中国科学院大连化学物理研究所生物技术研究部刘扬

zhuxiaonan

姓名：刘扬        
性别： 男
类别：研究员;百人        
学科：生物医学
职称：研究员        
学历：博士研究生
电话：0411-82463004        
Email：yliuqq@dicp.ac.cn
地址：大连市中山路457号        
邮编：116023        
简历介绍：
　　刘扬，研究员，硕士生导师，生物技术部转化医学科学中心疾病基因组学负责人，2007于中国医科大学获得细胞生物学博士学位，刘扬研究员于2007年毕业于中国医科大学，同年至2014年间赴美留学，分别在波士顿大学医学院和哈佛医学院从事肿瘤方面的转化医学研究工作。于2014年10月到大连化物所转化医学科学中心担任副研究员工作。2015年获中国科学院“百人计划”A类择优支持。刘扬研究员在人类遗传性疾病及多种肿瘤的前临床研究方面有着较突出的贡献，对肿瘤表观遗传学研究方面也获得了一些重要新的发现和成绩。他的文章发表在国际著名杂志如Nature Genetics, Blood, Clinical Cancer Research , Molecular Cancer Therapeutics, FASEB J以及PlosOne等。


研究方向：
　　目前主要从事罕见肿瘤遗传学机制的发现和致癌代谢物与肝癌形成关系及其调控机制的研究。其中主要以MYC癌基因驱动的肝癌作为研究模型，系统的研究MYC基因的异常与肝癌代谢组学及致病机制和临床转化意义。另一方面，系统阐明肿瘤突变及相关信号通路激活与肿瘤发生，耐药机制的相关性，从而研发新的治疗。


代表论著：
　　1. Liu Y, Xiafei Hong, Guowang Xu, David J. Kwiatkowski. Targeting PI3K/AKT/mTORC signals in human Kidney Cancer. (Oncogene，Under Review, Corresponding Author)


　　2. Liu Y, David J. Kwiatkowski. Combined CDKN1A/TP53 mutation in bladder cancer is a therapeutic target.(Mol Cancer Ther, 2015 Jan;14(1):174-82)


　　3. Liu Y, Quang P, Gayane Badalian, Esteban Braggio, Azab F, Azab AK, Maiso P, Flores LM, Quang P, Roccaro AM, Sacco A, Ngo HT, Zhang Y, Morgan B, Carrasco R, Barrett Rollins, Ghobrial IM. Novel Tumor Suppressor Function of Glucocorticoid-Induced TNF Receptor GITR in Multiple Myeloma. Plos One. 2013 Jun 13; 8 (6).


　　4.Wen Y*, Liu Y*, Xu Y*, Zhao Y, Hua R, Wang K, Sun M, Li Y, Yang S, Zhang XJ, Kruse R, Cichon S, Betz RC, Nothen MM, van Steensel MA, van Geel M, Steijlen PM, Hohl D, Huber M, Dunnill GS, Kennedy C, Messenger A, Munro CS, Terrinoni A, Hovnanian A, Bodemer C, de Prost Y, Paller AS, Irvine AD, Sinclair R, Green J, Shang D, Liu Q, Luo Y, Jiang L, Chen HD, Lo WH, McLean WH, He CD, Zhang X. Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis. Nat Genet. 2009 Feb; 41(2):228-33 (*Equal Contribution)


　　5. Liu Y*, Zhou Fei*, Zhen Yan, Daiming Fan, Alice Alexandra, Jing-Hua Yang. Targeting dsRNA for a rapid and broad antiviral prophylaxis. FASEB J. 2011, Feb 25(5):1767-74 (*Equal contribution)


　　6. Sacco A, Issa GC, Zhang Y, Liu Y, Maiso P, Ghobrial IM, Roccaro AM. Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology. J Hematol Oncol. 2010 Oct 7;3:38


　　7. Sacco A, Maiso P, Azab A, Azab F, Zhang Y, Liu Y, Ngo HT, Morgan B, Quang P, Issa G, Ghobrial IM, Roccaro AM. Key Role of MicroRNAs in Waldenstrm's Macroglobulinemia Pathogenesis. Clin Lymphoma Myeloma Leuk. 2011 Feb 1;11(1):109-11.


　　8. Ghobrial IM, Zhang Y, Liu Y, Ngo H, Azab F, Sacco A, Azab A, Maiso P, Morgan B, Quang P, Issa G, Roccaro A. The Bone Marrow Niche in Waldenstrom's Macroglobulinemia. Clin Lymphoma Myeloma Leuk. 2011 Feb 1; 11(1):118-20


　　9. Sacco A, Aujay M, Morgan B, Azab AK, Maiso P, Zhang Y, Liu Y, Azab F, Ngo HT, Issa GC, Quang P, Roccaro AM, Ghobrial IM. Carfilzomib-dependent selective inhibition of the chymotrypsin-like activity of the proteasome leads to anti-tumor activity in Waldesntrom's macroglobulinemia. Clin Cancer Res. 2011 Apr 1;17(7):1753-64


　　10. Zhu H, Shang D, Sun M, Choi S, Liu Q, Hao J, Figuera LE, Zhang F, Choy KW, Ao Y, Liu Y, Zhang XL, Yue F, Wang MR, Jin L, Patel PI, Jing T, Zhang X. XLinked Congenital Hypertrichosis Syndrome Is Associated with Interchromosomal Insertions Mediated by a Human-Specific Palindrome near SOX3. Am J Hum Genet. 2011 Jun 10; 88(6):819-26.


　　11. Ghobrial IM, Zhang Y, Liu Y, Ngo H, Azab F, Sacco A, Azab A, Maiso P, Morgan B, Quang P, Issa GC, Leleu X, Roccaro AM. Targeting the bone marrow in Waldenstrom macroglobulinemia. Clin Lymphoma Myeloma Leuk. 2011 Jun;11 Epub 2011 Apr 30.


　　12. Azab AK, Azab F, Quang P, Maiso P, Morgan B, Sacco A, Ngo HT, Liu Y, Zhang Y, Roccaro AM, Ghobrial IM. FGFR3 is overexpressed in Waldenstrom macroglobulinemia and its inhibition by Dovitinib induces apoptosis, and overcomes stroma-induced proliferation. Clin Cancer Res. 2011 Jul 1; 17(13):4389-99.


　　13. Maiso P, Liu Y, Morgan B, Azab A, Ren P, Martin MB, Zhang Y, Liu Y, Sacco A,Ngo H, Azab F, Quang P, Rodig SJ, Lin CP, Roccaro A, Rommel C, Ghobrial IM. Defining the role of TORC1 and TORC2 in multiple myeloma. Blood. 2011 Dec 22;118 (26):6860-70


　　14. Azab F, Azab AK, Maiso P, Calimeri T, Flores LM, Liu Y, Quang P, Roccaro AM, Sacco A, Ngo HT, Zhang Y, Morgan B, Carrasco R, Ghobrial IM. Eph-B2/ephrin-B2 interaction plays a major role in the adhesion and proliferation of Waldenstrom's Macroglobulinemia. Clin Cancer Res. 2012 Jan 1; 18(1):91-104


　　15. LNA-mediated anti-microRNA-155 silencing in low-grade B cell lymphomas. Zhang Y, Roccaro AM, Rombaoa C, Flores L, Obad S, Fernandes SM, Sacco A, Liu Y, Ngo H, Quang P, Azab AK, Azab F, Maiso P, Reagan M, Brown JR, Thai TH, Kauppinen S, Ghobrial IM. Blood. 2012 Aug 23;120(8):1678-86