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房新强,男，理学博士，中国科学院福建物质结构研究所研究员、课题组长、博士生导师。2005年硕士毕业于中国科学技术大学（指导教师：刘有成院士），2009年博士毕业于中国科学院上海有机化学研究所（指导教师：李超忠研究员）；2009-2011年在新加坡南洋理工大学从事博士后研究；2011年至2013年，在美国康奈尔大学和德州农工大学从事博士后研究工作。至今已在Journal of The American Chemical Society、Angewandte Chemie International Edition、Chemical Science、Organic Letters等杂志上发表论文二十多篇。2013年9月以“海西院百人计划”高层次人才引进到中国科学院福建物质结构研究所工作，任研究员，课题组长。2015年入选第十一批“##计划”青年人才 ，同年入选福建省百人计划。
研究方向：有机化学-有机合成-不对称催化，尤其是有机小分子催化、新型催化剂和配体的设计合成及其应用、药物活性分子的合成
电子邮件：xqfang@fjirsm.ac.cn
联系电话：0591-63173513
办公室地址：新区1号楼1313房间
Fang group publication.docx
25. N-Heterocyclic Carbene-Catalyzed Umpolung of Alkynyl 1,2-Diketones, Xiangwen Kong, Guoxiang Zhang, Shuang Yang, Xiaozhi Liu, and Xinqiang Fang,* Adv. Synth. Catal. 2017, DOI: 10.1002/adsc.201700700.
24. Enantioselective Synthesis of 1,2-Dihydronaphthalenes via Oxidative N-Heterocyclic Carbene Catalysis, Saima Perveen, Zhifei Zhao, Guoxiang Zhang, Jian Liu, Muhammad Anwar, and Xinqiang Fang,* Org. Lett. 2017, 19, 2470−2473.
23. Kinetic Resolutions Enabled by N-Heterocyclic Carbene Catalysis, Shuang Yang, Xinqiang Fang,* Curr. Org. Syn. 2017, 14, DOI: 10.2174/1570179414666170215093134. (review paper)
22. A Genetically Encoded Allysine for the Synthesis of Proteins with Site-Specific Lysine Dimethylation, Zhipeng A. Wang, Yu Zeng, Yadagiri Kurra, Xin Wang, Jeffery M. Tharp, Erol C. Vatansever, Willie W. Hsu, Susie Dai, Xinqiang Fang,* and Wenshe R. Liu,* Angew. Chem., Int. Ed. 2017, 56, 212-216.
21. Stereodivergent Synthesis of Chromanones and Flavanones via Intramolecular Benzoin Reaction, Genfa Wen, Yingpeng Su, Guoxiang Zhang, Qiqiao Lin, Yujin Zhu, Qianqian Zhang, and Xinqiang Fang*, Org. Lett. 2016, 18, 3980‒3983.
20. Dynamic Kinetic Resolution Enabled by Intramolecular Benzoin Reaction: Synthetic Applications and Mechanistic Insights, Guoxiang Zhang, Shuang Yang, Xiaoyan Zhang, Qiqiao Lin, Deb K. Das, Jian Liu, and Xinqiang Fang*, J. Am. Chem. Soc. 2016, 138, 7932-7938. (Highlighted by Synfacts 2016, 972)
19. N-Heterocyclic Carbene-catalyzed Desymmetrization of Functionalized 1,4-Dienes via Stetter Reaction, Qiqiao Lin, Yuanzhen Li, Deb Kumar Das, Guoxiang Zhang, Zhifei Zhao, Shuang Yang* and Xinqiang Fang*, Chem. Commun. 2016, 52, 6459-6462.
18. Asymmetric Desymmetrization of 1,3-Diketones via Intramolecular Benzoin Reaction, Yuanzhen Li, Shuang Yang, Genfa Wen, Qiqiao Lin, Guoxiang Zhang, Lin Qiu, Xiaoyan Zhang, Guangfen Du,* Xinqiang Fang*. J. Org. Chem., 2016, 81, 2763-2769.
17. Stereoselectivity of 6-Exo Cyclization of α-Carbamoyl Radicals, Song, L.; Fang, X.; Wang, Z.; Liu, K.; Li, C.* J. Org. Chem. 2016, 81, 2442-2450.
16. The Genetic Incorporation of Thirteen Novel non-Canonical Amino Acids. Tuley, A.; Wang, Y.-S.; Fang, X.; Kurra, Y.; Rezenom, Y. H.; Liu, W. R.* Chem. Comm. 2014, 50, 2673-2675.
Before Independence:
15 Fang, X.¶; Fu, Y.¶; Long, M. C.; Haegele, J. A.; Ge, E. J.; Parvez, S.; Aye, Y.* Temporally Controlled Targeting of 4-Hydroxynonenal to Specific Proteins in Living Cells. J. Am. Chem. Soc. 2013, 135, 14496-14499. (¶ contributed equally).
14. Sun, H.; Fang, X.; Chi, Y. R.*; Li, G.* Theoretical Study of N-Heterocyclic Carbenes-Catalyzed Cascade Annulation of Benzodienones and Enals. Chirality 2013, 25, 521-528.
13. Lee, Y.-J. C.; Wu, B.; Raymond, J. E.; Zeng, Y.; Fang, X.; Wooley, K. L.; Liu, W. R.* A Genetically Encoded Acrylamide Functionality. ACS Chem. Biol. 2013, 8 ,1664-1670.
12. Chen, X.¶; Fang, X.¶; Chi, Y. R.* Cis-Enals in N-Heterocyclic Carbene-Catalyzed Reactions: Distinct Stereo-Selectivity and Reactivity. Chem. Sci. 2013, 4, 2613-2618. (¶ contributed equally)
11. Wang, Y.-S.¶; Fang, X.¶; Chen, H.-Y.; Wu, B.; Wang, Z. U.; Hilty, C.; Liu, W. R.* Genetic Incorporation of Twelve meta-Substituted Phenylalanine Derivatives Using a Single Pyrrolysyl-tRNA Synthetase Mutant. ACS Chem. Biol. 2013, 8, 405-415. (¶ contributed equally)
10. Wang, Y.-S.; Fang, X.; Wallace, A. L.; Wu, B.; Liu, W. R.* A Rationally Designed Pyrrolysyl-tRNA Synthetase Mutant with a Broad Substrate Spectrum. J. Am. Chem. Soc. 2012, 134, 2950-2953.
9. Fang, X.; Chen, X.; Lv, H.; Chi, Y. R.* Enantioselective Stetter Reactions of Enals and Modified Chalcones Catalyzed by N-Heterocyclic Carbene. Angew. Chem. Int. Ed. 2011, 50, 11782-11785.
8. Lv, H.; Mo, J.; Fang, X.; Chi, Y. R.* Formal Diels-Alder Reactions of Chalcones and Formylcyclopropanes Catalyzed by Chiral N-Heterocyclic Carbenes. Org. Lett. 2011, 13, 5366-5369.
7. Fang, X.; Chen, X.; Chi, Y. R.* Enantioselective Diels-Alder Reactions of Enals and Alkylidene Diketones Catalyzed by N-Heterocyclic Carbenes. Org. Lett. 2011, 13, 4708-4711.
6. Fang, X.; Jiang, K.; Xing, C.; Hao, L.; Chi, Y. R.* A Highly Regio- and Stereoselective Cascade Annulation of Enals and Benzodi(enone)s Catalyzed by N-Heterocyclic Carbenes. Angew. Chem. Int. Ed. 2011, 50, 1910-1913.
5. Fang, X.; Liu, K.; Li, C.* Efficient Regio- and Stereoselective Formation of Azocan-2-ones via 8-Endo Cyclization of α-Carbamoyl Radicals. J. Am. Chem. Soc. 2010, 132, 2274-2283.
4. Fang, X.; Xu, H.-J.; Jiang, H.; Liu, Y.-C.*; Fu, Y.; Wu, Y.-D.* A Study on the Reactions of NADH Models with Electron Deficient Alkenes. A Probe for the Extreme of Concerted Electron-hydrogen Atom Transfer Mechanism. Tetrahedron Lett. 2009, 50, 312-315.
3. Pan, Y.; Lu, H.; Fang, Y.; Fang, X.; Chen, L.; Qian, J.; Wang, J.; Li, C.* Synthesis of Pyrroles via Copper-Catalyzed Coupling of Amines with Bromoenones. Synthesis 2007, 1242-1246.
2. Fang, X.; Liu, Y.-C.*; Li, C.* 9-Phenyl-10-methylacridinium: A Highly Efficient and Reusable Organocatalyst for Mild Aromatization of 1,4-Dihydropyridines by Molecular Oxygen. J. Org. Chem. 2007, 72, 8608-8610.
1. Fang, X.; Liu, Y.-C.*; Wang, G.-W.; Ke, Y.-P. A Novel Coenzyme NADH Model 1-Benzyl-1,4-dihydronicotinamide-mediated Reaction: A Single Intermediate Serves two Mechanisms. Res. Chem. Intermediat. 2006, 32, 603-611.
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发表于 2017-9-29 16:28:07
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