四川大学化学学院刘波

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刘波，1976年5月出生，男，四川大学化学学院教授，博士生导师。国家杰出青年基金获得者，1998年7月，在西南师范大学获理学学士学位；2001年，在中科院成都有机化学研究所，获理学硕士学位；2004年，在中科院上海有机化学研究所，获理学博士学位；2004年-2007年，在美国德克萨斯大学西南医学中心从事博士后研究。2007年6月至今，任职四川大学化学学院教授。主要奖项包括：教育部新世纪优秀人才支持计划（2009）、国家自然科学基金委优秀青年基金（2013）、Thieme Chemistry Journal Award (2014）、中国化学会维善天然产物合成奖（2015）、国家自然科学基金委杰出青年基金（2019）等。研究兴趣主要以有重要生理活性的多环复杂天然产物为合成目标，借助仿生合成策略，注重结合串联反应和一锅多组分反应，开展目标分子的高效全合成和相关合成方法学研究工作。在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Org. Lett.,Chem. Commun., Eur. J. Chem.等专业期刊上发表SCI论文60多篇。承担了国家自然科学基金、科技部“973”计划、教育部新世纪优秀人才支持计划等多个项目的研究工作。


刘 波
职称与职务  教 授、博士生导师、副院长
专      业  有机化学
电      话  028－85413712
E-Mail  chembliu@scu.edu.cn
简  历
1994.9.---1998.7.  在西南师范大学化学化工学院学习，环境学专业；获理学学士学位
1998.9.---2001.7.  在中科院成都有机化学研究所学习，有机合成专业，主要从事不对称催化反应研究；获理学硕士学位；导师：冯小明 研究员；蒋耀忠 研究员
2001.9.---2004.7.  在中科院上海有机化学研究所学习，有机合成专业，主要从事天然产物全合成研究；获理学博士学位；导师：周维善 研究员
2004.9.---2007.3.  在美国德克萨斯大学西南医学中心作博士后研究，主要从事过渡金属催化的反应研究及天然产物全合成；导师：Prof. Jef K. De Brabander
2007.6.---至今    四川大学化学学院从事教学和科研
主要研究方向
1. 具有重要生物活性的复杂天然产物全合成
2. 天然产物分子探针的生物学功能开发
3. 合成导向的反应方法学研究
4. 药物合成
科研项目
1．基于去芳香化/[5+2]  环加成策略的二萜及其类天然产物合成研究，国家自然科学基金面上项目（2017-2020）
2．具有重要药用价值的多环天然产物的高效合成，国家自然科学基金重大项目（2013-2017）。
3．瑞香烷型二萜Trigoxyphin A的全合成研究，国家自然科学基金面上项目（2012-2015），项目负责人。
4．具有重要生物活性的天然产物的化学合成，国家重点基础研究计划（科技部973计划， 2010-2014）。
5．四川大学优秀青年学者科研基金（B类），2011-2014。
6．天然产物Chlorahololide A（钾离子通道抑制剂）的全合成研究，国家自然科学基金面上项目（2009-2011），项目负责人。
7．教育部新世纪优秀人才支持计划（2009-2011）, 项目负责人。
8．抗真菌天然产物金粟兰内酯 A 的全合成研究，教育部留学回国人员基金（2009-2011），项目负责人。
9．抗结核天然产物 Hirsutellones A-F 的全合成研究，国家自然科学基金青年基金项目（2008-2010），项目负责人。
主要工作业绩
    完成了orostanal、palmerolide A、heliespirones A & C、cuevaene A、金粟兰内酯A&D、银线草内酯E、leucosceptroid B、bolivianine、crotobarin、shizukaol D和sarcandrolide J等天然产物在国际上的首次合成；完成了海洋天然产物Phorboxazoles的片段合成及Peloruside A的大环骨架的合成；同时，发展了贵金属催化炔烃的碳-杂原子键形成反应，以及碱性条件下缩酮的脱保护方法等。
    目前运用机理和构象分析为工具，结合前沿的串联反应、原子经济性、氧化-还原经济性、步骤经济性、无保护基合成、集合合成和可放大合成等高效策略，重点围绕以萜类为主的多环复杂天然产物开展工作。
    截止2017年5月，在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Org. Lett.,Chem. Commun., Eur. J. Chem.等专业期刊上发表SCI论文50多篇。一些研究成果被评选为Org. Lett.和J. Am. Chem. Soc.的most read articles, 被收录进入化学专业网站 Organic Chemistry Highlights，被化学博客brsmbog.com和chemblogs.net以及专业评述性杂志Synfacts收录和正面评价，被化学专业微信平台X-MOL报导。
  课题组成立以来，完成全合成的部分天然产物结构如下（2010-现在）：
获得奖励
教育部新世纪优秀人才支持计划（2009）
国家自然科学基金委优秀青年基金（2013）
Thieme Chemistry Journal Award 2014
ACP Lectureship Awards to Japan & Malaysia (2014)
ACP Lectureship Awards to Taiwan (2015)
中国化学会维善天然产物合成奖（2015）
ACP Lectureship Awards to Singapore (2016)
代表性成果 （获奖成果、专著、论文、专利）
论著目录：
1. Heping Deng, Wei Cao, Rong Liu, Yanhui Zhang, and Bo Liu*, Asymmetric Total Synthesis of Hispidanin A, Angew. Chem. Int. Ed., 2017, 56, 5849-5852.
Selected as Hot paper
Highlighted by AdvancedScienceNews
2. Changchun Yuan, Biao Du, Heping Deng, Yi Man, Bo Liu*, Total Synthesis of Sarcandrolide J and Shizukaol D: Lindenane Sesquiterpenoid [4+2] Dimers, Angew. Chem. Int. Ed., 2017, 56, 637-640.
Highlighted by Synfacts (2017, 227)
Selected as Synfact of the month
Highlighted by X-MOL
Highlighted by Chin. J. Org. Chem.（有机化学，2017, 37, 774）
3. Liqiang Song, Guili Zhu, Yongjiang Liu, Bo Liu*, Song Qin, Total Synthesis of Atisane-type Diterpenoids: Application of Diels-Alder Cycloadditions of Podocarpane-type Unmasked ortho-Benzoquinones, J. Am. Chem. Soc.2015, 137, 13706-13714.
Highlighted by Synfacts (2016, 6)
Highlighted by X-MOL
4. Changchun Yuan, Biao Du, Li Yang, Bo Liu* Bioinspired Total Synthesis of Bolivianine: A Diels-Alder/ Intramolecular Hetero-Diels-Alder Cascade Approach, J. Am. Chem. Soc. 2013, 135, 9291-9294.
One of Most Read Articles in J. Am. Chem. Soc.
Highlighted by Synfacts (2013, 915)
Selected as Synfact of the month
Highlighted by Chin. J. Org. Chem.（有机化学，2013, 33, 2028）
Highlighted by RSC/Chemistry World (2013-06-27)
5. Xuan Huang, Liqiang Song, Jiao Xu, Guili Zhu, Bo Liu* Asymmetric Total Synthesis of Leucosceptroid B, Angew. Chem. Int. Ed.  2013, 52,   952-955.
Highlighted by Synfacts (2013, 246)
Highlighted by Chin. J. Org. Chem.（有机化学，2013, 33, 654）
6. Yan-Hui Zhang, Rong Liu, Bo Liu*, Total Synthesis of Nannocystin Ax, Chem. Commun., 2017, 53, 5549-5552.
7. Yang Yang, Jinpeng Li, Biao Du, Changchun Yuan, Bo Liu*, Song Qin*,   An Entry to Vinylcyclopropane through Palladium-catalyzed Intramolecular Cyclopropanation of Alkenes with Unstabilized Allylic tosylhydrazones, Chem.  Commun.2015, 51, 6179-6182.
l Highlighted by Synfacts (2015, 744)
8. Biao Du, Changchun Yuan, Tianzi Yu, Li Yang, Yang Yang, Bo Liu*, Song Qin* Asymmetric Total Synthesis of Onoseriolide, Bolivianine and Isobolivianine, Chem. Eur. J.2014, 20, 2613-2622.
9. Guizhou Yue, Li Yang, Changchun Yuan, Xiaoling Jiang, Bo Liu* Total synthesis of chloranthalactone A, Org. Lett.2011, 13, 5406-5408.
One of Most Read Articles in Org. Lett.
Highlighted by Organic Chemistry Highlights (2012-12-31)
Highlighted in brsmblog.com and chemblogs.net
10. Mingzheng Huang, Liqiang Song, Bo Liu* Construction of the Cyclophane Core of
    the Hirsutellones via a RCM Strategy, Org. Lett.2010, 12, 2504-2507.
11. Chong Huang, Bo Liu* Asymmetric total synthesis ent-heliespirones A & C, Chem. Commun.2010, 46, 5280-5282
12. Guili Zhu, Bo Liu*, Synthesis of derivatives of podocarpane-type diterpenoids through Diels-Alder cycloaddition and photo-decarbonylation from unmasked ortho-benzoquinone, Tetrahedron, 2017, DOI: 10.1016/j.tet.2017.02.032.
13. Guili Zhu, Sachin B. Wadavrao, Bo Liu*, Divergent total synthesis of atisane-type diterpenoids, Chem. Rec., in press, DOI: 10.1002/tcr.201600096.
14. Zhijiang Zhang, Bo Liu*, Total synthesis and confirmation of the revised structures of jiangrines A, C and D, Org. Biomol. Chem., 2017, 15, 207-212.
15. Jinpeng Li, Changchun Yuan, Biao Du, Bo Liu*,   An Alternative Total Synthesis of Bolivianine  , Chin. Chem. Lett.2017, 28, 113-116.
16. Zhijiang Zhang, Bo Liu*, Total Synthesis of Proposed Structures of Jiangrines C and D, Sci. Chin. Chem.  2016,  59, 1205-1210.
17. Hongli Yin, Zhe Meng, Bo Liu*,   Construction of the Core Structure of Trichotomone  , Synthesis, 2016,48, 3951-3956.
18. Heping Deng, Wei Cao, Zhijiang Zhang, Bo Liu*, Asymmetric Synthesis and Absolute Stereochemistry of A Labdane-type Diterpenoid Isolated from the Rhizomes of Isodan yuennanensis, Org. Biomol. Chem.2016, 14, 6225-6230.
19. Li Yang, Liqiang Song, Chong Huang, Mingzheng Huang, Bo Liu*, Exploiting Ortho- Substitution Effect on Formation of Oxygen-containing [10]Paracyclophane through Ring-Closing Metathesis, Org. Chem. Front.2016, 3, 319-323.
20. Rong Liu, Jing Feng, Bo Liu*, Synthetic Progress of Daphnane-type Diterpenoids, Acta Chim. Sinica2016, 74, 24-43.
21. Tianzi Yu, Bo Liu*, Asymmetric Total Synthesis of 3-Furanoeudesmene, A Metabolite from Antarctic Gorgonian and Determination of Its Absolute Configuration, Chin. J. Org. Chem.2015, 35, 2157-2161.
22. Jiao Xu, Bo Liu* Total synthesis of norleucosceptroids F and G, Chin. Chem. Lett. 2015, 26, 1341–1344.
23. Guili Zhu, Rong Liu, Bo Liu*, Total Synthesis of Atisane-type   Diterpenoids and Related Diterpenoid Alkaloids  , Synthesis2015, 47, 2691-2708. (Invited review)
24. Li Yang, Jing Feng, Jinpeng Li, Bo Liu*, Total synthesis of heliespirone B, Tetrahedron Lett.2015, 56, 4931-4933.
25. Liqiang Song, Chong Huang, Mingzheng Huang, Bo Liu*, Toward the synthesis of hirsutellone B via an intramolecular Diels-Alder /ketene-trapping strategy, Tetrahedron2015, 71, 3602-3607.
26. Jing Feng, Bo Liu*, Formal Carbo [3+3] Annulation and Its Application in Organic Synthesis, Tetrahedron Lett.2015, 56, 1474-1485.
27. Li Yang, Guizhou Yue, Changchun Yuan, Biao Du, Heping Deng, Bo Liu*, Synthetic Studies toward Lindenane-Type Sesquiterpenoid Dimers, Synlett2014, 25, 2471-2474.
28. Hai Tong, Bo Liu*, A   Diels-Alder Approach toward the scaffolds of   Polycyclic sesquiterpenoids with 2-Pyrone, Synlett2014, 25, 681-686.
29. Biao Du, Changchun Yuan, Langzhong Zhang, Li Yang, Bo Liu* Deprotection of 1,3-Oxathiolanes to Ketones Promoted by Base, Tetrahedron Lett.2013, 54,   2217-2220  .
30. Guizhou Yue, Xuan Huang, Bo Liu* Progress in the Total Synthesis of trans-Hydrindane- Containing Terpenoids, Chin. J. Org. Chem. 2013, 33, 1167-1185.
31. Jing Feng, Guili Zhu, Bo Liu*, Xiangdong Zhou* Expedient Synthesis of (R)-Curcuphenol: A Chiral Pool Strategy, Chin, J. Chem.2013, 31, 23-26.
32. Guizhou Yue, Li Yang, Changchun Yuan, Biao Du, Bo Liu* Progress in Total Syntheses of Lindenane-type Sesquiterpenoids and Their Dimers, Chin. J. Org. Chem. 2013, 33, 90-100.
33. Hang Su, Ting Zhou, Bo Liu* Total Synthesis of (±)-Spirobenzofuran, Synlett2013, 615-618.
34. Changchun Yuan, Li Yang, Biao Du, Bo Liu* A Base-promoted deprotection of 1,3-dioxolanes to ketones, Tetrahedron Lett.2012, 53, 6972-6976.
35. Guizhou Yue, Li Yang, Changchun Yuan, Biao Du, Bo Liu* Total Syntheses of Lindenane- type Sesquiterpenoids: (±)-Chloranthalactones A, B, F, (±)-9-Hydroxy Heterogorgiolide and (±)-Shizukanolide E, Tetrahedron, 2012, 68, 9624-9637.
36. Ting Zhou, Guili Zhu, Xuan Huang, Bo Liu* Zeise’s dimmer-catalyzed regioselective hydration of homopropargyl tertiary ether, Tetrahedron Lett.2012, 53, 4955-4958
37. Yongjiang Liu, Chong Huang, Bo Liu* Asymmetric total syntheses of heliannuol E and epi-heliannuol E, Tetrahedron Lett.2011, 52, 5802-5804.
38. Chong Huang, Wenhan Zhang, Bo Liu* Racemic and enantioselective total synthesis of heliespirones A & C, Sci. China. Chem.2011, 54, 43-55.
39. Daxing Yang, Jianfeng Huang, Bo Liu* Platinum-Catalyzed Regioselective Formation of β-Alkoxy Ketones from Internal Alkynes, Eur. J. Org. Chem.2010, 4185-4188.
40. Jianfeng Huang, Xuan Huang, Bo Liu* Gold-catalyzed synthesis of nitrogen-containing heterocycles from ε-N-protected propargylic esters, Org. Biomol. Chem. 2010, 8, 2697-2699.
41. Yunxiu Chen, Jianfeng Huang, Bo Liu* Total syntheses of the proposed structures of cuevaene A, Tetrahedron Lett.2010, 51, 4655-4657.
42. Mingzheng Huang, Chong Huang, Bo Liu* Studies toward the total synthesis of the hirsutellones, Tetrahedron Lett. 2009, 50, 2797-2800.
43. Jef K. De Brabander*, Bo Liu, Mingxing Qian Au(I)- and Pt(II)-Catalyzed Cycloetherification of ω-Hydroxy Propargylic Esters, Org. Lett. 2008, 10, 2533.
44. Xin Jiang, Bo Liu, Sylvain Lebreton, Jef K. De Brabander* Total Synthesis and Structure Revision of the Marine Metabolite Palmerolide A, J. Am. Chem. Soc.2007, 129, 6386. (One of the Most-Accessed Articles in 2007）
45. Bo Liu, Jef K. De Brabander* Metal-Catalyzed Regioselective Oxy-Functionalization of Internal Alkynes: An Entry into Ketones, Acetals, and Spiroketals, Org. Lett.2006, 8, 4907.
46. De-Run Li, Dong-Hui Zhang, Cai-Yun Sun, Ji-Wen Zhang, Li Yang, Jian Chen, Bo Liu, Ce Su, Wei-Shan Zhou*, Guo-Qiang Lin* Total Synthesis of Phorboxazole B, Chem. Eur. J.2006, 12, 1185.
47. Bo Liu, Wei-Shan Zhou* Towards the total synthesis of natural peloruside A: stereoselective synthesis of the backbone of the core, Org. Lett.2004, 6, 71.
48. Bo Liu, Wei-Shan Zhou*, Stereoselective synthesis of the C21-C27 fragment of the phorboxazoles, Tetrahedron Lett.2003, 44, 4933.
49. Bo Liu, Wei-Shan Zhou* The first stereoselective synthesis of orostanal, a novel abeo-sterol inducing apoptosis in leukemia cells, Tetrahedron2003, 59, 3379.
50. Zhigang Jiao, Xiaoming Feng * , Bo Liu , Fuxue Chen, Guolin Zhang, Yaozhong Jiang, Enantioselective Strecker reactions between aldimines and trimethylsilyl cyanide promoted by chiral N,N’51. Bo Liu, Wei-Shan Zhou* The first stereoselective synthesis of orostanal, a novel abeo-sterol inducing apoptosis in leukemia cells, Tetrahedron Lett.2002, 43, 4187.
52. Bo Liu, Xiaoming Feng*, Fuxue Chen, Guolin Zhang, Xin Cui, Yaozhong Jiang, Enantioselective Strecker reaction promoted by chiral N –oxides, Synlett2001, 1551.
53. 获准美国专利一项：Jef K. De Brabander, Xin Jiang, Bo Liu，Palmerolides: Methods of preparation and derivatives thereof, US patent, US2008249162-A1; WO2008124072-A1; TW200906387-A; US7838691-B2.