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郭炜，男，1972年出生于山西省长治市，2002年毕业于南开大学化学系并获博士学位，现为山西大学化学化工学院院长，二级教授，博士生导师。主要从事荧光染料及探针的开发及生物传感研究工作，在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Chem. Sci.、Biomaterials、ACS Appl. Mater. Interfaces等国际权威学术期刊发表学术论文60余篇，他引2000余次。入选教育部新世纪优秀人才、山西省高等学校中青年拔尖人才、山西省高等学校优秀青年学术带头人、山西省学术技术带头人、山西省131领军人才。研究项目“荧光探针的构建及生物传感研究”获2015年度山西省科学技术（自然科学类）二等奖。
教育经历：
1991-1995 山西大学化学系 本科
1995-1998 山西大学化学系 硕士研究生
1999-2002 南开大学化学系 博士研究生
工作经历：
1998至今 山西大学化学化工学院
讲授课程：
基础有机化学；物理有机化学；高等有机化学
科研方向：
分子发光与生物传感
科研项目：
1．环二肽催化的不对称Baylis-Hillman反应研究，山西省青年科学基金，2004-2006，3.5万元。
2．新型有机负氢转移试剂，N1,N2-二取代的咪唑啉啶在有机合成中的应用研究，国家青年科学基金，2006-2008，26万元。
3．新型Tripodal氧杂、氮杂醚类化合物的构建以及对阳离子的选择性识别研究，国家自然科学基金，2008-2010，28万元。
4．山西省高校青年科技带头人，山西省教育厅，2009，10万元。
5．咪达那新的新工艺开发研究，太原市科技局项目，2010-2011，10万元。
6．罗丹明传感器的设计、合成及在离子传感、生物细胞中离子成像方面的应用，国家自然科学基金，2011-2011，12万元。
7．新型罗丹明传感器的设计、合成及在离子传感、细胞成像方面的应用，教育部博士点基金，2011-2013，6万元。
8．山西大学英才计划，山西大学，2011，8万元。
9．新世纪优秀人才支持计划，教育部，2011，50万元。
10．通键能量转移（TBET）近红外荧光功能分子的构建及化学传感研究，国家自然科学基金，2012-2015，65万元。
11. 一氧化氮其下游产物过氧亚硝基新型有机荧光探针的构建及生物传感研究，国家自然科学基金，2016.01-2019.12，70万元。
12.“分子发光与生物传感”基础研究提升计划，山西省教育厅1331工程重点学科建设计划-2017年度一般性重点，2017.
论著一览：
62. Yingying Huo, Junfeng Miao, Lingjun Han, Yaping Li, Zhe Li, Yawei Shi, and Wei Guo*; Selective and Sensitive Visualization of Endogenous Nitric Oxide in Living Cells and Animals by a Si-Rhodamine Deoxylactam-Based Near-Infrared Fluorescent Probe; Chem. Sci., 2017, DOI: 10.1039/c7sc02608k.
61. Hongxing Zhang, Jing Liu, Chenlu Liu, Pengcheng Yu, Minjia Sun, Xiaohan Yan, Jian-Ping Guo, Wei Guo*; Imaging lysosomal highly reactive oxygen species and lighting up cancer cells and tumors enabled by a Si-rhodamine-based near-infrared fluorescent probe; Biomaterials, 2017, 133, 60-69.
60. Yun Zhao*, Yuanyuan Xue, Haoyang Li, Ruitao Zhu Yuehong Ren, Qinghua Shi, Song Wang, Wei Guo*; An excited state intramolecular proton transfer dye based fluorescence turn-on probe for fast detection of thiols and its applications in bioimaging; Spectrochim. Acta, Part A, 2017, 175, 215-221.
59. Yue Wang, Xin Lv*, Wei Guo**; A reaction-based and highly selective fluorescent probe for hydrogen sulfide; Dyes and Pigments, 2017, 139, 482-486.
58. Yingying Huo, Junfeng Miao, Yaping Li, Yawei Shi, Heping Shi and Wei Guo*; Aromatic primary monoamine-based fast-response and highly specific fluorescent probes for imaging the biological signaling molecule nitric oxide in living cells and organisms; J. Mater. Chem. B, 2017, 5, 2483-2490.
57. Junfeng Miao, Yingying Huo, Qian Liu, Zhe Li, Heping Shi, Yawei Shi, and Wei Guo*; A new class of fast-response and highly selective fluorescent probes for visualizing peroxynitrite in live cells, subcellular organelles, and kidney tissue of diabetic rats; Biomaterials, 2016, 107, 33-43.
56. Junfeng Miao, Yingying Huo, Xin Lv, Zhe Li, Hualiang Cao, Heping Shi, Yawei Shi, and Wei Guo*; Fast-response and highly selective fluorescent probes for biological signaling molecule NO based on N-nitrosation of electron-rich aromatic secondary amines; Biomaterials, 2016, 78, 11.
55. Jing Liu, Yuan-Qiang Sun, Hongxing Zhang, Heping Shi, Yawei Shi, and Wei Guo*; Sulfone-Rhodamines: A New Class of Near-Infrared Fluorescent Dyes for Bioimaging; ACS Applied Materials & Interfaces. 2016, 8, 22953.
54. Jian Zhang, Yaping Li, Jingjing Zhao, and Wei Guo*; An arylboronate-based fluorescent probe for selective and sensitive detection of peroxynitrite and its applications for fluorescence imaging in living cells; Sensors and Actuators B, 2016, 237, 67–74.
53. Yue WangAuthor Vitae, Yawei LiuAuthor Vitae, Junfeng Miao, Minghao Ren, Wei GuoAuthor Vitae, Xin Lv*; A novel Bodipy-based fluorescent probe for Au3+ ions with high selectivity and its application to bioimaging; Sensors and Actuators B, 2016, 226, 364–369.
52. Yun Zhao, Yuehong Ren, Haoyang Li, Taihe Han, Huanhuan Chen, Wei Guo*; A new far-red naphthorhodamine dye: Synthesis, fluorescent probe and bioimaging applications; Dyes and Pigments, 2016, 132, 255-261.
51. Yawei Liu, Xin Lv, Min Hou, Yawei Shi, and Wei Guo*; Selective Fluorescence Detection of Cys over Hcy and GSH Based on a Cys-Triggered Dual Michael Addition/Retro-aza-aldol Cascade Reaction; Anal. Chem., 2015, 87, 11475.
50. Yawei Liu, Xin Lv, Jing Liu, Yuan-Qiang Sun, and Wei Guo*; Construction of a Selective Fluorescent Probe for GSH Based on a Chloro-functionalized Coumarin-enone Dye Platform; Chem. Eur. J., 2015, 21, 4747.
49. Hongxing Zhang, Jing Liu Yuan-Qiang Sun, Yingying Huo, Yaohua Li, Weizhi Liu, Xiao Wu, Nishu Zhu, Yawei Shi, and Wei Guo*; A Mitochondria-Targetable Fluorescent Probe for Peroxynitrite: Fast Response and High Selectivity; Chem. Commun., 2015, 51, 2721.
48. Xin Lv, Yue Wang, Song Zhang, Yawei Liu, Jian Zhang and Wei Guo*; A specific fluorescent probe for NO based on a new NO-binding group; Chem. Commun., 2014, 50, 7499.
47. Yuan-Qiang Sun,§ Jing Liu, Hongxing Zhang, Yingying Huo, Xin Lv, Yawei Shi, and Wei Guo*; A Mitochondria-Targetable Fluorescent Probe for Dual-Channel NO Imaging Assisted by Intracellular Cysteine and Glutathione; J. Am. Chem. Soc., 2014, 136, 12520.
46. Yawei Liu, Song Zhang, Xin Lv, Yuan-Qiang Sun, Jing Liu, and Wei Guo*; Constructing fluorescent probe for specific detection of cysteine over homocysteine and glutathione based on a novel cysteine-binding group but-3-yn-2-one; Analyst, 2014, 139, 4081.
45. Jing Liu, Yuan-Qiang Sun, Yingying Huo, Hongxing Zhang, Linfang Wang, Pei Zhang, Yawei Shi, and Wei Guo*; Simultaneous Fluorescence Sensing of Cys and GSH from Different Emission Channels; J. Am. Chem. Soc., 2014, 136, 574.
44. Jing Liu, Yuan-Qiang Sun, Hongxing Zhang, Yingying Huo, Yawei Shi, Heping Shi, and Wei Guo*; A Carboxylic acid-Functionalized Coumarin-Hemicyanine Fluorescent Dye and Its Application to Construct a Fluorescent Probe for Selective Detection of Cysteine over Homocysteine and Glutathione; RSC Adv., 2014, 4, 64542.
43. Jing Liu, Yuan-Qiang Sun, Hongxing Zhang, Yingying Huo, Yawei Shi, and Wei Guo*; Simultaneous Fluorescent Imaging of Cys/Hcy and GSH from Different Emission Channels; Chem. Sci., 2014, 5, 3183.
42. Jingyu Zhang and Wei Guo*; A new fluorescent probe for gasotransmitter H2S: high sensitivity and selectivity, and a significant fluorescence off–on response; Chem. Commun., 2014, 50, 4214.
41. Jingyu Zhang, Yuan-Qiang Sun, Jing Liu, Yawei Shi and Wei Guo*; A fluorescent probe for the biological signaling molecule H2S based on a specific H2S trap group; Chem. Commun., 2013, 49, 11305.
40. Jing Liu, Yuan-Qiang Sun, Pi Wang, Jingyu Zhang and Wei Guo*; Construction of NIR and Ratiometric Fluorescent Probe for Hg2+ Based on a Rhodamine-Inspired Dye Platform; Analyst, 2013, 138, 2654.
39. Jing Liu, Yuan-Qiang Sun, Jingyu Zhang, Ting Yang, Jianbin Cao, Lishen Zhang, and Wei Guo*; A Ratiometric Fluorescent Probe for Biological Signaling Molecule H2S: Fast Response and High Selectivity; Chem. Eur. J., 2013, 19, 4717.
38. Yuan-Qiang Sun,za Jing Liu,za Jingyu Zhang,a Ting Yangb and Wei Guo*; Fluorescent probe for biological gas SO2 derivatives bisulfite and sulfite; Chem. Commun., 2013, 49, 2637.
37. Jing Liu, Yuan-Qiang Sun, Xin Lv, and Wei Guo*; Fluorescent detection of biothiols based on a novel cascade reaction; Anal. Methods, 2013, 5, 3642.
36. Yuan-Qiang Sun, Pi Wang, Jing Liu, Jingyu Zhang and Wei Guo*; A fluorescent turn-on probe for bisulfite based on hydrogen bond-inhibited C=N isomerization mechanism; Analyst, 2012, 137, 3430.
35. Yuan-Qiang Sun, Jing Liu, Pi Wang, Jingyu Zhang, and Wei Guo*; D-Luciferin Analogues: a Multicolor Toolbox for Bioluminescence Imaging; Angew. Chem. Int. Ed., 2012, 51, 8428.
34. Yuan-Qiang Sun, Jing Liu, Xin Lv, Yunlong Liu, Yun Zhao, and Wei Guo*; Rhodamine-Inspired Far-Red to Near-Infrared Dyes and Their Application as Fluorescence Probes; Angew. Chem. Int. Ed. 2012, 51, 7634.
33. Yun Zhao, Xin Lv, Yunlong Liu, Jing Liu, Yan Zhang, Heping Shi, and Wei Guo*; The emission enhancement of the NIR distyryl Bodipy dyes by the indirected S0→S2 excitation and its application towards Hg2+ probe; J. Mater. Chem. 2012, 22, 11475.
32. Xianshu Zhou, Xin Lv, Junsheng Hao, Diansheng Liu, Wei Guo*; Coumarin-indanedione conjugate as a doubly activated Michael addition type probe for the colorimetric and ratiometric fluorescent detection of cyanide; Dyes and Pigments 2012, 95, 168.
31. Xianshu Zhou, Hengquan Yang, Junsheng Hao, Caixia Yin, Diansheng Liu,* and Wei Guo*; A Fluorescence Turn-on Sensor for CN￣ Based on Exciplex Signaling Mechanism; Chem. Lett. 2012, 41, 518.
30. Pi Wang, Jing Liu, Xin Lv, Yunlong Liu, Yun Zhao, and Wei Guo*; A Naphthalimide-based Glyoxal Hydrazone for Selective Fluorescence Turn-on Sensing of Cys and Hcy; Org. Lett. 2012, 14, 520.
29. Yunlong Liu, Xin Lv, Yun Zhao, Maliang Chen, Jing Liu, Pi Wang and Wei Guo*; A naphthalimide-rhodamine ratiometric fluorescent probe for Hg2+ based on fluorescence resonance energy transfer; Dyes and Pigments 2012, 92, 909.
28. Yunlong Liu, Xin Lv, Yun Zhao, Jing Liu, Yuan-Qiang Sun, Pi Wang and Wei Guo*; A Cu(II)-based chemosensing ensemble bearing rhodamine B fluorophore for fluorescence turn-on detection of cyanide; J. Mater. Chem. 2011, 22, 1747.
27. Xin Lv, Jing Liu, Yunlong Liu, Yun Zhao, Yuan-Qiang Sun, Pi Wang and Wei Guo*; Ratiometric fluorescent detection of cyanide based a hybrid coumarin-hemicyanine dye: the large emission shift and the high selectivity; Chem. Commun. 2011, 47, 12843.
26. Yuan-Qiang Sun, Maliang Chen, Jing Liu, Xin Lv, Jun-fei Li and Wei Guo*; Nitroolefin-based coumarin as a colorimetric and fluorescent dual probe for biothiols; Chem. Commun. 2011, 47, 11029.
25. Yun Zhao, Yan Zhang, Xin Lv, Yunlong Liu, Maliang Chen, Pi Wang, Jing Liu and Wei Guo*; Through-bond energy transfer cassettes based on coumarin-bodipy/distyryl bodipys dyads with efficient energy efficiences and large pseudo-Stokes’ shift; J. Mater. Chem. 2011, 21, 13168.
24. Xin Lv, Jing Liu, Yunlong Liu, Yun Zhao, Maliang Chen, Pi Wang and Wei Guo*; Rhodafluor-based Chromo- and Fluorogenic Probe for Cyanide Anion; Sensors and Actuators B 2011, 158, 405.
23. Xin Lv, Jing Liu, Yunlong Liu, Yun Zhao, Maliang Chen, Pi Wang and Wei Guo*; A Ratiometric Fluorescent Probe for Cyanide Based on FRET; Org. Biomol. Chem. 2011, 9, 4954.
22. Maliang Chen, Xin Lv, Yunlong Liu, Yun Zhao, Jing Liu, Pi Wang and Wei Guo*; An 2-(2'-aminophenyl)benzoxazole-based OFF-ON fluorescent chemosensor for Zn2+ in aqueous solution; Org. Biomol. Chem 2011, 9, 2345.
21. Yunlong Liu, Yue Sun, Jun Du, Xin Lv, Yun Zhao, Maliang Chen, Pi Wang, and Wei Guo*; Highly Sensitive and Selective Turn-on Fluorescent and Chromogenic Probe for Cu2+ and ClOˉ Based on a N-Picolinyl Rhodamine B-Hydrazide Derivative; Org. Biomol. Chem. 2011, 9, 432.
20. Yun Zhao, Yue Sun, Xin Lv, Yunlong Liu, Maliang Chen, and Wei Guo*; Rhodamine-based chemosensor for Hg2+ in aqueous solution with abroad pH range and its application in live cell imaging; Org. Biomol. Chem. 2010, 8, 4143.
19. Yue Sun, Yunlong Liu, Maliang Chen and Wei Guo*; A novel fluorescent and chromogenic probe for cyanide detection in water based on the nucleophilic addition of cyanide to imine group; Talanta 2009, 80, 996.
18. Yue Sun, Yunlong Liu and Wei Guo*; Fluorescent and chromogenic probes bearing salicylaldehyde hydrazone functionality for cyanide detection in aqueous solution; Sensors and Actuators B 2009, 143, 171.
17. Yongbin Zhang, Guofu Zhou, Donghong Li, Wei Guo*; Tetrahydropyrimidine Derivatives as Efficient Organic Reductants for Transfer Hydrogenation; Heterocycles, 2009, 78, 1541.
16. Yue Sun, Guofeng, Wang, Wei Guo*; Colorimetric Detection of Cyanide with N-Nitrophenyl Benzamide Derivatives; Tetrahedron, 2009, 65, 3480.
15. Donghong Li, Yongbin Zhang, Guofu Zhou, Wei Guo*; 1-Acetyl-2,3-Dimethylimidazolidine: an Novel Organic Reductant for Transfer Hydrogenation; Synlett, 2008, 2, 225.
14. Yongbin Zhang, Donghong Li, Guofu Zhou, Chizhong Xia, Wei Guo*; Synthesis of Functionalized b-Enamino Compounds by Carbon-Fragment Transfer Reaction of C(2)-Substituted Imidazolidines with Amines; Heterocycles, 2008, 75, 1123.
13. Zhengang Wu, Guofu Zhou, Jieyu Zhou, Wei Guo*; Aza-Baylis-Hillman Reaction of N-Tosylated Imines with Acrylamide or N-Arylacrylamide; Synthetic. Commun. 2006, 36, 2491.
12.Yongbin Zhang, Donghong Li, Chizhong Xia, Wei Guo*; 1-(3-Nitro-Benzenesulfonyl)-3,4-Dimethylimidazolinium Iodide: A More Active Tetrahydrofolate Coenzyme Model; Heterocycles 2005, 65, 2893.
11. Donghong Li, Yongbin Zhang, Chizhong Xia, Wei Guo*; A Convenient Preparation of a Series of 2-Aryl-Substituted Imidazolidines Through Diamine Transfer Reaction; Heterocycles 2005, 65, 1829.
10. Donghong Li, Yongbin Zhang, Wei Guo*; Synthesis of Functionalized Tetrahydro-β-carboline Derivatives by Modified Pictet-Spengler Reaction; Heterocycles 2005, 65, 1063.
9. Wei Guo, Xueling Mi, Jing Wang, Jiaqi, He, and Jin-Pei Cheng*; C–H···O Hydrogen Bonding Assisted Self-assembly of Biphenyl-bridged, Amino Acid-based Macrocycles; Chemical Journal of Chinese University，2005, 26, 1086.
8. Wei Guo*, Weiwei Wu, Ningjuan Fan, Zhengang Wu, Chizhong Xia; Synthesis of a-Substituted N-Aryl Acryamide Derivatives through Baylis-Hillman Reaction; Synthetic Commun. 2005, 35, 1239.
7. Wei Guo*, Junfei Li, Ningjuan Fan, Peiwen Zhou, and Chizhong Xia; A Simple and Effective Method for Chemoselective Esterification of Phenolic Acids; Synthetic Commun. 2005, 35, 145.
6. Donghong Li, Junsheng Hao, Bing Deng, Wei Guo, Fangjun Huo, Yongbing Zhang, Chizhong, Xia*; A Convenient Synthesis of 1-Tosyl-3,4-Dimethyl Imidazolium Salt and N,N,N1-Trisubstituted Ethylendiamine Derivatives; Synthetic Commun. 2004, 34, 3535.
5. Donghong Li, Junsheng Hao, Wei Guo*; A General and Efficient Method for Synthesis of Functionalized Ethylenediamine Derivatives; Heterocycles 2004, 63, 2515.
4. Wei Guo, Jing Wang, Jiaqi He, Zucheng Li, and Jin-Pei Cheng*; Polymethylene-bridged Cystine-glycine-containing Cyclopeptides as Hydrogen-bonding Electroneutral Anion Receptor: Design, Synthesis, and Halide Ion Recognition Research; Supramol. Chem. 2004, 16, 171.
3. Wei Guo, Jiaqi He, Zucheng Li, Jin-Pei Cheng*; Chain-like assembly of threonine-based cyclophanes through p-p interaction and C-H×××O hydrogen bond; Tetrahedron Lett., 2004, 45, 5763.
2. Wei Guo, Jing Wang, Jiaqi He, Chizhong Xia, and Jin-Pei Cheng*; Nicotinoyl Disubstituted Pseudo-Cyclopeptide: Synthesis and Coordination Behavior with Cu(II)”; Chemical Journal of Chinese University，2003, 24, 837.
1. Wei Guo, Jing wang, Chun Wang, Jiaqi He, Xiwen He, and Jin-Pei Cheng*; Design, synthesis, and enantiomeric recognition of dicyclodipeptide-bearing calix[4]arenas: a promising family for chiral gas sensor coatings; Tetrahedron Lett., 2002, 43, 5665.
联系方式
13934532998 (M)
0351-7198890 (O)
Email: guow@sxu.edu.cn
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发表于 2017-11-29 08:56:04
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