暨南大学化学与材料学院化学系刘杰

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刘杰，暨南大学化学与材料学院教授，博士生导师。主要从事生物创新药物（包括化学合成药物、纳米药物、纳米载药）的研究，作为通讯作者在ACS Nano、Adv. Funct. Mater.、Biomaterials、ACS Appl.Mater. Int.、Acta Biomaterialia.等高水平期刊上发表论文140多篇，个人科研指数h-index 41, 获得授权专利12项。


刘杰
性别：女
职称：教授，博导
学位：博士后
电子邮件：tliuliu@jnu.edu.cn


学习及工作简历
2007.12-至今，暨南大学生命科学技术学院化学系，教授，博士生导师。
2000.9-2007.11，中山大学化学与化学工程学院，副教授，博士生导师；
1998-2000，中山大学化学与化学工程学院，博士后；
1995-1998，东北师范大学化学院；博士生。
研究方向
生物无机化学，化学生物学，生物化学与分子生物学；主要从事创新药物（包括化学合成药物、纳米药物、纳米载药、生物医药）、药物化学、分子生物学、细胞生物学等交叉学科的研究；研究兴趣主要集中在以下几个方面：(1) 开展了阿尔兹海默综合症（老年痴呆症，AD）抑制剂的研究：针对AD药物的多个主要靶点，开展了多靶点纳米颗粒抑制阿尔兹海默综合症药物的研究与开发，发现有可能成为AD候选药物的多功能纳米颗粒。(2) 靶向纳米药物制备及生物活性的研究，主要研究功能化纳米硒、纳米金等对肿瘤血管的抑制作用及抑制肿瘤转移的功能；(3) 肿瘤诊断试剂的研究与应用，设计合成一类近红外的小分子荧光探针，该探针能够识别肿瘤细胞，具有作为肿瘤诊断试剂的可能性。 (4) 金属配合物抗肿瘤作用机制，包括抗肿瘤作用靶点，诱导细胞凋亡信号传导途径，基因组学和蛋白组学方法研究金属配合物对肿瘤相关基因、蛋白的调控和生物效应的影响。(5) 配合物稳定端粒DNA的能力及其以端粒酶为靶点的抗肿瘤活性；重点研究手性异构体配合物及微环境的改变对其生物功能的影响，以及选择性识别并诱导端粒DNA构型的改变等。
作为通讯作者在Adv. Fun. Materials,Nanoscale.;  Biomaterials.；Acta Biomaterialia.; ACS Applied Materials & Int.; Chem. Eur. J.； PLOS One.;Biochimie;Inorg. Chem.；Dalton. Trans.；Eur. J. Med.Chem.；等国际期刊发表论文近100余篇。申报专利14项，已经获得授权7项。作为项目负责人，获得国家自然科学基金、广东省自然科学基金重点项目、广东省科技计划项目和广州市科技计划项目等资助等20余项。
课题研究
1. 广东省社会发展领域科技项目，多肽功能化纳米颗粒SQT/SRQT作为治疗阿尔兹海默综合症候选
药物的研究（2016A020217011），2016.01-2017.12
2.广东省自然科学基金重点项目，钌配合物功能化纳米硒双载药物及siRNA体系的构建及其靶向肿
瘤血管的研究（2014A030311025），2015.01-2017.12
3. 国家自然科学基金，双靶点抑制血管生成和肿瘤的钌功能化纳米硒及其细胞吸收机制的研究
（21371075），2014.01-2017.12
4. 国家自然科学基金,基于单细胞成像研究钌配合物作为识别肿瘤细胞的荧光探针和对凋亡信号通路
的影响（21171070），2012.01-2015.12，项目负责人
5. 国家自然科学基金，钌配合物在肺癌细胞中调控（20871056），2009.01-2011.12
6. 国家自然科学基金，钌配合物诱导肺癌A549细胞的凋亡及对细胞端粒酶活性的影响（20471070），2005.01-2007.12
7. 广东省科技计划项目，靶向基因VEGF启动区G-四链体的钌配合物抑制血管生成及其PI3K介导的信号通路研究（c1211220800571），2013.01-2014.12
8. 广东省科技计划项目，Ru-Se作为识别肿瘤细胞的荧光探针和肿瘤诊断试剂的研究，（c1011220800060），2011.01-2012.12
授权专利
1.刘杰，周艳晖，刘亚楠，孙冬冬，张蓉，功能化纳米硒在抑制肿瘤血管生成和抗肿瘤药物中的应用，中国，中国专利局， ZL2012 1 0101200.7
2.刘杰，袁方，周艳晖，孙冬冬，刘亚楠，一种能抑制血管形成的钌配合物及其制备方法与应用，中国，中国专利局，ZL2011 10327452.7
3.刘杰，张小年，杨喜成，郑文杰，陈填烽，刘亚楠，钌硒配合物及其在制备荧光探针和抗肿瘤药物中的用途，中国，中国专利局，ZL 2010 10259488.1
4.张小年，杨喜成，刘杰，刘亚楠，郑文杰，一种钌配合物及其制备方法和在制备抗肿瘤药物中的应用，中国，中国专利局，ZL 2010 1 0281547.5
5.刘杰，吴硕，郑文杰，刘亚楠，陈填烽，杨芳，一种钌配合物及其制备方法和应用，中国，中国专利局，ZL 2009 10193499.1
6.刘杰, 黄小全，刘亚楠，陈旭. 功能化纳米硒及其制备和在制备抑菌、杀菌药物中的应用;中国发明专利。ZL 201410686293.3
7.刘杰，郑楚萍，刘亚楠. 钌配合物修饰纳米硒在促进间充质干细胞成骨分化的应用；中国发明专利, ZL 201410222487.8
获奖情况
毛宗万，巢晖，计亮年，刘建忠，鲁统部，刘杰，高峰，陈小明。金属酶模型化合物的结构、生物功能和作用机制研究，广东省科学技术奖励，一等奖， 2012年3月。
代表性科研论文(*为通讯作者)
2016年
1.Xiaoquan Huang,Xu Chen,Qingchang Chen,Qianqian Yu,Dongdong Sun,bJie Liu. “Investigation of Functional Selenium Nanoparticles as Potent Antimicrobial Agents against superbugs.” Acta Biomaterialia(2016),(IF=6.02)
2.Wenjing Zheng, Qingchang Chen, Xiuying Qin, Xiaoquan Huang, Shuang Zhao, Taoyuan Xu, Lanmei Chen, Jie Liu. “Co-delivery of Se Nanoparticles and Pooled SiRNAs for Overcoming Drug Resistance Mediated by P-glycoprotein  and Class III β-tubulin in Drug-resistant Breast Cancers”. Acta Biomaterialia (2016), (IF=6.02)
3.Yanhui Zhou, Qianqian Yu, Xiuying Qin, Dhairya Bhavsar, Licong Yang, Qingchang Chen, Wenjing Zheng, Lanmei Chen, and Jie Liu.“Improving the Anticancer Efficacy of Laminin Receptor-Specific Therapeutic Ruthenium Nanoparticles (RuBB-Loaded EGCG-RuNPs) via ROS-Dependent Apoptosis in SMMC-7721 Cells.” ACS Applied Materials & Interfaces,DOI: 10.1021/acsami.5b02261，(IF=6.73)
2015年
4.Tiantian Yin, Licong Yang, Yanan Liu, Xianbo Zhou, Jing Sun, Jie Liu.“Sialic acid (SA)-modified selenium nanoparticles coated with a high blood–brain barrier permeability peptide-B6 peptide for potential use in Alzheimer’s disease”.Acta Biomaterialia,2015,25,172-180, (IF=6.02)
5.Xianbo Zhou, Chengwen Cao, Qingchang Chen, Qianqian Yu, Yanan Liu, Tiantian Yin and Jie Liu. “PEG Modified Graphene Oxide loaded with EALYLV Peptides for Inhibiting the Aggregation of hIAPP Associated with Type-2 Diabetes”. Journal of Materials Chemistry B,2015,3,7055-7067,(IF=4.72)
6.Xianbo Zhou, Jing Sun, Tiantian Yin, Fangling Le, Licong Yang, Yanan Liu and Jie Liu.“Enantiomers of cysteine-modified SeNPs (D/LSeNPs) as inhibitors of metal-induced Aβ aggregation in Alzheimer's disease”. Journal of Materials Chemistry B, 2015，3( 39), 7764-7774,(IF=4.72).
7.Xu Chen, Xiaoquan Huang, Chuping Zheng, Yanan Liu, Taoyuan Xu and Jie Liu. “Preparation of different sized nano-silver loaded on functionalized graphene oxide with highly effective antibacterial properties”. Journal of Materials Chemistry B, 2015,3,7020-7029, (IF=4.72).
8.Wenjing Zheng, Chengwen Cao, Yanan Liu, Qianqian Yu, Chuping Zheng, Dongdong Sun, Xiaofan Ren, Jie Liu. “Multifunctional polyamidoamine-modified selenium nanoparticles dual-delivering siRNA and cisplatin to A549/DDP cells for reversal multidrug resistance”. Acta Biomaterialia, 2015,11,368-380, (IF=6.02)
9.Qingchang Chen, Qianqian Yu, Yanan Liu, Dhairya Bhavsar, Licong Yang, Xiaofan Ren, Dongdong Sun, Wenjing Zheng, and Jie Liu. “Multifunctional selenium nanoparticles: Chiral selectivity of delivering MDR-siRNA for reversal of multidrug resistance and real-time biofluorescence imaging”. Nanomedicine: Nanotechnology, Biology, and Medicine.2015，11，1773–1784, (IF=6.15)
10.Jing Sun, Yongchao Huang,  Chuping Zheng, Yanhui Zhou, Ying Liu,  Jie Liu. Ruthenium (II) Complexes Interact with Human Serum Albuminand Induce Apoptosis of Tumor Cells
Biol Trace Elem Res (2015) 163:266–274
11.Dongdong Sun , Yanan Liu, Qianqian Yu, Du Liu, Yanhui Zhou, Jie Liu, Selective nuclei accumulation of ruthenium(II) complex enantiomers that target G-quadruplex DNA. J. Inorg. Biochem.2015,150, 90–99.
2014年
12.Chuping Zheng, Jinsheng Wang, Yanan Liu,Qianqian Yu, Ying Liu, Ning Deng*, Jie Liu*. Functional Selenium Nanoparticles Enhanced Stem Cell Osteoblastic Differentiation through BMPSignaling Pathways. Advanced Functional Materials,2014, 24, 6872-6883(已接受）(IF=10.4).
13.Ying Liu, Yanan Liu*, Licong Yang,Chengwen Cao, Yanhui Zhou, Qianling Zhang, Jie Liu*
Stabilization for Loop Isomers of C-Myc G-Quadruplex DNA and Anticancer Activity by Ruthenium Complexes. MedChemComm. 2014，5，1724–1728
14.Qingchang Chen, Licong Yang, Chuping Zheng, Wenjing Zheng, Jingnan Zhang, Yunshan Zhou, Jie  Liu*. Mo polyoxometalate nanoclusters capable of inhibiting the aggregation of Ab-peptide associated with Alzheimer’s diseas.Nanoscale.2014, 6 (12), 6886 - 6897 (IF=7.3)
15.Qianqian Yu, Yanan Liu*, Lei Xu, Chuping Zheng, Fangling Le, Xiuying Qin,Yanyu Liu, Jie  Liu*.Ruthenium(II) polypyridyl complexes: Cellular uptake, cell image andapoptosis of HeLa cancer cells induced by double targets.Eur. J. Med. Chem. 2014,82-95.
16.Licong Yang, Qingchang Chen, Ying Liu, Jingnan Zhang,Dongdong Sun, Yanhui Zhou, Jie  Liu*. Se/Ru nanoparticles as inhibitors of metal-induced Aβaggregation in Alzheimer's disease. Journal of Materials Chemistry B. 2014, 2,1977-1987.4.7
17.Qianqian Yu, Yanan Liu, Chengwen Cao, Fangling Le, Xiuying Qin, DongdongSun, Jie Liu*.The Use of pH-sensitive Functional Selenium NanoparticlesShows Enhanced in vivo VEGF-siRNA Silencing and Fluorescence Imaging. Nanoscale, 2014,6, 9279–9292(IF=6.7)
18.Jingnan Zhang,Xianbo Zhou,Qianqian Yu, Licong Yang, Dongdong Sun, Yanhui Zhou, Jie Liu*. Epigallocatechin-3-gallate (EGCG)-Stabilized Selenium Nanoparticles Coated with Tet‑1Peptide To Reduce Amyloid‑β Aggregation andCytotoxicity. ACS. Appl. Mater. Int.2014, 6, 8475−8487(IF=5.9)
19.Xiu-Ying Qin, Ya-Nan Liu, Qian-Qian Yu, Li-Cong Yang, Ying Liu, Yan-Hui Zhou*,Jie Liu*. Mixed-Ligand Mononuclear Copper(II) Complex: Crystal Structure and Anticancer  Activity. ChemMedChem.2014,9(8):1665-71
20.Wenjing Zheng, Licong Yang, Ying Liu, Xiuying Qin, Yanhui Zhou, YunshanZhou*, Jie Liu*, Mo polyoxometalates nanoparticles inhibit tumor growth and vascularendothelial growth factor induced angiogenesis.Science and Technology of Advanced Materials. 15 (2014) 035010,1-14
21.Jingnan Zhang, Qianqian Yu, Qian Li, Licong Yang, Lanmei Chen, Yanhui Zhou*,Jie Liu*.  A ruthenium(II) complex capable of inducing and stabilizing bcl-2G-quadruplex formation as a potential cancer inhibitor.J. Inorg. Biochem. 2014,134,1–11
22.DongdongSun,YananLiu,QianqianYu,XiuyingQin,LicongYang,Yanhui Zhou,LanmeiChen,JieLiu *. Inhibition of Tumor Growth and Vasculature and Fluorescence Imaging Using Functionalized Ruthenium-thiol Protected Selenium Nanoparticles.Biomaterials, 2014, 35,1572-1583. (IF=8.7)
23.LijunWang, Chuping Zheng, Yanyu Liu, Fangling Le, Fang Yang, Xiuying Qin, Chuan Wang,Jie Liu*Anticancer Activity for Targeting Telomeric G-Quadruplexand Antiangiogenesis of a Novel Ru(II)–Se Complex.Biol Trace Elem Res (2014) 157:175–182
24.Licong Yang, Jingnan Zhang, Chuan Wang, Xiuying Qin, Qianqian Yu, Yanhui Zhou*,Jie Liu*Interaction between 8-hydroxyquinoline ruthenium (II) complexes and basic fibroblast growth factors (bFGF): inhibiting angiogenesis and tumor growth through ERK and AKT signaling pathways.Metallomics,2014, 6 (3), 518 - 531
25.Qian Li,Jingnan Zhang,Qingchang Chen,Licong Yang,Xiuying Qin, Fangling Le,Qianling Zhang*,Jie Liu*Stabilization of G-Quadruplex DNA and Inhibition of Telomerase Activity Studies of Ruthenium(II) Complexes.J. Inorg. Biochem.2014, 122-129.
26.刘莹陈小曼张朗棋孙冬冬周艳晖陈兰美*,刘杰*,钌配合物稳定端粒DNA 的作用及其诱导细胞凋亡分子机制的研究.化学学报，Acta Cheim.Sinica,2014,72,473-480
2013年
27.Shi, Shuo; Gao, Shane; Cao, Tongcheng; Liu, Jie; Gao, Xing; Hao, Jian; Lv,Chunyan; Huang, Hailiang; Xu, Jun; Yao, Tianming. Targeting Human TelomericG-Quadruplex DNA and Inhibition of Telomerase Activity With [(dmb)(2)Ru(obip)Ru(dmb)(2)](4+). PLOS ONE,2013,8(12),e84419
28.Xiuying Qin，Li Cong Yang，Fang Ling Le，QianQian Yu， DongDong Sun，YaNan Liu，Jie Liu*.Structures and Anti-cancer Properties of Two Binuclear Copper Complexes. Dalton Trans., 2013, 42 (41), 14681 - 14684. (IF=4.1)4.2
29.Dongdong Sun, Yanan Liu, Qianqian Yu, Yanhui Zhou, Rong Zhang,Xiaojia Chen, An Hong*and Jie Liu*,The effects of luminescent ruthenium(II) polypyridyl functionalized seleniumnanoparticles on bFGF-induced angiogenesis and AKT/ERK signaling.Biomaterials, 2013，34,171-180(IF=8.7)
30.Fangling Le, Dongdong Sun , Du Liu, Chuping Zheng, Ying Liu, *. Stabilization of G-quadruplex DNA and anti-tumor activity by different structures of nickel(II) complexes. Inorg. Chem.Commun. 38 (2013) 20-27
31.Yu Xia, Qingchang Chen, Xiuying Qin, Dongdong Sun, Jingnan Zhangand Jie Liu*. Studies of Ruthenium(II)-2,2′-biiminazole on binding to G-quadruplex DNA and inducing apoptosis in HeLa cells. New J. Chem. 2013, 37 (11), 3706 - 3715
32.Qianqian Yu, Yanyu Liu, Jingnan Zhang, Fang Yang, Dongdong Sun, Du Liu,Yanhui Zhou*, Jie Liu*.  Ruthenium(II) polypyridyl complexes as G-quadruplex inducing and stabilizing ligands in telomeric DNA. Metallomics,2013, 222 - 231.
33. Liu, Yanan, Chen Tianfeng, Liu Jie, Wong Yum-Shing.Identification of fluorescent ruthenium complexes containing imidazole derivatives as a new class of apoptosis inducers by living cell real-time imaging.MedChemComm. 2013,4,865-869
2012年
34. Dongdong Sun, Yanan Liu, Rong Zhang, Xicheng Yang, and Jie Liu*.Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity and Live Cell Imaging Studies of Chiral Ruthenium (II) Complexes.Chemistry A European Journal. 2012, 18, 4285 -4295.
35. Qianqian Yu, Yanan Liu, Chuan Wang, Dongdong Sun, Xicheng Yang, Yanyu Liu, and Jie Liu,*Chiral Ruthenium(II) Polypyridyl Complexes: Stabilization of G-quadruplex DNA, Inhibition of Telomerase Activity and Cellular Uptake. PLoS One , 2012, 7(12), e50902
36. Chuan Wang,Qianqian Yu, Licong Yang, Yanyu Liu,Dongdong Sun,Yongchao Huang, Yanhui Zhou,Qianling Zhang*,Jie Liu*. Ruthenium (II) polypyridyl complexes stabilize the bcl-2promoter quadruplex and induce apoptosis of Hela tumorcells.Biometals,2013，26:387–402
37. Yanyu Liu, Qianqian Yu, Chuan Wang, Dongdong Sun, Yongchao Huang, Yanhui Zhou, Jie Liu*Ruthenium (II) complexes binding to human serum albumin and inducing apoptosis of tumor cells.Inorganic Chemistry Communications , 2012, 24 ,104–109
38.Guo-Bi Li, Xu-Jia Hong, Zhi-Gang Gu, Zhi-Peng Zheng, Yang-Yang Wu, Hong-Yang Jia, Jie Liu, Yue-Peng CaiEfficient synthesis and characterization of the low dimensional heteronuclear complexes with a N2O2-donor Schiff base ligand. Inorganica Chimica Acta. 2012, 392(30) 177–183ISSN:0020-1693
39. Du Liu，Yanan Liu, Feng Gao, Shuo Shi, Dongdong Sun, Chuan Wang, Qianling Zhang*,Jie Liu*，Polypyridyl Complexes of Ruthenium(II): Stabilization ofG-quadruplex DNA and Inhibition ofTelomerase Activity. ChemPlusChem. 2012. 77,551-562.(封面文章)
40. Dongdong Sun, Rong Zhang,Fang Yuan, Du Liu,Yanhui Zhou, Jie Liu*. Studies on synthesis, characterization, visual observation and G-quadruplex binding of η6-arene ruthenium complexes with 1,10-phenanthroline-derived ligands. Dalton Transactiosn. 2012,41 (6), 1734 – 1741.
41. Dong-dong Sun, Wei-zhang Wang, Jian-wen Mao, Wen-jie Mei* and Jie Liu*. Imidazo [4, 5f][1, 10] phenanthroline derivatives as inhibitor of c-myc gene expression in A549 cells via NF-kB pathway.  Bioorg Med Chem Lett. 2012,22, 102–105.
42. Fang Yuan，Xiaojia Chen, Yanhui Zhou, Fang Yang, Qianling Zhang*, Jie Liu*,Synthesis ruthenium(Ⅱ) polypyridyl complex with 1,10-phenanthrolineselenazole as ligand and investigate its G-quadruplex DNA-binding properties. Journal Coordination Chemistry.2012, 65, 1246-1257.
43.Qian Li，Dongdong Sun, Yanhui Zhou, Du Liu, Qianling Zhang*, Jie Liu*,  Anticancer Activity of novel ruthenium complex with 1,10-phenanthrolineselenazole as potent telomeric G-quadruplex inhibitor. Inorg.Chem.Commun. 2012, 20, 142–146
44. Xiaoxin Yang, Lanmei Chen, Yanan Liu, Yongguang Yang, Tianfeng Chen, Wenjie Zheng,  Jie Liu*, Qing-Yu He* Ruthenium methylimidazole complexes induced apoptosis in lung cancer A549 cells through intrinsic mitochondrial pathway.Biochimie,2012, 94,345-352.
45. Fang Yuan，XiaoJia Chen，YaNan Liu，TingTing Zhang，DongDong Sun，Jie Liu*. Chiral ruthenium complexes induce apoptosis of tumor cell and interact with bovine serum albumin.Chirality. 2012，24:174-180

xiaoqiuyu

2018自然科学基金项目-微泡及超声介导BBB开放递送纳米硒/硫及其载药 抑制阿尔兹海默病的研究
批准号        21877051        学科分类        环境污染模式与预测 ( B070504 )
负责人        刘杰        职称                单位名称        暨南大学
资助金额        67万元        项目类别        面上项目        起止年月        2019年01月01日 至 2022年12月31日

chandler

近日，我院陈填烽教授、刘杰教授入选爱思唯尔(Elsevier)2020年中国高被引学者榜单。本次国内共有来自373个高校/科研单位/企业的4023位学者入选，覆盖了教育部10个学科领域、84个一级学科。其中，暨南大学共有21位学者上榜，分布在15个一级学科。
       中国高被引学者从纯论文影响力的角度遴选学术人才，标准客观统一，有利于视角多元地看待人才，具有重要的参考价值，一直是软科中国大学排名的核心评价指标。
       刘杰，暨南大学化学与材料学院教授，博士生导师。主要从事生物创新药物（包括化学合成药物、纳米药物、纳米载药）的研究，作为通讯作者在ACS Nano、Adv. Funct. Mater.、Biomaterials、ACS Appl.Mater. Int.、Acta Biomaterialia.等高水平期刊上发表论文140多篇，个人科研指数h-index 41, 获得授权专利12项。