天津大学化工学院仰大勇

xianghong

仰大勇 博士，天津大学化工学院教授、院长助理，入选国家级海外人才计划、国家优青、天津市杰青。现任天津大学校学术委员会委员、中国生物医学工程学会纳米医学与工程分会委员。课题组研究方向是材料化学与生物医学的交叉领域，聚焦DNA合成与智能制造，利用材料化学的手段理解生命系统运行机制，探索重大疾病的诊断治疗新途径。

仰大勇
现任职称/职务：教授/博士生导师
通讯地址：天津市津南区海河教育园天津大学54教-E328
电子邮箱：dayong.yang@tju.edu.cn
办公电话：
研究方向:
研究方向：
1）DNA功能高分子
2）疾病诊断/食品安全检测
3）无细胞合成生物学

人才称号：
国家优青、国家青年##、天津市青年##、天津大学“北洋学者-海外杰出青年人才”

在研项目：
1）国家自然科学基金“优秀青年基金”
2）国家自然科学基金“面上项目”
3）中组部“国家青年##计划”启动基金
4）天津大学“北洋学者-海外杰出青年人才”启动基金
5）天津市自然科学基金


硕士、博士招生（生物工程系，生物化工、合成生物学、食品科学专业）
欢迎具有化学化工、高分子、生物学习背景的同学报考（含免试保送研究生），请将个人信息发送至dayong.yang@tju.edu.cn。


博士后招聘
岗位描述：开展DNA分子工程、超细纤维、疾病检测诊断、体外生物合成、人工合成细胞等相关领域的研究工作。
岗位要求：具有与岗位相关的研究经历与技能；责任心、事业心、进取心强；身心健康、待人友善、具有团队精神；有较好的研究经验与论文发表记录。
待遇：薪资按天津大学博士后标准执行，业绩突出有额外奖励。
申请方式：请将个人详细简历（包括教育经历、文章发表情况、推荐人信息、个人联系方式等）发送至dayong.yang@tju.edu.cn。

发表论文

51) Xiaocui Guo+, Feng Li+, Lihui Bai, Wenting Yu, Xue Zhang, Yi Zhu, Dayong Yang*. Gene Circuit Compartment on Nano-interface Facilitates Cascade Gene Expression. Journal of the American Chemical Society, 2019.

50) Yuhang Dong+, Chi Yao+, Zhi Wang, Dan Luo, Dayong Yang*. Target-triggered polymerization of branched DNA enables enzyme-free and fast discrimination of single-base changes. iScience, 2019.

49) Feng Li+, Jianpu Tang+, Jinhui Geng, Dan Luo, Dayong Yang*. Polymeric DNA Hydrogel: Design, Synthesis and Applications. Progress in Polymer Science, 2019.

48) Feng Li+, Wenting Yu+, Xue Zhang, Xiaocui Guo, Xihan Xu, Xiaolei Sun, Dayong Yang*. Preparation of Biomimetic Gene Hydrogel via Polymerase Chain Reaction for Cell-Free Protein Expression. SCIENCE CHINA Chemistry, 2019.

47) Huaixin Zhao+*, Gang Shu+, Jinye Zhu, Yanyan Fu, Zi Gu, Dayong Yang*. Persistent Luminescent Metal-Organic Frameworks with Long-Lasting Near Infrared Emission for Tumor Site Activated Imaging and Drug Delivery. Biomaterials, 2019. DOI: 10.1016/j.biomaterials.2019.119332

46) Jie Zhang+, Yuhang Dong+, Wenfeng Zhu, Dan Xie, Yuliang Zhao, Dayong Yang*, and Min Li*. Ultra-sensitive Detection of Circulating Tumor DNA of Lung Cancer via Enzymatically Amplified SERS Based Frequency Shift Assay. ACS Applied Materials & Interfaces, 2019. DOI: 10.1021/acsami.9b02953.

45) Lihui Bai+, Xiaocui Guo+, Xue Zhang, Wenting Yu, Dayong Yang*. Saccharides create crowding environment for gene expression in cell-free systems. Langmuir, 2019. DOI: 10.1021/acs.langmuir.8b03744.

44) Xiaocui Guo, Lihui Bai, Feng Li, Wilhelm Huck, Dayong Yang*. Branched DNA architectures via PCR‐based assembly as gene compartment for cell‐free gene expression reactions. ChemBioChem, 2019. DOI: 10.1002/cbic.201900094.

43) Ye Yuan, Zi Gu, Chi Yao, Dan Luo*, Dayong Yang*. Nucleic acid-based functional nanomaterials as advanced cancer therapeutics. Small, 2019. DOI: 10.1002/smll.201900172.

42) Jiaojiao Zhang+, Feng Li+, Dayong Yang*. DNA: From carrier of genetic information to polymeric materials. Transactions of Tianjin University, 2019. DOI: 10.1007/s12209-019-00188-w.

41) Jinpeng Han, Likun Xiong, Xingyu Jiang, Xiaoyan Yuan*, Yong Zhao*, Dayong Yang*. Bio-functional electrospun nanomaterials: from topology design to biological applications. Progress in Polymer Science, 2019, 9, 1-28. DOI: 10.1016/j.progpolymsci.2019.02.006.

40) Ke Meng+, Chi Yao+, Qianmin Ma, Zhaohui Xue, Yaping Du, Wenguang Liu, Dayong Yang*. A reversibly responsive fluorochromic hydrogel based on lanthanide-mannose complex. Advanced Science, 2019, 1802112. DOI: 10.1002/advs.201802112.

39) Chi Yao+, Ye Yuan+, Dayong Yang*. Magnetic DNA nanogels for targeting delivery and multistimuli-triggered release of anticancer drugs. ACS Applied Bio Materials, 2018, 1, 2012–2020. DOI: 10.1021/acsabm.8b00516.

38) Yang Liu, Dayong Yang*. Cell lysates and egg white create homeostatic microenvironment for gene expression in cell-free system. Synthetic and Systems Biotechnology, 2018, 3, 211-216. DOI: 10.1016/j.synbio.2018.10.004. WOS: 000451425500001.

37) Jinpeng Han+, Chenyu Liang+, Yuchen Cui, Likun Xiong, Xiaocui Guo, Xiaoyan Yuan, Dayong Yang*. Encapsulating microorganisms inside electrospun microfibers as a living material enables room-temperature storage of microorganisms. ACS Applied Materials & Interfaces, 2018, 10, 38799-38806. DOI: 10.1021/acsami.8b14978. WOS: 000451100500015.

36) Qianmin Ma+, Feng Li+, Jianpu Tang, Ke Meng, Xihan Xu, Dayong Yang*. Luminescent ultralong microfiber prepared via supramolecular self-assembly of lanthanide and thymidine in water. Chemistry - A European Journal, 2018, 24, 18890-18896. DOI: 10.1002/chem.201804785.

35) Linxiu Cheng+, Zhikun Zhang+, Duo Zuo, Wenfeng Zhu, Jie Zhang, Qingdao Zeng*, Dayong Yang*, Min Li*, Yuliang Zhao. Ultrasensitive detection of serum microRNA using branched-DNA based SERS platform combining simultaneous detection of α-fetoprotein for early diagnosis of liver cancer. ACS Applied Materials & Interfaces, 2018, 10, 34869-34877. DOI: 10.1021/acsami.8b10252. WOS: 000447954600008.

34) Feng Li*, Dayong Yang, Huaping Xu*. Nonmetal heteroatom doped carbon dots: synthesis and property. Chemistry-A European Journal, 2018, 24, 1–13. DOI:10.1002/chem.201802793.

33) Yi Jiao, Yang Liu, Dan Luo, Wilhelm T. S. Huck, Dayong Yang*. Microfluidic assisted fabrication of clay microgels for cell-free protein synthesis. ACS Applied Materials & Interfaces, 2018, 10, 29308-29313. DOI: 10.1021/acsami.8b09324. WOS: 000444355700011.

32) Feng Li+, Yuhang Dong+, Zhikun Zhang+, Man Lv+, Zhi Wang, Xinhua Ruan, Dayong Yang*. A recyclable biointerface based on cross-linked branched DNA nanostructures for ultrasensitive nucleic acid detection. Biosensors and Bioelectronics, 2018, 117, 562-566. DOI: 10.1016/j.bios.2018.06.053. WOS: 000442191900069. .

31) Feng Li+, Yiye Li+, Xiao Yang, Xuexiang Han, Yang Jiao, Taotao Wei, Dayong Yang, Huaping Xu*, Guangjun Nie*. Highly fluorescent chiral N-S-doped carbon dots from cysteine affect cellular energy metabolism. Angewandte Chemie International Edition, 2018, 57, 2377-2382. DOI: 10.1002/anie.201712453. WOS: 000425453300016.

30) Lu Yang+, Chi Yao+, Feng Li, Yuhang Dong, Zhikun Zhang, and Dayong Yang*. Synthesis of branched DNA scaffolded super-nanoclusters with enhanced antibacterial performance. Small, 2018, 14, 1800185. DOI: 10.1002/smll.201800185. WOS: 000430398600028.

29) Renkuan Liao, Peiling Yang, Wenyong Wu, Dan Luo*, Dayong Yang*. A DNA tracer system for hydrological environment investigations. Environmental Science & Technology, 2018, 52, 1695-1703. DOI: 10.1021/acs.est.7b02928. WOS: 000426143300004.

28) Man Lv+, Yang Liu+, Jinhui Geng, Xiaohong Kou, Zhihong Xin, Dayong Yang*. Engineering nanomaterials-based biosensors for food safety detection. Biosensors and Bioelectronics, 2018, 106, 122-128. DOI: 10.1016/j.bios.2018.01.049. WOS: 000427209700019.

27) Jinhui Geng+, Chi Yao+, Xiaohong Kou+, Jianpu Tang, Dan Luo and Dayong Yang*. A fluorescent bio-functional DNA hydrogel prepared by enzymatic polymerization. Advanced Healthcare Materials, 2017, 7, 1700998. DOI: 10.1002/adhm.201700998. WOS: 000426758500019.

26) Zhikun Zhang+, Yang Liu+, Peifeng Liu, Lu Yang, Xingyu Jiang, Dan Luo, Dayong Yang*. Non-invasive detection of gastric cancer relevant D-amino acids with luminescent DNA/silver nanoclusters. Nanoscale, 2017, 9, 19367-19373. DOI: 10.1039/c7nr07337b. WOS: 000418098000044.

25) Yang Liu+, Xiaocui Guo+, Jinhui Geng, Yi Jiao, Jinpeng Han, Zhikun Zhang, Xiao Zhou, Dayong Yang*, in vitro synthetic biology: cell-free protein synthesis. Chinese Science Bulletin, 2017, 62, 3851-3860. DOI: 10.1360/N972017-00419. CSCD:6145720.

24) Dayong Yang, Mark Hartman, Thomas Derrien, Shogo Hamada, Duo An, Kenneth Yancey, Ru Cheng, Dan Luo*, DNA materials: bridging nanotechnology and biotechnology. Accounts of Chemical Research, 2014, 47, 1902-1911. DOI: 10.1021/ar5001082. WOS: 000337645100029.

23) Dayong Yang*, Chuanying Xu, Songming Peng, Jinhui Cui, Yan Yu, Wei Han, Haixin Cui, Dan Luo*, Molecular design, synthesis and applications of DNA hydrogel, Chinese Science Bulletin, 2014, 2, 107-115. DOI: 10.1360/972013-384. CSCD:5061347.

22) Dayong Yang, Songming Peng, Mark Hartman, Tiffany Gupton-Campolongo, Edward J. Rice, Anna Kathryn Chang, Zi Gu, G.Q. (Max) Lu, Dan Luo*, Enhanced transcription and translation in clay hydrogel environment and implications for early life evolution, Scientific Reports, 2013, 3, 3165-3170. DOI: 10.1038/srep03165. WOS: 000326618400009.

21) Mark R. Hartman+, Dayong Yang+ (Co-first author), Thua N. N. Tran, Kwang Lee, Jason S. Kahn, Pichamon Kiatwuthinon, Kenneth G. Yancey, Oleksandr Trotsenko, Sergiy Minko, Dan Luo* Thermostable branched DNA nanostructures as modular primers for polymerase chain reaction, Angewandte Chemie International Edition, 2013, 52, 8699-8702. DOI: 10.1002/anie.201302175. WOS: 000322835700045.

20) Thua N. N. Tran, Jinhui Cui, Mark R. Hartman, Songming Peng, Hisakage Funabashi, Faping Duan, Dayong Yang, John C. March, John T. Lis, Haixin Cui, Dan Luo*, A universal DNA-based protein detection system, Journal of the American Chemical Society, 2013, 135, 14008-14011. DOI: 10.1021/ja405872g. WOS: 000330162900003.

19) Jong Bum Lee+, Songming Peng+, Dayong Yang, Young Hoon Roh, Hisakage Funabashi, Nokyoung Park, Edward J. Rice, Liwei Chen, Rong Long, Mingming Wu, Dan Luo*, A mechanical metamaterial made from a DNA hydrogel, Nature Nanotechnology, 2012, 7, 816-820. DOI: 10.1038/NNANO.2012.211. WOS: 000312003700017.

18) Mengmeng Li, Yunze Long*, Dayong Yang, Jiashu Sun, Hongxing Yin, Zhili Zhao, Wenhao Kong, Xingyu, Jiang*, Zhiyong Fan, Fabrication of one dimensional superfine polymer fibers by double-spinning, Journal of Materials Chemistry, 2011, 21, 13159-13162. DOI: 10.1039/c1jm12240a. WOS: 000294176600006.

17) Michael J. Campolongo, Jason S. Kahn, Wenlong Chen, Dayong Yang, Tiffany Gupton-Campolongo, Dan Luo, Adaptive DNA-based materials for switching, sensing, and logic devices, Journal of Materials Chemistry, 2011, 21, 6113-6121. DOI: 10.1039/c0jm03854g. WOS: 000289524300001.

16) Dayong Yang, Michael J. Campolongo, Thua Nguyen Nhi Tran, Roanna C. H. Ruiz, Jason S. Kahn, Dan Luo, Novel DNA materials and their applications, Wiley Interdisciplinary Reviews: Nanomedicine- and Nanobiotechnology, 2010, 2, 648-669. DOI: 10.1002/wnan.111. WOS: 000283387000006.

15) Xing Liu, Dayong Yang*, Gang Jin, Hongwei Ma*, Nanofibrous membrane with tunable surface chemistry: preparation and application in protein microarrays, Journal of Materials Chemistry, 2010, 20, 10228-10233. DOI: 10.1039/c0jm01409e. WOS: 000284067200023.

14) Ying Zhu, Dayong Yang*, Hongwei Ma*, One-step fabrication of porous polymeric microcage via electrified jetting, Nanoscale, 2010, 2, 910-912. DOI: 10.1039/c0nr00081g. WOS: 000278588300010.

13) Mengmeng Li, Dayong Yang*, Yunze Long, Hongwei Ma*, Arranging junctions for nanofibers, Nanoscale, 2010, 2, 218-221. DOI: 10.1039/b9nr00212j. WOS: 000275577100005.

12) Yu Jin, Dayong Yang*, Dongyang Kang, Xingyu Jiang*, Fabrication of necklace-like structures via electrospinning, Langmuir, 2010, 26, 1186-1190. DOI: 10.1021/la902313t. WOS: 000273403400078.

11) Mengmeng Li, Ying Zhu, Dayong Yang*, Xingyu Jiang, Hongwei Ma, Progress in applications of electrospun nanofibrous membranes, Polymer Bulletin, 2010, 9, 42-51. DOI:10.14028/j.cnki.1003-3726.2010.09.005. CSCD:3991269.

10) Lina Zhao, Dayong Yang, Mingdong Dong, Ting Xu, Yu Jin, Sailong Xu*, Fazhi Zhang, David G. Evans, Xingyu Jiang, Fabrication and wettability of colloidal layered double hydroxide-containing PVA electrospun nanofibrous mats, Industry and Engineering Chemistry Research, 2010, 49, 5610-5615. DOI: 10.1021/ie902037z. WOS: 000278416800017.

9) Pengfei Zhang, Dayong Yang, Zhong Li and Hongwei Ma*, Controlled wrinkle formation via bubble inflation strain engineering, Soft Matter, 2010, 6, 4580-4584. DOI: 10.1039/c0sm00298d. WOS: 000281613700040.

8) Dayong Yang, Xing Liu, Yu Jin, Ying Zhu, Dongdong Zeng, Xingyu Jiang*, Hongwei Ma*, Electrospinning of poly(dimethylsiloxane)/poly(methyl methacrylate) nanofibrous membrane: fabrication and application in protein microarrays, Biomacromolecules, 2009, 10, 3335-3340. DOI: 10.1021/bm900955p. WOS: 000272561800022.

7) Zhong Li, Dayong Yang*, Xing Liu, Hongwei Ma*, Substrate induced controllable wrinkling for facile nanofabrication, Macromolecular Rapid Communications, 2009, 30, 1549-1553. DOI: 10.1002/marc.200900284. WOS: 000270330100005.

6) Yingyi Liu, Dayong Yang*, Tao Yu, Xingyu Jiang*, Incorporation of electrospun nanofibrous PVDF membranes into a microfluidic chip assembled by PDMS and scotch tape for immunoassays, Electrophoresis, 2009, 30, 3269-3275. DOI: 10.1002/elps.200900128. WOS: 000270446200022.

5) Dayong Yang, Yang Wang, Dongzhou Zhang, Yingyi Liu, Xingyu Jiang*, The control of the morphology of micro/nano-structures of polycarbonate via electrospinning, Chinese Science Bulletin, 2009, 54, 2911-2917. DOI: 10.1007/s11434-009-0241-0. WOS: 000269529800001.

4) Dayong Yang, Xin Niu, Xuan Gu, Yang Wang, Yingyi Liu, Xingyu Jiang*, Electrospun nanofibrous membrane: a novel solid substrate for microfluidic immunoassays for HIV, Advanced Materials, 2008, 20, 4770-4775. DOI: 10.1002/adma.200801302. WOS: 000262292200024.

3) Dayong Yang, Bo Lu, Yong Zhao, Xingyu Jiang*, Fabrication of aligned fibrous arrays by magnetic electrospinning, Advanced Materials, 2007, 19, 3702-3706. DOI: 10.1002/adma.200700171. WOS: 000250992000053.

2) Yangfei Zhang, Shulin Bai*, Dayong Yang, Zhong Zhang, Sharon Kao-Walter, Study on the viscoelastic properties of the epoxy surface by means of nanodynamic mechanical analysis, Journal of Polymer Science: Part B: Polymer Physics, 2007, 46, 281-288. DOI: 10.1002/polb.21365. WOS: 000252906000007.

1) Dayong Yang, Qinxi Liu, Xiaolin Xie*, Fandi Zeng, Structure and thermal properties of exfoliated PVC/layered silicate nanocomposites via in situ polymerization, Journal of Thermal Analysis and Calorimetry, 2006, 84, 355-359. DOI: 10.1007/s10973-005-6936-9. WOS: 000237436900008

wangfei

近期，天津大学化工学院仰大勇教授联合天津大学材料学院袁晓燕教授、北京航空航天大学赵勇教授和国家纳米科学中心蒋兴宇研究员在高分子领域权威综述期刊《Progress in Polymer Science》（IF=24.558）上发表了题为“Bio-functional electrospun nanomaterials: from topology design to biological applications”的综述论文，系统评述了生物功能电纺纳米材料领域的最新进展。论文第一作者为天津大学化工学院博士生韩金鹏。该工作在国家自然科学基金资助下完成。

  生物功能高分子材料广泛应用于生物医学领域，其中静电纺丝是制备生物功能高分子材料最简单、最直接的技术之一。早期电纺材料主要是聚合物，形貌主要是纤维。在过去的二十年中，科研人员在选材和形貌方面都取得了很多进展，制备了包括金属、金属氧化物、碳材料和有机/无机复合材料的静电纺丝，以及制造了珠、管以及多级结构等纤维之外的更多拓扑结构。还探索了多种有前景的应用，主要包括生物医学、能源、催化、环境和机械增强，其中一半以上专注于生物医学应用。比如，设计电纺纳米材料以模拟细胞外基质的结构特征，用于细胞生长和营养物转运；封装或附着有生物活性分子和药物的电纺纳米材料可用于分子递送；由于高孔隙率和大比表面积，它们还可以用于医学诊断以增强特异性、灵敏度和信号转导能力。此外，电纺纳米材料可以组装成各种有趣的仿生结构。所有这些特点使得静电纺丝成为制造生物功能纳米材料的有力工具，并应用于涉及人类健康的一系列生物医学应用，主要包括组织工程、伤口愈合、药物/生物活性分子递送、医学诊断和仿生学。

  作者结合自身的研究对电纺纳米材料拓扑结构进行分类，制作了一张 “拓扑结构周期表”，根据内在逻辑关系分为三类：个体、杂化体和组装体；对该领域进行简洁明了的总结，为研究者提供有价值的参考，以便针对特殊应用功能选择特定拓扑结构和相应制造策略；深入系统地讨论了各类拓扑结构在生物医学应用中的最新进展，阐明材料结构与功能和应用之间的关系；最后，指出领域存在的挑战和未来发展方向。

  论文链接：https://doi.org/10.1016/j.progpolymsci.2019.02.006