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赵美萍，北京大学教授。1968年生。1990年、1993年、2002年先后获北京大学理学学士、硕士和博士学位。1997-1998年，荷兰阿姆斯特丹大学环境与毒理化学系访问学者；1998年，荷兰能源研究机构环境分析部访问学者。
赵美萍
分析化学，教授，博士生导师
电话：62758153
电子信箱： mpzhao@pku.edu.cn
主讲课程：
1．定量化学分析
2．环境化学
出版教材：
《环境化学》（北京大学出版社，2005年9月）
研究领域和兴趣：
探索和构建新颖的分子识别体系，发展实时、在线的荧光分析方法，为生命科学研究、临床检验、环境监测和食品安全监控提供高效的分析测量手段。目前主要开展以下四个方向的研究工作：
(1) 单细胞内核酸修复酶的荧光成像方法；
(2) 低丰度基因突变的超高灵敏检测及其在临床检验中的应用；
(3) 新型功能化分子识别新材料的设计、合成和应用；
(4) 与脑科学相关的活性物质的在体、实时检测。
详细内容见课题组主页：
http://www.chem.pku.edu.cn/mpzhao
代表性论文：
1. TB Wu, YF Yang, W Chen, JY Wang, ZY Yang, SL Wang, XJ Xiao, MY Li, MP Zhao*, Noncanonical substrate preference of lambda exonuclease for 5'-nonphosphate-ended dsDNA and a mismatch-induced acceleration effect on the enzymatic reaction, Nucleic Acids Research, 2018, DOI: 10.1093/nar/gky154.
2. TB Wu, W Chen, ZY Yang, HC Tan, JY Wang, XJ Xiao, MY Li, MP Zhao*, DNA terminal structure-mediated enzymatic reaction for ultra-sensitive discrimination of single nucleotide variations in circulating cell-free DNA, Nucleic Acids Research, 2018, DOI: 10.1093/nar/gkx1218.
3. JT Dong, TB Wu, Y Xiao, L Chen, L Xu, MY Li*, MP Zhao*, Target-triggered transcription machinery for ultra-selective and sensitive fluorescence detection of nucleoside triphosphates in one minute, Biosensors and Bioelectronics, 2017, 100, 333.
4. XJ Xiao, TB Wu, L Xu, W Chen, MP Zhao*, A branch-migration based fluorescent probe for straightforward, sensitive and specific discrimination of DNA mutations, Nucleic Acids Research, 2017, 45 (10): e90.
5. JQ Zhai, YB Liu, S Huang, SM Fang, MP Zhao*, A specific DNA-nanoprobe for optically tracking the activities of human apurinic/apyrimidinic endonuclease 1 in living cells, Nucleic Acids Research, 2017, 45(6), e45.
6. L Chen, SM Fang, XJ Xiao*, B Zheng, MP Zhao*, Single-stranded DNA assisted Cell penetrating peptide−DNA conjugation strategy for intracellular imaging of nucleases, Analytical Chemistry, 2016, 88, 11306.
7. JT Dong, MP Zhao*, In-vivo fluorescence imaging of adenosine 5′-triphosphate, TrAC Trends in Analytical Chemistry, 2016, 80, 190.
8. XJ Xiao, TB Wu, FD Gu, MP Zhao*, Generation of artificial sequence-specific nucleases via preassembled inert-template,Chemical Science, 2016, 7, 2051.
9. SM Fang, L Chen, MP Zhao*, Unimolecular chemically modified DNA fluorescent probe for one-step quantitative measurement of the activity of human apurinic/ apyrimidinic endonuclease 1 in biological samples, Analytical Chemistry, 2015, 87, 11952.
10. YB Liu, SM Fang, JQ Zhai, MP Zhao*, Construction of antibody-like nanoparticles for selective protein sequestration in living cells, Nanoscale, 2015, 7, 7162.
11. TB Wu, XJ Xiao, Z Zhang, MP Zhao*, Enzyme-mediated single-nucleotide variation detection at room temperature with high discrimination factor, Chemical Science, 2015, 6, 1206.
12. X Su, C Zhang, XC Zhu, SM Fang, R Weng, XJ Xiao, MP Zhao*, Simultaneous fluorescence imaging of the activities of DNases and 3’ exonucleases in living cells with chimeric oligonucleotide probes, Analytical Chemistry, 2013, 85, 9939.
13. YB Liu, SS Wang, C Zhang, X Su, S Huang, MP Zhao*, Enhancing the selectivity of enzyme detection by using tailor-made nanoparticles, Analytical Chemistry, 2013, 85, 4853.
14. XJ Xiao, Y Liu, MP Zhao*, Endonuclease IV discriminates mismatches next to the apurinic/apyrimidinic site in DNA strands: Constructing DNA sensing platforms with extremely high selectivity, Chemical Communications, 2013, 49, 2819.
15. XJ Xiao, C Zhang, X Su, C Song, MP Zhao*, A universal mismatch-directed signal amplification platform for ultra-selective and sensitive DNA detection under mild isothermal conditions, Chemical Science, 2012, 3, 2257.
16. Q Pan, S Hong, XC Zhu, MP Zhao*, LP Lee*, On-line electrophoretic sample clean-up for sensitive and reproducible μCE immunoassay, Lab on a Chip, 2012, 12, 932.
17. XJ Xiao, C Song, C Zhang, X Su, MP Zhao*, Ultra-selective and sensitive DNA detection by a universal apurinic/ apyrimidinic probe-based Endonuclease IV signal amplification system, Chemical Communications, 2012, 48, 1964.
18. ZY Chen, L Xu, Y Liang, MP Zhao*, pH-Sensitive water-soluble nanospheric imprinted hydrogels prepared as horseradish peroxidase mimetic enzyme, Advanced Materials, 2010, 22, 1488.
19. Q Pan, MP Zhao*, SR Liu*, Combination of on-chip field amplification and bovine serum albumin sweeping for ultra-sensitive detection of green fluorescent protein, Analytical Chemistry, 2009, 81, 5333.
20. C Song, MP Zhao*, Real-time monitoring of the activity and kinetics of T4 polynucleotide kinase by a singly labeled DNA-hairpin smart probe coupled with l exonuclease cleavage, Analytical Chemistry, 2009, 81, 1383.
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发表于 2018-3-23 08:27:46
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