,Sensors and Actuators B: Chemical, 2015, 219, 179-184.
• Li Hui，Sun De-En，Liu Zhihong(*)，Ultrasensitive Biosensing Platform Based on Luminescence Quenching Ability of Plasmonic Palladium Nanoparticles,Chemistry-A European Journal，2015, 21, 4944-4948.
• Zeng Lingyu，Chen Shiyu，Xia Tian，Hu Wei，Li Chunya，Liu Zhihong(*)，Two-Photon Fluorescent Probe for Detection of Exogenous and Endogenous Hydrogen Persulfide and Polysulfide in Living Organisms，Analytical Chemistry，2015，87, 3004-3010.
• Wu Zhengjun，Li Hui，Liu Zhihong(*), An aptasensor for carcinoembryonic antigen based on upconversion fluorescence resonance energy transfer,Sensors and Actuators B: Chemical，2015，206, 531-537.